| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chen Fu, Xinyang Zhang, Zixiu Zeng, Yang Tian, Xianglan Jin, Fengli Wang, Zhenmin Xu, Baoxin Chen, Hong Zheng, Xuemei Li. Neuroprotective Effects of Qingnao Dripping Pills Against Cerebral Ischemia Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32153398. |
studies have shown that in cerebral ischemia, nod-like receptor family pyrin domain containing 3 (nlrp3) inflammasome is a key mediator in mediating inflammatory responses and results in activation of apoptosis signaling pathways. |
2020-09-28 |
2023-08-13 |
Not clear |
| b' Ang\\xc3\\xa9lique Chevriaux, Thomas Pilot, Valentin Derang\\xc3\\xa8re, Harmonie Simonin, Pierre Martine, Fanny Chalmin, Fran\\xc3\\xa7ois Ghiringhelli, C\\xc3\\xa9dric R\\xc3\\xa9b\\xc3\\xa. Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32328491.' |
it is well established that oligomerized nlrp3 interacts with apoptosis associated speck-like protein containing a card domain (asc) which polymerizes into filaments recruiting procaspase-1, leading to its activation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ji Eun Park, Heaji Lee, Hyunkyung Rho, Seong Min Hong, Sun Yeou Kim, Yunsook Li. Effect of Antioxidants (Basel, Switzerland). vol 9. issue 6. 2020-09-28. PMID:32471242. |
especially, hyperglycemia causes hyper-inflammation through activation of nlrp3 inflammasome, which can lead to cell apoptosis, hypertrophy, and fibrosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xiaoying Lin, Tiejuan Shao, Lin Huang, Xianghui Wen, Mingzhu Wang, Chengping Wen, Zhixing H. Simiao Decoction Alleviates Gouty Arthritis by Modulating Proinflammatory Cytokines and the Gut Ecosystem. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32670069. |
in the murine of model of gouty arthritis, simiao decoction could suppress nlrp3 inflammasomes expression, reduce gut apoptosis through modulating tnf-α, caspase 8, and aifm1 protein expressions, affect lipid metabolism by regulating apob, lpl, pparα protein expressions and restore gut microbiota |
2020-09-28 |
2023-08-13 |
mouse |
| Yang Liu, Min Zhu, Ruowen Gong, Xin Wang, Lei Li, Gezhi X. Pre-treatment With Ranibizumab Aggravates PDT Injury and Alleviates Inflammatory Response in Choroid-Retinal Endothelial Cells. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32733897. |
pdt activates apoptosis, necroptosis and nlrp3 inflammasome in rf/6a cells. |
2020-09-28 |
2023-08-13 |
monkey |
| Yang Liu, Min Zhu, Ruowen Gong, Xin Wang, Lei Li, Gezhi X. Pre-treatment With Ranibizumab Aggravates PDT Injury and Alleviates Inflammatory Response in Choroid-Retinal Endothelial Cells. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32733897. |
pre-treatment with rani promotes pdt-caused apoptosis via triggering caspase 8-mediated extrinsic apoptosis, and caspase 8 might also play a pivotal role in the rani's function of suppressing pdt-induced necroptosis and nlrp3 inflammasome activation. |
2020-09-28 |
2023-08-13 |
monkey |
| Bo Deng, Ying Hu, Xia Sheng, Huijun Zeng, Yanan Hu. miR-223-3p reduces high glucose and high fat-induced endothelial cell injury in diabetic mice by regulating NLRP3 expression. Experimental and therapeutic medicine. vol 20. issue 2. 2020-09-28. PMID:32765674. |
flow cytometry was used to observe apoptosis and targetscan to predict the target relationship between mir-223-3p and nlrp3. |
2020-09-28 |
2023-08-13 |
mouse |
| Bo Deng, Ying Hu, Xia Sheng, Huijun Zeng, Yanan Hu. miR-223-3p reduces high glucose and high fat-induced endothelial cell injury in diabetic mice by regulating NLRP3 expression. Experimental and therapeutic medicine. vol 20. issue 2. 2020-09-28. PMID:32765674. |
after modeling, mir-223-3p overexpression downregulated the expression levels of nlrp3 mrna, bax and nlrp3 protein, as well as inhibited endothelial cell apoptosis (p<0.05), while the inhibition of mir-223-3p expression upregulated the expression levels and promoted apoptosis. |
2020-09-28 |
2023-08-13 |
mouse |
| Bo Deng, Ying Hu, Xia Sheng, Huijun Zeng, Yanan Hu. miR-223-3p reduces high glucose and high fat-induced endothelial cell injury in diabetic mice by regulating NLRP3 expression. Experimental and therapeutic medicine. vol 20. issue 2. 2020-09-28. PMID:32765674. |
mir-223-3p reduces the injury of mcmecs and inhibits endothelial cell apoptosis in mice by regulating the expression of nlrp3. |
2020-09-28 |
2023-08-13 |
mouse |
| Liwei Tan, Yeye Wang, Yu Jiang, Rong Wang, Jingzhi Zu, Rui Ta. Hydroxysafflor Yellow A Together with Blood-Brain Barrier Regulator Lexiscan for Cerebral Ischemia Reperfusion Injury Treatment. ACS omega. vol 5. issue 30. 2020-09-28. PMID:32775917. |
the down-regulative expression of cytokines, including nlrp3, asc, caspase-1, gsdmd, il-1β, il-18, ldh, nf-κb, and p-p56, suggested that hsya could both suppress pyroptosis and apoptosis pathway activation during the nerve injury. |
2020-09-28 |
2023-08-13 |
Not clear |
| Wenqiang Quan, Qinghua Luo, Qiqiang Tang, Tomomi Furihata, Dong Li, Klaus Fassbender, Yang Li. NLRP3 Is Involved in the Maintenance of Cerebral Pericytes. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32973459. |
we further treated cultured pericytes with nlrp3 inhibitor, mcc950, and demonstrated that nlrp3 inhibition attenuated cell proliferation but did not induce apoptosis. |
2020-09-28 |
2023-08-13 |
mouse |
| Lingjuan Cui, Xiaoyan Jiang, Chengjun Zhang, Danxia Li, Shengqiang Yu, Fengchun Wan, Yue Ma, Wei Guo, Zhengfei Sha. Ketamine induces endoplasmic reticulum stress in rats and SV-HUC-1 human uroepithelial cells by activating NLRP3/TXNIP aix. Bioscience reports. vol 39. issue 10. 2020-09-15. PMID:31652453. |
furthermore, knocking down txnip reversed the effects of ketamine on apoptosis and nlrp3 inflammatory body in sv-huc-1 cells. |
2020-09-15 |
2023-08-13 |
human |
| Qingsong Yang, Sizhen Li, Zixiu Zhou, Min Fu, Xiaodong Yang, Kuanxiao Hao, Yating Li. HDAC6 inhibitor Cay10603 inhibits high glucose-induced oxidative stress, inflammation and apoptosis in retinal pigment epithelial cells via regulating NF-κB and NLRP3 inflammasome pathway. General physiology and biophysics. vol 39. issue 2. 2020-09-03. PMID:32329444. |
hdac6 inhibitor cay10603 inhibits high glucose-induced oxidative stress, inflammation and apoptosis in retinal pigment epithelial cells via regulating nf-κb and nlrp3 inflammasome pathway. |
2020-09-03 |
2023-08-13 |
human |
| Qingsong Yang, Sizhen Li, Zixiu Zhou, Min Fu, Xiaodong Yang, Kuanxiao Hao, Yating Li. HDAC6 inhibitor Cay10603 inhibits high glucose-induced oxidative stress, inflammation and apoptosis in retinal pigment epithelial cells via regulating NF-κB and NLRP3 inflammasome pathway. General physiology and biophysics. vol 39. issue 2. 2020-09-03. PMID:32329444. |
taken together, these findings demonstrated that cay suppressed hg-induced oxidative stress, inflammation and apoptosis via regulating nf-κb and nlrp3 inflammasome pathway in hg-induced arpe-19 cells, suggesting that cay might be a therapeutic agent for the treatment of diabetic retinopathy. |
2020-09-03 |
2023-08-13 |
human |
| Sujuan Ding, Sheng Xu, Yong Ma, Gang Liu, Hongmei Jang, Jun Fan. Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes. Biomolecules. vol 9. issue 12. 2020-09-02. PMID:31835423. |
this review summarizes the regulation of type 1 diabetes mellitus (t1dm) and type 2 diabetes mellitus (t2dm) by nlrp3 via modulation of glucose tolerance, insulin resistance, inflammation, and apoptosis mediated by endoplasmic reticulum stress in adipose tissue. |
2020-09-02 |
2023-08-13 |
mouse |
| Dan Xu, Xiuzhen Zhang, Xuan Chen, Shufen Yang, Hongmei Che. Inhibition of miR-223 attenuates the NLRP3 inflammasome activation, fibrosis, and apoptosis in diabetic cardiomyopathy. Life sciences. vol 256. 2020-08-31. PMID:32561396. |
inhibition of mir-223 attenuates the nlrp3 inflammasome activation, fibrosis, and apoptosis in diabetic cardiomyopathy. |
2020-08-31 |
2023-08-13 |
rat |
| Dan Xu, Xiuzhen Zhang, Xuan Chen, Shufen Yang, Hongmei Che. Inhibition of miR-223 attenuates the NLRP3 inflammasome activation, fibrosis, and apoptosis in diabetic cardiomyopathy. Life sciences. vol 256. 2020-08-31. PMID:32561396. |
we discovered that mir-223 was highly expressed in the hg-induced cardiomyocyte injury model, and mir-223 inhibitor could further relieve the myocardial fibrosis and apoptosis, and inhibit nlrp3 inflammasome of hg-induced h9c2 cells. |
2020-08-31 |
2023-08-13 |
rat |
| Dan Xu, Xiuzhen Zhang, Xuan Chen, Shufen Yang, Hongmei Che. Inhibition of miR-223 attenuates the NLRP3 inflammasome activation, fibrosis, and apoptosis in diabetic cardiomyopathy. Life sciences. vol 256. 2020-08-31. PMID:32561396. |
moreover, we verified that inhibition of mir-223 could suppress the nlrp3 inflammasome activation, and alleviate myocardial fibrosis and apoptosis of the dcm model rats. |
2020-08-31 |
2023-08-13 |
rat |
| Dan Xu, Xiuzhen Zhang, Xuan Chen, Shufen Yang, Hongmei Che. Inhibition of miR-223 attenuates the NLRP3 inflammasome activation, fibrosis, and apoptosis in diabetic cardiomyopathy. Life sciences. vol 256. 2020-08-31. PMID:32561396. |
in conclusion, our results suggested that mir-223 might be an underlying therapeutic target for dcm by reducing nlrp3 inflammasome activation, fibrosis, and apoptosis. |
2020-08-31 |
2023-08-13 |
rat |
| Yunyun Liu, Yuanpei Zhang, Jialing Peng, Hongxuan Wang, Xiangpen Li, Xiaoyu Li, Xiaoming Rong, Jingrui Pan, Ying Pen. Autophagy alleviates ethanol-induced memory impairment in association with anti-apoptotic and anti-inflammatory pathways. Brain, behavior, and immunity. vol 82. 2020-08-25. PMID:31376498. |
further, ethanol-induced autophagy suppressed the nlrp3 inflammatory and apoptosis pathways in the hippocampus in mice and in vitro. |
2020-08-25 |
2023-08-13 |
mouse |