| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Jiang, Haiming Wang, Zifan Liu, Lejian Lin, Lin Wang, Manjiang Xie, Danyang Li, Jibin Zhang, Ran Zhan. Endoplasmic reticulum stress-dependent activation of iNOS/NO-NF-κB signaling and NLRP3 inflammasome contributes to endothelial inflammation and apoptosis associated with microgravity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-03-01. PMID:32592441. |
the increase of apoptosis in huvecs during clinorotation was significantly suppressed by inhibiting er stress, inos activity, nf-κb/iκb, and the nlrp3 inflammasome signaling pathway. |
2021-03-01 |
2023-08-13 |
human |
| Min Jiang, Haiming Wang, Zifan Liu, Lejian Lin, Lin Wang, Manjiang Xie, Danyang Li, Jibin Zhang, Ran Zhan. Endoplasmic reticulum stress-dependent activation of iNOS/NO-NF-κB signaling and NLRP3 inflammasome contributes to endothelial inflammation and apoptosis associated with microgravity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-03-01. PMID:32592441. |
therefore, simulated microgravity causes er stress in huvecs, and subsequently activates inos/no-nf-κb/iκb and the nlrp3 inflammasome signaling pathway, which have key roles in the induction of endothelial inflammation and apoptosis. |
2021-03-01 |
2023-08-13 |
human |
| Ting-Ting Xu, Han Li, Zhao Dai, George K Lau, Ben-Yue Li, Wen-Li Zhu, Xiao-Qi Liu, Hao-Fei Liu, Wei-Wu Cai, Shui-Qing Huang, Qi Wang, Shi-Jie Zhan. Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. Aging. vol 12. issue 7. 2021-02-25. PMID:32268299. |
in addition, western blot results (bcl-2, bax and caspase-3, nlrp3, il-18, il-1β) showed that spermidine and spermine prevented apoptosis and inflammation, and elevate the expression of neurotrophic factors, including ngf, psd95and psd93 and bdnf in neurons of samp8 mice. |
2021-02-25 |
2023-08-13 |
mouse |
| Xiaohui Xu, Xiaoyun Zhou, Zhenju Chen, Chao Gao, Luo Zhao, Yushang Cu. Silencing of lncRNA XIST inhibits non-small cell lung cancer growth and promotes chemosensitivity to cisplatin. Aging. vol 12. issue 6. 2021-02-22. PMID:32209729. |
moreover, xist's oncogenic effects and ability to promote ddp chemoresistance were largely related to its binding to the tgf-β effector smad2, which inhibited its translocation to the nucleus and prevented the transcription of p53 and nlrp3, crucial regulators of apoptosis and pyroptosis, respectively. |
2021-02-22 |
2023-08-13 |
mouse |
| Igor Y Iskusnykh, Evgenii D Kryl'skii, Darya A Brazhnikova, Tatyana N Popova, Khidmet S Shikhaliev, Konstantin K Shulgin, Larisa V Matasova, Sergey S Popov, Dmitry A Zhaglin, Anastasia A Zakharova, Nelli R Popova, Nikolai Fattakho. Novel Antioxidant, Deethylated Ethoxyquin, Protects against Carbon Tetrachloride Induced Hepatotoxicity in Rats by Inhibiting NLRP3 Inflammasome Activation and Apoptosis. Antioxidants (Basel, Switzerland). vol 10. issue 1. 2021-02-18. PMID:33467773. |
novel antioxidant, deethylated ethoxyquin, protects against carbon tetrachloride induced hepatotoxicity in rats by inhibiting nlrp3 inflammasome activation and apoptosis. |
2021-02-18 |
2023-08-13 |
rat |
| Ziqi Ren, Kelaier Yang, Meng Zhao, Wenxiu Liu, Xin Zhang, Jinyu Chi, Zhiyu Shi, Xiaohui Zhang, Yu Fu, Yue Liu, Xinhua Yi. Calcium-Sensing Receptor on Neutrophil Promotes Myocardial Apoptosis and Fibrosis After Acute Myocardial Infarction via NLRP3 Inflammasome Activation. The Canadian journal of cardiology. vol 36. issue 6. 2021-02-16. PMID:32224080. |
calcium-sensing receptor on neutrophil promotes myocardial apoptosis and fibrosis after acute myocardial infarction via nlrp3 inflammasome activation. |
2021-02-16 |
2023-08-13 |
Not clear |
| Sannula Kesavardhana, Thirumala-Devi Kannegant. ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease. The Journal of experimental medicine. vol 217. issue 7. 2021-02-12. PMID:32584411. |
zbp1 triggers nlrp3 inflammasome activation/pyroptosis, apoptosis, and necroptosis; the specific ligand for zbp1 activation remains ambiguous. |
2021-02-12 |
2023-08-13 |
Not clear |
| Jiaji Hu, Zhoujie Zhu, Hanglu Ying, Jie Yao, Huabin Ma, Long Li, Yufen Zha. Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice. Frontiers in pharmacology. vol 11. 2021-02-06. PMID:33536915. |
together, these findings demonstrated that oea protect against the lps/d-gal-induced acute liver injury in mice through the inhibition of apoptosis, oxidative stress and inflammation, and its mechanisms might be associated with the nrf-2/ho-1 and nlrp3 inflammasome signaling pathways. |
2021-02-06 |
2023-08-13 |
mouse |
| Junna He, Xiangjian Zhan. miR-668 inhibitor attenuates mitochondrial membrane potential and protects against neuronal apoptosis in cerebral ischemic stroke. Folia neuropathologica. vol 58. issue 1. 2021-02-04. PMID:32337954. |
in conclusion, the results of the present study indicated that inhibition of mir-668 prevented neuronal apoptosis in cerebral i/r-induced stroke by modulating mitochondrial function and regulating nlrp3 signalling. |
2021-02-04 |
2023-08-13 |
rat |
| Pankaj Deo, Seong H Chow, Mei-Ling Han, Mary Speir, Cheng Huang, Ralf B Schittenhelm, Subhash Dhital, Jack Emery, Jian Li, Benjamin T Kile, James E Vince, Kate E Lawlor, Thomas Nadere. Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation. Nature microbiology. vol 5. issue 11. 2021-02-02. PMID:32807891. |
here, we show that macrophages exposed to omvs from neisseria gonorrhoeae, uropathogenic escherichia coli and pseudomonas aeruginosa induce mitochondrial apoptosis and nlrp3 inflammasome activation. |
2021-02-02 |
2023-08-13 |
Not clear |
| Pankaj Deo, Seong H Chow, Mei-Ling Han, Mary Speir, Cheng Huang, Ralf B Schittenhelm, Subhash Dhital, Jack Emery, Jian Li, Benjamin T Kile, James E Vince, Kate E Lawlor, Thomas Nadere. Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation. Nature microbiology. vol 5. issue 11. 2021-02-02. PMID:32807891. |
in parallel with caspase-11-mediated pyroptosis, mitochondrial apoptosis and potassium ion efflux activate the nlrp3 inflammasome after omv exposure in vitro. |
2021-02-02 |
2023-08-13 |
Not clear |
| Shanshan Wei, Wanjun Ma, Xiaohui Li, Chuanhao Jiang, Taoli Sun, Yuanjian Li, Bikui Zhang, Wenqun L. Involvement of ROS/NLRP3 Inflammasome Signaling Pathway in Doxorubicin-Induced Cardiotoxicity. Cardiovascular toxicology. vol 20. issue 5. 2021-01-25. PMID:32607760. |
dox (1 μm for 48 h) induced the apoptosis of h9c2 cells and primary cardiomyocytes concomitantly with up-regulation of nlrp3, asc and caspase-1 p20 expressions, as well as the increased il-1β secretion, suggesting the activation of nlrp3 inflammasome. |
2021-01-25 |
2023-08-13 |
mouse |
| Shanshan Wei, Wanjun Ma, Xiaohui Li, Chuanhao Jiang, Taoli Sun, Yuanjian Li, Bikui Zhang, Wenqun L. Involvement of ROS/NLRP3 Inflammasome Signaling Pathway in Doxorubicin-Induced Cardiotoxicity. Cardiovascular toxicology. vol 20. issue 5. 2021-01-25. PMID:32607760. |
decreasing ros level by nac can inhibit the nlrp3 inflammasome activation, secretion of il-1β and apoptosis in dox-treating h9c2 cells and primary cardiomyocytes. |
2021-01-25 |
2023-08-13 |
mouse |
| Yuanyuan Zou, Bingjie Cui, Pei Liang, Xiaoyu Tian, Yiming Ma, Shaozhen Zha. Inhibition of NLRP3 Protects Human Lens Epithelial Cells against Oxidative Stress-Induced Apoptosis by NF-κB Signaling. Ophthalmic research. vol 63. issue 2. 2021-01-07. PMID:31805556. |
inhibition of nlrp3 protects human lens epithelial cells against oxidative stress-induced apoptosis by nf-κb signaling. |
2021-01-07 |
2023-08-13 |
human |
| Yara A Samra, Mohamed F Hamed, Ahmed R El-Sheak. Hepatoprotective effect of allicin against acetaminophen-induced liver injury: Role of inflammasome pathway, apoptosis, and liver regeneration. Journal of biochemical and molecular toxicology. vol 34. issue 5. 2021-01-07. PMID:32040233. |
therefore, we assessed allicin's protective effect on apap-induced hepatotoxicity and studied its effect on nlrp3 inflammasome and apoptosis. |
2021-01-07 |
2023-08-13 |
mouse |
| Yicong Chang, Liang Yuan, Jiarui Liu, Ishfaq Muhammad, Chuanbao Cao, Chenxi Shi, Yuanyuan Zhang, Rui Li, Changwen Li, Fangping Li. Dihydromyricetin attenuates Escherichia coli lipopolysaccharide-induced ileum injury in chickens by inhibiting NLRP3 inflammasome and TLR4/NF-κB signalling pathway. Veterinary research. vol 51. issue 1. 2021-01-05. PMID:32448367. |
in summary, dhm attenuated the ileum mucosal damage, oxidative stress and apoptosis, maintained barrier function, inhibited nlrp3 inflammasome and tlr4/nf-κb signalling pathway activation triggered by escherichia coli lps. |
2021-01-05 |
2023-08-13 |
chicken |
| Sannula Kesavardhana, R K Subbarao Malireddi, Amanda R Burton, Shaina N Porter, Peter Vogel, Shondra M Pruett-Miller, Thirumala-Devi Kannegant. The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development. The Journal of biological chemistry. vol 295. issue 24. 2020-12-30. PMID:32350114. |
zbp1 activation triggers inflammation and pyroptosis, necroptosis, and apoptosis (panoptosis) by activating receptor-interacting ser/thr kinase 3 (ripk3), caspase-8, and the nlrp3 inflammasome. |
2020-12-30 |
2023-08-13 |
Not clear |
| Marisol Fernández-Ortiz, Ramy K A Sayed, José Fernández-Martínez, Antonia Cionfrini, Paula Aranda-Martínez, Germaine Escames, Tomás de Haro, Darío Acuña-Castroviej. Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging. Antioxidants (Basel, Switzerland). vol 9. issue 12. 2020-12-26. PMID:33260800. |
with the aim of investigating the impact of nlrp3 inflammasome and the actions and target of melatonin in aged myocardium, we analyzed the expression of proteins implied in mitochondria dynamics, autophagy, apoptosis, nrf2-dependent antioxidant response and mitochondria ultrastructure in heart of wild-type and nlrp3-knockout mice of 3, 12, and 24 months-old, with and without melatonin treatment. |
2020-12-26 |
2023-08-13 |
mouse |
| Shuai Zhao, Fan Chen, Qiliang Yin, Dunwei Wang, Wei Han, Yuan Zhan. Reactive Oxygen Species Interact With NLRP3 Inflammasomes and Are Involved in the Inflammation of Sepsis: From Mechanism to Treatment of Progression. Frontiers in physiology. vol 11. 2020-12-17. PMID:33324236. |
nlrp3 inflammasomes enlarge the inflammatory response and trigger apoptosis of immune cells to exacerbate sepsis progression. |
2020-12-17 |
2023-08-13 |
Not clear |
| Tao Pan, Qiu-Jiao Zhu, Li-Xiao Xu, Xin Ding, Jian-Qin Li, Bin Sun, Jun Hua, Xing Fen. Knocking down TRPM2 expression reduces cell injury and NLRP3 inflammasome activation in PC12 cells subjected to oxygen-glucose deprivation. Neural regeneration research. vol 15. issue 11. 2020-12-11. PMID:32394974. |
taken together, these results suggest that trpm2 knockdown reduces ogd-induced neuronal injury, potentially by inhibiting apoptosis and reducing oxidative stress levels, mitochondrial membrane potentials, intracellular calcium concentrations, and nlrp3 inflammasome activation. |
2020-12-11 |
2023-08-13 |
Not clear |