| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Huang, Wen Xu, Rongbin Zho. NLRP3 inflammasome activation and cell death. Cellular & molecular immunology. vol 18. issue 9. 2021-09-25. PMID:34321623. |
recent studies have revealed that nlrp3 inflammasome activation contributes to not only pyroptosis but also other types of cell death, including apoptosis, necroptosis, and ferroptosis. |
2021-09-25 |
2023-08-13 |
Not clear |
| Yuan Yue, Zhilin Du, Jie Tao, Lei Sh. Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via SIRT3. Canadian journal of physiology and pharmacology. 2021-09-24. PMID:34559973. |
after mir-297 antagomir and nlrp3 adenovirus vector delivery, thle-2 cell proliferation and apoptosis were measured by mtt, edu and tunel assays, respectively. |
2021-09-24 |
2023-08-13 |
Not clear |
| Yuan Yue, Zhilin Du, Jie Tao, Lei Sh. Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via SIRT3. Canadian journal of physiology and pharmacology. 2021-09-24. PMID:34559973. |
furthermore, nlrp3 overexpression normalized the promoting effects of mir-297 antagomir on proliferation and its inhibitory effects on apoptosis and inflammation in h/r-induced thle-2 cells. |
2021-09-24 |
2023-08-13 |
Not clear |
| Bin Sun, Xiaoxian Liu, Han Peng, Xin Xiang, Hua Yan. Circular RNA _NLRP1 targets mouse microRNA-199b-3p to regulate apoptosis and pyroptosis of hippocampal neuron under oxygen-glucose deprivation exposure. Bioengineered. vol 12. issue 1. 2021-09-22. PMID:34227902. |
after the cell model was pre-treated with short hairpin (sh)-circ_nlrp1 or mmu-mir-199b-3p inhibitor, ldh release and cell apoptosis were detected by ldh kit and tunel staining, respectively, while the expression of nlrp3 pyroptosis-related makers was analyzed through immunofluorescence (if) assay and western blot, respectively. |
2021-09-22 |
2023-08-13 |
mouse |
| Zhen Huang, Hui Chen, Shenglin Wang, Hongxiang Wei, Xinwen Wang, Rongkai Shen, Yunqing Wang, Rongjin Lin, Jianhua Li. NLRP3 Overexpression Associated With Poor Prognosis and Presented as an Effective Therapeutic Target in Osteosarcoma. Frontiers in pharmacology. vol 12. 2021-09-20. PMID:34393801. |
cell counting kit-8, colony formation, wound healing, transwell, and flow cytometry assays were used to explore the contribution of nlrp3 to the proliferation, migration, invasion, apoptosis and cell cycle distribution of osteosarcoma cells |
2021-09-20 |
2023-08-13 |
Not clear |
| Zhengxiao Ren, Ping Che, Ziwei Li, Mei Mo, Shanshan Zhang, Yingying Zhan. [Progress in the relationship between NLRP3 inflammasome and lung injury in COVID-19]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 9. 2021-09-20. PMID:34533131. |
sars-cov-2 enters lung cells via ace2, and the nlr family pyrin domain containing 3 (nlrp3) inflammasome and the pro-caspase-1 are then activated, followed by release of mature il-1β and il-18 and other inflammatory cytokines, thereby leading to inflammation and apoptosis. |
2021-09-20 |
2023-08-13 |
Not clear |
| Xu Wu, Linjing Gong, Liang Xie, Wenyu Gu, Xinyuan Wang, Zilong Liu, Shanqun L. NLRP3 Deficiency Protects Against Intermittent Hypoxia-Induced Neuroinflammation and Mitochondrial ROS by Promoting the PINK1-Parkin Pathway of Mitophagy in a Murine Model of Sleep Apnea. Frontiers in immunology. vol 12. 2021-09-15. PMID:33717152. |
compared with wild-type mice, nlrp3 deficiency protected them from cih-induced neuronal damage, as indicated by the restoration of fear-conditioning test results and amelioration of neuron apoptosis. |
2021-09-15 |
2023-08-13 |
mouse |
| Hongwei Zhou, Cheng Zhang, Changren Huan. Verbascoside Attenuates Acute Inflammatory Injury Caused by an Intracerebral Hemorrhage Through the Suppression of NLRP3. Neurochemical research. vol 46. issue 4. 2021-09-14. PMID:33400023. |
in this study, we investigated whether vb limited inflammation induced by ich through the targeting of nlrp3, which is associated with acute inflammation and apoptosis. |
2021-09-14 |
2023-08-13 |
rat |
| Nada H Eisa, Mohamed El-Sherbiny, Nada F Abo El-Mag. Betulin alleviates cisplatin-induced hepatic injury in rats: Targeting apoptosis and Nek7-independent NLRP3 inflammasome pathways. International immunopharmacology. vol 99. 2021-09-08. PMID:34217992. |
betulin alleviates cisplatin-induced hepatic injury in rats: targeting apoptosis and nek7-independent nlrp3 inflammasome pathways. |
2021-09-08 |
2023-08-13 |
rat |
| Donghua Du, Wenting Lv, Rina Su, Chunwei Yu, Xiaoxia Jing, Nuwenqimuge Bai, Surong Has. Hydrolyzed camel whey protein alleviated heat stress-induced hepatocyte damage by activated Nrf2/HO-1 signaling pathway and inhibited NF-κB/NLRP3 axis. Cell stress & chaperones. vol 26. issue 2. 2021-09-03. PMID:33405053. |
s-cwp suppressed hs-induced inflammatory response by reducing the phosphorylation of nf-κb p65, the expression of nlrp3, and caspase-1 and finally alleviated caspase-3-mediated apoptosis. |
2021-09-03 |
2023-08-13 |
cat |
| Dongdong Li, Luobing Wang, Jiaoying Ou, Chuanxu Wang, Jiabao Zhou, Lili Lu, Yanshneg Wu, Jiandong Ga. Reactive oxygen species induced by uric acid promote NRK‑52E cell apoptosis through the NEK7‑NLRP3 signaling pathway. Molecular medicine reports. vol 24. issue 4. 2021-08-31. PMID:34414459. |
the ros inhibitor, n‑acetyl‑l‑cysteine, exerted a protective effect on the ua‑induced apoptosis of tubular epithelial cells by reducing excess ros production, which significantly inhibited nek7 and nlrp3 inflammasome activation. |
2021-08-31 |
2023-08-13 |
Not clear |
| Tayier Gulifeire, Chunbo Yang, Xiang Li, Yi Wang, Xiangyou Y. [Activation of NOD-like receptor protein 3 inflammasome mediates inflammatory response and apoptosis in septic intestinal injury model]. Zhonghua wei zhong bing ji jiu yi xue. vol 33. issue 7. 2021-08-23. PMID:34412757. |
to investigate the expression of nod-like receptor protein 3 (nlrp3) inflammasome in intestinal injury models with different severity of sepsis and the inflammatory response and apoptosis mediated by nlrp3 inflammasome. |
2021-08-23 |
2023-08-13 |
Not clear |
| Kaiqiang Sun, Xiaofei Sun, Jingchuan Sun, Yan Jiang, Feng Lin, Fanqi Kong, Fudong Li, Jian Zhu, Le Huan, Bing Zheng, Yuan Wang, Weiguo Zou, Lu Gao, Ximing Xu, Jiangang Sh. Tissue Renin-Angiotensin System (tRAS) Induce Intervertebral Disc Degeneration by Activating Oxidative Stress and Inflammatory Reaction. Oxidative medicine and cellular longevity. vol 2021. 2021-08-21. PMID:34413926. |
then, in vitro experiment suggested that ang ii could decrease the cell viability of human np cells and promote np cell apoptosis, senescence, oxidative stress, and nlrp3 activation in human np cells. |
2021-08-21 |
2023-08-13 |
human |
| Lin Xie, Zhiming Zhao, Zhenhao Chen, Xiaosheng Ma, Xinlei Xia, Hongli Wang, Chaojun Zheng, Jianyuan Jian. Melatonin Alleviates Radiculopathy Against Apoptosis and NLRP3 Inflammasomes Via the Parkin-Mediated Mitophagy Pathway. Spine. vol 46. issue 16. 2021-08-18. PMID:34398134. |
melatonin alleviates radiculopathy against apoptosis and nlrp3 inflammasomes via the parkin-mediated mitophagy pathway. |
2021-08-18 |
2023-08-13 |
Not clear |
| Xin Mao, Rong-Mei Yao, Yan-Yan Bao, Jing Sun, Xiao-Lan Cui, Hai-Jiang Zhang, Yu-Jing Sh. [Effect of polysaccharides from seeds of Vaccaria segetalis in alleviating urinary tract infection induced bladder injury by inhibiting NLRP3 inflammasome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 13. 2021-08-17. PMID:34396759. |
western blot and immunofluorescence staining were used to detect the expressions of sonic hedgehog( shh) and nlrp3 inflammasome [nod-like receptor thermoprotein domain 3( nlrp3),apoptosis associated speck like protein( asc) and pro-caspase-1]. |
2021-08-17 |
2023-08-13 |
rat |
| Jae Ryong Lim, Hyun Jik Lee, Young Hyun Jung, Jun Sung Kim, Chang Woo Chae, Seo Yihl Kim, Ho Jae Ha. Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation. Cell communication and signaling : CCS. vol 18. issue 1. 2021-08-10. PMID:32787872. |
ethanol-activated camkii signaling induces neuronal apoptosis through drp1-mediated excessive mitochondrial fission and jnk1-dependent nlrp3 inflammasome activation. |
2021-08-10 |
2023-08-13 |
Not clear |
| Lijuan A. Exposure to mono (2-ethylhexyl) phthalate facilitates apoptosis and pyroptosis of human endometrial microvascular endothelial cells through NLRP3 inflammasome. Journal of applied toxicology : JAT. vol 41. issue 5. 2021-07-27. PMID:33159713. |
exposure to mono (2-ethylhexyl) phthalate facilitates apoptosis and pyroptosis of human endometrial microvascular endothelial cells through nlrp3 inflammasome. |
2021-07-27 |
2023-08-13 |
human |
| Lijuan A. Exposure to mono (2-ethylhexyl) phthalate facilitates apoptosis and pyroptosis of human endometrial microvascular endothelial cells through NLRP3 inflammasome. Journal of applied toxicology : JAT. vol 41. issue 5. 2021-07-27. PMID:33159713. |
nlrp3 knockdown markedly ameliorated the increase in ldh release and apoptosis induced by mehp exposure in hemecs. |
2021-07-27 |
2023-08-13 |
human |
| Lijuan A. Exposure to mono (2-ethylhexyl) phthalate facilitates apoptosis and pyroptosis of human endometrial microvascular endothelial cells through NLRP3 inflammasome. Journal of applied toxicology : JAT. vol 41. issue 5. 2021-07-27. PMID:33159713. |
our findings suggested that exposure to mehp facilitates apoptosis and pyroptosis of hemecs through nlrp3 inflammasome. |
2021-07-27 |
2023-08-13 |
human |
| Pengfei Liu, Quansheng Gao, Lei Guan, Yanting Hu, Jingwen Jiang, Teng Gao, Weixuan Sheng, Xinying Xue, Hui Qiao, Tianzuo L. Atorvastatin attenuates surgery-induced BBB disruption and cognitive impairment partly by suppressing NF-κB pathway and NLRP3 inflammasome activation in aged mice. Acta biochimica et biophysica Sinica. vol 53. issue 5. 2021-07-16. PMID:33674828. |
atorvastatin could also reverse the surgery-induced increase of systemic and hippocampal cytokines, including il-1β, tnf-α, and il-6, accompanied by inhibiting the nuclear factor kappa-b (nf-κb) pathway and nucleotide-binding oligomerization domain, or leucine rich repeat and pyrin domain containing 3 (nlrp3) inflammasome activation, as well as hippocampal neuronal apoptosis. |
2021-07-16 |
2023-08-13 |
mouse |