| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M F Nagoor Meeran, Sheikh Azimullah, Hebaallah Hashiesh Mamoudh, Charu Sharma, Sanjay Kumar, Sameer N Goyal, Shreesh Ojh. Nerolidol, a Sesquiterpene from the Essential Oils of Aromatic Plants, Attenuates Doxorubicin-Induced Chronic Cardiotoxicity in Rats. Journal of agricultural and food chemistry. vol 69. issue 26. 2021-07-08. PMID:34170670. |
dox activated nlrp3 inflammasome-mediated pyroptotic cell death along with fibrosis, mitochondrial dysfunction, dna damage, and apoptosis in the myocardium. |
2021-07-08 |
2023-08-13 |
rat |
| Yang Yao, Yinglei Xu, Yong Wan. Protective roles and mechanisms of rosmarinic acid in cyclophosphamide-induced premature ovarian failure. Journal of biochemical and molecular toxicology. vol 34. issue 12. 2021-07-02. PMID:32711407. |
the results suggested that ra exhibited a protective effect against cp-induced pof potentially by suppressing apoptosis and the nlrp3 inflammasome. |
2021-07-02 |
2023-08-13 |
mouse |
| Ming Xu, Xiao-Yong Li, Laichun Song, Chao Tao, Jihui Fang, Liang Ta. miR-484 targeting of Yap1-induced LPS-inhibited proliferation, and promoted apoptosis and inflammation in cardiomyocyte. Bioscience, biotechnology, and biochemistry. vol 85. issue 2. 2021-07-02. PMID:33604630. |
cell counting kit-8, flow cytometry, western blotting, and elisa showed that mir-484 inhibitor significantly improved cell viability, decreased apoptosis, suppressed nlrp3 inflammasome formation, and reduced secretion of inflammatory cytokines tnf-α, il-1β, and il-6. |
2021-07-02 |
2023-08-13 |
Not clear |
| Yinling Jiang, Xiaoqiong Wang, Wanchun Yang, Shuyu Gu. Procyanidin B2 Suppresses Lipopolysaccharides-Induced Inflammation and Apoptosis in Human Type II Alveolar Epithelial Cells and Lung Fibroblasts. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 40. issue 1. 2021-07-01. PMID:31603717. |
we tested the effects of pcb2 on cell permeability, viability, apoptosis, nuclear factor-kappab (nf-κb) activation, nlrp3 inflammasome activation, and proinflammatory cytokines production in lps-treated human aecs and lfs. |
2021-07-01 |
2023-08-13 |
human |
| Yinling Jiang, Xiaoqiong Wang, Wanchun Yang, Shuyu Gu. Procyanidin B2 Suppresses Lipopolysaccharides-Induced Inflammation and Apoptosis in Human Type II Alveolar Epithelial Cells and Lung Fibroblasts. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 40. issue 1. 2021-07-01. PMID:31603717. |
pcb2 suppressed lps-induced inflammation and apoptosis in human aecs and lfs by inhibiting nf-κb and nlrp3 inflammasome. |
2021-07-01 |
2023-08-13 |
human |
| Dongdong Liu, Yushu Dong, Gen Li, Zheng Zou, Guangzhi Hao, Hua Feng, Pengyu Pan, Guobiao Lian. Melatonin Attenuates White Matter Injury via Reducing Oligodendrocyte Apoptosis After Subarachnoid Hemorrhage in Mice. Turkish neurosurgery. vol 30. issue 5. 2021-06-28. PMID:32705666. |
to determine whether melatonin (mlt) mitigates white matter (wm) injury by attenuating nod-like receptor family pyrin domain-containing 3 (nlrp3)-associated oligodendrocyte apoptosis after subarachnoid hemorrhage (sah). |
2021-06-28 |
2023-08-13 |
mouse |
| Pinfang Kang, Jiahui Wang, Dian Fang, Tingting Fang, Ying Yu, Weiping Zhang, Lin Shen, Zhenghong Li, Hongju Wang, Hongwei Ye, Qin Ga. Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis. Free radical biology & medicine. vol 146. 2021-06-18. PMID:31689484. |
in contrast to normal glucose group, in hg group, with the decreases of aldh2 activity, mrna and protein levels, the cardiomyocytes viability was decreased, reactive oxygen species (ros), the inflammation factors - tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), interleukin-1β (il-1β) levels, collagen i (col i) and col iii mrna expressions and tissue inhibitors of matrix metalloproteinase 4 (timp4) protein expression were increased, while matrix metalloproteinase 14 (mmp14) protein level, the ratio of mmp14/timp4 were decreased, and the necroptosis key factors - the receptor interacting protein 1 (rip1), rip3 and mixed lineage kinase domain-like protein (mlkl) at mrna and protein expressions were increased, the inflammasome core proteins - nlrp3 and asc protein expressions were also increased, the apoptosis rate and necrosis rate were also increased. |
2021-06-18 |
2023-08-13 |
rat |
| Pinfang Kang, Jiahui Wang, Dian Fang, Tingting Fang, Ying Yu, Weiping Zhang, Lin Shen, Zhenghong Li, Hongju Wang, Hongwei Ye, Qin Ga. Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis. Free radical biology & medicine. vol 146. 2021-06-18. PMID:31689484. |
when the cardiomyocytes were treated with alda-1 (the aldh2 agonist) in hg intervention, the cell viability, aldh2 activity, mrna and protein levels, mmp14 protein level, the ratio of mmp14/timp4 were higher, ros and tnf-α, il-6, il-1β levels, rip1, rip3, mlkl, nlrp3 and asc expressions, col i and col iii, timp4 expressions, the apoptosis rate and necrosis rate were lower than in hg group. |
2021-06-18 |
2023-08-13 |
rat |
| Peng Song, Di-Fei Shen, Yan-Yan Meng, Chun-Yan Kong, Xin Zhang, Yu-Pei Yuan, Ling Yan, Qi-Zhu Tang, Zhen-Guo M. Geniposide protects against sepsis-induced myocardial dysfunction through AMPKα-dependent pathway. Free radical biology & medicine. vol 152. 2021-06-18. PMID:32081748. |
in conclusion, our findings revealed that ge activated ampkα to suppress myocardial ros accumulation, thus blocking nlrp3 inflammasome-mediated cardiomyocyte apoptosis and pyroptosis and improving cardiac function in mice with sepsis. |
2021-06-18 |
2023-08-13 |
mouse |
| Liuping Cai, Qu Chen, Zhihao Yao, Qinwei Sun, Lei Wu, Yingdong N. Glucocorticoid receptors involved in melatonin inhibiting cell apoptosis and NLRP3 inflammasome activation caused by bacterial toxin pyocyanin in colon. Free radical biology & medicine. vol 162. 2021-06-18. PMID:33189867. |
glucocorticoid receptors involved in melatonin inhibiting cell apoptosis and nlrp3 inflammasome activation caused by bacterial toxin pyocyanin in colon. |
2021-06-18 |
2023-08-13 |
Not clear |
| Maja Wyczanska, Bärbel Lange-Sperandi. DAMPs in Unilateral Ureteral Obstruction. Frontiers in immunology. vol 11. 2021-06-17. PMID:33117389. |
in adult uuo, soluble uric acid is upregulated and activates the nod-like receptor family, pyrin domain containing-3 (nlrp3) inflammasome, which promotes fibrosis, apoptosis, and reactive oxygen species (ros) injury. |
2021-06-17 |
2023-08-13 |
mouse |
| Guangning Zhao, Long Yang, Liming Li, Zhongqiang Fa. NaHS Alleviated Cell Apoptosis and Mitochondrial Dysfunction in Remote Lung Tissue after Renal Ischemia and Reperfusion via Nrf2 Activation-Mediated NLRP3 Pathway Inhibition. BioMed research international. vol 2021. 2021-06-17. PMID:33954183. |
nahs alleviated cell apoptosis and mitochondrial dysfunction in remote lung tissue after renal ischemia and reperfusion via nrf2 activation-mediated nlrp3 pathway inhibition. |
2021-06-17 |
2023-08-13 |
mouse |
| Feifei Shao, Lingmin Zhou, Yu Zhang, Hongping Chen, Yu Zhang, Zhihui Gua. Gastrodin alleviates inflammatory injury of cardiomyocytes in septic shock mice via inhibiting NLRP3 expression. In vitro cellular & developmental biology. Animal. vol 57. issue 5. 2021-06-16. PMID:34106415. |
after culture in vitro and treatment with gastrodin, lipopolysaccharide (lps), and nlrp3 vector, the cell viability and apoptosis of cardiomyocytes were detected by cell counting kit-8 and flow cytometry respectively. |
2021-06-16 |
2023-08-13 |
mouse |
| G Chao-Yang, C Peng, Z Hai-Hon. Roles of NLRP3 inflammasome in intervertebral disc degeneration. Osteoarthritis and cartilage. vol 29. issue 6. 2021-06-14. PMID:33609693. |
with the exploration of the mechanism of ivdd, recent studies have shown that activation of the nlrp3 inflammasome is associated with intervertebral disc (ivd) inflammation, pyroptosis, extracellular matrix degradation and apoptosis of ivd cells. |
2021-06-14 |
2023-08-13 |
Not clear |
| Tayier Gulifeire, Chunbo Yang, Xiang Li, Yi Wang, Xiangyou Y. [Effects of resveratrol-mediated inhibition of NOD-like receptor protein 3 inflammasomevia activating silent information regulator 1 on the injury of intestinal mucosal barrier function after sepsis]. Zhonghua wei zhong bing ji jiu yi xue. vol 33. issue 5. 2021-06-14. PMID:34112288. |
to explore whether resveratrol (rsv) could activate silent information regulator 1 (sirt1) to regulate the activation of nod-like receptor protein 3 (nlrp3) inflammasome in sepsis induced intestinal injury model, and then reduce intestinal inflammation and cell apoptosis, so as to play a protective role in intestinal barrier function. |
2021-06-14 |
2023-08-13 |
Not clear |
| Ivan Luzardo-Ocampo, Guadalupe Loarca-Piña, Elvira Gonzalez de Meji. Gallic and butyric acids modulated NLRP3 inflammasome markers in a co-culture model of intestinal inflammation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 146. 2021-06-11. PMID:33130239. |
compared to nlrp3 positive control, fndf components decreased nlrp3 markers (caspase-1 activity, il-1β, and apoptosis). |
2021-06-11 |
2023-08-13 |
Not clear |
| Yang Deng, Yunzhao Fu, Longxiang Sheng, Yixin Hu, Lishi Su, Jiawen Luo, Chun Yan, Wei Ch. The Regulatory NOD-Like Receptor NLRC5 Promotes Ganglion Cell Death in Ischemic Retinopathy by Inducing Microglial Pyroptosis. Frontiers in cell and developmental biology. vol 9. 2021-06-08. PMID:34095138. |
notably, we found that nlrc5 directly bound to nlrp3 and nlrc4 in inflammasomes to cooperatively drive microglial pyroptosis and apoptosis mediating retinal ischemic damage. |
2021-06-08 |
2023-08-13 |
Not clear |
| Nanhe Lin, Xin Song, Bin Chen, Hao Ye, Youlin Wang, Xi Cheng, Hongxiang Wan. Leptin is upregulated in epididymitis and promotes apoptosis and IL-1β production in epididymal epithelial cells by activating the NLRP3 inflammasome. International immunopharmacology. vol 88. 2021-05-27. PMID:33182054. |
leptin is upregulated in epididymitis and promotes apoptosis and il-1β production in epididymal epithelial cells by activating the nlrp3 inflammasome. |
2021-05-27 |
2023-08-13 |
rat |
| Nanhe Lin, Xin Song, Bin Chen, Hao Ye, Youlin Wang, Xi Cheng, Hongxiang Wan. Leptin is upregulated in epididymitis and promotes apoptosis and IL-1β production in epididymal epithelial cells by activating the NLRP3 inflammasome. International immunopharmacology. vol 88. 2021-05-27. PMID:33182054. |
western blots were used to detect molecular related to cell apoptosis, il-1β maturation, and nlrp3 inflammasome. |
2021-05-27 |
2023-08-13 |
rat |
| Ya-Jie Ji, Hui-Lin Wang, Bian-Li Yin, Xiang-Yang Re. Down-regulation of DJ-1 Augments Neuroinflammation via Nrf2/Trx1/NLRP3 Axis in MPTP-induced Parkinson's Disease Mouse Model. Neuroscience. vol 442. 2021-05-14. PMID:32526245. |
dj-1 and nrf2 knockdown promoted inflammation and cell apoptosis in bv2 microglia, while nlrp3 knockdown had opposite effects. |
2021-05-14 |
2023-08-13 |
mouse |