| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ines Diaz-Del-Olmo, Jonathan Worboys, Fatima Martin-Sanchez, Anna Gritsenko, Ashley R Ambrose, Gillian M Tannahill, Eva-Maria Nichols, Gloria Lopez-Castejon, Daniel M Davi. Internalization of the Membrane Attack Complex Triggers NLRP3 Inflammasome Activation and IL-1β Secretion in Human Macrophages. Frontiers in immunology. vol 12. 2021-11-18. PMID:34650553. |
the mac is first internalized into endosomes and then colocalizes with inflammasome components; adapter protein apoptosis associated speck-like protein containing a card (asc) and nlrp3. |
2021-11-18 |
2023-08-13 |
human |
| Qing Wang, Lujing Ying, Bing Wei, Yikui Ji, Yi X. Effects of quercetin on apoptosis and extracellular matrix degradation of chondrocytes induced by oxidative stress-mediated pyroptosis. Journal of biochemical and molecular toxicology. 2021-11-18. PMID:34791735. |
results showed that quercetin could reduce lps-induced c28/i2 cell apoptosis, extracellular matrix (ecm) degradation, and cell pyroptosis, and overexpression of nucleotide-binding domain and leucine-rich-repeat-containing (nlr) family, pyrin domain-containing 3 (nlrp3) revealed that quercetin reduced chondrocyte apoptosis and ecm degradation by inhibiting nlrp3-mediated pyroptosis. |
2021-11-18 |
2023-08-13 |
rat |
| Xiaohe Li, Ling Ma, Yuli Wei, Jinying Gu, Jingjing Liang, Shimeng Li, Yunyao Cui, Rui Liu, Hui Huang, Cheng Yang, Honggang Zho. Cabozantinib ameliorates lipopolysaccharide-induced lung inflammation and bleomycin--induced early pulmonary fibrosis in mice. International immunopharmacology. vol 101. issue Pt B. 2021-11-17. PMID:34741997. |
the results of in vitro studies showed that cabozantinib could inhibit the inflammatory response and apoptosis of alveolar epithelial cells by inhibiting the activation of tlr4/nf-κb and nlrp3 inflammasome pathways. |
2021-11-17 |
2023-08-13 |
mouse |
| Qisheng Lin, Shu Li, Na Jiang, Haijiao Jin, Xinghua Shao, Xuying Zhu, Jingkui Wu, Minfang Zhang, Zhen Zhang, Jianxiao Shen, Wenyan Zhou, Leyi Gu, Renhua Lu, Zhaohui N. Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy. Autophagy. vol 17. issue 10. 2021-11-16. PMID:33345685. |
inhibiting nlrp3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of hif1a and bnip3-mediated mitophagy. |
2021-11-16 |
2023-08-13 |
Not clear |
| Qian Li, Mingming Zhang, Ying Zhao, Maolong Don. Irisin Protects Against LPS-Stressed Cardiac Damage Through Inhibiting Inflammation, Apoptosis, and Pyroptosis. Shock (Augusta, Ga.). vol 56. issue 6. 2021-11-16. PMID:34779800. |
after stimuli of lps, the function of myocardium was distinctly impaired, which was closely related to increased level of apoptosis (decreased expression of bcl-2 and elevated expression of caspase-3 and bax), pyroptosis (increased expression of caspase1, nlr family pyrin domain containing 3 (nlrp3), and gasdermin d) and inflammatory mediators (increased level of il-1β, tnf-α, and il-6). |
2021-11-16 |
2023-08-13 |
mouse |
| Qian Li, Mingming Zhang, Ying Zhao, Maolong Don. Irisin Protects Against LPS-Stressed Cardiac Damage Through Inhibiting Inflammation, Apoptosis, and Pyroptosis. Shock (Augusta, Ga.). vol 56. issue 6. 2021-11-16. PMID:34779800. |
in general, irisin suppressed inflammation, apoptosis, and pyroptosis by blocking the tlr4 and nlrp3 inflammasome signalings to mitigate myocardial dysfunction in sepsis. |
2021-11-16 |
2023-08-13 |
mouse |
| Jinghui Zhai, Huan Gao, Shuo Wang, Sixi Zhang, Xiaoyu Qu, Yueming Zhang, Lina Tao, Jingmeng Sun, Yanqing Song, Li F. Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3. Journal of biochemical and molecular toxicology. vol 35. issue 11. 2021-11-15. PMID:34423507. |
ginsenoside rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited nlrp3. |
2021-11-15 |
2023-08-13 |
human |
| Xiaoyan Li, Hongmei Wang, Chen Li, Jihong Wu, Jun Lu, Jian-You Guo, Ya T. Acupuncture inhibits NLRP3 inflammasome activation in the prefrontal cortex of a chronic stress rat model of depression. Anatomical record (Hoboken, N.J. : 2007). vol 304. issue 11. 2021-11-15. PMID:34636496. |
these results suggested that acupuncture has antidepressant-like effects, and its mechanism appears to be involved in the inhibition of nlrp3 inflammasome activation and apoptosis in the pfc. |
2021-11-15 |
2023-08-13 |
rat |
| Qian Li, Ying Tan, Sainan Chen, Xiaochan Xiao, Mingming Zhang, Qi Wu, Maolong Don. Irisin alleviates LPS-induced liver injury and inflammation through inhibition of NLRP3 inflammasome and NF-κB signaling. Journal of receptor and signal transduction research. vol 41. issue 3. 2021-11-12. PMID:32814473. |
increased activity of nlrp3 inflammasome was discovered in lps-challenged raw264.7 cells, along with elevated levels of inflammation and apoptosis, the effects of which were mediated by activation of ros and nuclear factor κb (nf-κb) signaling. |
2021-11-12 |
2023-08-13 |
Not clear |
| Yonghong Su, Yaoqi Wang, Min Liu, Hongguang Che. Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition. Molecular medicine reports. vol 24. issue 1. 2021-11-08. PMID:34013370. |
hydrogen sulfide attenuates renal i/r‑induced activation of the inflammatory response and apoptosis via regulating nrf2‑mediated nlrp3 signaling pathway inhibition. |
2021-11-08 |
2023-08-13 |
mouse |
| Yonghong Su, Yaoqi Wang, Min Liu, Hongguang Che. Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition. Molecular medicine reports. vol 24. issue 1. 2021-11-08. PMID:34013370. |
the present study investigated whether nrf2 and nlrp3 pathway participate in hydrogen sulfide‑regulated renal i/r‑induced activation of the inflammatory response and apoptosis. |
2021-11-08 |
2023-08-13 |
mouse |
| Yonghong Su, Yaoqi Wang, Min Liu, Hongguang Che. Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition. Molecular medicine reports. vol 24. issue 1. 2021-11-08. PMID:34013370. |
renal tissue and blood were collected from the i/r model mice to analyze nlrp3 and nrf2 mrna expression levels, nlrp3, pyd and card domain containing, caspase‑1, il‑1β, nrf2 and heme oxygenase 1 protein expression levels, cell apoptosis, the secretion of tumor necrosis factor‑α, il‑1β and il‑6 cytokines and renal histopathology and function. |
2021-11-08 |
2023-08-13 |
mouse |
| Yonghong Su, Yaoqi Wang, Min Liu, Hongguang Che. Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition. Molecular medicine reports. vol 24. issue 1. 2021-11-08. PMID:34013370. |
conversely, mcc950 treatment inhibited activation of the nlrp3 signaling pathway, and prevented i/r‑induced renal injury, release of cytokines and apoptosis in renal i/r model mice. |
2021-11-08 |
2023-08-13 |
mouse |
| Yonghong Su, Yaoqi Wang, Min Liu, Hongguang Che. Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition. Molecular medicine reports. vol 24. issue 1. 2021-11-08. PMID:34013370. |
sodium hydrosulfide (nahs) not only alleviated upregulation of nlrp3 protein expression levels, but also relieved renal injury, release of cytokines and cell apoptosis induced by renal i/r in wild‑type mice, but not in nrf2‑ko mice. |
2021-11-08 |
2023-08-13 |
mouse |
| Yonghong Su, Yaoqi Wang, Min Liu, Hongguang Che. Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition. Molecular medicine reports. vol 24. issue 1. 2021-11-08. PMID:34013370. |
nahs alleviated nlrp3 inflammasome activation, renal injury, the inflammatory response and cell apoptosis via the nrf2 signaling pathway in renal i/r model mice. |
2021-11-08 |
2023-08-13 |
mouse |
| Rong Rong, Rongliang Yang, Haibo Li, Mengling You, Zhuotao Liang, Zhou Zeng, Rongrong Zhou, Xiaobo Xia, Dan J. The roles of mitochondrial dynamics and NLRP3 inflammasomes in the pathogenesis of retinal light damage. Annals of the New York Academy of Sciences. 2021-11-06. PMID:34741555. |
further experiments revealed that dynamin-related protein 1 (drp1)-mediated excessive mitochondrial fission induced overproduction of reactive oxygen species in the retinal cells, leading to apoptosis, activation of microglia, and formation of the nlrp3 inflammasome. |
2021-11-06 |
2023-08-13 |
mouse |
| Jianqing Jiang, Mingsong Ca. Cardamonin Inhibited IL-1β Induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO-1 Signaling Pathway in Chondrocyte. Journal of microbiology and biotechnology. vol 31. issue 6. 2021-10-27. PMID:34024891. |
in chon-001 cells, il-1β suppressed cell viability and collagen ii level while promoting cell apoptosis and expression of pro-inflammatory cytokines (il-6, il-8, tnf-α), mmps (mmp-3, mmp-13), nqo-1, and nlrp3 inflammasome (nlrp3, caspase 1 and asc), with no significant influence on nrf2. |
2021-10-27 |
2023-08-13 |
Not clear |
| Jianqing Jiang, Mingsong Ca. Cardamonin Inhibited IL-1β Induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO-1 Signaling Pathway in Chondrocyte. Journal of microbiology and biotechnology. vol 31. issue 6. 2021-10-27. PMID:34024891. |
cardamonin reversed the effect of il-1β on cell viability, cell apoptosis, pro-inflammatory cytokines, mmps, collagen ii, and nlrp3 inflammasome levels. |
2021-10-27 |
2023-08-13 |
Not clear |
| Jianqing Jiang, Mingsong Ca. Cardamonin Inhibited IL-1β Induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO-1 Signaling Pathway in Chondrocyte. Journal of microbiology and biotechnology. vol 31. issue 6. 2021-10-27. PMID:34024891. |
sinrf2 reversed the function of cardamonin on il-1β-induced cell apoptosis and expression of pro-inflammatory cytokines, nrf2, nqo-1, and nlrp3 inflammasome in chondrocytes. |
2021-10-27 |
2023-08-13 |
Not clear |
| Jing Luo, Jialei Chen, Changhong Yang, Junyi Tan, Jing Zhao, Ning Jiang, Yong Zha. 6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 / FAF1 complex dissociation-mediated autophagy. International immunopharmacology. vol 100. 2021-10-27. PMID:34537481. |
6-gingerol protects against cerebral ischemia/reperfusion injury by inhibiting nlrp3 inflammasome and apoptosis via trpv1 / faf1 complex dissociation-mediated autophagy. |
2021-10-27 |
2023-08-13 |
Not clear |