| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoqing Zhang, Dandan Zhao, Jiling Feng, Xiaoli Yang, Zhenzhen Lan, Tao Yang, Xiaoni Kong, Huiyan Qu, Hua Zho. LuQi Formula Regulates NLRP3 Inflammasome to Relieve Myocardial-Infarction-Induced Cardiac Remodeling in Mice. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-07-15. PMID:34257682. |
this study aimed to evaluate whether lqf could alleviate cardiac injury and apoptosis by regulating the nlrp3 inflammasome and the caspase-3/bax pathway. |
2021-07-15 |
2023-08-13 |
mouse |
| Wenyu Dai, Manyi Wang, Peiqi Wang, Ji Wen, Jiangyue Wang, Sa Cha, Xueling Xiao, Yiruo He, Rui Shu, Ding Ba. lncRNA NEAT1 ameliorates LPS‑induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome. International journal of molecular medicine. vol 47. issue 2. 2021-07-12. PMID:33416115. |
lps upregulated the expression of inflammatory cytokines and nlrp3, inhibited the expression of autophagy‑related and osteogenesis‑related proteins, promoted apoptosis and altered the cell cycle, which was partially inhibited by neat1 overexpression and promoted by bexarotene. |
2021-07-12 |
2023-08-13 |
human |
| Wenjun Zou, Shasha Luo, Zhengwei Zhang, Libo Cheng, Xiaoli Huang, Nannan Ding, Ying Pan, Zhifeng W. ASK1/p38‑mediated NLRP3 inflammasome signaling pathway contributes to aberrant retinal angiogenesis in diabetic retinopathy. International journal of molecular medicine. vol 47. issue 2. 2021-07-12. PMID:33416127. |
in the present study, an animal model of dr and a cell model using primary human retinal microvascular endothelial cells exposed to high glucose were constructed to examine the association between apoptosis signal‑regulating kinase 1 (ask1)/p38 and nlr family pyrin domain containing 3 (nlrp3) in dr. |
2021-07-12 |
2023-08-13 |
human |
| Rui Xiong, Wenyang Jiang, Ning Li, Bohao Liu, Ruyuan He, Bo Wang, Qing Gen. PM2.5-induced lung injury is attenuated in macrophage-specific NLRP3 deficient mice. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34146983. |
we constructed macrophage-specific nlrp3 knockout mice to explore the mechanism of pm2.5-induced lung injury in terms of inflammatory response, oxidative stress, and apoptosis levels, including the relationship between these effects and pyroptosis. |
2021-07-12 |
2023-08-13 |
mouse |
| Man Luo, Dongsheng Yan, Qingsong Sun, Jiali Tao, Liang Xu, Hong Sun, Hongmei Zha. Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4/NF-kB/NLRP3 pathway. Journal of cellular biochemistry. vol 121. issue 4. 2021-07-09. PMID:31709615. |
in addition, treatment with tlr4 small interfering rna (sirna), a p-nf-κb inhibitor, or nlrp3 sirna suppressed lps-induced apoptosis and inflammation. |
2021-07-09 |
2023-08-13 |
mouse |
| M F Nagoor Meeran, Sheikh Azimullah, Hebaallah Hashiesh Mamoudh, Charu Sharma, Sanjay Kumar, Sameer N Goyal, Shreesh Ojh. Nerolidol, a Sesquiterpene from the Essential Oils of Aromatic Plants, Attenuates Doxorubicin-Induced Chronic Cardiotoxicity in Rats. Journal of agricultural and food chemistry. vol 69. issue 26. 2021-07-08. PMID:34170670. |
dox activated nlrp3 inflammasome-mediated pyroptotic cell death along with fibrosis, mitochondrial dysfunction, dna damage, and apoptosis in the myocardium. |
2021-07-08 |
2023-08-13 |
rat |
| Yang Yao, Yinglei Xu, Yong Wan. Protective roles and mechanisms of rosmarinic acid in cyclophosphamide-induced premature ovarian failure. Journal of biochemical and molecular toxicology. vol 34. issue 12. 2021-07-02. PMID:32711407. |
the results suggested that ra exhibited a protective effect against cp-induced pof potentially by suppressing apoptosis and the nlrp3 inflammasome. |
2021-07-02 |
2023-08-13 |
mouse |
| Ming Xu, Xiao-Yong Li, Laichun Song, Chao Tao, Jihui Fang, Liang Ta. miR-484 targeting of Yap1-induced LPS-inhibited proliferation, and promoted apoptosis and inflammation in cardiomyocyte. Bioscience, biotechnology, and biochemistry. vol 85. issue 2. 2021-07-02. PMID:33604630. |
cell counting kit-8, flow cytometry, western blotting, and elisa showed that mir-484 inhibitor significantly improved cell viability, decreased apoptosis, suppressed nlrp3 inflammasome formation, and reduced secretion of inflammatory cytokines tnf-α, il-1β, and il-6. |
2021-07-02 |
2023-08-13 |
Not clear |
| Yinling Jiang, Xiaoqiong Wang, Wanchun Yang, Shuyu Gu. Procyanidin B2 Suppresses Lipopolysaccharides-Induced Inflammation and Apoptosis in Human Type II Alveolar Epithelial Cells and Lung Fibroblasts. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 40. issue 1. 2021-07-01. PMID:31603717. |
we tested the effects of pcb2 on cell permeability, viability, apoptosis, nuclear factor-kappab (nf-κb) activation, nlrp3 inflammasome activation, and proinflammatory cytokines production in lps-treated human aecs and lfs. |
2021-07-01 |
2023-08-13 |
human |
| Yinling Jiang, Xiaoqiong Wang, Wanchun Yang, Shuyu Gu. Procyanidin B2 Suppresses Lipopolysaccharides-Induced Inflammation and Apoptosis in Human Type II Alveolar Epithelial Cells and Lung Fibroblasts. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 40. issue 1. 2021-07-01. PMID:31603717. |
pcb2 suppressed lps-induced inflammation and apoptosis in human aecs and lfs by inhibiting nf-κb and nlrp3 inflammasome. |
2021-07-01 |
2023-08-13 |
human |
| Dongdong Liu, Yushu Dong, Gen Li, Zheng Zou, Guangzhi Hao, Hua Feng, Pengyu Pan, Guobiao Lian. Melatonin Attenuates White Matter Injury via Reducing Oligodendrocyte Apoptosis After Subarachnoid Hemorrhage in Mice. Turkish neurosurgery. vol 30. issue 5. 2021-06-28. PMID:32705666. |
to determine whether melatonin (mlt) mitigates white matter (wm) injury by attenuating nod-like receptor family pyrin domain-containing 3 (nlrp3)-associated oligodendrocyte apoptosis after subarachnoid hemorrhage (sah). |
2021-06-28 |
2023-08-13 |
mouse |
| Pinfang Kang, Jiahui Wang, Dian Fang, Tingting Fang, Ying Yu, Weiping Zhang, Lin Shen, Zhenghong Li, Hongju Wang, Hongwei Ye, Qin Ga. Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis. Free radical biology & medicine. vol 146. 2021-06-18. PMID:31689484. |
in contrast to normal glucose group, in hg group, with the decreases of aldh2 activity, mrna and protein levels, the cardiomyocytes viability was decreased, reactive oxygen species (ros), the inflammation factors - tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), interleukin-1β (il-1β) levels, collagen i (col i) and col iii mrna expressions and tissue inhibitors of matrix metalloproteinase 4 (timp4) protein expression were increased, while matrix metalloproteinase 14 (mmp14) protein level, the ratio of mmp14/timp4 were decreased, and the necroptosis key factors - the receptor interacting protein 1 (rip1), rip3 and mixed lineage kinase domain-like protein (mlkl) at mrna and protein expressions were increased, the inflammasome core proteins - nlrp3 and asc protein expressions were also increased, the apoptosis rate and necrosis rate were also increased. |
2021-06-18 |
2023-08-13 |
rat |
| Pinfang Kang, Jiahui Wang, Dian Fang, Tingting Fang, Ying Yu, Weiping Zhang, Lin Shen, Zhenghong Li, Hongju Wang, Hongwei Ye, Qin Ga. Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis. Free radical biology & medicine. vol 146. 2021-06-18. PMID:31689484. |
when the cardiomyocytes were treated with alda-1 (the aldh2 agonist) in hg intervention, the cell viability, aldh2 activity, mrna and protein levels, mmp14 protein level, the ratio of mmp14/timp4 were higher, ros and tnf-α, il-6, il-1β levels, rip1, rip3, mlkl, nlrp3 and asc expressions, col i and col iii, timp4 expressions, the apoptosis rate and necrosis rate were lower than in hg group. |
2021-06-18 |
2023-08-13 |
rat |
| Peng Song, Di-Fei Shen, Yan-Yan Meng, Chun-Yan Kong, Xin Zhang, Yu-Pei Yuan, Ling Yan, Qi-Zhu Tang, Zhen-Guo M. Geniposide protects against sepsis-induced myocardial dysfunction through AMPKα-dependent pathway. Free radical biology & medicine. vol 152. 2021-06-18. PMID:32081748. |
in conclusion, our findings revealed that ge activated ampkα to suppress myocardial ros accumulation, thus blocking nlrp3 inflammasome-mediated cardiomyocyte apoptosis and pyroptosis and improving cardiac function in mice with sepsis. |
2021-06-18 |
2023-08-13 |
mouse |
| Liuping Cai, Qu Chen, Zhihao Yao, Qinwei Sun, Lei Wu, Yingdong N. Glucocorticoid receptors involved in melatonin inhibiting cell apoptosis and NLRP3 inflammasome activation caused by bacterial toxin pyocyanin in colon. Free radical biology & medicine. vol 162. 2021-06-18. PMID:33189867. |
glucocorticoid receptors involved in melatonin inhibiting cell apoptosis and nlrp3 inflammasome activation caused by bacterial toxin pyocyanin in colon. |
2021-06-18 |
2023-08-13 |
Not clear |
| Maja Wyczanska, Bärbel Lange-Sperandi. DAMPs in Unilateral Ureteral Obstruction. Frontiers in immunology. vol 11. 2021-06-17. PMID:33117389. |
in adult uuo, soluble uric acid is upregulated and activates the nod-like receptor family, pyrin domain containing-3 (nlrp3) inflammasome, which promotes fibrosis, apoptosis, and reactive oxygen species (ros) injury. |
2021-06-17 |
2023-08-13 |
mouse |
| Guangning Zhao, Long Yang, Liming Li, Zhongqiang Fa. NaHS Alleviated Cell Apoptosis and Mitochondrial Dysfunction in Remote Lung Tissue after Renal Ischemia and Reperfusion via Nrf2 Activation-Mediated NLRP3 Pathway Inhibition. BioMed research international. vol 2021. 2021-06-17. PMID:33954183. |
nahs alleviated cell apoptosis and mitochondrial dysfunction in remote lung tissue after renal ischemia and reperfusion via nrf2 activation-mediated nlrp3 pathway inhibition. |
2021-06-17 |
2023-08-13 |
mouse |
| Feifei Shao, Lingmin Zhou, Yu Zhang, Hongping Chen, Yu Zhang, Zhihui Gua. Gastrodin alleviates inflammatory injury of cardiomyocytes in septic shock mice via inhibiting NLRP3 expression. In vitro cellular & developmental biology. Animal. vol 57. issue 5. 2021-06-16. PMID:34106415. |
after culture in vitro and treatment with gastrodin, lipopolysaccharide (lps), and nlrp3 vector, the cell viability and apoptosis of cardiomyocytes were detected by cell counting kit-8 and flow cytometry respectively. |
2021-06-16 |
2023-08-13 |
mouse |
| G Chao-Yang, C Peng, Z Hai-Hon. Roles of NLRP3 inflammasome in intervertebral disc degeneration. Osteoarthritis and cartilage. vol 29. issue 6. 2021-06-14. PMID:33609693. |
with the exploration of the mechanism of ivdd, recent studies have shown that activation of the nlrp3 inflammasome is associated with intervertebral disc (ivd) inflammation, pyroptosis, extracellular matrix degradation and apoptosis of ivd cells. |
2021-06-14 |
2023-08-13 |
Not clear |
| Tayier Gulifeire, Chunbo Yang, Xiang Li, Yi Wang, Xiangyou Y. [Effects of resveratrol-mediated inhibition of NOD-like receptor protein 3 inflammasomevia activating silent information regulator 1 on the injury of intestinal mucosal barrier function after sepsis]. Zhonghua wei zhong bing ji jiu yi xue. vol 33. issue 5. 2021-06-14. PMID:34112288. |
to explore whether resveratrol (rsv) could activate silent information regulator 1 (sirt1) to regulate the activation of nod-like receptor protein 3 (nlrp3) inflammasome in sepsis induced intestinal injury model, and then reduce intestinal inflammation and cell apoptosis, so as to play a protective role in intestinal barrier function. |
2021-06-14 |
2023-08-13 |
Not clear |