| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aixia Song, Yuying Yang, Hongmei He, Jian Sun, Qing Chang, Qian Xu. Inhibition of Long Non-Coding RNA KCNQ1OT1 Attenuates Neuroinflammation and Neuronal Apoptosis Through Regulating NLRP3 Expression via Sponging miR-30e-3p. Journal of inflammation research. vol 14. 2021-05-14. PMID:33981152. |
inhibition of long non-coding rna kcnq1ot1 attenuates neuroinflammation and neuronal apoptosis through regulating nlrp3 expression via sponging mir-30e-3p. |
2021-05-14 |
2023-08-13 |
Not clear |
| Hailong Zhang, Yuting Ma, Run Cao, Guanli Wang, Shaowei Li, Yue Cao, Hao Zhang, Meichen Liu, Guangchao Liu, Jun Zhang, Shulian Li, Yaohui Wang, Yuanfang M. Soluble uric acid induces myocardial damage through activating the NLRP3 inflammasome. Journal of cellular and molecular medicine. vol 24. issue 15. 2021-05-13. PMID:32558367. |
we found that sua was able to activate nlrp3 inflammasome, which was responsible for h9c2 cell apoptosis induced by sua. |
2021-05-13 |
2023-08-13 |
rat |
| Yang Hu, Xinyu Wang, Qingju Li, Yunzheng Pan, Li X. Salvianolic acid B alleviates myocardial ischemic injury by promoting mitophagy and inhibiting activation of the NLRP3 inflammasome. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174042. |
in vitro, the results of reactive oxygen species (ros) detection, jc‑1 staining, western blotting and tunel assays showed that sal b treatment significantly inhibited intracellular ros production, increased the mitochondrial membrane potential, regulated the expression of mitophagy‑related proteins, inhibited the activation of the nlrp3 inflammasome and inhibited apoptosis in h9c2 cells. |
2021-05-13 |
2023-08-13 |
rat |
| Junmei Zhang, Xuyuan Sun, Lingling Zhong, Bei She. IL-32 exacerbates adenoid hypertrophy via activating NLRP3-mediated cell pyroptosis, which promotes inflammation. Molecular medicine reports. vol 23. issue 3. 2021-05-04. PMID:33495843. |
il-32 (2, 10 and 50 ng/ml) also resulted in differing degrees of apoptosis, gsdmd activation, release of il-1β, il-6 and tnf-α, and increased protein expression levels of nlrp3, cleaved-caspase-1, activated gsdmd, nucleotide-binding oligomerization domain-containing protein (nod) 1/2 and toll-like receptor (tlr)4 in a concentration-dependent manner. |
2021-05-04 |
2023-08-13 |
human |
| Junmei Zhang, Xuyuan Sun, Lingling Zhong, Bei She. IL-32 exacerbates adenoid hypertrophy via activating NLRP3-mediated cell pyroptosis, which promotes inflammation. Molecular medicine reports. vol 23. issue 3. 2021-05-04. PMID:33495843. |
in addition, compared with the lps group, il-32 knockdown significantly inhibited lps-induced enhancement of cell proliferation, cell apoptosis, gsdmd activation and production of inflammatory cytokines, and reversed the increased protein expression of nlrp3, cleaved-caspase-1, activated gsdmd, nod1/2 and tlr4. |
2021-05-04 |
2023-08-13 |
human |
| Hongming Lv, Yuanyuan Liu, Boxi Zhang, Yuwei Zheng, Hong Ji, Shize L. The improvement effect of gastrodin on LPS/GalN-induced fulminant hepatitis via inhibiting inflammation and apoptosis and restoring autophagy. International immunopharmacology. vol 85. 2021-04-30. PMID:32473572. |
taken together, our investigation indicated that gtd played an essential role in liver protection by relieving hepatocyte apoptosis and inflammation reaction, which may be closely involved in the inhibition of nlrp3 inflammasome and nf-κb activation, regulation of apoptosis-related proteins expression, and the recovery of ampk/acc/autophagy. |
2021-04-30 |
2023-08-13 |
mouse |
| Yueming Zhang, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song, Jie Zhan. Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway. International immunopharmacology. vol 85. 2021-04-28. PMID:32492628. |
quercetin attenuates nlrp3 inflammasome activation and apoptosis to protect inh-induced liver injury via regulating sirt1 pathway. |
2021-04-28 |
2023-08-13 |
rat |
| Yueming Zhang, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song, Jie Zhan. Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway. International immunopharmacology. vol 85. 2021-04-28. PMID:32492628. |
however, sirt1 inhibitor ex527 reversed the suppression of que on nlrp3 inflammasome activation and the protection of que on rat liver injury and cell apoptosis. |
2021-04-28 |
2023-08-13 |
rat |
| Yueming Zhang, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song, Jie Zhan. Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway. International immunopharmacology. vol 85. 2021-04-28. PMID:32492628. |
in short, our findings showed that que exhibited protective effects against inh-induced liver damage via inhibiting the activation of nlrp3 inflammasome and apoptosis in a sirt-dependent manner. |
2021-04-28 |
2023-08-13 |
rat |
| Ping Li, Yu Liu, Qiang H. Anisodamine Suppressed the Growth of Hepatocellular Carcinoma Cells, Induced Apoptosis and Regulated the Levels of Inflammatory Factors by Inhibiting NLRP3 Inflammasome Activation. Drug design, development and therapy. vol 14. 2021-03-10. PMID:32425506. |
anisodamine suppressed the growth of hepatocellular carcinoma cells, induced apoptosis and regulated the levels of inflammatory factors by inhibiting nlrp3 inflammasome activation. |
2021-03-10 |
2023-08-13 |
Not clear |
| Huahong Yang, Cong Hua, Xiaolin Yang, Xiaoye Fan, Hongyu Song, Liping Peng, Xinxin C. Pterostilbene prevents LPS-induced early pulmonary fibrosis by suppressing oxidative stress, inflammation and apoptosis in vivo. Food & function. vol 11. issue 5. 2021-03-08. PMID:32377661. |
in conclusion, oxidative stress, apoptosis and inflammation are involved in early pulmonary fibrosis and pts exerts a protective effect by activating keap-1/nrf2, inhibiting caspase-dependent a20/nf-κb and nlrp3 signaling pathways. |
2021-03-08 |
2023-08-13 |
mouse |
| S Li, Z Guo, Z Y Zhan. Protective effects of NLRP3 inhibitor MCC950 on sepsis-induced myocardial dysfunction. Journal of biological regulators and homeostatic agents. vol 35. issue 1. 2021-03-05. PMID:33550789. |
in conclusion, the nlrp3 inhibitor mcc950 can reduce the release of ldh and other cellular inflammatory factors in the cytoplasm, thereby improving the cardiac function and slowing down the apoptosis of cardiomyocytes, which may be related to the inhibition of nlrp3/caspase-1/il-1β pathway. |
2021-03-05 |
2023-08-13 |
rat |
| Dongxu Wang, Qiang Gao, Taotao Wang, Zhipeng Kan, Xin Li, Lizhen Hu, Chuan-Yi Peng, Frank Qian, Yijun Wang, Daniel Granat. Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation. Food research international (Ottawa, Ont.). vol 127. 2021-03-01. PMID:31882076. |
moreover, gtps and egcg ameliorated hepatic oxidative stress, cell apoptosis, necrosis, steatosis, edema, and degeneration, reduced hepatic inflammation and nlrp3 inflammasome activation caused by a moderate dose of pfda. |
2021-03-01 |
2023-08-13 |
mouse |
| Min Jiang, Haiming Wang, Zifan Liu, Lejian Lin, Lin Wang, Manjiang Xie, Danyang Li, Jibin Zhang, Ran Zhan. Endoplasmic reticulum stress-dependent activation of iNOS/NO-NF-κB signaling and NLRP3 inflammasome contributes to endothelial inflammation and apoptosis associated with microgravity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-03-01. PMID:32592441. |
endoplasmic reticulum stress-dependent activation of inos/no-nf-κb signaling and nlrp3 inflammasome contributes to endothelial inflammation and apoptosis associated with microgravity. |
2021-03-01 |
2023-08-13 |
human |
| Min Jiang, Haiming Wang, Zifan Liu, Lejian Lin, Lin Wang, Manjiang Xie, Danyang Li, Jibin Zhang, Ran Zhan. Endoplasmic reticulum stress-dependent activation of iNOS/NO-NF-κB signaling and NLRP3 inflammasome contributes to endothelial inflammation and apoptosis associated with microgravity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-03-01. PMID:32592441. |
we examined markers of er stress, inducible nitric oxide (no) synthase (inos)/no content, proinflammatory cytokine production, nuclear factor kappa b (nf-κb)/iκb signaling, nlrp3 inflammasome, and detected apoptosis in huvecs. |
2021-03-01 |
2023-08-13 |
human |
| Min Jiang, Haiming Wang, Zifan Liu, Lejian Lin, Lin Wang, Manjiang Xie, Danyang Li, Jibin Zhang, Ran Zhan. Endoplasmic reticulum stress-dependent activation of iNOS/NO-NF-κB signaling and NLRP3 inflammasome contributes to endothelial inflammation and apoptosis associated with microgravity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-03-01. PMID:32592441. |
the increase of apoptosis in huvecs during clinorotation was significantly suppressed by inhibiting er stress, inos activity, nf-κb/iκb, and the nlrp3 inflammasome signaling pathway. |
2021-03-01 |
2023-08-13 |
human |
| Min Jiang, Haiming Wang, Zifan Liu, Lejian Lin, Lin Wang, Manjiang Xie, Danyang Li, Jibin Zhang, Ran Zhan. Endoplasmic reticulum stress-dependent activation of iNOS/NO-NF-κB signaling and NLRP3 inflammasome contributes to endothelial inflammation and apoptosis associated with microgravity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-03-01. PMID:32592441. |
therefore, simulated microgravity causes er stress in huvecs, and subsequently activates inos/no-nf-κb/iκb and the nlrp3 inflammasome signaling pathway, which have key roles in the induction of endothelial inflammation and apoptosis. |
2021-03-01 |
2023-08-13 |
human |
| Ting-Ting Xu, Han Li, Zhao Dai, George K Lau, Ben-Yue Li, Wen-Li Zhu, Xiao-Qi Liu, Hao-Fei Liu, Wei-Wu Cai, Shui-Qing Huang, Qi Wang, Shi-Jie Zhan. Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. Aging. vol 12. issue 7. 2021-02-25. PMID:32268299. |
in addition, western blot results (bcl-2, bax and caspase-3, nlrp3, il-18, il-1β) showed that spermidine and spermine prevented apoptosis and inflammation, and elevate the expression of neurotrophic factors, including ngf, psd95and psd93 and bdnf in neurons of samp8 mice. |
2021-02-25 |
2023-08-13 |
mouse |
| Xiaohui Xu, Xiaoyun Zhou, Zhenju Chen, Chao Gao, Luo Zhao, Yushang Cu. Silencing of lncRNA XIST inhibits non-small cell lung cancer growth and promotes chemosensitivity to cisplatin. Aging. vol 12. issue 6. 2021-02-22. PMID:32209729. |
moreover, xist's oncogenic effects and ability to promote ddp chemoresistance were largely related to its binding to the tgf-β effector smad2, which inhibited its translocation to the nucleus and prevented the transcription of p53 and nlrp3, crucial regulators of apoptosis and pyroptosis, respectively. |
2021-02-22 |
2023-08-13 |
mouse |
| Igor Y Iskusnykh, Evgenii D Kryl'skii, Darya A Brazhnikova, Tatyana N Popova, Khidmet S Shikhaliev, Konstantin K Shulgin, Larisa V Matasova, Sergey S Popov, Dmitry A Zhaglin, Anastasia A Zakharova, Nelli R Popova, Nikolai Fattakho. Novel Antioxidant, Deethylated Ethoxyquin, Protects against Carbon Tetrachloride Induced Hepatotoxicity in Rats by Inhibiting NLRP3 Inflammasome Activation and Apoptosis. Antioxidants (Basel, Switzerland). vol 10. issue 1. 2021-02-18. PMID:33467773. |
novel antioxidant, deethylated ethoxyquin, protects against carbon tetrachloride induced hepatotoxicity in rats by inhibiting nlrp3 inflammasome activation and apoptosis. |
2021-02-18 |
2023-08-13 |
rat |