| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoju Ding, Haijuan Xie, Wuqiang Shan, Ligang L. Agonism of GPR120 Prevented High Glucose-Induced Apoptosis of Retinal Endothelial Cells through Inhibiting NLRP3 Inflammasome. Klinische Monatsblatter fur Augenheilkunde. 2022-05-18. PMID:35584771. |
in this study, gw9508, the gpr120 agonist, was utilized in human retinal microvascular endothelial cells (hrmecs) exposed to high glucose (hg) to investigate the involvement of gpr120 in cellular viability and apoptosis as well as the association with the nlrp3 inflammasome. |
2022-05-18 |
2023-08-13 |
human |
| Yu Zhang, Cheng-Jun Xing, Xiao Liu, Ya-Hong Li, Jing Jia, Jian-Guo Feng, Cheng-Jie Yang, Ye Chen, Jun Zho. Thioredoxin-Interacting Protein (TXNIP) Knockdown Protects against Sepsis-Induced Brain Injury and Cognitive Decline in Mice by Suppressing Oxidative Stress and Neuroinflammation. Oxidative medicine and cellular longevity. vol 2022. 2022-05-16. PMID:35571246. |
furthermore, the alterations in microglial activity, oxidative response, proinflammatory factors, apoptosis, protein levels (txnip and nlrp3 inflammasome), and apoptosis were examined in the hippocampal tissues. |
2022-05-16 |
2023-08-13 |
mouse |
| Lin Liu, Tingting Zhou, Tao Li, Zhanhua Liang, Xiaoguang Lu. LncRNA DLX6-AS1 promotes microglial inflammatory response in Parkinson's disease by regulating the miR-223-3p/NRP1 axis. Behavioural brain research. 2022-05-13. PMID:35550840. |
meanwhile, the cell number of th+/caspase3+/iba1+ in substantia nigra, cell viability, and apoptosis rate of bv2 microglia, inflammatory levels, and nlr family pyrin domain containing 3 (nlrp3) inflammasome were determined using immunohistochemistry, mtt assay, flow cytometry, elisa assay, and western blot. |
2022-05-13 |
2023-08-13 |
mouse |
| Xin-Hua Guo, Yang Zheng, Jia-Hui Wang, Hong-Hong Wang, Shu-Juan Luo, Na Huang, Tie-Jian Zhao, Bo-Wen Zheng, Xin-Yun Liang, Ri-Zhou Wu, Qiu-Yi Re. [Research progress on role of traditional Chinese medicine in hepatic fibrosis based on miRNA-mediated activation of NLRP3 inflammasome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 9. 2022-05-09. PMID:35531688. |
different mirna molecules regulated liver fibrosis by mediating nlrp3 inflammasome activation, including mirna-350-3 p(mir-350-3 p)/interleukin-6(il-6)-mediated signal transducer and activator of transcription 3(stat3)/c-myc signaling pathway, mir-148 a-induced autophagy and apoptosis of hepatic stellate cells via hedgehog signaling pathway, mir-155-mediated nlrp3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(socs-1), mir-181 a-mediated downstream nlrp3 inflammatory pathway activation through mitogen-activated protein kinase kinase(mek)/extracellular signal-regulated kinase(erk)/nuclear transcription factor κb(nf-κb) inflammatory pathway, mir-21-promoted expression of nf-κb and nlrp3 of raw264.7 cells in mice by inhibiting tumor necrosis factor-α inducible protein 3(a20), and mir-20 b-promoted expression of il-1β and il-18 by activating nlrp3 signaling pathway. |
2022-05-09 |
2023-08-13 |
mouse |
| Ahmed M Kabel, Samir A Salama, Hany M Borg, Dina A Ali, Maaly A Abd Elmaabou. Targeting p-AKT/mTOR/MAP kinase signaling, NLRP3 inflammasome and apoptosis by fluvastatin with or without taxifolin mitigates gonadal dysfunction induced by bisphenol-A in male rats. Human & experimental toxicology. vol 41. 2022-04-25. PMID:35465754. |
targeting p-akt/mtor/map kinase signaling, nlrp3 inflammasome and apoptosis by fluvastatin with or without taxifolin mitigates gonadal dysfunction induced by bisphenol-a in male rats. |
2022-04-25 |
2023-08-13 |
human |
| Shih-Che Hung, Lu-Chu Ke, Te-Sheng Lien, Hsuan-Shun Huang, Der-Shan Sun, Chia-Liang Cheng, Hsin-Hou Chan. Nanodiamond-Induced Thrombocytopenia in Mice Involve P-Selectin-Dependent Nlrp3 Inflammasome-Mediated Platelet Aggregation, Pyroptosis and Apoptosis. Frontiers in immunology. vol 13. 2022-04-21. PMID:35444640. |
nanodiamond-induced thrombocytopenia in mice involve p-selectin-dependent nlrp3 inflammasome-mediated platelet aggregation, pyroptosis and apoptosis. |
2022-04-21 |
2023-08-13 |
mouse |
| Wei Zhang, Qi Zh. Punicalagin suppresses inflammation in ventilator-induced lung injury through PAR2 inhibition-induced inhibition of NLRP3 inflammasome activation. Chemical biology & drug design. 2022-04-18. PMID:35434894. |
the levels of inflammatory cytokines (tumor necrosis factor (tnf)-α, interleukin (il)-1β, and il-6), par2, nlr family pyrin domain containing-3 (nlrp3) and apoptosis associated speck-like protein containing a card (asc) in the balf lungs or cells were analyzed by enzyme-linked immune-sorbent assay (elisa), qrt-pcr or/and western blot. |
2022-04-18 |
2023-08-13 |
mouse |
| Hui Kong, Hongran Zhao, Tianran Chen, Yanling Song, Yan Cu. Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy. Cell death & disease. vol 13. issue 4. 2022-04-12. PMID:35410316. |
the expression of inflammasome-related proteins p2x7 and nlrp3, and apoptosis in the retinas of 3tc-treated diabetic mice were compared to those of untreated diabetic mice. |
2022-04-12 |
2023-08-13 |
mouse |
| Zi-Tan Peng, Hui Li. Puerarin attenuates LPS-induced inflammatory injury in gastric epithelial cells by repressing NLRP3 inflammasome-mediated apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. 2022-03-25. PMID:35331853. |
puerarin attenuates lps-induced inflammatory injury in gastric epithelial cells by repressing nlrp3 inflammasome-mediated apoptosis. |
2022-03-25 |
2023-08-13 |
Not clear |
| Zi-Tan Peng, Hui Li. Puerarin attenuates LPS-induced inflammatory injury in gastric epithelial cells by repressing NLRP3 inflammasome-mediated apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. 2022-03-25. PMID:35331853. |
puerarin ameliorated lps-induced cytotoxicity and apoptosis, while repressing lps-stimulated nlrp3 inflammasome-mediated pyroptosis in ges-1 cells, as evidenced by significantly decreased expression of nlrp3, asc, cleaved caspase-1, il-1β and il-18. |
2022-03-25 |
2023-08-13 |
Not clear |
| Zi-Tan Peng, Hui Li. Puerarin attenuates LPS-induced inflammatory injury in gastric epithelial cells by repressing NLRP3 inflammasome-mediated apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. 2022-03-25. PMID:35331853. |
our findings suggest that puerarin may ameliorate lps-induced inflammatory injury in ges-1 cells by activating the ampk/sirt1 signaling pathway and thereby repressing nlrp3 inflammasome-mediated apoptosis. |
2022-03-25 |
2023-08-13 |
Not clear |
| Yamei Li, Bo Peng, Yi Li, Airu Huang, Yinian Peng, Qian Yu, Yufeng L. MiR-203a-3p/153-3p improves cognitive impairments induced by ischemia/reperfusion via blockade of SRC-mediated MAPK signaling pathway in ischemic stroke. Chemico-biological interactions. 2022-03-20. PMID:35305977. |
moreover, mir-203a-3p and mir-153-3p relieved the apoptosis, decreases nlrp3 inflammasome activity, decreases oxidative stress and inflammation in hippocampal neuron through targeting src. |
2022-03-20 |
2023-08-13 |
rat |
| Nadine A Kerr, Juliana Sanchez, Gregory O'Connor, Brant D Watson, Sylvia Daunert, Helen M Bramlett, W Dalton Dietric. Inflammasome-Regulated Pyroptotic Cell Death in Disruption of the Gut-Brain Axis After Stroke. Translational stroke research. 2022-03-20. PMID:35306629. |
we examined the time course of inflammasome protein expression in brain and intestinal lysate using western blot analysis at 1-, 3-, and 7-days post-injury for caspase-1, interleukin-1β, nod-like receptor protein 3 (nlrp3), and apoptosis speck-like protein containing a caspase-recruiting domain (asc) and gasdermin-d (gsdmd) cleavage. |
2022-03-20 |
2023-08-13 |
mouse |
| Wei He, Qian Wang, Weiping Sha, Liming Wang, Di Li, Gang Che. P2X4 Inhibition reduces microglia inflammation and apoptosis by NLRP3 and improves nervous system defects in rat brain trauma model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 99. 2022-03-15. PMID:35290938. |
p2x4 inhibition reduces microglia inflammation and apoptosis by nlrp3 and improves nervous system defects in rat brain trauma model. |
2022-03-15 |
2023-08-13 |
rat |
| Wei He, Qian Wang, Weiping Sha, Liming Wang, Di Li, Gang Che. P2X4 Inhibition reduces microglia inflammation and apoptosis by NLRP3 and improves nervous system defects in rat brain trauma model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 99. 2022-03-15. PMID:35290938. |
the inhibition of p2x4 effectively reduced the inflammation and apoptosis of microglia, and nlrp3 may be involved in this process. |
2022-03-15 |
2023-08-13 |
rat |
| Chunyan Bai, Yingfei Zhu, Qiaoliang Dong, Yuwei Zhan. Chronic intermittent hypoxia induces the pyroptosis of renal tubular epithelial cells by activating the NLRP3 inflammasome. Bioengineered. vol 13. issue 3. 2022-03-09. PMID:35263214. |
pyroptosis is a programmed mode of cell death following cell apoptosis and cell necrosis, which is mediated by nlrp3 signaling. |
2022-03-09 |
2023-08-13 |
rat |
| Min Shi, Jianqiang Wang, Fangfang Bi, Zhangyong Ba. Diosmetin alleviates cerebral ischemia-reperfusion injury through Keap1-mediated Nrf2/ARE signaling pathway activation and NLRP3 inflammasome inhibition. Environmental toxicology. 2022-02-22. PMID:35191607. |
in conclusion, diosmetin attenuated ogd/r-induced pc12 cell viability inhibition, apoptosis, oxidative stress and inflammation through keap1-mediated nrf2/are signaling activation and nlrp3 inflammasome inhibition, and alleviated cir-induced neurological injury in mcao rat model. |
2022-02-22 |
2023-08-13 |
rat |
| Jingyang Chen, Meiru Bian, Lingxiao Pan, Hanshi Yan. α-Mangostin protects lipopolysaccharide-stimulated nucleus pulposus cells against NLRP3 inflammasome-mediated apoptosis via the NF-κB pathway. Journal of applied toxicology : JAT. 2022-02-21. PMID:35187677. |
α-mangostin protects lipopolysaccharide-stimulated nucleus pulposus cells against nlrp3 inflammasome-mediated apoptosis via the nf-κb pathway. |
2022-02-21 |
2023-08-13 |
human |
| Jingyang Chen, Meiru Bian, Lingxiao Pan, Hanshi Yan. α-Mangostin protects lipopolysaccharide-stimulated nucleus pulposus cells against NLRP3 inflammasome-mediated apoptosis via the NF-κB pathway. Journal of applied toxicology : JAT. 2022-02-21. PMID:35187677. |
moreover, inhibition of nf-κb by pdtc aggravated the inhibitory effects of α-mangostin on nlrp3 inflammasome activation and apoptosis in lps-induced npcs. |
2022-02-21 |
2023-08-13 |
human |
| Jingyang Chen, Meiru Bian, Lingxiao Pan, Hanshi Yan. α-Mangostin protects lipopolysaccharide-stimulated nucleus pulposus cells against NLRP3 inflammasome-mediated apoptosis via the NF-κB pathway. Journal of applied toxicology : JAT. 2022-02-21. PMID:35187677. |
these findings suggested that α-mangostin exerted a protective effect on nlrp3 inflammasome-mediated apoptosis in lps-induced npcs through regulating nf-κb signaling. |
2022-02-21 |
2023-08-13 |
human |