| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Li, Mingming Zhang, Ying Zhao, Maolong Don. Irisin Protects Against LPS-Stressed Cardiac Damage Through Inhibiting Inflammation, Apoptosis, and Pyroptosis. Shock (Augusta, Ga.). vol 56. issue 6. 2021-11-16. PMID:34779800. |
in general, irisin suppressed inflammation, apoptosis, and pyroptosis by blocking the tlr4 and nlrp3 inflammasome signalings to mitigate myocardial dysfunction in sepsis. |
2021-11-16 |
2023-08-13 |
mouse |
| Jinghui Zhai, Huan Gao, Shuo Wang, Sixi Zhang, Xiaoyu Qu, Yueming Zhang, Lina Tao, Jingmeng Sun, Yanqing Song, Li F. Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3. Journal of biochemical and molecular toxicology. vol 35. issue 11. 2021-11-15. PMID:34423507. |
ginsenoside rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited nlrp3. |
2021-11-15 |
2023-08-13 |
human |
| Xiaoyan Li, Hongmei Wang, Chen Li, Jihong Wu, Jun Lu, Jian-You Guo, Ya T. Acupuncture inhibits NLRP3 inflammasome activation in the prefrontal cortex of a chronic stress rat model of depression. Anatomical record (Hoboken, N.J. : 2007). vol 304. issue 11. 2021-11-15. PMID:34636496. |
these results suggested that acupuncture has antidepressant-like effects, and its mechanism appears to be involved in the inhibition of nlrp3 inflammasome activation and apoptosis in the pfc. |
2021-11-15 |
2023-08-13 |
rat |
| Qian Li, Ying Tan, Sainan Chen, Xiaochan Xiao, Mingming Zhang, Qi Wu, Maolong Don. Irisin alleviates LPS-induced liver injury and inflammation through inhibition of NLRP3 inflammasome and NF-κB signaling. Journal of receptor and signal transduction research. vol 41. issue 3. 2021-11-12. PMID:32814473. |
increased activity of nlrp3 inflammasome was discovered in lps-challenged raw264.7 cells, along with elevated levels of inflammation and apoptosis, the effects of which were mediated by activation of ros and nuclear factor κb (nf-κb) signaling. |
2021-11-12 |
2023-08-13 |
Not clear |
| Yonghong Su, Yaoqi Wang, Min Liu, Hongguang Che. Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition. Molecular medicine reports. vol 24. issue 1. 2021-11-08. PMID:34013370. |
hydrogen sulfide attenuates renal i/r‑induced activation of the inflammatory response and apoptosis via regulating nrf2‑mediated nlrp3 signaling pathway inhibition. |
2021-11-08 |
2023-08-13 |
mouse |
| Yonghong Su, Yaoqi Wang, Min Liu, Hongguang Che. Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition. Molecular medicine reports. vol 24. issue 1. 2021-11-08. PMID:34013370. |
the present study investigated whether nrf2 and nlrp3 pathway participate in hydrogen sulfide‑regulated renal i/r‑induced activation of the inflammatory response and apoptosis. |
2021-11-08 |
2023-08-13 |
mouse |
| Yonghong Su, Yaoqi Wang, Min Liu, Hongguang Che. Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition. Molecular medicine reports. vol 24. issue 1. 2021-11-08. PMID:34013370. |
renal tissue and blood were collected from the i/r model mice to analyze nlrp3 and nrf2 mrna expression levels, nlrp3, pyd and card domain containing, caspase‑1, il‑1β, nrf2 and heme oxygenase 1 protein expression levels, cell apoptosis, the secretion of tumor necrosis factor‑α, il‑1β and il‑6 cytokines and renal histopathology and function. |
2021-11-08 |
2023-08-13 |
mouse |
| Yonghong Su, Yaoqi Wang, Min Liu, Hongguang Che. Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition. Molecular medicine reports. vol 24. issue 1. 2021-11-08. PMID:34013370. |
conversely, mcc950 treatment inhibited activation of the nlrp3 signaling pathway, and prevented i/r‑induced renal injury, release of cytokines and apoptosis in renal i/r model mice. |
2021-11-08 |
2023-08-13 |
mouse |
| Yonghong Su, Yaoqi Wang, Min Liu, Hongguang Che. Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition. Molecular medicine reports. vol 24. issue 1. 2021-11-08. PMID:34013370. |
sodium hydrosulfide (nahs) not only alleviated upregulation of nlrp3 protein expression levels, but also relieved renal injury, release of cytokines and cell apoptosis induced by renal i/r in wild‑type mice, but not in nrf2‑ko mice. |
2021-11-08 |
2023-08-13 |
mouse |
| Yonghong Su, Yaoqi Wang, Min Liu, Hongguang Che. Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition. Molecular medicine reports. vol 24. issue 1. 2021-11-08. PMID:34013370. |
nahs alleviated nlrp3 inflammasome activation, renal injury, the inflammatory response and cell apoptosis via the nrf2 signaling pathway in renal i/r model mice. |
2021-11-08 |
2023-08-13 |
mouse |
| Rong Rong, Rongliang Yang, Haibo Li, Mengling You, Zhuotao Liang, Zhou Zeng, Rongrong Zhou, Xiaobo Xia, Dan J. The roles of mitochondrial dynamics and NLRP3 inflammasomes in the pathogenesis of retinal light damage. Annals of the New York Academy of Sciences. 2021-11-06. PMID:34741555. |
further experiments revealed that dynamin-related protein 1 (drp1)-mediated excessive mitochondrial fission induced overproduction of reactive oxygen species in the retinal cells, leading to apoptosis, activation of microglia, and formation of the nlrp3 inflammasome. |
2021-11-06 |
2023-08-13 |
mouse |
| Jianqing Jiang, Mingsong Ca. Cardamonin Inhibited IL-1β Induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO-1 Signaling Pathway in Chondrocyte. Journal of microbiology and biotechnology. vol 31. issue 6. 2021-10-27. PMID:34024891. |
in chon-001 cells, il-1β suppressed cell viability and collagen ii level while promoting cell apoptosis and expression of pro-inflammatory cytokines (il-6, il-8, tnf-α), mmps (mmp-3, mmp-13), nqo-1, and nlrp3 inflammasome (nlrp3, caspase 1 and asc), with no significant influence on nrf2. |
2021-10-27 |
2023-08-13 |
Not clear |
| Jianqing Jiang, Mingsong Ca. Cardamonin Inhibited IL-1β Induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO-1 Signaling Pathway in Chondrocyte. Journal of microbiology and biotechnology. vol 31. issue 6. 2021-10-27. PMID:34024891. |
cardamonin reversed the effect of il-1β on cell viability, cell apoptosis, pro-inflammatory cytokines, mmps, collagen ii, and nlrp3 inflammasome levels. |
2021-10-27 |
2023-08-13 |
Not clear |
| Jianqing Jiang, Mingsong Ca. Cardamonin Inhibited IL-1β Induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO-1 Signaling Pathway in Chondrocyte. Journal of microbiology and biotechnology. vol 31. issue 6. 2021-10-27. PMID:34024891. |
sinrf2 reversed the function of cardamonin on il-1β-induced cell apoptosis and expression of pro-inflammatory cytokines, nrf2, nqo-1, and nlrp3 inflammasome in chondrocytes. |
2021-10-27 |
2023-08-13 |
Not clear |
| Jing Luo, Jialei Chen, Changhong Yang, Junyi Tan, Jing Zhao, Ning Jiang, Yong Zha. 6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 / FAF1 complex dissociation-mediated autophagy. International immunopharmacology. vol 100. 2021-10-27. PMID:34537481. |
6-gingerol protects against cerebral ischemia/reperfusion injury by inhibiting nlrp3 inflammasome and apoptosis via trpv1 / faf1 complex dissociation-mediated autophagy. |
2021-10-27 |
2023-08-13 |
Not clear |
| Lu Wang, Xiaohui Wang, Lina Kong, Shuyuan Wang, Kai Huang, Jingjing Wu, Changyuan Wang, Huijun Sun, Kexin Liu, Qiang Men. Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response. International immunopharmacology. vol 100. 2021-10-27. PMID:34555641. |
in conclusion, isl improves the ability of anti-oxidative stress, alleviates inflammatory reaction, apoptosis, and inhibits nlrp3 inflammasome to protect lipopolysaccharide/d-galactosamine (lps/d-galn)-induced alf through activating the pgc-1α/nrf2 pathway, which provides the possibility for the treatment of alf. |
2021-10-27 |
2023-08-13 |
Not clear |
| Jiaye Liu, Zhanjun Jia, Wei Gon. Circulating Mitochondrial DNA Stimulates Innate Immune Signaling Pathways to Mediate Acute Kidney Injury. Frontiers in immunology. vol 12. 2021-10-26. PMID:34248963. |
mitochondrial dna (mtdna) released from damaged mitochondria could serve as a danger-associated molecular pattern (damp) and activate the innate immune system through sting, tlr9, nlrp3, and some other adaptors, and further mediate tubular cell inflammation and apoptosis. |
2021-10-26 |
2023-08-13 |
Not clear |
| Sarah Adriana Scuderi, Giovanna Casili, Rossella Basilotta, Marika Lanza, Alessia Filippone, Gabriele Raciti, Ivana Puliafito, Lorenzo Colarossi, Emanuela Esposito, Irene Paternit. NLRP3 Inflammasome Inhibitor BAY-117082 Reduces Oral Squamous Cell Carcinoma Progression. International journal of molecular sciences. vol 22. issue 20. 2021-10-26. PMID:34681768. |
it has been proven that excessive nlrp3 inflammasome activation and apoptosis alteration may contribute to oral cancer progression. |
2021-10-26 |
2023-08-13 |
human |
| Sarah Adriana Scuderi, Giovanna Casili, Rossella Basilotta, Marika Lanza, Alessia Filippone, Gabriele Raciti, Ivana Puliafito, Lorenzo Colarossi, Emanuela Esposito, Irene Paternit. NLRP3 Inflammasome Inhibitor BAY-117082 Reduces Oral Squamous Cell Carcinoma Progression. International journal of molecular sciences. vol 22. issue 20. 2021-10-26. PMID:34681768. |
therefore, based on these results, the use of bay-117082 could be considered a promising strategy to counteract oral cancer progression, thanks its ability to modulate the nlrp3 inflammasome and apoptosis pathways. |
2021-10-26 |
2023-08-13 |
human |
| Rupak Dey Sarkar, Samraj Sinha, Nabendu Biswa. Manipulation of Inflammasome: A Promising Approach Towards Immunotherapy of Lung Cancer. International reviews of immunology. vol 40. issue 3. 2021-10-25. PMID:33508984. |
of these, five complexes-nlrp1, nlrp3, nlrc4, pyrin, and aim2 are of importance in the context of cancer for their activities in modulating immune responses, cell proliferation, and apoptosis. |
2021-10-25 |
2023-08-13 |
Not clear |