| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kaiwen W Chen, Benjamin Demarco, Rosalie Heilig, Kateryna Shkarina, Andreas Boettcher, Christopher J Farady, Pawel Pelczar, Petr Bro. Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly. The EMBO journal. vol 38. issue 10. 2020-01-06. PMID:30902848. |
extrinsic and intrinsic apoptosis activate pannexin-1 to drive nlrp3 inflammasome assembly. |
2020-01-06 |
2023-08-13 |
Not clear |
| Jin Wang, Yanjin Feng, Haiyan Huo, Xumei Zhang, Jiping Yue, Wenting Zhang, Zi Yan, Xiangying Jia. NLRP3 inflammasome mediates angiotensin II-induced islet β cell apoptosis. Acta biochimica et biophysica Sinica. vol 51. issue 5. 2019-12-20. PMID:30939192. |
nlrp3 inflammasome mediates angiotensin ii-induced islet β cell apoptosis. |
2019-12-20 |
2023-08-13 |
rat |
| Jin Wang, Yanjin Feng, Haiyan Huo, Xumei Zhang, Jiping Yue, Wenting Zhang, Zi Yan, Xiangying Jia. NLRP3 inflammasome mediates angiotensin II-induced islet β cell apoptosis. Acta biochimica et biophysica Sinica. vol 51. issue 5. 2019-12-20. PMID:30939192. |
the aim of the present study was to explore the role of nod-like receptor protein 3 (nlrp3) inflammasome in ang ii-induced apoptosis of pancreatic islet β cells and investigate the possible underlying mechanism. |
2019-12-20 |
2023-08-13 |
rat |
| Jin Wang, Yanjin Feng, Haiyan Huo, Xumei Zhang, Jiping Yue, Wenting Zhang, Zi Yan, Xiangying Jia. NLRP3 inflammasome mediates angiotensin II-induced islet β cell apoptosis. Acta biochimica et biophysica Sinica. vol 51. issue 5. 2019-12-20. PMID:30939192. |
the results showed that ang ii was able to reduce ins-1 cell viability and promote apoptosis and at the same time up-regulate the expressions of txnip and nlrp3 components. |
2019-12-20 |
2023-08-13 |
rat |
| Jin Wang, Yanjin Feng, Haiyan Huo, Xumei Zhang, Jiping Yue, Wenting Zhang, Zi Yan, Xiangying Jia. NLRP3 inflammasome mediates angiotensin II-induced islet β cell apoptosis. Acta biochimica et biophysica Sinica. vol 51. issue 5. 2019-12-20. PMID:30939192. |
ang ii-induced apoptosis was inhibited after administration of the nlrp3 inhibitor mcc950, and txnip silencing could reduce the nlrp3 expression and apoptosis, while both effects of ang ii on txnip-nlrp3 and its apoptosis-inducing effect were inhibited by angiotensin ii type i receptor (at1r) blocker telmisartan. |
2019-12-20 |
2023-08-13 |
rat |
| Wentao Fan, Xiaona Gao, Chenchen Ding, Yanan Lv, Tongtong Shen, Guangpeng Ma, Liping Yan, Suquan Son. Estrogen receptors participate in carcinogenesis signaling pathways by directly regulating NOD-like receptors. Biochemical and biophysical research communications. vol 511. issue 2. 2019-12-16. PMID:30797557. |
furthermore, we identified that nlrp3 was differentially expressed in colon normal and cancer cells, selective erα antagonist could significantly decrease pro-inflammatory cytokines expression, suppress proliferation and promote apoptosis by inhibited nlrp3 expression and inflammasome activity. |
2019-12-16 |
2023-08-13 |
Not clear |
| Giselli Scaini, Tatiana Barichello, Gabriel R Fries, Elizabeth A Kennon, Taylor Andrews, Bobby R Nix, Giovana Zunta-Soares, Samira S Valvassori, Jair C Soares, João Queved. TSPO upregulation in bipolar disorder and concomitant downregulation of mitophagic proteins and NLRP3 inflammasome activation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 7. 2019-12-10. PMID:30575805. |
the data reported here suggest that tspo-vdac complex upregulation in bd patients, the simultaneous downregulation of mitophagic proteins and nlrp3 inflammasome activation could lead to an accumulation of dysfunctional mitochondria, resulting in inflammation and apoptosis. |
2019-12-10 |
2023-08-13 |
Not clear |
| Teneema Kuriakose, Si Ming Man, R K Subbarao Malireddi, Rajendra Karki, Sannula Kesavardhana, David E Place, Geoffrey Neale, Peter Vogel, Thirumala-Devi Kannegant. ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways. Science immunology. vol 1. issue 2. 2019-11-20. PMID:27917412. |
zbp1 regulates nlrp3 inflammasome activation as well as induction of apoptosis, necroptosis and pyroptosis in iav-infected cells. |
2019-11-20 |
2023-08-13 |
mouse |
| Daniela Carlos, Frederico R C Costa, Camila A Pereira, Fernanda A Rocha, Juliana N U Yaochite, Gabriela G Oliveira, Fernando S Carneiro, Rita C Tostes, Simone G Ramos, Dario S Zamboni, Niels O S Camara, Bernhard Ryffel, João S Silv. Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model. Frontiers in immunology. vol 8. 2019-11-20. PMID:28289409. |
similar increases in gene expression of nlrp3, apoptosis associated speck like protein (asc) and pro-il-1β were induced by multiple low doses of streptozotocin (stz) in c57bl/6 mice. |
2019-11-20 |
2023-08-13 |
mouse |
| Xia Zhao, Chen Zhang, Mingqiang Hua, Ruiqing Wang, Chaoqin Zhong, Jie Yu, Fengjiao Han, Na He, Yanan Zhao, Guoqiang Liu, Ni Zheng, Chunyan Ji, Daoxin M. NLRP3 inflammasome activation plays a carcinogenic role through effector cytokine IL-18 in lymphoma. Oncotarget. vol 8. issue 65. 2019-11-20. PMID:29312552. |
nlrp3 inflammasome activation promoted lymphoma cells proliferation and inhibited apoptosis through up-regulation of c-myc and bcl-2, and down-regulation of tp53 and bax, and then reduced the anti-tumor effect of dexamethasone. |
2019-11-20 |
2023-08-13 |
Not clear |
| Stephanie W Lee, Shyam Gajavelli, Markus S Spurlock, Cody Andreoni, Juan Pablo de Rivero Vaccari, M Ross Bullock, Robert W Keane, W Dalton Dietric. Microglial Inflammasome Activation in Penetrating Ballistic-Like Brain Injury. Journal of neurotrauma. vol 35. issue 14. 2019-11-06. PMID:29439605. |
tissues were assessed by immunoblot analysis for expression of il-1β, il-18, and components of the inflammasome: apoptosis-associated speck-like protein containing a caspase-activation and recruitment domain (asc), caspase-1, x-linked inhibitor of apoptosis protein (xiap), nucleotide-binding oligomerization domain (nod)-like receptor protein 3 (nlrp3), and gasdermin-d (gsdmd). |
2019-11-06 |
2023-08-13 |
rat |
| Pawan Kumar Raut, Sang-Hyun Kim, Dong Young Choi, Gil-Saeng Jeong, Pil-Hoon Par. Growth of breast cancer cells by leptin is mediated via activation of the inflammasome: Critical roles of estrogen receptor signaling and reactive oxygen species production. Biochemical pharmacology. vol 161. 2019-10-23. PMID:30633869. |
moreover, suppression of apoptosis and cell cycle promotion by leptin were also significantly abolished by gene silencing of nlrp3, clearly indicating a crucial role of nlrp3 inflammasomes in leptin-induced breast cancer growth. |
2019-10-23 |
2023-08-13 |
Not clear |
| Wei Cheng, Fei Zhao, Cheng-Yuan Tang, Xu-Wei Li, Min Luo, Shao-Bin Dua. Comparison of iohexol and iodixanol induced nephrotoxicity, mitochondrial damage and mitophagy in a new contrast-induced acute kidney injury rat model. Archives of toxicology. vol 92. issue 7. 2019-10-07. PMID:29860548. |
taken together, our results indicate that iohexol induced more severe nephrotoxicity than iodixanol in vivo due to apoptosis, destruction of antioxidative defense machinery, activation of nlrp3 inflammasome, mitochondrial damage and mitophagy. |
2019-10-07 |
2023-08-13 |
rat |
| Qiufang Gao, Hengting Zh. The Overexpression of Sirtuin1 (SIRT1) Alleviated Lipopolysaccharide (LPS)-Induced Acute Kidney Injury (AKI) via Inhibiting the Activation of Nucleotide-Binding Oligomerization Domain-Like Receptors (NLR) Family Pyrin Domain Containing 3 (NLRP3) Inflammasome. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:30980521. |
however, the overexpression of sirt1 could upregulate cell viability and expression of caspase-1 and downregulate apoptosis rate, expressions of nlrp3, il-1ß, il-18, and cleaved caspase-1. |
2019-09-10 |
2023-08-13 |
Not clear |
| Susanne Schuster, Casey D Johnson, Marie Hennebelle, Theresa Holtmann, Ameer Y Taha, Irina A Kirpich, Akiko Eguchi, Christopher E Ramsden, Bettina G Papouchado, Craig J McClain, Ariel E Feldstei. Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice. Journal of lipid research. vol 59. issue 9. 2019-09-09. PMID:30084831. |
oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and nlrp3 activation in mice. |
2019-09-09 |
2023-08-13 |
mouse |
| Xinxu Yuan, Owais M Bhat, Nan Meng, Hannah Lohner, Pin-Lan L. Protective Role of Autophagy in Nlrp3 Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries. The American journal of pathology. vol 188. issue 12. 2019-08-20. PMID:30273598. |
we first demonstrated that 7-ketocholesterol stimulated nlrp3 inflammasome formation and activation as shown by increased colocalization of inflammasome components [nlrp3 versus apoptosis associated speck-like protein (asc) or caspase-1] and enhanced cleavage of caspase-1 into active caspase-1 to generate il-1β in coronary artery smooth muscle cells. |
2019-08-20 |
2023-08-13 |
mouse |
| Kai Shen, Quangao Mao, Xiaoqin Yin, Chunyan Zhang, Yi Jin, Aiqing Deng, Zhifeng Gu, Bohua Che. NLRP3 Inflammasome Activation Leads to Epileptic Neuronal Apoptosis. Current neurovascular research. vol 15. issue 4. 2019-07-30. PMID:30468127. |
nlrp3 inflammasome activation leads to epileptic neuronal apoptosis. |
2019-07-30 |
2023-08-13 |
Not clear |
| Guangfu Zhao, Fang He, Chenlu Wu, Pan Li, Nengzhang Li, Jinping Deng, Guoqiang Zhu, Wenkai Ren, Yuanyi Pen. Betaine in Inflammation: Mechanistic Aspects and Applications. Frontiers in immunology. vol 9. 2019-07-26. PMID:29881379. |
mechanistically, betaine ameliorates sulfur amino acid metabolism against oxidative stress, inhibits nuclear factor-κb activity and nlrp3 inflammasome activation, regulates energy metabolism, and mitigates endoplasmic reticulum stress and apoptosis. |
2019-07-26 |
2023-08-13 |
human |
| Na-Na Sun, Chang-Hui Yu, Miao-Xia Pan, Yue Zhang, Bo-Jun Zheng, Qian-Jie Yang, Ze-Mao Zheng, Ying Men. Mir-21 Mediates the Inhibitory Effect of Ang (1-7) on AngII-induced NLRP3 Inflammasome Activation by Targeting Spry1 in lung fibroblasts. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:29084974. |
this study's aim was to investigate whether mir-21 activates the nlrp3 inflammasome and mediates the different effects of angii and ace2/ang(1-7) on lung fibroblast apoptosis and collagen synthesis. |
2019-07-01 |
2023-08-13 |
rat |
| Na-Na Sun, Chang-Hui Yu, Miao-Xia Pan, Yue Zhang, Bo-Jun Zheng, Qian-Jie Yang, Ze-Mao Zheng, Ying Men. Mir-21 Mediates the Inhibitory Effect of Ang (1-7) on AngII-induced NLRP3 Inflammasome Activation by Targeting Spry1 in lung fibroblasts. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:29084974. |
over-expression of mir-21 activated the nlrp3 inflammasome via the erk/nf-κb pathway by targeting spry1, resulting in apoptosis resistance and collagen synthesis in lung fibroblasts. |
2019-07-01 |
2023-08-13 |
rat |