| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin Sui, Jun Yang, Guangzhou Zhang, XiaoFeng Yuan, WanHua Li, JianHai Long, Yuan Luo, Yunfeng Li, Yongan Wan. NLRP3 inflammasome inhibition attenuates subacute neurotoxicity induced by acrylamide in vitro and in vivo. Toxicology. vol 432. 2020-08-14. PMID:32014472. |
similarly, aa exposure (50 mg/kg) for 10 consecutive days caused significant activation of nlrp3 inflammasomes and neuroinflammation in c57bl/6 mice, whereas inhibiting these effects through specific nlrp3 inflammasome blocker mcc950 (5 mg/kg) intervention or nlrp3 knock-out significantly ameliorated aa-induced ataxia, cerebellar purkinje cells degeneration, and apoptosis. |
2020-08-14 |
2023-08-13 |
mouse |
| Sameh Saber, Amal M H Ghanim, Eman El-Ahwany, Eman M Abd El-Kade. Novel complementary antitumour effects of celastrol and metformin by targeting IκBκB, apoptosis and NLRP3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis. Cancer chemotherapy and pharmacology. vol 85. issue 2. 2020-08-13. PMID:31989218. |
novel complementary antitumour effects of celastrol and metformin by targeting iκbκb, apoptosis and nlrp3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis. |
2020-08-13 |
2023-08-13 |
mouse |
| R K Subbarao Malireddi, Sannula Kesavardhana, Thirumala-Devi Kannegant. ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis). Frontiers in cellular and infection microbiology. vol 9. 2020-08-11. PMID:31850239. |
zbp1 and tak1: master regulators of nlrp3 inflammasome/pyroptosis, apoptosis, and necroptosis (pan-optosis). |
2020-08-11 |
2023-08-13 |
Not clear |
| Jialong Yan, Aiping Wang, Jiangang Cao, Linxi Che. Apelin/APJ system: an emerging therapeutic target for respiratory diseases. Cellular and molecular life sciences : CMLS. vol 77. issue 15. 2020-07-31. PMID:32128601. |
also, apelin protects against ali/ards by reducing mitochondrial ros-triggered oxidative damage, mitochondria apoptosis, and inflammatory responses induced by the activation of nf-κb and nlrp3 inflammasome. |
2020-07-31 |
2023-08-13 |
Not clear |
| Yansong Xue, Daniel Enosi Tuipulotu, Wei Hong Tan, Callum Kay, Si Ming Ma. Emerging Activators and Regulators of Inflammasomes and Pyroptosis. Trends in immunology. vol 40. issue 11. 2020-07-23. PMID:31662274. |
studies have now provided additional insights into the activation mechanisms and regulation of established inflammasome complexes, including nlrp1b, nlrp3, nod-like receptor family apoptosis inhibitory protein (naip)-nlrc4, absent in melanoma (aim)2, caspase-11, and pyrin. |
2020-07-23 |
2023-08-13 |
Not clear |
| L J Cai, M F Wang, X L Wang, H F Zhu, X Z Che. Effects of sDR5-Fc fusion protein on infant mice with ulcerative colitis via the TRAIL-DR5 pathway. Journal of biological regulators and homeostatic agents. vol 34. issue 2. 2020-07-17. PMID:32425017. |
thus, sdr5-fc could inhibit the activation of nlrp3 inflammasomes induced by trail, thereby decreasing the apoptosis of ncm460 cells. |
2020-07-17 |
2023-08-13 |
mouse |
| Kaiwen W Chen, Benjamin Demarco, Petr Bro. Pannexin-1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation. European journal of immunology. vol 50. issue 2. 2020-07-13. PMID:31411729. |
pannexin-1 promotes nlrp3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation. |
2020-07-13 |
2023-08-13 |
Not clear |
| Kaiwen W Chen, Benjamin Demarco, Petr Bro. Pannexin-1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation. European journal of immunology. vol 50. issue 2. 2020-07-13. PMID:31411729. |
pannexin-1 is channel-forming glycoprotein that promotes membrane permeability and atp release during apoptosis; and was implicated in canonical nlrp3 or noncanonical inflammasome activation. |
2020-07-13 |
2023-08-13 |
Not clear |
| Yang Gyun Kim, Su-Mi Kim, Ki-Pyo Kim, Sang-Ho Lee, Ju-Young Moo. The Role of Inflammasome-Dependent and Inflammasome-Independent NLRP3 in the Kidney. Cells. vol 8. issue 11. 2020-07-08. PMID:31694192. |
inflammasome-independent nlrp3 regulates apoptosis in tubular epithelial cells by interacting with mitochondria and mediating mitochondrial reactive oxygen species production and mitophagy. |
2020-07-08 |
2023-08-13 |
Not clear |
| Guanwen Huang, Jiwen Bao, Xinghua Shao, Wenyan Zhou, Bei Wu, Zhaohui Ni, Ling Wan. Inhibiting pannexin-1 alleviates sepsis-induced acute kidney injury via decreasing NLRP3 inflammasome activation and cell apoptosis. Life sciences. vol 254. 2020-06-29. PMID:32416166. |
inhibiting pannexin-1 alleviates sepsis-induced acute kidney injury via decreasing nlrp3 inflammasome activation and cell apoptosis. |
2020-06-29 |
2023-08-13 |
Not clear |
| Jun Li, Sha-Sha Zuo, Xiao-Xuan Qiu, Xi Xu, Ying-Ying Luo, Hong-Wei Gao, Yu-Lin Feng, Li-Jun DU, Qin Gon. [Expression characteristics of inflammatory and apoptosis factors and regulatory effect of anemoside B4 in mice with acute kidney injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 1. 2020-06-25. PMID:32237425. |
after the serum was separated, serum urea nitrogen(bun), creatinine(cre), total protein(tp), and albumin(alb) were tested by using an automatic biochemical analyzer; the changes of kidney pathological morphology were observed by pas staining; the protein expression levels of inflammatory factors including nucleotide binding oligomerization domain-like receptor(nlrp3), cysteinyl aspartate specific proteinase 1(caspase-1), interleukin-18(il-18), interleukin-1β(il-1β), tumor necrosis factor(tnf-α), and interleukin-6(il-6) and apoptosis factors including p53, caspase-3, cleaved-caspase-3, bcl-2 associated x protein(bax), and b-cell lymphoma-2(bcl-2) were analyzed by western blot. |
2020-06-25 |
2023-08-13 |
mouse |
| Qiang Sun, Songlin Wang, Jun Chen, Hongxia Cai, Wei Huang, Yueliang Zhang, Lei Wang, Yu Xin. MicroRNA-190 alleviates neuronal damage and inhibits neuroinflammation via Nlrp3 in MPTP-induced Parkinson's disease mouse model. Journal of cellular physiology. vol 234. issue 12. 2020-06-08. PMID:31232472. |
furthermore, upregulation of mir-190 or knockdown of nlrp3 inhibited lps-induced apoptosis in bv2 cells. |
2020-06-08 |
2023-08-13 |
mouse |
| Qiang Sun, Songlin Wang, Jun Chen, Hongxia Cai, Wei Huang, Yueliang Zhang, Lei Wang, Yu Xin. MicroRNA-190 alleviates neuronal damage and inhibits neuroinflammation via Nlrp3 in MPTP-induced Parkinson's disease mouse model. Journal of cellular physiology. vol 234. issue 12. 2020-06-08. PMID:31232472. |
however, the apoptosis inhibition effect of mir-190 was abrogated by overexpression of nlrp3. |
2020-06-08 |
2023-08-13 |
mouse |
| Zhenen Zhang, Nannan Han, Ye She. S100A12 promotes inflammation and cell apoptosis in sepsis-induced ARDS via activation of NLRP3 inflammasome signaling. Molecular immunology. vol 122. 2020-06-08. PMID:32298873. |
s100a12 promotes inflammation and cell apoptosis in sepsis-induced ards via activation of nlrp3 inflammasome signaling. |
2020-06-08 |
2023-08-13 |
mouse |
| Maki Inoue, Toshinori Okinaga, Michihiko Usui, Aki Kawano, Chuencheewit Thongsiri, Keisuke Nakashima, Wataru Ariyoshi, Tatsuji Nishihar. β-glucan suppresses cell death of ASC deficient macrophages invaded by periodontopathic bacteria through the caspase-11 pathway. FEMS microbiology letters. vol 366. issue 8. 2020-06-03. PMID:31098636. |
members of the nucleotide-binding domain leucine-rich repeat-containing (nlr) protein family, such as nlr protein 3 (nlrp3), nlr family apoptosis inhibitory protein (naip), and nlr family card domain-containing protein 4 (nlrc4), as well as an associated protein, caspase-11, were clearly detected in a. actinomycetemcomitans-invaded control raw cells (c-raw cells; negative control). |
2020-06-03 |
2023-08-13 |
mouse |
| Wu Jiang, Maoqiang Li, Fan He, Liulong Zh. Inhibition of NLRP3 inflammasome attenuates spinal cord injury-induced lung injury in mice. Journal of cellular physiology. vol 234. issue 5. 2020-03-30. PMID:30589073. |
hence, it is inescapable to explore the effect of inhibition of nlrp3 inflammasome by inhibitors in a mouse sci model, which was conducted by using the method of 30-g closing force aneurysm clipping at t6-t7 spinal segment for 1 min, followed by assessment of edema, histology, alveolar type ii cell apoptosis, mitochondrial dysfunction, and neutrophil infiltration. |
2020-03-30 |
2023-08-13 |
mouse |
| Wu Jiang, Maoqiang Li, Fan He, Liulong Zh. Inhibition of NLRP3 inflammasome attenuates spinal cord injury-induced lung injury in mice. Journal of cellular physiology. vol 234. issue 5. 2020-03-30. PMID:30589073. |
in brief, our results showed that, nlrp3 inflammasome inhibitor bay 11-7082 or a438079 inhibited activation of nlrp3 inflammasome, alleviated mitochondrial dysfunction, the number of macrophage and neutrophil, thereby attenuating alveolar type ii cell apoptosis, lung edema, and histological injury. |
2020-03-30 |
2023-08-13 |
mouse |
| Jiezhi Dai, Hua Chen, Yimin Cha. Advanced Glycation End Products (AGEs) Induce Apoptosis of Fibroblasts by Activation of NLRP3 Inflammasome via Reactive Oxygen Species (ROS) Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-03-09. PMID:31587010. |
advanced glycation end products (ages) induce apoptosis of fibroblasts by activation of nlrp3 inflammasome via reactive oxygen species (ros) signaling pathway. |
2020-03-09 |
2023-08-13 |
human |
| Jiezhi Dai, Hua Chen, Yimin Cha. Advanced Glycation End Products (AGEs) Induce Apoptosis of Fibroblasts by Activation of NLRP3 Inflammasome via Reactive Oxygen Species (ROS) Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-03-09. PMID:31587010. |
human dermal fibroblasts exposed to ages were used to study the links among apoptosis, ros, and nlrp3 inflammasome activation. |
2020-03-09 |
2023-08-13 |
human |
| Jiezhi Dai, Hua Chen, Yimin Cha. Advanced Glycation End Products (AGEs) Induce Apoptosis of Fibroblasts by Activation of NLRP3 Inflammasome via Reactive Oxygen Species (ROS) Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-03-09. PMID:31587010. |
ages-induced apoptosis was blocked by bay 11-7082, an inhibitor of the nlrp3 inflammasome. |
2020-03-09 |
2023-08-13 |
human |