| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenning Liu, Mingli Sun, Yu Wang, Lichun Zhang, Hang Zhao, Min Zha. Silymarin attenuated paraquat-induced cytotoxicity in macrophage by regulating Trx/TXNIP complex, inhibiting NLRP3 inflammasome activation and apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. vol 46. 2018-07-20. PMID:29054699. |
in conclusion, silymarin attenuated paraquat-induced cytotoxicity in macrophage by inhibiting oxidative stress, nlrp3 inflammasome activation, cytokines secretion and apoptosis. |
2018-07-20 |
2023-08-13 |
Not clear |
| Jianxiao Shen, Ling Wang, Na Jiang, Shan Mou, Minfang Zhang, Leyi Gu, Xinghua Shao, Qin Wang, Chaojun Qi, Shu Li, Wanpeng Wang, Xiajing Che, Zhaohui N. NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis. Scientific reports. vol 6. 2018-07-02. PMID:27721494. |
nlrp3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis. |
2018-07-02 |
2023-08-13 |
mouse |
| Jianxiao Shen, Ling Wang, Na Jiang, Shan Mou, Minfang Zhang, Leyi Gu, Xinghua Shao, Qin Wang, Chaojun Qi, Shu Li, Wanpeng Wang, Xiajing Che, Zhaohui N. NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis. Scientific reports. vol 6. 2018-07-02. PMID:27721494. |
emerging evidence indicates that nlrp3 inflammasome triggers inflammation, apoptosis and tissue injury during aki. |
2018-07-02 |
2023-08-13 |
mouse |
| Jianxiao Shen, Ling Wang, Na Jiang, Shan Mou, Minfang Zhang, Leyi Gu, Xinghua Shao, Qin Wang, Chaojun Qi, Shu Li, Wanpeng Wang, Xiajing Che, Zhaohui N. NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis. Scientific reports. vol 6. 2018-07-02. PMID:27721494. |
moreover, genetic disruption of nlrp3 notably reversed contrast-induced expression of apoptosis related proteins and secretion of proinflammatory factors, similarly to the effects of asc deletion. |
2018-07-02 |
2023-08-13 |
mouse |
| Jianxiao Shen, Ling Wang, Na Jiang, Shan Mou, Minfang Zhang, Leyi Gu, Xinghua Shao, Qin Wang, Chaojun Qi, Shu Li, Wanpeng Wang, Xiajing Che, Zhaohui N. NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis. Scientific reports. vol 6. 2018-07-02. PMID:27721494. |
consistent with above results, absence of nlrp3 in mice undergoing unilateral nephrectomy also protected against contrast media-induced renal cells phenotypic alteration and cell apoptosis via modulating expression level of apoptotic proteins. |
2018-07-02 |
2023-08-13 |
mouse |
| Giulia Poli, Giovanni Cochetti, Andrea Boni, Maria Giulia Egidi, Stefano Brancorsini, Ettore Mearin. Characterization of inflammasome-related genes in urine sediments of patients receiving intravesical BCG therapy. Urologic oncology. vol 35. issue 12. 2018-07-02. PMID:28888400. |
nucleotide oligomerization domain-like receptors (nlrs) are key components of this molecular platform and the increase in expression of some members of nucleotide oligomerization domain-like receptors family (nlrp3, nlrp4, nlrp9, and nlr family apoptosis inhibitory protein [naip]) in urothelial carcinoma was already demonstrated in our previous work. |
2018-07-02 |
2023-08-13 |
human |
| Ping Gan, Zhenqiu Gao, Xiuyun Zhao, Gaofu Q. Surfactin inducing mitochondria-dependent ROS to activate MAPKs, NF-κB and inflammasomes in macrophages for adjuvant activity. Scientific reports. vol 6. 2018-06-19. PMID:27966632. |
ros also induced macrophages apoptosis to release endogenous danger signals, following activated inflammasomes of nlrp1, nlrp3, ipaf and aim2 in vitro and only nlrp1 in vivo, as well caspase-1 and il-1 in macrophages, which were significantly inhibited by pre-treatment with ros inhibitors. |
2018-06-19 |
2023-08-13 |
Not clear |
| Wen-Yu Zhao, Lei Zhang, Ming-Xing Sui, You-Hua Zhu, Li Zen. Protective effects of sirtuin 3 in a murine model of sepsis-induced acute kidney injury. Scientific reports. vol 6. 2018-06-04. PMID:27620507. |
sirt3 deletion increased the clp-induced upregulation of the nlrp3 inflammasome and apoptosis-associated speck-like protein, resulting in the activation of oxidative stress, increased production of the proinflammatory cytokines interleukin (il)-1β and il-18, and the enhancement of apoptosis, and these effects were reversed by antioxidant nac. |
2018-06-04 |
2023-08-13 |
mouse |
| Venkata Subba Rao Atluri, Sudheesh Pilakka-Kanthikeel, Gabriella Garcia, Rahul Dev Jayant, Vidya Sagar, Thangavel Samikkannu, Adriana Yndart, Madhavan Nai. Effect of Cocaine on HIV Infection and Inflammasome Gene Expression Profile in HIV Infected Macrophages. Scientific reports. vol 6. 2018-04-19. PMID:27321752. |
these results indicate that in case of hiv infected macrophages exposed to cocaine, increased ros production and il-1β transcription serve as an activators for the formation of nlrp3 and aim2 mediated inflammasomes that leads to caspase 1 mediated apoptosis. |
2018-04-19 |
2023-08-13 |
human |
| Abderrahim Naji, Basilua André Muzembo, Ken-Ichi Yagyu, Nobuyasu Baba, Frédéric Deschaseaux, Luc Sensebé, Narufumi Suganum. Endocytosis of indium-tin-oxide nanoparticles by macrophages provokes pyroptosis requiring NLRP3-ASC-Caspase1 axis that can be prevented by mesenchymal stem cells. Scientific reports. vol 6. 2018-04-11. PMID:27194621. |
however, exposing activated thp-1 cells with nlrp3 or asc knockdown to ito-nps resulted in cell death but without cytolysis, with deficiency in il-1β/tnf-α, and revealing features of apoptosis. |
2018-04-11 |
2023-08-13 |
mouse |
| Yi Zhang, Xuehua Lv, Zizhong Hu, Xiaojian Ye, Xinhua Zheng, Yuzhi Ding, Ping Xie, Qinghuai Li. Protection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction. Cell death & disease. vol 8. issue 7. 2018-04-05. PMID:28726778. |
moreover, in high-glucose-stimulated hrecs, increased production of the nlrp3 inflammasome activation and severe apoptosis were rescued with mcc950 treatment. |
2018-04-05 |
2023-08-13 |
human |
| Erica Salaro, Alessia Rambaldi, Simonetta Falzoni, Francesca Saveria Amoroso, Alessia Franceschini, Alba Clara Sarti, Massimo Bonora, Francesco Cavazzini, Gian Matteo Rigolin, Maria Ciccone, Valentina Audrito, Silvia Deaglio, Pablo Pelegrin, Paolo Pinton, Antonio Cuneo, Francesco Di Virgili. Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death. Scientific reports. vol 6. 2018-04-02. PMID:27221966. |
on the contrary, nlrp3 overexpression caused accelerated apoptosis. |
2018-04-02 |
2023-08-13 |
mouse |
| Erica Salaro, Alessia Rambaldi, Simonetta Falzoni, Francesca Saveria Amoroso, Alessia Franceschini, Alba Clara Sarti, Massimo Bonora, Francesco Cavazzini, Gian Matteo Rigolin, Maria Ciccone, Valentina Audrito, Silvia Deaglio, Pablo Pelegrin, Paolo Pinton, Antonio Cuneo, Francesco Di Virgili. Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death. Scientific reports. vol 6. 2018-04-02. PMID:27221966. |
in conclusion, we show that nlrp3 down-modulation stimulates p2x7r expression and promotes growth, while nlrp3 overexpression inhibits cell proliferation and stimulates apoptosis. |
2018-04-02 |
2023-08-13 |
mouse |
| H Chung, A Vilaysane, A Lau, M Stahl, V Morampudi, A Bondzi-Simpson, J M Platnich, N A Bracey, M-C French, P L Beck, J Chun, B A Vallance, D A Muruv. NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis. Cell death and differentiation. vol 23. issue 8. 2018-01-08. PMID:26891693. |
nlrp3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis. |
2018-01-08 |
2023-08-13 |
mouse |
| H Chung, A Vilaysane, A Lau, M Stahl, V Morampudi, A Bondzi-Simpson, J M Platnich, N A Bracey, M-C French, P L Beck, J Chun, B A Vallance, D A Muruv. NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis. Cell death and differentiation. vol 23. issue 8. 2018-01-08. PMID:26891693. |
primary mouse tubular epithelial cells (tec) lacking nlrp3 displayed reduced apoptosis downstream of the tumor necrosis factor (tnf) receptor and cd95. |
2018-01-08 |
2023-08-13 |
mouse |
| H Chung, A Vilaysane, A Lau, M Stahl, V Morampudi, A Bondzi-Simpson, J M Platnich, N A Bracey, M-C French, P L Beck, J Chun, B A Vallance, D A Muruv. NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis. Cell death and differentiation. vol 23. issue 8. 2018-01-08. PMID:26891693. |
in cell fractionation studies and by confocal microscopy, nlrp3 colocalized with asc and caspase-8 in speck-like complexes at the mitochondria during apoptosis. |
2018-01-08 |
2023-08-13 |
mouse |
| H Chung, A Vilaysane, A Lau, M Stahl, V Morampudi, A Bondzi-Simpson, J M Platnich, N A Bracey, M-C French, P L Beck, J Chun, B A Vallance, D A Muruv. NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis. Cell death and differentiation. vol 23. issue 8. 2018-01-08. PMID:26891693. |
these data show that nlrp3 and asc form a conserved non-canonical platform for caspase-8 activation, independent of the inflammasome that regulates apoptosis within epithelial cells. |
2018-01-08 |
2023-08-13 |
mouse |
| Sumra Nazir, Ihsan Gadi, Moh'd Mohanad Al-Dabet, Ahmed Elwakiel, Shrey Kohli, Sanchita Ghosh, Jayakumar Manoharan, Satish Ranjan, Fabian Bock, Ruediger C Braun-Dullaeus, Charles T Esmon, Tobias B Huber, Eric Camerer, Chris Dockendorff, John H Griffin, Berend Isermann, Khurrum Shahza. Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition. Blood. vol 130. issue 24. 2017-12-27. PMID:28882883. |
kinetic in vivo analyses revealed that nlrp3 inflammasome activation preceded myocardial injury and apoptosis, corroborating a pathogenic role of the nlrp3 inflammasome. |
2017-12-27 |
2023-08-13 |
mouse |
| Xiaohui Zhang, Liya Pan, Kelaier Yang, Yu Fu, Yue Liu, Jinyu Chi, Xin Zhang, Siting Hong, Xiao Ma, Xinhua Yi. H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 43. issue 4. 2017-12-18. PMID:28992627. |
apoptosis, fibrosis and nlrp3 inflammasome activation are involved in the development of diabetic cardiomyopathy (dcm). |
2017-12-18 |
2023-08-13 |
human |
| Zahra Hoseini, Fatemeh Sepahvand, Bahman Rashidi, Amirhossein Sahebkar, Aria Masoudifar, Hamed Mirzae. NLRP3 inflammasome: Its regulation and involvement in atherosclerosis. Journal of cellular physiology. vol 233. issue 3. 2017-12-11. PMID:28345767. |
notably, nlrp3 inflammasome can also cause apoptosis in macrophages, suggesting that nlrp3 inflammasome may mediate jnk-induced apoptosis, and the apoptotic function of nlrp3 inflammasome may be a reason for the conflicting results reported. |
2017-12-11 |
2023-08-13 |
Not clear |