| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susanne Schuster, Casey D Johnson, Marie Hennebelle, Theresa Holtmann, Ameer Y Taha, Irina A Kirpich, Akiko Eguchi, Christopher E Ramsden, Bettina G Papouchado, Craig J McClain, Ariel E Feldstei. Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice. Journal of lipid research. vol 59. issue 9. 2019-09-09. PMID:30084831. |
oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and nlrp3 activation in mice. |
2019-09-09 |
2023-08-13 |
mouse |
| Xinxu Yuan, Owais M Bhat, Nan Meng, Hannah Lohner, Pin-Lan L. Protective Role of Autophagy in Nlrp3 Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries. The American journal of pathology. vol 188. issue 12. 2019-08-20. PMID:30273598. |
we first demonstrated that 7-ketocholesterol stimulated nlrp3 inflammasome formation and activation as shown by increased colocalization of inflammasome components [nlrp3 versus apoptosis associated speck-like protein (asc) or caspase-1] and enhanced cleavage of caspase-1 into active caspase-1 to generate il-1β in coronary artery smooth muscle cells. |
2019-08-20 |
2023-08-13 |
mouse |
| Kai Shen, Quangao Mao, Xiaoqin Yin, Chunyan Zhang, Yi Jin, Aiqing Deng, Zhifeng Gu, Bohua Che. NLRP3 Inflammasome Activation Leads to Epileptic Neuronal Apoptosis. Current neurovascular research. vol 15. issue 4. 2019-07-30. PMID:30468127. |
nlrp3 inflammasome activation leads to epileptic neuronal apoptosis. |
2019-07-30 |
2023-08-13 |
Not clear |
| Guangfu Zhao, Fang He, Chenlu Wu, Pan Li, Nengzhang Li, Jinping Deng, Guoqiang Zhu, Wenkai Ren, Yuanyi Pen. Betaine in Inflammation: Mechanistic Aspects and Applications. Frontiers in immunology. vol 9. 2019-07-26. PMID:29881379. |
mechanistically, betaine ameliorates sulfur amino acid metabolism against oxidative stress, inhibits nuclear factor-κb activity and nlrp3 inflammasome activation, regulates energy metabolism, and mitigates endoplasmic reticulum stress and apoptosis. |
2019-07-26 |
2023-08-13 |
human |
| Na-Na Sun, Chang-Hui Yu, Miao-Xia Pan, Yue Zhang, Bo-Jun Zheng, Qian-Jie Yang, Ze-Mao Zheng, Ying Men. Mir-21 Mediates the Inhibitory Effect of Ang (1-7) on AngII-induced NLRP3 Inflammasome Activation by Targeting Spry1 in lung fibroblasts. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:29084974. |
this study's aim was to investigate whether mir-21 activates the nlrp3 inflammasome and mediates the different effects of angii and ace2/ang(1-7) on lung fibroblast apoptosis and collagen synthesis. |
2019-07-01 |
2023-08-13 |
rat |
| Na-Na Sun, Chang-Hui Yu, Miao-Xia Pan, Yue Zhang, Bo-Jun Zheng, Qian-Jie Yang, Ze-Mao Zheng, Ying Men. Mir-21 Mediates the Inhibitory Effect of Ang (1-7) on AngII-induced NLRP3 Inflammasome Activation by Targeting Spry1 in lung fibroblasts. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:29084974. |
over-expression of mir-21 activated the nlrp3 inflammasome via the erk/nf-κb pathway by targeting spry1, resulting in apoptosis resistance and collagen synthesis in lung fibroblasts. |
2019-07-01 |
2023-08-13 |
rat |
| Zefeng Wang, Songxue Guo, Junxing Wang, Yuanyuan Shen, Jianmin Zhang, Qun W. Nrf2/HO-1 mediates the neuroprotective effect of mangiferin on early brain injury after subarachnoid hemorrhage by attenuating mitochondria-related apoptosis and neuroinflammation. Scientific reports. vol 7. issue 1. 2019-06-25. PMID:28928429. |
the abovementioned findings indicate that mf is neuroprotective against ebi after sah and nrf2/ho-1 cascade may play a key role in mediating its effect through regulation of the mitochondrial apoptosis pathway and activation of the nlrp3 inflammasome and nf-κb. |
2019-06-25 |
2023-08-13 |
rat |
| Wenqi Gao, Wei Wang, Gang Liu, Jing Zhang, Jian Yang, Zhifang Den. Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome. Metabolic brain disease. vol 34. issue 1. 2019-06-06. PMID:30515710. |
allicin attenuated depressive-like behaviors of csds mice through reducing neuroinflammation, ameliorating iron abnromal accumulation, balacing oxidative stress, and attenuation neuronal apoptosis in the hippocampus via suppression of nlrp3 inflammasome. |
2019-06-06 |
2023-08-13 |
mouse |
| Hui Wang, Gangduo Wang, G A Shakeel Ansari, M Firoze Kha. Trichloroethene metabolite dichloroacetyl chloride induces apoptosis and compromises phagocytosis in Kupffer Cells: Activation of inflammasome and MAPKs. PloS one. vol 13. issue 12. 2019-05-20. PMID:30596806. |
dcac treatment resulted in significantly increased early and late-stage apoptosis, accompanied with inflammasome activation (nlrp3 increases). |
2019-05-20 |
2023-08-13 |
mouse |
| Ebrahim Abbasi-Oshaghi, Fatemeh Mirzaei, Mona Pourjafa. NLRP3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study. International journal of nanomedicine. vol 14. 2019-05-10. PMID:30936694. |
nlrp3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study. |
2019-05-10 |
2023-08-13 |
rat |
| S Ran, M Chu, S Gu, J Wang, J Lian. Enterococcus faecalis induces apoptosis and pyroptosis of human osteoblastic MG63 cells via the NLRP3 inflammasome. International endodontic journal. vol 52. issue 1. 2019-05-06. PMID:29904931. |
enterococcus faecalis induces apoptosis and pyroptosis of human osteoblastic mg63 cells via the nlrp3 inflammasome. |
2019-05-06 |
2023-08-13 |
human |
| Jiajia Lv, Wen Su, Qianying Yu, Meng Zhang, Caixia Di, Xiaoliang Lin, Min Wu, Zhenwei Xi. Heme oxygenase-1 protects airway epithelium against apoptosis by targeting the proinflammatory NLRP3-RXR axis in asthma. The Journal of biological chemistry. vol 293. issue 48. 2019-04-29. PMID:30333233. |
surprisingly, nod-like receptor protein 3 (nlrp3) inhibition, retinoid x receptor (rxr) deficiency, and ho-1 induction were associated with abrogated apoptosis. |
2019-04-29 |
2023-08-13 |
mouse |
| Jiajia Lv, Wen Su, Qianying Yu, Meng Zhang, Caixia Di, Xiaoliang Lin, Min Wu, Zhenwei Xi. Heme oxygenase-1 protects airway epithelium against apoptosis by targeting the proinflammatory NLRP3-RXR axis in asthma. The Journal of biological chemistry. vol 293. issue 48. 2019-04-29. PMID:30333233. |
mcc950, a selective small-molecule inhibitor of canonical and noncanonical nlrp3 activation, reduced rxr expression, leading to decreased paec apoptosis that was reversed by the rxr agonist adapalene. |
2019-04-29 |
2023-08-13 |
mouse |
| David E Place, Parimal Samir, Rajendra Karki, Benoit Briard, Peter Vogel, Thirumala-Devi Kannegant. ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming. The American journal of pathology. vol 188. issue 4. 2019-04-15. PMID:29353059. |
because nlrp3 responds broadly to cellular insults and regulates cell death similar to the stress-activated apoptosis signal-regulating kinases 1 and 2 (ask1/2), we hypothesized that ask1/2 may regulate nlrp3 activity. |
2019-04-15 |
2023-08-13 |
mouse |
| Bingqing Cao, Tao Wang, Qiumin Qu, Tao Kang, Qian Yan. Long Noncoding RNA SNHG1 Promotes Neuroinflammation in Parkinson's Disease via Regulating miR-7/NLRP3 Pathway. Neuroscience. vol 388. 2019-03-29. PMID:30031125. |
in the microglial culture supernatant transfer model, knockdown of snhg1 or nlrp3 in lps-stimulated bv2 cells inhibited primary neurons from apoptosis and elevated caspase-3 activity. |
2019-03-29 |
2023-08-13 |
mouse |
| Xuejun Yang, You Wu, Qianqian Li, Gaofu Zhang, Mo Wang, Haiping Yang, Qiu L. CD36 Promotes Podocyte Apoptosis by Activating the Pyrin Domain-Containing-3 (NLRP3) Inflammasome in Primary Nephrotic Syndrome. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-19. PMID:30258045. |
cd36 promotes podocyte apoptosis by activating the pyrin domain-containing-3 (nlrp3) inflammasome in primary nephrotic syndrome. |
2018-12-19 |
2023-08-13 |
mouse |
| Xuejun Yang, You Wu, Qianqian Li, Gaofu Zhang, Mo Wang, Haiping Yang, Qiu L. CD36 Promotes Podocyte Apoptosis by Activating the Pyrin Domain-Containing-3 (NLRP3) Inflammasome in Primary Nephrotic Syndrome. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-19. PMID:30258045. |
this study investigated whether cd36 activates the nucleotide-binding domain leucine-rich repeat-containing family, pyrin domain-containing-3 (nlrp3) inflammasome and promotes podocytes apoptosis in primary nephrotic syndrome. |
2018-12-19 |
2023-08-13 |
mouse |
| Xuejun Yang, You Wu, Qianqian Li, Gaofu Zhang, Mo Wang, Haiping Yang, Qiu L. CD36 Promotes Podocyte Apoptosis by Activating the Pyrin Domain-Containing-3 (NLRP3) Inflammasome in Primary Nephrotic Syndrome. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-19. PMID:30258045. |
conclusions cd36 might play an important role in podocyte apoptosis by activating the nlrp3 inflammasome in primary nephrotic syndrome. |
2018-12-19 |
2023-08-13 |
mouse |
| Zhiwen Wang, Ai Zhang, Weixin Meng, Tingting Wang, Dandan Li, Zonghong Liu, Hongyu Li. Ozone protects the rat lung from ischemia-reperfusion injury by attenuating NLRP3-mediated inflammation, enhancing Nrf2 antioxidant activity and inhibiting apoptosis. European journal of pharmacology. vol 835. 2018-12-11. PMID:30075224. |
the aim of this study was to initially elucidate whether ozone induces oxidative preconditioning by activating nuclear factor (erythroid-derived 2)-like 2 (nrf2) and secondly to determine whether ozone oxidative preconditioning (ozoneop) protects the lung from iri by attenuating nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (nlrp3)-mediated inflammation, enhancing the antioxidant activity of nrf2 and inhibiting apoptosis. |
2018-12-11 |
2023-08-13 |
rat |
| Xiao-Feng Yin, Qiong Zhang, Zhuo-Yu Chen, Hai-Fang Wang, Xin Li, Hong-Xia Wang, Hai-Xia Li, Chun-Min Kang, Shuai Chu, Kai-Fei Li, Yao Li, Yu-Rong Qi. NLRP3 in human glioma is correlated with increased WHO grade, and regulates cellular proliferation, apoptosis and metastasis via epithelial-mesenchymal transition and the PTEN/AKT signaling pathway. International journal of oncology. vol 53. issue 3. 2018-11-26. PMID:30015880. |
nlrp3 in human glioma is correlated with increased who grade, and regulates cellular proliferation, apoptosis and metastasis via epithelial-mesenchymal transition and the pten/akt signaling pathway. |
2018-11-26 |
2023-08-13 |
human |