| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Khurrum Shahzad, Fabian Bock, Moh'd Mohanad Al-Dabet, Ihsan Gadi, Shrey Kohli, Sumra Nazir, Sanchita Ghosh, Satish Ranjan, Hongjie Wang, Thati Madhusudhan, Peter P Nawroth, Berend Iserman. Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy. Journal of the American Society of Nephrology : JASN. vol 27. issue 8. 2017-05-24. PMID:26832955. |
in vitro, increased levels of markers of inflammasome activation (nlrp3, caspase-1 cleavage) preceded those of markers of apoptosis activation (caspase-3 and -7, parp1 cleavage) in glucose-stressed podocytes. |
2017-05-24 |
2023-08-13 |
mouse |
| Amna Abderrazak, Khadija El Hadri, Elodie Bosc, Bertrand Blondeau, Mohamed-Naceur Slimane, Berthold Büchele, Thomas Simmet, Dominique Couchie, Mustapha Roui. Inhibition of the Inflammasome NLRP3 by Arglabin Attenuates Inflammation, Protects Pancreatic β-Cells from Apoptosis, and Prevents Type 2 Diabetes Mellitus Development in ApoE2Ki Mice on a Chronic High-Fat Diet. The Journal of pharmacology and experimental therapeutics. vol 357. issue 3. 2017-05-23. PMID:27044804. |
inhibition of the inflammasome nlrp3 by arglabin attenuates inflammation, protects pancreatic β-cells from apoptosis, and prevents type 2 diabetes mellitus development in apoe2ki mice on a chronic high-fat diet. |
2017-05-23 |
2023-08-13 |
mouse |
| Javier Oroz, Susana Barrera-Vilarmau, Carlos Alfonso, Germán Rivas, Eva de Alb. ASC Pyrin Domain Self-associates and Binds NLRP3 Protein Using Equivalent Binding Interfaces. The Journal of biological chemistry. vol 291. issue 37. 2017-05-15. PMID:27432880. |
the proteins apoptosis-associated speck-like protein containing a card (asc) and nlrp3 play key roles in the regulation of apoptosis and inflammation through self-association and protein-protein interactions mediated by their pyds. |
2017-05-15 |
2023-08-13 |
Not clear |
| Laurence D Towner, Richard A Wheat, Timothy R Hughes, B Paul Morga. Complement Membrane Attack and Tumorigenesis: A SYSTEMS BIOLOGY APPROACH. The Journal of biological chemistry. vol 291. issue 29. 2017-04-10. PMID:27226542. |
this is despite abundant evidence documenting the effects of this complex on cell behavior, including cell activation, protection from/induction of apoptosis, release of inflammatory cytokines, growth factors, and ecm components and regulators, and the triggering of the nlrp3 inflammasome. |
2017-04-10 |
2023-08-13 |
Not clear |
| Fang Zhang, Liang Wang, Jun-Jie Wang, Peng-Fei Luo, Xing-Tong Wang, Zhao-Fan Xi. The caspase-1 inhibitor AC-YVAD-CMK attenuates acute gastric injury in mice: involvement of silencing NLRP3 inflammasome activities. Scientific reports. vol 6. 2017-03-10. PMID:27053298. |
inhibiting caspase-1 activity in the nlrp3 inflammasome decreased gastric cell apoptosis, and the expression of bax and cleaved caspase-3. |
2017-03-10 |
2023-08-13 |
mouse |
| Fang Zhang, Liang Wang, Jun-Jie Wang, Peng-Fei Luo, Xing-Tong Wang, Zhao-Fan Xi. The caspase-1 inhibitor AC-YVAD-CMK attenuates acute gastric injury in mice: involvement of silencing NLRP3 inflammasome activities. Scientific reports. vol 6. 2017-03-10. PMID:27053298. |
overall, our results showed that the caspase-1 inhibitor ac-yvad-cmk protected against acute gastric injury in mice by affecting the nlrp3 inflammasome and attenuating inflammatory processes and apoptosis. |
2017-03-10 |
2023-08-13 |
mouse |
| Yanjie Li, Ning Li, Zhiling Yan, Hujun Li, Lili Chen, Zhiyao Zhang, Guoqin Fan, Kailin Xu, Zhenyu L. Dysregulation of the NLRP3 inflammasome complex and related cytokines in patients with multiple myeloma. Hematology (Amsterdam, Netherlands). vol 21. issue 3. 2017-03-03. PMID:26146985. |
the nlrp3 inflammasome complex, an important regulatory factor of inflammation and cell apoptosis, has attracted considerable attention in the development of tumor. |
2017-03-03 |
2023-08-13 |
Not clear |
| Wei Ding, Honglei Guo, Chengyan Xu, Bin Wang, Minmin Zhang, Feng Din. Mitochondrial reactive oxygen species-mediated NLRP3 inflammasome activation contributes to aldosterone-induced renal tubular cells injury. Oncotarget. vol 7. issue 14. 2017-02-09. PMID:27014913. |
mice harboring genetic knock-out of nlrp3 (nlrp3(-/-)) showed decreased maturation of renal il-1β and il-18, reduced renal tubular apoptosis, and improved renal epithelial cell phenotypic alternation, and attenuated renal function in response to aldo-infusion. |
2017-02-09 |
2023-08-13 |
mouse |
| Wei Ding, Honglei Guo, Chengyan Xu, Bin Wang, Minmin Zhang, Feng Din. Mitochondrial reactive oxygen species-mediated NLRP3 inflammasome activation contributes to aldosterone-induced renal tubular cells injury. Oncotarget. vol 7. issue 14. 2017-02-09. PMID:27014913. |
mito-tempo, the mitochondria-targeted antioxidant, significantly decreased hk-2 cell apoptosis, oxidative stress, and the activation of nlrp3 inflammasome. |
2017-02-09 |
2023-08-13 |
mouse |
| Hiroo Hasegawa, Reid P Bissonnette, Mireille Gillings, Daisuke Sasaki, Hiroaki Taniguchi, Hideaki Kitanosono, Kazuto Tsuruda, Kousuke Kosai, Naoki Uno, Yoshitomo Morinaga, Yoshitaka Imaizumi, Yasushi Miyazaki, Katsunori Yanagihar. Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma is associated with activation of Bim and NLRP3. Cancer science. vol 107. issue 8. 2017-02-01. PMID:27193821. |
induction of apoptosis by hbi-8000 in adult t-cell leukemia/lymphoma is associated with activation of bim and nlrp3. |
2017-02-01 |
2023-08-13 |
human |
| Jianru Li, Jingsen Chen, Hangbo Mo, Jingyin Chen, Cong Qian, Feng Yan, Chi Gu, Qiang Hu, Lin Wang, Gao Che. Minocycline Protects Against NLRP3 Inflammasome-Induced Inflammation and P53-Associated Apoptosis in Early Brain Injury After Subarachnoid Hemorrhage. Molecular neurobiology. vol 53. issue 4. 2016-12-26. PMID:26143258. |
minocycline protects against nlrp3 inflammasome-induced inflammation and p53-associated apoptosis in early brain injury after subarachnoid hemorrhage. |
2016-12-26 |
2023-08-13 |
rat |
| Jianru Li, Jingsen Chen, Hangbo Mo, Jingyin Chen, Cong Qian, Feng Yan, Chi Gu, Qiang Hu, Lin Wang, Gao Che. Minocycline Protects Against NLRP3 Inflammasome-Induced Inflammation and P53-Associated Apoptosis in Early Brain Injury After Subarachnoid Hemorrhage. Molecular neurobiology. vol 53. issue 4. 2016-12-26. PMID:26143258. |
minocycline protects against nlrp3 inflammasome-induced inflammation and p53-associated apoptosis in early brain injury following sah. |
2016-12-26 |
2023-08-13 |
rat |
| Yushu Dong, Chongxi Fan, Wei Hu, Shuai Jiang, Zhiqiang Ma, Xiaolong Yan, Chao Deng, Shouyin Di, Zhenlong Xin, Guiling Wu, Yang Yang, Russel J Reiter, Guobiao Lian. Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling. Journal of pineal research. vol 60. issue 3. 2016-12-13. PMID:26639408. |
melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating nlrp3 inflammasome and apoptosis signaling. |
2016-12-13 |
2023-08-13 |
mouse |
| Yushu Dong, Chongxi Fan, Wei Hu, Shuai Jiang, Zhiqiang Ma, Xiaolong Yan, Chao Deng, Shouyin Di, Zhenlong Xin, Guiling Wu, Yang Yang, Russel J Reiter, Guobiao Lian. Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling. Journal of pineal research. vol 60. issue 3. 2016-12-13. PMID:26639408. |
in summary, our results demonstrate that melatonin treatment attenuates the ebi following sah by inhibiting nlrp3 inflammasome-associated apoptosis. |
2016-12-13 |
2023-08-13 |
mouse |
| Shuk-Man Ka, Louis Kuoping Chao, Jung-Chen Lin, Shui-Tein Chen, Wen-Tai Li, Chien-Nan Lin, Jen-Che Cheng, Huei-Ling Jheng, Ann Chen, Kuo-Feng Hu. A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways. Free radical biology & medicine. vol 91. 2016-12-13. PMID:26675345. |
the underlying mechanisms for these renoprotective effects involved: (1) inhibited nlrp3 inflammasome activation; (2) decreased superoxide anion levels and apoptosis; and (3) suppressed activation of nf-κb and related downstream inflammatory mediators. |
2016-12-13 |
2023-08-13 |
mouse |
| Ismail Sergin, Somashubhra Bhattacharya, Roy Emanuel, Emel Esen, Carl J Stokes, Trent D Evans, Batool Arif, John A Curci, Babak Razan. Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis. Science signaling. vol 9. issue 409. 2016-10-17. PMID:26732762. |
lipid-loaded p62-null macrophages also exhibited increased secretion of interleukin-1β (il-1β) and had an increased tendency to undergo apoptosis, which depended on the p62 ubiquitin-binding domain and at least partly involved p62-mediated clearance of nlrp3 inflammasomes. |
2016-10-17 |
2023-08-13 |
mouse |
| Yujuan Wang, Jakub W Hanus, Mones S Abu-Asab, Defen Shen, Alexander Ogilvy, Jingxing Ou, Xi K Chu, Guangpu Shi, Wei Li, Shusheng Wang, Chi-Chao Cha. NLRP3 Upregulation in Retinal Pigment Epithelium in Age-Related Macular Degeneration. International journal of molecular sciences. vol 17. issue 1. 2016-10-13. PMID:26760997. |
inflammation and oxidative stress are involved in age-related macular degeneration (amd) and possibly associated with an activation of neuronal apoptosis inhibitor protein/class ii transcription activator of the major histocompatibility complex (mhc)/heterokaryon incompatibility/telomerase-associated protein 1, leucine-rich repeat or nucleotide-binding domain, leucine-rich repeat-containing family, and pyrin domain-containing 3 (nlrp3) inflammasome. |
2016-10-13 |
2023-08-13 |
mouse |
| Yong-Liang Zheng, Si-Si Zhong, Liu-Yan Xin, Yi-Jian Che. [Expression and Significance of NLRP3, ASC and AIM2 in Patients with Acute Leukemia]. Zhongguo shi yan xue ye xue za zhi. vol 24. issue 2. 2016-09-15. PMID:27150992. |
to explore the expression and significance of nlr family, pyrin domain containing 3 (nlrp3), apoptosis associated speck like protein containing a crad (asc) and absent in melanoma 2 (aim2) of patients with acute leukemia. |
2016-09-15 |
2023-08-13 |
Not clear |
| Wan-ting He, Haoqiang Wan, Lichen Hu, Pengda Chen, Xin Wang, Zhe Huang, Zhang-Hua Yang, Chuan-Qi Zhong, Jiahuai Ha. Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion. Cell research. vol 25. issue 12. 2016-08-17. PMID:26611636. |
the induction of apoptosis required nlrp3 or other inflammasome receptors and asc, and caspase-1 may partially contribute to the activation of apoptotic caspases in gsdmd(-/-) cells. |
2016-08-17 |
2023-08-13 |
human |
| C Lebeaupin, E Proics, C H D de Bieville, D Rousseau, S Bonnafous, S Patouraux, G Adam, V J Lavallard, C Rovere, O Le Thuc, M C Saint-Paul, R Anty, A S Schneck, A Iannelli, J Gugenheim, A Tran, P Gual, B Bailly-Maitr. ER stress induces NLRP3 inflammasome activation and hepatocyte death. Cell death & disease. vol 6. 2016-07-06. PMID:26355342. |
this, in turn, activates the nlrp3 inflammasome, subsequently initiating hepatocyte pyroptosis (caspase-1, -11, interleukin-1β secretion) and apoptosis (caspase-3, bh3-only proteins). |
2016-07-06 |
2023-08-13 |
mouse |