| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiying Mao, Wangyi Fang, Qinghuai Li. An emerging role of Alu RNA in geographic atrophy pathogenesis: the implication for novel therapeutic strategies. Discovery medicine. vol 22. issue 123. 2017-07-17. PMID:28147216. |
the accumulation of alu rna, resulting from dicer1 deficiency, is shown capable of triggering the activation of nlrp3 inflammasome and causing caspase-8-activated apoptosis in an il-18/myd88-dependent manner, which provides a new source of evidence for the interplay between cell death and inflammasome. |
2017-07-17 |
2023-08-13 |
Not clear |
| Chong-Shan Shi, John H Kehr. Cytochrome c Negatively Regulates NLRP3 Inflammasomes. PloS one. vol 11. issue 12. 2017-07-05. PMID:28030552. |
we propose that there is a crosstalk between the nlrp3 inflammasome and apoptosome pathways mediated by cytochrome c, whose release during apoptosis acts to limit nlrp3 inflammasome activation. |
2017-07-05 |
2023-08-13 |
Not clear |
| Chen Li, Huang Zhihong, Li Wenlong, Liu Xiaoyan, Chen Qing, Luo Wenzhi, Xie Siming, Liu Shengmin. The Nucleotide-Binding Oligomerization Domain-Like Receptor Family Pyrin Domain-Containing 3 Inflammasome Regulates Bronchial Epithelial Cell Injury and Proapoptosis after Exposure to Biomass Fuel Smoke. American journal of respiratory cell and molecular biology. vol 55. issue 6. 2017-06-30. PMID:27447246. |
when the nlrp3 expression was silenced, the average migration distance of 16hbe was increased in scratch assay, because the activation of nlrp3 induced apoptosis by the p53-bax mitochondrial pathway in the smoke-induced response. |
2017-06-30 |
2023-08-13 |
human |
| Xinchun Ye, Dandan Zuo, Lu Yu, Liang Zhang, Jiao Tang, Chengcheng Cui, Lei Bao, Kun Zan, Zuohui Zhang, Xinxin Yang, Hao Chen, Hai Tang, Jie Zu, Hongjuan Shi, Guiyun Cu. ROS/TXNIP pathway contributes to thrombin induced NLRP3 inflammasome activation and cell apoptosis in microglia. Biochemical and biophysical research communications. vol 485. issue 2. 2017-06-13. PMID:28202418. |
ros/txnip pathway contributes to thrombin induced nlrp3 inflammasome activation and cell apoptosis in microglia. |
2017-06-13 |
2023-08-13 |
human |
| Xinchun Ye, Dandan Zuo, Lu Yu, Liang Zhang, Jiao Tang, Chengcheng Cui, Lei Bao, Kun Zan, Zuohui Zhang, Xinxin Yang, Hao Chen, Hai Tang, Jie Zu, Hongjuan Shi, Guiyun Cu. ROS/TXNIP pathway contributes to thrombin induced NLRP3 inflammasome activation and cell apoptosis in microglia. Biochemical and biophysical research communications. vol 485. issue 2. 2017-06-13. PMID:28202418. |
we used western blot to detect nlrp3 inflammasome activation and the expression of thioredoxin binding protein (txnip), dcfh-da to investigate intracellular reactive oxygen species (ros), flow cytometry to analyze apoptosis. |
2017-06-13 |
2023-08-13 |
human |
| Xinchun Ye, Dandan Zuo, Lu Yu, Liang Zhang, Jiao Tang, Chengcheng Cui, Lei Bao, Kun Zan, Zuohui Zhang, Xinxin Yang, Hao Chen, Hai Tang, Jie Zu, Hongjuan Shi, Guiyun Cu. ROS/TXNIP pathway contributes to thrombin induced NLRP3 inflammasome activation and cell apoptosis in microglia. Biochemical and biophysical research communications. vol 485. issue 2. 2017-06-13. PMID:28202418. |
furthermore, the cell apoptosis and expression of apoptotic protein were significantly attenuated after treatment of thrombin with nac or nlrp3 antagonist (mcc950). |
2017-06-13 |
2023-08-13 |
human |
| Khurrum Shahzad, Fabian Bock, Moh'd Mohanad Al-Dabet, Ihsan Gadi, Shrey Kohli, Sumra Nazir, Sanchita Ghosh, Satish Ranjan, Hongjie Wang, Thati Madhusudhan, Peter P Nawroth, Berend Iserman. Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy. Journal of the American Society of Nephrology : JASN. vol 27. issue 8. 2017-05-24. PMID:26832955. |
accordingly, analysis of gene expression data in the nephromine database revealed persistently elevated glomerular expression of inflammasome markers (nlrp3, casp1, pycard, il-18, il-1β), but not of apoptosis markers (casp3, casp7, parp1), in patients with and murine models of dnp. |
2017-05-24 |
2023-08-13 |
mouse |
| Khurrum Shahzad, Fabian Bock, Moh'd Mohanad Al-Dabet, Ihsan Gadi, Shrey Kohli, Sumra Nazir, Sanchita Ghosh, Satish Ranjan, Hongjie Wang, Thati Madhusudhan, Peter P Nawroth, Berend Iserman. Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy. Journal of the American Society of Nephrology : JASN. vol 27. issue 8. 2017-05-24. PMID:26832955. |
in vitro, increased levels of markers of inflammasome activation (nlrp3, caspase-1 cleavage) preceded those of markers of apoptosis activation (caspase-3 and -7, parp1 cleavage) in glucose-stressed podocytes. |
2017-05-24 |
2023-08-13 |
mouse |
| Amna Abderrazak, Khadija El Hadri, Elodie Bosc, Bertrand Blondeau, Mohamed-Naceur Slimane, Berthold Büchele, Thomas Simmet, Dominique Couchie, Mustapha Roui. Inhibition of the Inflammasome NLRP3 by Arglabin Attenuates Inflammation, Protects Pancreatic β-Cells from Apoptosis, and Prevents Type 2 Diabetes Mellitus Development in ApoE2Ki Mice on a Chronic High-Fat Diet. The Journal of pharmacology and experimental therapeutics. vol 357. issue 3. 2017-05-23. PMID:27044804. |
inhibition of the inflammasome nlrp3 by arglabin attenuates inflammation, protects pancreatic β-cells from apoptosis, and prevents type 2 diabetes mellitus development in apoe2ki mice on a chronic high-fat diet. |
2017-05-23 |
2023-08-13 |
mouse |
| Javier Oroz, Susana Barrera-Vilarmau, Carlos Alfonso, Germán Rivas, Eva de Alb. ASC Pyrin Domain Self-associates and Binds NLRP3 Protein Using Equivalent Binding Interfaces. The Journal of biological chemistry. vol 291. issue 37. 2017-05-15. PMID:27432880. |
the proteins apoptosis-associated speck-like protein containing a card (asc) and nlrp3 play key roles in the regulation of apoptosis and inflammation through self-association and protein-protein interactions mediated by their pyds. |
2017-05-15 |
2023-08-13 |
Not clear |
| Laurence D Towner, Richard A Wheat, Timothy R Hughes, B Paul Morga. Complement Membrane Attack and Tumorigenesis: A SYSTEMS BIOLOGY APPROACH. The Journal of biological chemistry. vol 291. issue 29. 2017-04-10. PMID:27226542. |
this is despite abundant evidence documenting the effects of this complex on cell behavior, including cell activation, protection from/induction of apoptosis, release of inflammatory cytokines, growth factors, and ecm components and regulators, and the triggering of the nlrp3 inflammasome. |
2017-04-10 |
2023-08-13 |
Not clear |
| Fang Zhang, Liang Wang, Jun-Jie Wang, Peng-Fei Luo, Xing-Tong Wang, Zhao-Fan Xi. The caspase-1 inhibitor AC-YVAD-CMK attenuates acute gastric injury in mice: involvement of silencing NLRP3 inflammasome activities. Scientific reports. vol 6. 2017-03-10. PMID:27053298. |
inhibiting caspase-1 activity in the nlrp3 inflammasome decreased gastric cell apoptosis, and the expression of bax and cleaved caspase-3. |
2017-03-10 |
2023-08-13 |
mouse |
| Fang Zhang, Liang Wang, Jun-Jie Wang, Peng-Fei Luo, Xing-Tong Wang, Zhao-Fan Xi. The caspase-1 inhibitor AC-YVAD-CMK attenuates acute gastric injury in mice: involvement of silencing NLRP3 inflammasome activities. Scientific reports. vol 6. 2017-03-10. PMID:27053298. |
overall, our results showed that the caspase-1 inhibitor ac-yvad-cmk protected against acute gastric injury in mice by affecting the nlrp3 inflammasome and attenuating inflammatory processes and apoptosis. |
2017-03-10 |
2023-08-13 |
mouse |
| Yanjie Li, Ning Li, Zhiling Yan, Hujun Li, Lili Chen, Zhiyao Zhang, Guoqin Fan, Kailin Xu, Zhenyu L. Dysregulation of the NLRP3 inflammasome complex and related cytokines in patients with multiple myeloma. Hematology (Amsterdam, Netherlands). vol 21. issue 3. 2017-03-03. PMID:26146985. |
the nlrp3 inflammasome complex, an important regulatory factor of inflammation and cell apoptosis, has attracted considerable attention in the development of tumor. |
2017-03-03 |
2023-08-13 |
Not clear |
| Wei Ding, Honglei Guo, Chengyan Xu, Bin Wang, Minmin Zhang, Feng Din. Mitochondrial reactive oxygen species-mediated NLRP3 inflammasome activation contributes to aldosterone-induced renal tubular cells injury. Oncotarget. vol 7. issue 14. 2017-02-09. PMID:27014913. |
mice harboring genetic knock-out of nlrp3 (nlrp3(-/-)) showed decreased maturation of renal il-1β and il-18, reduced renal tubular apoptosis, and improved renal epithelial cell phenotypic alternation, and attenuated renal function in response to aldo-infusion. |
2017-02-09 |
2023-08-13 |
mouse |
| Wei Ding, Honglei Guo, Chengyan Xu, Bin Wang, Minmin Zhang, Feng Din. Mitochondrial reactive oxygen species-mediated NLRP3 inflammasome activation contributes to aldosterone-induced renal tubular cells injury. Oncotarget. vol 7. issue 14. 2017-02-09. PMID:27014913. |
mito-tempo, the mitochondria-targeted antioxidant, significantly decreased hk-2 cell apoptosis, oxidative stress, and the activation of nlrp3 inflammasome. |
2017-02-09 |
2023-08-13 |
mouse |
| Hiroo Hasegawa, Reid P Bissonnette, Mireille Gillings, Daisuke Sasaki, Hiroaki Taniguchi, Hideaki Kitanosono, Kazuto Tsuruda, Kousuke Kosai, Naoki Uno, Yoshitomo Morinaga, Yoshitaka Imaizumi, Yasushi Miyazaki, Katsunori Yanagihar. Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma is associated with activation of Bim and NLRP3. Cancer science. vol 107. issue 8. 2017-02-01. PMID:27193821. |
induction of apoptosis by hbi-8000 in adult t-cell leukemia/lymphoma is associated with activation of bim and nlrp3. |
2017-02-01 |
2023-08-13 |
human |
| Jianru Li, Jingsen Chen, Hangbo Mo, Jingyin Chen, Cong Qian, Feng Yan, Chi Gu, Qiang Hu, Lin Wang, Gao Che. Minocycline Protects Against NLRP3 Inflammasome-Induced Inflammation and P53-Associated Apoptosis in Early Brain Injury After Subarachnoid Hemorrhage. Molecular neurobiology. vol 53. issue 4. 2016-12-26. PMID:26143258. |
minocycline protects against nlrp3 inflammasome-induced inflammation and p53-associated apoptosis in early brain injury after subarachnoid hemorrhage. |
2016-12-26 |
2023-08-13 |
rat |
| Jianru Li, Jingsen Chen, Hangbo Mo, Jingyin Chen, Cong Qian, Feng Yan, Chi Gu, Qiang Hu, Lin Wang, Gao Che. Minocycline Protects Against NLRP3 Inflammasome-Induced Inflammation and P53-Associated Apoptosis in Early Brain Injury After Subarachnoid Hemorrhage. Molecular neurobiology. vol 53. issue 4. 2016-12-26. PMID:26143258. |
minocycline protects against nlrp3 inflammasome-induced inflammation and p53-associated apoptosis in early brain injury following sah. |
2016-12-26 |
2023-08-13 |
rat |
| Yushu Dong, Chongxi Fan, Wei Hu, Shuai Jiang, Zhiqiang Ma, Xiaolong Yan, Chao Deng, Shouyin Di, Zhenlong Xin, Guiling Wu, Yang Yang, Russel J Reiter, Guobiao Lian. Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling. Journal of pineal research. vol 60. issue 3. 2016-12-13. PMID:26639408. |
melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating nlrp3 inflammasome and apoptosis signaling. |
2016-12-13 |
2023-08-13 |
mouse |