| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenichi Shimada, Timothy R Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V Krishnan Ramanujan, Andrea J Wolf, Laurent Vergnes, David M Ojcius, Altan Rentsendorj, Mario Vargas, Candace Guerrero, Yinsheng Wang, Katherine A Fitzgerald, David M Underhill, Terrence Town, Moshe Ardit. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. vol 36. issue 3. 2012-05-18. PMID:22342844. |
these results provide a missing link between apoptosis and inflammasome activation, via binding of cytosolic oxidized mtdna to the nlrp3 inflammasome. |
2012-05-18 |
2023-08-12 |
Not clear |
| Nao Jounai, Kouji Kobiyama, Masaaki Shiina, Kazuhiro Ogata, Ken J Ishii, Fumihiko Takeshit. NLRP4 negatively regulates autophagic processes through an association with beclin1. Journal of immunology (Baltimore, Md. : 1950). vol 186. issue 3. 2011-03-07. PMID:21209283. |
in this article, we show that nlr members, such as nlrc4, nlrp3, nlrp4, and nlrp10 interact with beclin1, an important regulator of autophagy, through their neuronal apoptosis inhibitory protein, mhc class ii transcription activator, incompatibility locus protein from podospora anserina, and telomerase-associated protein domain. |
2011-03-07 |
2023-08-12 |
Not clear |
| Kou Motani, Kouji Kawase, Ryu Imamura, Takeshi Kinoshita, Hiroko Kushiyama, Takashi Sud. Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication. Cancer science. vol 101. issue 8. 2010-08-18. PMID:20500518. |
here, we found that asc activation using nlrc4 mimicry or an autoinflammatory disease-associated nlrp3 mutant induced necrosis in colo205 colon adenocarcinoma cells, but induced caspase-8-dependent apoptosis in nugc-4 stomach cancer cells. |
2010-08-18 |
2023-08-12 |
mouse |