| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Panyu Zhao, Junchao Liu, Chunling Pan, Yaping Pa. NLRP3 inflammasome is required for apoptosis of Aggregatibacter actinomycetemcomitans-infected human osteoblastic MG63 cells. Acta histochemica. vol 116. issue 7. 2015-05-19. PMID:25001390. |
finally, we found that the knockdown expression of nlrp3 by specific small interfering rna (sirna) attenuated apoptosis of a. actinomycetemcomitans-infected mg63 cells. |
2015-05-19 |
2023-08-13 |
human |
| Panyu Zhao, Junchao Liu, Chunling Pan, Yaping Pa. NLRP3 inflammasome is required for apoptosis of Aggregatibacter actinomycetemcomitans-infected human osteoblastic MG63 cells. Acta histochemica. vol 116. issue 7. 2015-05-19. PMID:25001390. |
our data suggest that a. actinomycetemcomitans promotes apoptosis of human osteoblasts at least partially through the nlrp3 inflammasome. |
2015-05-19 |
2023-08-13 |
human |
| Ramanjaneyulu Allam, Kate E Lawlor, Eric Chi-Wang Yu, Alison L Mildenhall, Donia M Moujalled, Rowena S Lewis, Francine Ke, Kylie D Mason, Michael J White, Katryn J Stacey, Andreas Strasser, Lorraine A O'Reilly, Warren Alexander, Benjamin T Kile, David L Vaux, James E Vinc. Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. EMBO reports. vol 15. issue 9. 2015-05-14. PMID:24990442. |
mitochondrial apoptosis is dispensable for nlrp3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. |
2015-05-14 |
2023-08-13 |
Not clear |
| Ramanjaneyulu Allam, Kate E Lawlor, Eric Chi-Wang Yu, Alison L Mildenhall, Donia M Moujalled, Rowena S Lewis, Francine Ke, Kylie D Mason, Michael J White, Katryn J Stacey, Andreas Strasser, Lorraine A O'Reilly, Warren Alexander, Benjamin T Kile, David L Vaux, James E Vinc. Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. EMBO reports. vol 15. issue 9. 2015-05-14. PMID:24990442. |
neither co-deletion of the essential executioners of mitochondrial apoptosis bak and bax, nor removal of the mitochondrial permeability transition pore component cyclophilin d, nor loss of the mitophagy regulator parkin, nor deficiency in mavs affects nlrp3 inflammasome function. |
2015-05-14 |
2023-08-13 |
Not clear |
| Ramanjaneyulu Allam, Kate E Lawlor, Eric Chi-Wang Yu, Alison L Mildenhall, Donia M Moujalled, Rowena S Lewis, Francine Ke, Kylie D Mason, Michael J White, Katryn J Stacey, Andreas Strasser, Lorraine A O'Reilly, Warren Alexander, Benjamin T Kile, David L Vaux, James E Vinc. Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. EMBO reports. vol 15. issue 9. 2015-05-14. PMID:24990442. |
collectively, these results demonstrate that mitochondrial apoptosis is not required for nlrp3 activation, and highlight an important non-apoptotic role for caspase-8 in regulating inflammasome activation and pro-inflammatory cytokine levels. |
2015-05-14 |
2023-08-13 |
Not clear |
| Pieter J Bakker, Loes M Butter, Nike Claessen, Gwendoline J D Teske, Fayyaz S Sutterwala, Sandrine Florquin, Jaklien C Leeman. A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion. The American journal of pathology. vol 184. issue 7. 2015-03-30. PMID:24823805. |
leukocyte-associated nlrp3 negatively affected tubular apoptosis in mice that lacked nlrp3 expression on leukocytes, which correlated with reduced macrophage influx. |
2015-03-30 |
2023-08-13 |
mouse |
| Pieter J Bakker, Loes M Butter, Nike Claessen, Gwendoline J D Teske, Fayyaz S Sutterwala, Sandrine Florquin, Jaklien C Leeman. A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion. The American journal of pathology. vol 184. issue 7. 2015-03-30. PMID:24823805. |
in conclusion, nlrp3 shows a tissue-specific role in which leukocyte-associated nlrp3 is associated with tubular apoptosis, whereas renal-associated nlrp3 impaired wound healing. |
2015-03-30 |
2023-08-13 |
mouse |
| Jia Xiao, Yinghui Zhu, Yingxia Liu, George L Tipoe, Feiyue Xing, Kwok-Fai S. Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway. International journal of biological macromolecules. vol 69. 2015-03-12. PMID:24858535. |
we found that 50μg/ml lbp pre-treatment significantly alleviated 24-h ethanol exposure-induced overexpression of txnip, increased cellular apoptosis, secretion of inflammatory cytokines, activation of nlrp3 inflammasome, production of ros, and reduced antioxidant enzyme expression. |
2015-03-12 |
2023-08-13 |
rat |
| Jia Xiao, Yinghui Zhu, Yingxia Liu, George L Tipoe, Feiyue Xing, Kwok-Fai S. Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway. International journal of biological macromolecules. vol 69. 2015-03-12. PMID:24858535. |
silence of txnip suppressed the activated nlrp3 inflammasome, increased oxidative stress and worsened apoptosis in the cells. |
2015-03-12 |
2023-08-13 |
rat |
| Jia Xiao, Yinghui Zhu, Yingxia Liu, George L Tipoe, Feiyue Xing, Kwok-Fai S. Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway. International journal of biological macromolecules. vol 69. 2015-03-12. PMID:24858535. |
in conclusion, inhibition of hepatic txnip by lbp contributes to the reduction of cellular apoptosis, oxidative stress and nlrp3 inflammasome-mediated inflammation. |
2015-03-12 |
2023-08-13 |
rat |
| Yi Liu, Kun Lian, Lijian Zhang, Rutao Wang, Fu Yi, Chao Gao, Chao Xin, Di Zhu, Yan Li, Wenjun Yan, Lize Xiong, Erhe Gao, Haichang Wang, Ling Ta. TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury. Basic research in cardiology. vol 109. issue 5. 2015-02-23. PMID:25015733. |
intramyocardial nlrp3 sirna injection or an intraperitoneal injection of bay 11-7028, an inflammasome inhibitor, attenuated macrophage and neutrophil infiltration and decreased mi/r injury, as measured by cardiomyocyte apoptosis and infarct size. |
2015-02-23 |
2023-08-13 |
mouse |
| Yibo Zhuang, Guixia Ding, Min Zhao, Mi Bai, Lingyun Yang, Jiajia Ni, Rong Wang, Zhanjun Jia, Songming Huang, Aihua Zhan. NLRP3 inflammasome mediates albumin-induced renal tubular injury through impaired mitochondrial function. The Journal of biological chemistry. vol 289. issue 36. 2015-01-28. PMID:25059664. |
in agreement with these results, albumin remarkably activated nlrp3 inflammasome in both in vitro renal tubular cells and in vivo kidneys in parallel with significant epithelial cell phenotypic alteration and cell apoptosis. |
2015-01-28 |
2023-08-13 |
mouse |
| Yibo Zhuang, Guixia Ding, Min Zhao, Mi Bai, Lingyun Yang, Jiajia Ni, Rong Wang, Zhanjun Jia, Songming Huang, Aihua Zhan. NLRP3 inflammasome mediates albumin-induced renal tubular injury through impaired mitochondrial function. The Journal of biological chemistry. vol 289. issue 36. 2015-01-28. PMID:25059664. |
genetic disruption of nlrp3 inflammasome remarkably attenuated albumin-induced cell apoptosis and phenotypic changes under both in vitro and in vivo conditions. |
2015-01-28 |
2023-08-13 |
mouse |
| Yoshiyuki Inoue, Koumei Shirasuna, Hiroaki Kimura, Fumitake Usui, Akira Kawashima, Tadayoshi Karasawa, Kenji Tago, Katsuya Dezaki, Satoshi Nishimura, Junji Sagara, Tetsuo Noda, Yoichiro Iwakura, Hiroko Tsutsui, Shun'ichiro Taniguchi, Ken Yanagisawa, Toshihiko Yada, Yoshikazu Yasuda, Masafumi Takahash. NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes. Journal of immunology (Baltimore, Md. : 1950). vol 192. issue 9. 2014-06-06. PMID:24696236. |
nlrp3(-/-) mice showed reduced inflammatory responses, reactive oxygen species production, and apoptosis in i/r liver. |
2014-06-06 |
2023-08-13 |
mouse |
| Heather D Jones, Timothy R Crother, Romer A Gonzalez-Villalobos, Madhulika Jupelli, Shuang Chen, Jargalsaikhan Dagvadorj, Moshe Arditi, Kenichi Shimad. The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury. American journal of respiratory cell and molecular biology. vol 50. issue 2. 2014-04-25. PMID:24007300. |
mv resulted in increased bronchoalveolar lavage extracellular atp and alveolar macrophage apoptosis as triggers of nlrp3 inflammasome activation. |
2014-04-25 |
2023-08-12 |
mouse |
| Heather D Jones, Timothy R Crother, Romer A Gonzalez-Villalobos, Madhulika Jupelli, Shuang Chen, Jargalsaikhan Dagvadorj, Moshe Arditi, Kenichi Shimad. The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury. American journal of respiratory cell and molecular biology. vol 50. issue 2. 2014-04-25. PMID:24007300. |
mv causes alveolar macrophage apoptosis, a key step in the activation of nlrp3 inflammasome and production of il-1β. |
2014-04-25 |
2023-08-12 |
mouse |
| Francis M Hughes, Nivardo P Vivar, James G Kennis, Jeffery D Pratt-Thomas, Danielle W Lowe, Brooke E Shaner, Paul J Nietert, Laura S Spruill, J Todd Purve. Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation. American journal of physiology. Renal physiology. vol 306. issue 3. 2014-04-08. PMID:24285499. |
we now demonstrate that nlrp3 and nlrc4, and their binding partners apoptosis-associated speck-like protein containing a cooh-terminal caspase recruitment domain (asc) and nlr family apoptosis inhibitory protein (naip), are expressed in the bladder and localized predominantly to the urothelia. |
2014-04-08 |
2023-08-12 |
Not clear |
| Jibran A Wali, Seth L Masters, Helen E Thoma. Linking metabolic abnormalities to apoptotic pathways in Beta cells in type 2 diabetes. Cells. vol 2. issue 2. 2014-04-08. PMID:24709700. |
activation of the nlrp3 inflammasome may not be important for glucose or palmitate induced apoptosis in islets but may be important for iapp mediated cell death. |
2014-04-08 |
2023-08-13 |
Not clear |
| Kathy Triantafilou, Timothy R Hughes, Martha Triantafilou, B Paul Morga. The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation. Journal of cell science. vol 126. issue Pt 13. 2014-01-16. PMID:23613465. |
nlrp3 co-localises with the mitochondria, probably sensing the increase in calcium and the resultant mitochondrial dysfunction, leading to caspase activation and apoptosis. |
2014-01-16 |
2023-08-12 |
Not clear |
| Hyun-Jung Kim, Dong Won Lee, Kameswaran Ravichandran, Daniel O Keys, Ali Akcay, Quocan Nguyen, Zhibin He, Alkesh Jani, Danica Ljubanovic, Charles L Edelstei. NLRP3 inflammasome knockout mice are protected against ischemic but not cisplatin-induced acute kidney injury. The Journal of pharmacology and experimental therapeutics. vol 346. issue 3. 2013-11-04. PMID:23833276. |
nlrp3(-/-) mice with ischemic aki had significantly lower blood urea nitrogen, serum creatinine, and acute tubular necrosis and apoptosis scores than the wild-type controls. |
2013-11-04 |
2023-08-12 |
mouse |