| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia Xiao, Yinghui Zhu, Yingxia Liu, George L Tipoe, Feiyue Xing, Kwok-Fai S. Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway. International journal of biological macromolecules. vol 69. 2015-03-12. PMID:24858535. |
silence of txnip suppressed the activated nlrp3 inflammasome, increased oxidative stress and worsened apoptosis in the cells. |
2015-03-12 |
2023-08-13 |
rat |
| Jia Xiao, Yinghui Zhu, Yingxia Liu, George L Tipoe, Feiyue Xing, Kwok-Fai S. Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway. International journal of biological macromolecules. vol 69. 2015-03-12. PMID:24858535. |
in conclusion, inhibition of hepatic txnip by lbp contributes to the reduction of cellular apoptosis, oxidative stress and nlrp3 inflammasome-mediated inflammation. |
2015-03-12 |
2023-08-13 |
rat |
| Yi Liu, Kun Lian, Lijian Zhang, Rutao Wang, Fu Yi, Chao Gao, Chao Xin, Di Zhu, Yan Li, Wenjun Yan, Lize Xiong, Erhe Gao, Haichang Wang, Ling Ta. TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury. Basic research in cardiology. vol 109. issue 5. 2015-02-23. PMID:25015733. |
intramyocardial nlrp3 sirna injection or an intraperitoneal injection of bay 11-7028, an inflammasome inhibitor, attenuated macrophage and neutrophil infiltration and decreased mi/r injury, as measured by cardiomyocyte apoptosis and infarct size. |
2015-02-23 |
2023-08-13 |
mouse |
| Yibo Zhuang, Guixia Ding, Min Zhao, Mi Bai, Lingyun Yang, Jiajia Ni, Rong Wang, Zhanjun Jia, Songming Huang, Aihua Zhan. NLRP3 inflammasome mediates albumin-induced renal tubular injury through impaired mitochondrial function. The Journal of biological chemistry. vol 289. issue 36. 2015-01-28. PMID:25059664. |
in agreement with these results, albumin remarkably activated nlrp3 inflammasome in both in vitro renal tubular cells and in vivo kidneys in parallel with significant epithelial cell phenotypic alteration and cell apoptosis. |
2015-01-28 |
2023-08-13 |
mouse |
| Yibo Zhuang, Guixia Ding, Min Zhao, Mi Bai, Lingyun Yang, Jiajia Ni, Rong Wang, Zhanjun Jia, Songming Huang, Aihua Zhan. NLRP3 inflammasome mediates albumin-induced renal tubular injury through impaired mitochondrial function. The Journal of biological chemistry. vol 289. issue 36. 2015-01-28. PMID:25059664. |
genetic disruption of nlrp3 inflammasome remarkably attenuated albumin-induced cell apoptosis and phenotypic changes under both in vitro and in vivo conditions. |
2015-01-28 |
2023-08-13 |
mouse |
| Yoshiyuki Inoue, Koumei Shirasuna, Hiroaki Kimura, Fumitake Usui, Akira Kawashima, Tadayoshi Karasawa, Kenji Tago, Katsuya Dezaki, Satoshi Nishimura, Junji Sagara, Tetsuo Noda, Yoichiro Iwakura, Hiroko Tsutsui, Shun'ichiro Taniguchi, Ken Yanagisawa, Toshihiko Yada, Yoshikazu Yasuda, Masafumi Takahash. NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes. Journal of immunology (Baltimore, Md. : 1950). vol 192. issue 9. 2014-06-06. PMID:24696236. |
nlrp3(-/-) mice showed reduced inflammatory responses, reactive oxygen species production, and apoptosis in i/r liver. |
2014-06-06 |
2023-08-13 |
mouse |
| Heather D Jones, Timothy R Crother, Romer A Gonzalez-Villalobos, Madhulika Jupelli, Shuang Chen, Jargalsaikhan Dagvadorj, Moshe Arditi, Kenichi Shimad. The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury. American journal of respiratory cell and molecular biology. vol 50. issue 2. 2014-04-25. PMID:24007300. |
mv resulted in increased bronchoalveolar lavage extracellular atp and alveolar macrophage apoptosis as triggers of nlrp3 inflammasome activation. |
2014-04-25 |
2023-08-12 |
mouse |
| Heather D Jones, Timothy R Crother, Romer A Gonzalez-Villalobos, Madhulika Jupelli, Shuang Chen, Jargalsaikhan Dagvadorj, Moshe Arditi, Kenichi Shimad. The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury. American journal of respiratory cell and molecular biology. vol 50. issue 2. 2014-04-25. PMID:24007300. |
mv causes alveolar macrophage apoptosis, a key step in the activation of nlrp3 inflammasome and production of il-1β. |
2014-04-25 |
2023-08-12 |
mouse |
| Francis M Hughes, Nivardo P Vivar, James G Kennis, Jeffery D Pratt-Thomas, Danielle W Lowe, Brooke E Shaner, Paul J Nietert, Laura S Spruill, J Todd Purve. Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation. American journal of physiology. Renal physiology. vol 306. issue 3. 2014-04-08. PMID:24285499. |
we now demonstrate that nlrp3 and nlrc4, and their binding partners apoptosis-associated speck-like protein containing a cooh-terminal caspase recruitment domain (asc) and nlr family apoptosis inhibitory protein (naip), are expressed in the bladder and localized predominantly to the urothelia. |
2014-04-08 |
2023-08-12 |
Not clear |
| Jibran A Wali, Seth L Masters, Helen E Thoma. Linking metabolic abnormalities to apoptotic pathways in Beta cells in type 2 diabetes. Cells. vol 2. issue 2. 2014-04-08. PMID:24709700. |
activation of the nlrp3 inflammasome may not be important for glucose or palmitate induced apoptosis in islets but may be important for iapp mediated cell death. |
2014-04-08 |
2023-08-13 |
Not clear |
| Kathy Triantafilou, Timothy R Hughes, Martha Triantafilou, B Paul Morga. The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation. Journal of cell science. vol 126. issue Pt 13. 2014-01-16. PMID:23613465. |
nlrp3 co-localises with the mitochondria, probably sensing the increase in calcium and the resultant mitochondrial dysfunction, leading to caspase activation and apoptosis. |
2014-01-16 |
2023-08-12 |
Not clear |
| Hyun-Jung Kim, Dong Won Lee, Kameswaran Ravichandran, Daniel O Keys, Ali Akcay, Quocan Nguyen, Zhibin He, Alkesh Jani, Danica Ljubanovic, Charles L Edelstei. NLRP3 inflammasome knockout mice are protected against ischemic but not cisplatin-induced acute kidney injury. The Journal of pharmacology and experimental therapeutics. vol 346. issue 3. 2013-11-04. PMID:23833276. |
nlrp3(-/-) mice with ischemic aki had significantly lower blood urea nitrogen, serum creatinine, and acute tubular necrosis and apoptosis scores than the wild-type controls. |
2013-11-04 |
2023-08-12 |
mouse |
| Ginevra Licandro, Hwei Ling Khor, Ottavio Beretta, Junyun Lai, Heidi Derks, Federica Laudisi, Cristina Conforti-Andreoni, Hong Liang Qian, Gim Gee Teng, Paola Ricciardi-Castagnoli, Alessandra Mortellar. The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells. European journal of immunology. vol 43. issue 8. 2013-10-31. PMID:23619996. |
using a transcriptomic approach, we found that dcs from nlrp3(-/-) mice responded to msu with differential expression of genes involved in the dna damage response and apoptosis. |
2013-10-31 |
2023-08-12 |
mouse |
| Stefanie Haasken, Fayyaz S Sutterwal. Damage control: management of cellular stress by the NLRP3 inflammasome. European journal of immunology. vol 43. issue 8. 2013-10-31. PMID:23928964. |
in addition, activation of the nlrp3 inflammasome modulates a number of pathways involved in dna damage repair, cell cycle, and apoptosis, suggesting a novel role for the nlrp3 inflammasome in dna damage responses following cellular stress. |
2013-10-31 |
2023-08-12 |
Not clear |
| Ryan W Grant, Vishwa D Dixi. Mechanisms of disease: inflammasome activation and the development of type 2 diabetes. Frontiers in immunology. vol 4. 2013-03-14. PMID:23483669. |
the secretion of bioactive il-1β is predominantly controlled by activation of caspase-1 through assembly of a multiprotein scaffold, "inflammasome" that is composed of nlrp3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) asc (apoptosis associated speck-like protein containing a card) and procaspase-1. |
2013-03-14 |
2023-08-12 |
Not clear |
| Takhellambam S Devi, Icksoo Lee, Maik Hüttemann, Ashok Kumar, Kwaku D Nantwi, Lalit P Sing. TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal Muller glia under chronic hyperglycemia: implications for diabetic retinopathy. Experimental diabetes research. vol 2012. 2012-07-26. PMID:22474421. |
various cellular defense mechanisms are activated by hg: (i) nlrp3 inflammasome, (ii) er stress response (sxbp1), (iii) hypoxic-like hif-1α induction, (iv) autophagy/mitophagy, and (v) apoptosis. |
2012-07-26 |
2023-08-12 |
rat |
| Kenichi Shimada, Timothy R Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V Krishnan Ramanujan, Andrea J Wolf, Laurent Vergnes, David M Ojcius, Altan Rentsendorj, Mario Vargas, Candace Guerrero, Yinsheng Wang, Katherine A Fitzgerald, David M Underhill, Terrence Town, Moshe Ardit. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. vol 36. issue 3. 2012-05-18. PMID:22342844. |
oxidized mitochondrial dna activates the nlrp3 inflammasome during apoptosis. |
2012-05-18 |
2023-08-12 |
Not clear |
| Kenichi Shimada, Timothy R Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V Krishnan Ramanujan, Andrea J Wolf, Laurent Vergnes, David M Ojcius, Altan Rentsendorj, Mario Vargas, Candace Guerrero, Yinsheng Wang, Katherine A Fitzgerald, David M Underhill, Terrence Town, Moshe Ardit. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. vol 36. issue 3. 2012-05-18. PMID:22342844. |
nlrp3 secondary signal activators such as atp induced mitochondrial dysfunction and apoptosis, resulting in release of oxidized mitochondrial dna (mtdna) into the cytosol, where it bound to and activated the nlrp3 inflammasome. |
2012-05-18 |
2023-08-12 |
Not clear |
| Kenichi Shimada, Timothy R Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V Krishnan Ramanujan, Andrea J Wolf, Laurent Vergnes, David M Ojcius, Altan Rentsendorj, Mario Vargas, Candace Guerrero, Yinsheng Wang, Katherine A Fitzgerald, David M Underhill, Terrence Town, Moshe Ardit. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. vol 36. issue 3. 2012-05-18. PMID:22342844. |
mitochondrial dna directly induced nlrp3 inflammasome activation, because macrophages lacking mtdna had severely attenuated il-1β production, yet still underwent apoptosis. |
2012-05-18 |
2023-08-12 |
Not clear |
| Kenichi Shimada, Timothy R Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V Krishnan Ramanujan, Andrea J Wolf, Laurent Vergnes, David M Ojcius, Altan Rentsendorj, Mario Vargas, Candace Guerrero, Yinsheng Wang, Katherine A Fitzgerald, David M Underhill, Terrence Town, Moshe Ardit. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. vol 36. issue 3. 2012-05-18. PMID:22342844. |
these results provide a missing link between apoptosis and inflammasome activation, via binding of cytosolic oxidized mtdna to the nlrp3 inflammasome. |
2012-05-18 |
2023-08-12 |
Not clear |