| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yushu Dong, Chongxi Fan, Wei Hu, Shuai Jiang, Zhiqiang Ma, Xiaolong Yan, Chao Deng, Shouyin Di, Zhenlong Xin, Guiling Wu, Yang Yang, Russel J Reiter, Guobiao Lian. Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling. Journal of pineal research. vol 60. issue 3. 2016-12-13. PMID:26639408. |
in summary, our results demonstrate that melatonin treatment attenuates the ebi following sah by inhibiting nlrp3 inflammasome-associated apoptosis. |
2016-12-13 |
2023-08-13 |
mouse |
| Shuk-Man Ka, Louis Kuoping Chao, Jung-Chen Lin, Shui-Tein Chen, Wen-Tai Li, Chien-Nan Lin, Jen-Che Cheng, Huei-Ling Jheng, Ann Chen, Kuo-Feng Hu. A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways. Free radical biology & medicine. vol 91. 2016-12-13. PMID:26675345. |
the underlying mechanisms for these renoprotective effects involved: (1) inhibited nlrp3 inflammasome activation; (2) decreased superoxide anion levels and apoptosis; and (3) suppressed activation of nf-κb and related downstream inflammatory mediators. |
2016-12-13 |
2023-08-13 |
mouse |
| Ismail Sergin, Somashubhra Bhattacharya, Roy Emanuel, Emel Esen, Carl J Stokes, Trent D Evans, Batool Arif, John A Curci, Babak Razan. Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis. Science signaling. vol 9. issue 409. 2016-10-17. PMID:26732762. |
lipid-loaded p62-null macrophages also exhibited increased secretion of interleukin-1β (il-1β) and had an increased tendency to undergo apoptosis, which depended on the p62 ubiquitin-binding domain and at least partly involved p62-mediated clearance of nlrp3 inflammasomes. |
2016-10-17 |
2023-08-13 |
mouse |
| Yujuan Wang, Jakub W Hanus, Mones S Abu-Asab, Defen Shen, Alexander Ogilvy, Jingxing Ou, Xi K Chu, Guangpu Shi, Wei Li, Shusheng Wang, Chi-Chao Cha. NLRP3 Upregulation in Retinal Pigment Epithelium in Age-Related Macular Degeneration. International journal of molecular sciences. vol 17. issue 1. 2016-10-13. PMID:26760997. |
inflammation and oxidative stress are involved in age-related macular degeneration (amd) and possibly associated with an activation of neuronal apoptosis inhibitor protein/class ii transcription activator of the major histocompatibility complex (mhc)/heterokaryon incompatibility/telomerase-associated protein 1, leucine-rich repeat or nucleotide-binding domain, leucine-rich repeat-containing family, and pyrin domain-containing 3 (nlrp3) inflammasome. |
2016-10-13 |
2023-08-13 |
mouse |
| Yong-Liang Zheng, Si-Si Zhong, Liu-Yan Xin, Yi-Jian Che. [Expression and Significance of NLRP3, ASC and AIM2 in Patients with Acute Leukemia]. Zhongguo shi yan xue ye xue za zhi. vol 24. issue 2. 2016-09-15. PMID:27150992. |
to explore the expression and significance of nlr family, pyrin domain containing 3 (nlrp3), apoptosis associated speck like protein containing a crad (asc) and absent in melanoma 2 (aim2) of patients with acute leukemia. |
2016-09-15 |
2023-08-13 |
Not clear |
| Wan-ting He, Haoqiang Wan, Lichen Hu, Pengda Chen, Xin Wang, Zhe Huang, Zhang-Hua Yang, Chuan-Qi Zhong, Jiahuai Ha. Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion. Cell research. vol 25. issue 12. 2016-08-17. PMID:26611636. |
the induction of apoptosis required nlrp3 or other inflammasome receptors and asc, and caspase-1 may partially contribute to the activation of apoptotic caspases in gsdmd(-/-) cells. |
2016-08-17 |
2023-08-13 |
human |
| C Lebeaupin, E Proics, C H D de Bieville, D Rousseau, S Bonnafous, S Patouraux, G Adam, V J Lavallard, C Rovere, O Le Thuc, M C Saint-Paul, R Anty, A S Schneck, A Iannelli, J Gugenheim, A Tran, P Gual, B Bailly-Maitr. ER stress induces NLRP3 inflammasome activation and hepatocyte death. Cell death & disease. vol 6. 2016-07-06. PMID:26355342. |
this, in turn, activates the nlrp3 inflammasome, subsequently initiating hepatocyte pyroptosis (caspase-1, -11, interleukin-1β secretion) and apoptosis (caspase-3, bh3-only proteins). |
2016-07-06 |
2023-08-13 |
mouse |
| Moo-Seung Lee, Haenaem Kwon, Eun-Young Lee, Dong-Jae Kim, Jong-Hwan Park, Vernon L Tesh, Tae-Kwang Oh, Myung Hee Ki. Shiga Toxins Activate the NLRP3 Inflammasome Pathway To Promote Both Production of the Proinflammatory Cytokine Interleukin-1β and Apoptotic Cell Death. Infection and immunity. vol 84. issue 1. 2016-05-24. PMID:26502906. |
in stx-intoxicated cells, the nlrp3 inflammasome triggered the activation of caspase-8/3, leading to the initiation of apoptosis, in addition to caspase-1-dependent pyroptotic cell death. |
2016-05-24 |
2023-08-13 |
Not clear |
| Allison J Greaney, Nolan K Maier, Stephen H Leppla, Mahtab Moayer. Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism. Journal of leukocyte biology. vol 99. issue 1. 2016-05-13. PMID:26269198. |
we discovered that sulforaphane inhibits caspase-1 autoproteolytic activation and interleukin-1β maturation and secretion downstream of the nucleotide-binding oligomerization domain-like receptor leucine-rich repeat proteins nlrp1 and nlrp3, nlr family apoptosis inhibitory protein 5/nlr family caspase-1 recruitment domain-containing protein 4 (naip5/nlrc4), and absent in melanoma 2 (aim2) inflammasome receptors. |
2016-05-13 |
2023-08-13 |
Not clear |
| Vijay Ramani, Shanjana Awasth. Toll-like receptor 4-interacting SPA4 peptide suppresses the NLRP3 inflammasome in response to LPS and ATP stimuli. Journal of leukocyte biology. vol 98. issue 6. 2016-03-25. PMID:26254306. |
crosstalk between toll-like receptor-4 signaling and the neuronal apoptosis inhibitor protein, major histocompatibility class 2 transcription activator, incompatibility locus protein from podospora anserina, and telomerase-associated protein (nacht), leucine-rich repeat (lrr), and pyrin domain-containing protein 3 (nlrp3) inflammasome against pathogen- or damage-associated molecular patterns can cause exaggerated inflammation. |
2016-03-25 |
2023-08-13 |
Not clear |
| Takanori Komada, Fumitake Usui, Akira Kawashima, Hiroaki Kimura, Tadayoshi Karasawa, Yoshiyuki Inoue, Motoi Kobayashi, Yoshiko Mizushina, Tadashi Kasahara, Shun'ichiro Taniguchi, Shigeaki Muto, Daisuke Nagata, Masafumi Takahash. Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury. Scientific reports. vol 5. 2016-03-24. PMID:26045078. |
furthermore, nlrp3 deficiency strikingly suppressed the expression of renal injury markers and inflammatory cytokines and apoptosis of renal tubular cells. |
2016-03-24 |
2023-08-13 |
mouse |
| Takanori Komada, Fumitake Usui, Akira Kawashima, Hiroaki Kimura, Tadayoshi Karasawa, Yoshiyuki Inoue, Motoi Kobayashi, Yoshiko Mizushina, Tadashi Kasahara, Shun'ichiro Taniguchi, Shigeaki Muto, Daisuke Nagata, Masafumi Takahash. Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury. Scientific reports. vol 5. 2016-03-24. PMID:26045078. |
these results demonstrated that nlrp3 inflammasomes contribute to inflammation, apoptosis, and tissue injury during the early phase of riaki and provide new insights into the mechanism underlying the pathogenesis of riaki. |
2016-03-24 |
2023-08-13 |
mouse |
| Wei Liu, Jun Gu, Jun Qi, Xiao-Ning Zeng, Juan Ji, Zheng-Zhen Chen, Xiu-Lan Su. Lentinan exerts synergistic apoptotic effects with paclitaxel in A549 cells via activating ROS-TXNIP-NLRP3 inflammasome. Journal of cellular and molecular medicine. vol 19. issue 8. 2016-02-22. PMID:25858687. |
moreover, co-treatment with paclitaxel and lentinan enhanced txnip-nlrp3 interaction, and activated nlrp3 inflammasome whereat interleukin-1β levels were increased and cell apoptosis was induced. |
2016-02-22 |
2023-08-13 |
Not clear |
| Yusuf Omosun, Danielle McKeithen, Khamia Ryans, Caroline Kibakaya, Uriel Blas-Machado, Duo Li, Rajesh Singh, Koichi Inoue, Zhi-Gang Xiong, Francis Eko, Carolyn Black, Joseph Igietseme, Qing H. Interleukin-10 modulates antigen presentation by dendritic cells through regulation of NLRP3 inflammasome assembly during Chlamydia infection. Infection and immunity. vol 83. issue 12. 2016-02-16. PMID:26371131. |
in addition, nlrp3 inflammasome assembly was suppressed in il-10(-/-) dcs through the inhibition of the p2x purinoceptor 7 (p2x7) receptor (p2x7r), an atp-gated ion channel, and a decrease in intracellular ca(2+) levels, which inhibited dc apoptosis. |
2016-02-16 |
2023-08-13 |
mouse |
| Roberto Scarpioni, Marco Ricardi, Vittorio Albertazz. Secondary amyloidosis in autoinflammatory diseases and the role of inflammation in renal damage. World journal of nephrology. vol 5. issue 1. 2016-01-20. PMID:26788465. |
additional mechanisms bringing to renal inflammatory, systemic diseases and fibrotic processes were recently reported, via the activation of the inflammasome that consists of nlrp3, apoptosis associated speck-like protein and caspase-1. |
2016-01-20 |
2023-08-13 |
human |
| Jie Wang, Mi-Young Song, Joo Young Lee, Keun Sang Kwon, Byung-Hyun Par. The NLRP3 inflammasome is dispensable for ER stress-induced pancreatic β-cell damage in Akita mice. Biochemical and biophysical research communications. vol 466. issue 3. 2016-01-11. PMID:26361146. |
tunicamycin-exposed islets from nlrp3 ko mice exhibited similar levels of er stress and apoptosis induction as islets from wt (ins2(+/+); nlrp3(+/+)) mice. |
2016-01-11 |
2023-08-13 |
mouse |
| Mark R Edwards, Pervez Sultan, Ana Gutierrez del Arroyo, John Whittle, Shamir N Karmali, S Ramani Moonesinghe, Fares S Haddad, Michael G Mythen, Mervyn Singer, Gareth L Acklan. Metabolic dysfunction in lymphocytes promotes postoperative morbidity. Clinical science (London, England : 1979). vol 129. issue 5. 2015-11-09. PMID:25891048. |
genetic ablation of the murine nlrp3 inflammasome failed to prevent glucocorticoid-induced lymphocyte apoptosis and caspase-1 activity, but increased nlrp1 protein expression. |
2015-11-09 |
2023-08-13 |
human |
| Ravikumar Aruna, Arumugam Geetha, Periyanayagam Sugun. Rutin modulates ASC expression in NLRP3 inflammasome: a study in alcohol and cerulein-induced rat model of pancreatitis. Molecular and cellular biochemistry. vol 396. issue 1-2. 2015-10-06. PMID:25060908. |
caspase activation recruitment domain (card) is an interaction motif found in all the major components of nlrp3 inflammasome such as apoptosis associated speck-like card containing protein (asc) and procaspase-1. |
2015-10-06 |
2023-08-13 |
rat |
| Yibo Zhuang, Caiyu Hu, Guixia Ding, Yue Zhang, Songming Huang, Zhanjun Jia, Aihua Zhan. Albumin impairs renal tubular tight junctions via targeting the NLRP3 inflammasome. American journal of physiology. Renal physiology. vol 308. issue 9. 2015-07-06. PMID:25715986. |
on the basis of our previous study showing that albumin stimulated nlrp3 [neuronal apoptosis inhibitor protein, major histocompatibility complex class 2 transcription activator, incompatibility locus protein from podospora anserina, and telomerase-associated protein (nacht); leucine-rich repeat (lrr); and pyrin domain (pyd) domains-containing protein 3] inflammasome activation in mptcs, we pretreated mptcs with nlrp3 sirna (sinlrp3) and found that nlrp3 knockdown significantly blocked the downregulation of zo-1 and claudin-1 induced by albumin. |
2015-07-06 |
2023-08-13 |
mouse |
| Panyu Zhao, Junchao Liu, Chunling Pan, Yaping Pa. NLRP3 inflammasome is required for apoptosis of Aggregatibacter actinomycetemcomitans-infected human osteoblastic MG63 cells. Acta histochemica. vol 116. issue 7. 2015-05-19. PMID:25001390. |
nlrp3 inflammasome is required for apoptosis of aggregatibacter actinomycetemcomitans-infected human osteoblastic mg63 cells. |
2015-05-19 |
2023-08-13 |
human |