| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zefeng Wang, Songxue Guo, Junxing Wang, Yuanyuan Shen, Jianmin Zhang, Qun W. Nrf2/HO-1 mediates the neuroprotective effect of mangiferin on early brain injury after subarachnoid hemorrhage by attenuating mitochondria-related apoptosis and neuroinflammation. Scientific reports. vol 7. issue 1. 2019-06-25. PMID:28928429. |
the abovementioned findings indicate that mf is neuroprotective against ebi after sah and nrf2/ho-1 cascade may play a key role in mediating its effect through regulation of the mitochondrial apoptosis pathway and activation of the nlrp3 inflammasome and nf-κb. |
2019-06-25 |
2023-08-13 |
rat |
| Wenqi Gao, Wei Wang, Gang Liu, Jing Zhang, Jian Yang, Zhifang Den. Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome. Metabolic brain disease. vol 34. issue 1. 2019-06-06. PMID:30515710. |
allicin attenuated depressive-like behaviors of csds mice through reducing neuroinflammation, ameliorating iron abnromal accumulation, balacing oxidative stress, and attenuation neuronal apoptosis in the hippocampus via suppression of nlrp3 inflammasome. |
2019-06-06 |
2023-08-13 |
mouse |
| Hui Wang, Gangduo Wang, G A Shakeel Ansari, M Firoze Kha. Trichloroethene metabolite dichloroacetyl chloride induces apoptosis and compromises phagocytosis in Kupffer Cells: Activation of inflammasome and MAPKs. PloS one. vol 13. issue 12. 2019-05-20. PMID:30596806. |
dcac treatment resulted in significantly increased early and late-stage apoptosis, accompanied with inflammasome activation (nlrp3 increases). |
2019-05-20 |
2023-08-13 |
mouse |
| Ebrahim Abbasi-Oshaghi, Fatemeh Mirzaei, Mona Pourjafa. NLRP3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study. International journal of nanomedicine. vol 14. 2019-05-10. PMID:30936694. |
nlrp3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study. |
2019-05-10 |
2023-08-13 |
rat |
| S Ran, M Chu, S Gu, J Wang, J Lian. Enterococcus faecalis induces apoptosis and pyroptosis of human osteoblastic MG63 cells via the NLRP3 inflammasome. International endodontic journal. vol 52. issue 1. 2019-05-06. PMID:29904931. |
enterococcus faecalis induces apoptosis and pyroptosis of human osteoblastic mg63 cells via the nlrp3 inflammasome. |
2019-05-06 |
2023-08-13 |
human |
| Jiajia Lv, Wen Su, Qianying Yu, Meng Zhang, Caixia Di, Xiaoliang Lin, Min Wu, Zhenwei Xi. Heme oxygenase-1 protects airway epithelium against apoptosis by targeting the proinflammatory NLRP3-RXR axis in asthma. The Journal of biological chemistry. vol 293. issue 48. 2019-04-29. PMID:30333233. |
surprisingly, nod-like receptor protein 3 (nlrp3) inhibition, retinoid x receptor (rxr) deficiency, and ho-1 induction were associated with abrogated apoptosis. |
2019-04-29 |
2023-08-13 |
mouse |
| Jiajia Lv, Wen Su, Qianying Yu, Meng Zhang, Caixia Di, Xiaoliang Lin, Min Wu, Zhenwei Xi. Heme oxygenase-1 protects airway epithelium against apoptosis by targeting the proinflammatory NLRP3-RXR axis in asthma. The Journal of biological chemistry. vol 293. issue 48. 2019-04-29. PMID:30333233. |
mcc950, a selective small-molecule inhibitor of canonical and noncanonical nlrp3 activation, reduced rxr expression, leading to decreased paec apoptosis that was reversed by the rxr agonist adapalene. |
2019-04-29 |
2023-08-13 |
mouse |
| David E Place, Parimal Samir, Rajendra Karki, Benoit Briard, Peter Vogel, Thirumala-Devi Kannegant. ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming. The American journal of pathology. vol 188. issue 4. 2019-04-15. PMID:29353059. |
because nlrp3 responds broadly to cellular insults and regulates cell death similar to the stress-activated apoptosis signal-regulating kinases 1 and 2 (ask1/2), we hypothesized that ask1/2 may regulate nlrp3 activity. |
2019-04-15 |
2023-08-13 |
mouse |
| Bingqing Cao, Tao Wang, Qiumin Qu, Tao Kang, Qian Yan. Long Noncoding RNA SNHG1 Promotes Neuroinflammation in Parkinson's Disease via Regulating miR-7/NLRP3 Pathway. Neuroscience. vol 388. 2019-03-29. PMID:30031125. |
in the microglial culture supernatant transfer model, knockdown of snhg1 or nlrp3 in lps-stimulated bv2 cells inhibited primary neurons from apoptosis and elevated caspase-3 activity. |
2019-03-29 |
2023-08-13 |
mouse |
| Xuejun Yang, You Wu, Qianqian Li, Gaofu Zhang, Mo Wang, Haiping Yang, Qiu L. CD36 Promotes Podocyte Apoptosis by Activating the Pyrin Domain-Containing-3 (NLRP3) Inflammasome in Primary Nephrotic Syndrome. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-19. PMID:30258045. |
cd36 promotes podocyte apoptosis by activating the pyrin domain-containing-3 (nlrp3) inflammasome in primary nephrotic syndrome. |
2018-12-19 |
2023-08-13 |
mouse |
| Xuejun Yang, You Wu, Qianqian Li, Gaofu Zhang, Mo Wang, Haiping Yang, Qiu L. CD36 Promotes Podocyte Apoptosis by Activating the Pyrin Domain-Containing-3 (NLRP3) Inflammasome in Primary Nephrotic Syndrome. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-19. PMID:30258045. |
this study investigated whether cd36 activates the nucleotide-binding domain leucine-rich repeat-containing family, pyrin domain-containing-3 (nlrp3) inflammasome and promotes podocytes apoptosis in primary nephrotic syndrome. |
2018-12-19 |
2023-08-13 |
mouse |
| Xuejun Yang, You Wu, Qianqian Li, Gaofu Zhang, Mo Wang, Haiping Yang, Qiu L. CD36 Promotes Podocyte Apoptosis by Activating the Pyrin Domain-Containing-3 (NLRP3) Inflammasome in Primary Nephrotic Syndrome. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-19. PMID:30258045. |
conclusions cd36 might play an important role in podocyte apoptosis by activating the nlrp3 inflammasome in primary nephrotic syndrome. |
2018-12-19 |
2023-08-13 |
mouse |
| Zhiwen Wang, Ai Zhang, Weixin Meng, Tingting Wang, Dandan Li, Zonghong Liu, Hongyu Li. Ozone protects the rat lung from ischemia-reperfusion injury by attenuating NLRP3-mediated inflammation, enhancing Nrf2 antioxidant activity and inhibiting apoptosis. European journal of pharmacology. vol 835. 2018-12-11. PMID:30075224. |
the aim of this study was to initially elucidate whether ozone induces oxidative preconditioning by activating nuclear factor (erythroid-derived 2)-like 2 (nrf2) and secondly to determine whether ozone oxidative preconditioning (ozoneop) protects the lung from iri by attenuating nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (nlrp3)-mediated inflammation, enhancing the antioxidant activity of nrf2 and inhibiting apoptosis. |
2018-12-11 |
2023-08-13 |
rat |
| Xiao-Feng Yin, Qiong Zhang, Zhuo-Yu Chen, Hai-Fang Wang, Xin Li, Hong-Xia Wang, Hai-Xia Li, Chun-Min Kang, Shuai Chu, Kai-Fei Li, Yao Li, Yu-Rong Qi. NLRP3 in human glioma is correlated with increased WHO grade, and regulates cellular proliferation, apoptosis and metastasis via epithelial-mesenchymal transition and the PTEN/AKT signaling pathway. International journal of oncology. vol 53. issue 3. 2018-11-26. PMID:30015880. |
nlrp3 in human glioma is correlated with increased who grade, and regulates cellular proliferation, apoptosis and metastasis via epithelial-mesenchymal transition and the pten/akt signaling pathway. |
2018-11-26 |
2023-08-13 |
human |
| Xiao-Feng Yin, Qiong Zhang, Zhuo-Yu Chen, Hai-Fang Wang, Xin Li, Hong-Xia Wang, Hai-Xia Li, Chun-Min Kang, Shuai Chu, Kai-Fei Li, Yao Li, Yu-Rong Qi. NLRP3 in human glioma is correlated with increased WHO grade, and regulates cellular proliferation, apoptosis and metastasis via epithelial-mesenchymal transition and the PTEN/AKT signaling pathway. International journal of oncology. vol 53. issue 3. 2018-11-26. PMID:30015880. |
the in vitro biological experiments demonstrated that nlrp3 downregulation significantly inhibited the proliferation, migration and invasion, and promoted the apoptosis of shg44 and a172 glioma cell lines. |
2018-11-26 |
2023-08-13 |
human |
| Xiao-Feng Yin, Qiong Zhang, Zhuo-Yu Chen, Hai-Fang Wang, Xin Li, Hong-Xia Wang, Hai-Xia Li, Chun-Min Kang, Shuai Chu, Kai-Fei Li, Yao Li, Yu-Rong Qi. NLRP3 in human glioma is correlated with increased WHO grade, and regulates cellular proliferation, apoptosis and metastasis via epithelial-mesenchymal transition and the PTEN/AKT signaling pathway. International journal of oncology. vol 53. issue 3. 2018-11-26. PMID:30015880. |
consistently, the upregulation of nlrp3 significantly increased the expression of asc, caspase‑1, il‑1β and phosphorylated-pten, promoted proliferation, migration, invasion and emt, inhibited apoptosis, and activated the akt signaling pathway. |
2018-11-26 |
2023-08-13 |
human |
| Shulin Fu, Huashan Liu, Lei Xu, Yinsheng Qiu, Yu Liu, Zhongyuan Wu, Chun Ye, Yongqing Hou, Chien-An Andy H. Baicalin modulates NF-κB and NLRP3 inflammasome signaling in porcine aortic vascular endothelial cells Infected by Haemophilus parasuis Causing Glässer's disease. Scientific reports. vol 8. issue 1. 2018-11-20. PMID:29339754. |
however, baicalin reduced the production of reactive oxygen species, apoptosis, and activation of the nf-κb and nlrp3 inflammasome signaling pathway in infected cells. |
2018-11-20 |
2023-08-13 |
Not clear |
| Donato Rigante, Bruno Frediani, Luca Cantarin. A Comprehensive Overview of the Hereditary Periodic Fever Syndromes. Clinical reviews in allergy & immunology. vol 54. issue 3. 2018-10-11. PMID:27068928. |
mefv, nlrp3, tnfrsf1a, and mvk are respectively the four causing genes of these conditions, all resulting in excessive il-1β signaling, though the encoded proteins act at different levels in cytoskeletal filament organization, apoptosis, and activation of the il-1β-structured inflammasome. |
2018-10-11 |
2023-08-13 |
Not clear |
| Paola Maura Tricarico, Angeladine Epate, Fulvio Celsi, Sergio Crovell. Alendronate treatment induces IL-1B expression and apoptosis in glioblastoma cell line. Inflammopharmacology. vol 26. issue 1. 2018-08-08. PMID:28646347. |
we observed that ald treatment, at the higher concentrations, induced a significant increase of il-1b, nlrp3, casp1 expression, provoked apoptosis and also mitochondrial damage in u87-mg. |
2018-08-08 |
2023-08-13 |
Not clear |
| Zhenning Liu, Mingli Sun, Yu Wang, Lichun Zhang, Hang Zhao, Min Zha. Silymarin attenuated paraquat-induced cytotoxicity in macrophage by regulating Trx/TXNIP complex, inhibiting NLRP3 inflammasome activation and apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. vol 46. 2018-07-20. PMID:29054699. |
silymarin attenuated paraquat-induced cytotoxicity in macrophage by regulating trx/txnip complex, inhibiting nlrp3 inflammasome activation and apoptosis. |
2018-07-20 |
2023-08-13 |
Not clear |