| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuanshui Liu, Hang Yang, Fei Zhu, Yanhong Ouyang, Pinhua Pa. Inhibition of STAT3 phosphorylation by colchicine regulates NLRP3 activation to alleviate sepsis-induced acute lung injury. Inflammopharmacology. 2023-04-28. PMID:37115345. |
colchicine significantly attenuated ali in mice caused by sepsis by alleviating respiratory dysfunction and pulmonary edema in mice, inhibiting nlrp3 inflammasome formation, and reducing oxidative stress, pyroptosis, and apoptosis of murine alveolar macrophage (j774a.1) cells. |
2023-04-28 |
2023-08-14 |
mouse |
| Lin Yang, Qiuling Zhao, Ting Chen, Wenbin Liu, Xiuliang Qiu, Jincan Chen, Shengqiang Huang, Ruyi Huang, Liangliang Don. An HPK1 inhibitor enhanced the tumour response to anti-PD-1 immunotherapy in non-Hodgkin's lymphoma. Clinical and experimental medicine. 2023-04-27. PMID:37106265. |
hpk1 inhibitor treatment increased pd-1, pd-l1, bax, p53 and nk-kb expression but decreased nlrp3 expression, indicating that the hpk1 inhibitor promoted apoptosis and blocked the nlrp3 inflammasome pathway to affect anti-pd-1-mediated t-cell cytotoxicity. |
2023-04-27 |
2023-08-14 |
zebrafish |
| Lin Yang, Qiuling Zhao, Ting Chen, Wenbin Liu, Xiuliang Qiu, Jincan Chen, Shengqiang Huang, Ruyi Huang, Liangliang Don. An HPK1 inhibitor enhanced the tumour response to anti-PD-1 immunotherapy in non-Hodgkin's lymphoma. Clinical and experimental medicine. 2023-04-27. PMID:37106265. |
in summary, this study provides evidence that an hpk1 inhibitor enhanced the tumour response to anti-pd-1 immunotherapy in nhl by promoting apoptosis and blocking the nlrp3 pathway. |
2023-04-27 |
2023-08-14 |
zebrafish |
| Wen-Yu Zeng, Wen-Yan Gu, Li Xyu, Ying Zhang, Cong Ha. [miR-99b-5p inhibits the activation of NLRP3 inflammasome to alleviate the neurotoxicity induced by paclitaxel chemotherapy]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 38. issue 5. 2023-04-23. PMID:37088748. |
to study the effects of mir-99b-5p (non-coding rna) in alleviating pathological neuropathic pain after paclitaxel chemotherapy by inhibiting nlrp3 inflammatory vesicle activation and the effects on neuronal cells pyrosis and apoptosis. |
2023-04-23 |
2023-08-14 |
Not clear |
| Lijuan He, Wei Zhou, Lamei Wang, Na Tang, Yongjia Wang, Hua Zhong, Yan Tang, Dongmei Xi, Fang H. Murine Cytomegalovirus Infection Induced miR-1929-3p Down-Regulation Promotes the Proliferation and Apoptosis of Vascular Smooth Muscle Cells in Mice by Targeting Endothelin A Receptor and Downstream NLRP3 Activation Pathway. Molecular biotechnology. 2023-04-06. PMID:37022597. |
murine cytomegalovirus infection induced mir-1929-3p down-regulation promotes the proliferation and apoptosis of vascular smooth muscle cells in mice by targeting endothelin a receptor and downstream nlrp3 activation pathway. |
2023-04-06 |
2023-08-14 |
mouse |
| Lijuan He, Wei Zhou, Lamei Wang, Na Tang, Yongjia Wang, Hua Zhong, Yan Tang, Dongmei Xi, Fang H. Murine Cytomegalovirus Infection Induced miR-1929-3p Down-Regulation Promotes the Proliferation and Apoptosis of Vascular Smooth Muscle Cells in Mice by Targeting Endothelin A Receptor and Downstream NLRP3 Activation Pathway. Molecular biotechnology. 2023-04-06. PMID:37022597. |
western blot detected proteins of cell proliferation, apoptosis, and the nlrp3 inflammasome. |
2023-04-06 |
2023-08-14 |
mouse |
| Shengyang Xiao, Xiaoning Song, Man Zheng, Xinran Cao, Guo Ai, Baona Li, Gang Zhao, Haitao Yua. Interleukin-37 ameliorates atherosclerosis by regulating autophagy-mediated endothelial cell apoptosis and inflammation. International immunopharmacology. vol 118. 2023-04-06. PMID:37023695. |
we observed that il-37 alleviated ox-ldl-induced endothelial cell inflammation and dysfunction, as evidenced by decreased nod-like receptor pyrin domain-containing 3 (nlrp3) inflammasome activation, ros production, apoptosis rate and secretion of inflammatory cytokines il-1β and tnf-α. |
2023-04-06 |
2023-08-14 |
mouse |
| Julia Ma, Xiaojing Wang, Raymond Gu, Dandan Guo, Changying Shi, Michaela Kollisch-Singule, Liye Suo, Juntao Luo, Qinghe Meng, Robert N Coone. PROPHYLACTIC nCMT-3 ATTENUATES SEPSIS-INDUCED ACUTE KIDNEY INJURY IN ASSOCIATION WITH NLRP3 INFLAMMASOME ACTIVATION AND APOPTOSIS. Shock (Augusta, Ga.). 2023-03-20. PMID:36939682. |
prophylactic ncmt-3 attenuates sepsis-induced acute kidney injury in association with nlrp3 inflammasome activation and apoptosis. |
2023-03-20 |
2023-08-14 |
Not clear |
| Xiaotao Feng, Wei Ren, Yuxiang Tang, Ruyan Wen, Huiming Duan, Li Ya. Palmitic acid impairs INS-1 cells and alters the global gene expression profile. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 9. 2023-03-11. PMID:36905272. |
moreover, pa promoted protein expression of chop, cleaved caspase-3, microtubule-associated proteins light chain 3 (lc3)-ii, nod-like receptor pyrin domain containing 3 (nlrp3), cleaved il-1β and lcn2, increased reactive oxygen species, apoptosis and the ratio of lc3-ii/i, and reduced p62 protein expression, intracellular glutathione peroxidase and catalase levels, suggesting activation of er stress, oxidative stress, autophagy and nlrp3 inflammasome. |
2023-03-11 |
2023-08-14 |
Not clear |
| Siqi Liu, Chongyang Wang, Yulian Zhang, Yalin Zhang, Yilan Song, Jingzhi Jiang, Ruobai Liu, Hainan Jin, Guanghai Yan, Yongde Ji. Polydatin inhibits mitochondrial damage and mitochondrial ROS by promoting PINK1-Parkin-mediated mitophagy in allergic rhinitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 4. 2023-03-11. PMID:36906289. |
the expressions of pink1, parkin, p62, lc3b, nlrp3 inflammasome proteins, and apoptosis proteins in nasal tissues and hnepcs were measured by western blot. |
2023-03-11 |
2023-08-14 |
mouse |
| Siqi Liu, Chongyang Wang, Yulian Zhang, Yalin Zhang, Yilan Song, Jingzhi Jiang, Ruobai Liu, Hainan Jin, Guanghai Yan, Yongde Ji. Polydatin inhibits mitochondrial damage and mitochondrial ROS by promoting PINK1-Parkin-mediated mitophagy in allergic rhinitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 4. 2023-03-11. PMID:36906289. |
meanwhile, pd enhanced pink1-parkin-mediated mitophagy but decreased mitochondrial reactive oxygen species (mtros) production, nlrp3 inflammasome activation, and apoptosis. |
2023-03-11 |
2023-08-14 |
mouse |
| Siqi Liu, Chongyang Wang, Yulian Zhang, Yalin Zhang, Yilan Song, Jingzhi Jiang, Ruobai Liu, Hainan Jin, Guanghai Yan, Yongde Ji. Polydatin inhibits mitochondrial damage and mitochondrial ROS by promoting PINK1-Parkin-mediated mitophagy in allergic rhinitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 4. 2023-03-11. PMID:36906289. |
moreover, mitochondrial damage, mtros production, nlrp3 inflammasome activation, and hnepcs apoptosis under il-13 exposure were more severe after pink1 knockdown or mdivi-1 treatment. |
2023-03-11 |
2023-08-14 |
mouse |
| Siqi Liu, Chongyang Wang, Yulian Zhang, Yalin Zhang, Yilan Song, Jingzhi Jiang, Ruobai Liu, Hainan Jin, Guanghai Yan, Yongde Ji. Polydatin inhibits mitochondrial damage and mitochondrial ROS by promoting PINK1-Parkin-mediated mitophagy in allergic rhinitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 4. 2023-03-11. PMID:36906289. |
conclusively, pd may exert protective effects on ar by promoting pink1-parkin-mediated mitophagy, which further suppresses apoptosis and tissue damage in ar through decreasing mtros production and nlrp3 inflammasome activation. |
2023-03-11 |
2023-08-14 |
mouse |
| Can Li, Yuying Zhu, Weiwei Liu, Toshihiko Hayashi, Wendie Xiang, Sijun He, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejim. Increased mitochondrial fission induces NLRP3/cGAS-STING mediated pro-inflammatory pathways and apoptosis in UVB-irradiated immortalized human keratinocyte HaCaT cells. Archives of biochemistry and biophysics. 2023-03-06. PMID:36878340. |
mitochondrial dynamics was discovered to be crucial for nlrp3 inflammasome and cgas-sting pathway activation, as well as the induction of apoptosis. |
2023-03-06 |
2023-08-14 |
human |
| Can Li, Yuying Zhu, Weiwei Liu, Toshihiko Hayashi, Wendie Xiang, Sijun He, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejim. Increased mitochondrial fission induces NLRP3/cGAS-STING mediated pro-inflammatory pathways and apoptosis in UVB-irradiated immortalized human keratinocyte HaCaT cells. Archives of biochemistry and biophysics. 2023-03-06. PMID:36878340. |
application of an antioxidant, n-acetyl-l-cysteine (nac), which scavenges excessive ros, attenuated inflammatory responses through suppressing nlrp3 inflammasome and cgas-sting pathway activation, and rescued cells from apoptosis caused by uvb-irradiation. |
2023-03-06 |
2023-08-14 |
human |
| Jing Ma, Yun Xu, Min Zhang, Yi L. Geraniol ameliorates acute liver failure induced by lipopolysaccharide/D-galactosamine via regulating macrophage polarization and NLRP3 inflammasome activation by PPAR-γ methylation Geraniol alleviates acute liver failure. Biochemical pharmacology. 2023-02-27. PMID:36849063. |
in vitro, ger reduced the activation of nlrp3 inflammasome and apoptosis through regulating ppar-γ methylation by inhibiting m1 macrophage polarization. |
2023-02-27 |
2023-08-14 |
mouse |
| Wanglong Zheng, Anjing Liu, Nengwen Xia, Nanhua Chen, François Meurens, Jianzhong Zh. How the Innate Immune DNA Sensing cGAS-STING Pathway Is Involved in Apoptosis. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769349. |
the cgas-sting pathway can induce apoptosis through er stress, nlrp3, nf-κb, irf3, and ifn signals. |
2023-02-11 |
2023-08-14 |
Not clear |
| Dongcai Liu, Qingquan Tian, Kuijie Liu, Feng Ren, Ganglei Liu, Jingyu Zhou, Lianwen Yuan, Zhixue Fang, Bing Zou, Shalong Wan. Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis. Journal of agricultural and food chemistry. 2023-02-08. PMID:36752740. |
the results showed that gin rg3 inhibited nlrp3 inflammasome activation, pyroptosis, and apoptosis in vitro and in vivo. |
2023-02-08 |
2023-08-14 |
mouse |
| Tahmineh Mokhtari, Lu-Peng Yue, Li H. Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis. Scientific reports. vol 13. issue 1. 2023-02-07. PMID:36747075. |
exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing nf-κb/ nlrp3 pathway and apoptosis. |
2023-02-07 |
2023-08-14 |
rat |
| Mélanie Bodnar-Wachtel, Anne-Laure Huber, Julie Gorry, Sabine Hacot, Delphine Burlet, Laetitia Gérossier, Baptiste Guey, Nadège Goutagny, Birke Bartosch, Elise Ballot, Julie Lecuelle, Caroline Truntzer, François Ghiringhelli, Bénédicte F Py, Yohann Couté, Annabelle Ballesta, Sylvie Lantuejoul, Janet Hall, Agnès Tissier, Virginie Petrill. Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress. Life science alliance. vol 6. issue 4. 2023-02-06. PMID:36746533. |
nlrp3 down-regulation in both broncho- and mammary human epithelial cells significantly impairs atm pathway activation, leading to lower p53 activation, and provides cells with the ability to resist apoptosis induced by acute genotoxic stress. |
2023-02-06 |
2023-08-14 |
human |