| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Chen, Junren Chen, Ziwei Xing, Cheng Peng, Dan L. Autophagy in Neuroinflammation: A Focus on Epigenetic Regulation. Aging and disease. 2023-08-07. PMID:37548945. |
inhibition of mtor and activation of ampk and foxo1 enhance autophagy and thereby suppress nlrp3 inflammasome activity and apoptosis, leading to the relief of neuroinflammatory response. |
2023-08-07 |
2023-08-14 |
Not clear |
| Lingyan Wang, Jin Liu, Zhuoran Wang, Xi Qian, Yu Zhao, Quan Wang, Na Dai, Yuhan Xie, Weijun Zeng, Wei Yang, Xiangfeng Bai, Yuqiao Yang, Jinqiao Qia. Dexmedetomidine abates myocardial ischemia reperfusion injury through inhibition of pyroptosis via regulation of miR-665/MEF2D/Nrf2 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-08-07. PMID:37549462. |
dex markedly augmented cell viability, while suppressing cell apoptosis and expressions of nlrp3, cleaved-caspase-1, asc, gsdmd, il-1β, and il-18 in h9c2 cells subjected to h/r injury. |
2023-08-07 |
2023-08-14 |
rat |
| Lixia Zhang, Weibing Yang, Jin Yang, Fu Su. GPRC5A regulates proliferation and oxidative stress by inhibiting the STAT3/Socs3/c-MYC pathway in hepatocellular carcinoma. Journal of clinical biochemistry and nutrition. vol 73. issue 1. 2023-08-03. PMID:37534091. |
these results suggest that gprc5a suppresses proliferation and emt, induces oxidative stress and leads to apoptosis of hcc cells, potentially by regulating stat3/socs3/c-myc signalling and the nlrp3 inflammasome. |
2023-08-03 |
2023-08-14 |
Not clear |
| Su-Bin Choi, Sehee Kwon, Ji-Hye Kim, Na-Hyun Ahn, Joo-Hee Lee, Seung-Hoon Yan. The Molecular Mechanisms of Neuroinflammation in Alzheimer's Disease, the Consequence of Neural Cell Death. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511515. |
neural cell death, occurring via apoptosis and autophagy, is widely observed in the ad brain in addition to neuroinflammation mediated by necroptosis and the nlrp3 inflammasome. |
2023-07-29 |
2023-08-14 |
Not clear |
| Sameh Saber, Mohannad Mohammad S Alamri, Jaber Alfaifi, Lobna A Saleh, Sameh Abdel-Ghany, Adel Mohamed Aboregela, Alshaimaa A Farrag, Abdulrahman H Almaeen, Masoud I E Adam, AbdulElah Al Jarallah AlQahtani, Ali M S Eleragi, Mustafa Ahmed Abdel-Reheim, Heba A Ramadan, Osama A Mohamme. (R,R)-BD-AcAc2 Mitigates Chronic Colitis in Rats: A Promising Multi-Pronged Approach Modulating Inflammasome Activity, Autophagy, and Pyroptosis. Pharmaceuticals (Basel, Switzerland). vol 16. issue 7. 2023-07-29. PMID:37513865. |
these effects were attributed to inhibiting nfκb and nlrp3 inflammasome activation and restraining pyroptosis and apoptosis while enhancing autophagy as revealed by reduced p62 and increased becn1. |
2023-07-29 |
2023-08-14 |
human |
| W Zhang, F J Hu, C X Yao, B P Li, M Zhang, X M Yan. [Visualization analysis of research hotspots in pathogenesis of diabetic nephropathy in China]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. vol 57. issue 7. 2023-07-24. PMID:37482743. |
the frontier hotspots in this field include biomarkers, nrf2, gut microbiota, nlrp3 inflammasome, apoptosis, microrna, etc. |
2023-07-24 |
2023-08-14 |
Not clear |
| Weiwei Wang, Dan Min. Oridonin attenuates apoptosis and NLRP3 inflammasome activation in IL-4-stimulated human bronchial epithelial cells in an in vitro pediatric asthma model. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2023-07-24. PMID:37486694. |
oridonin attenuates apoptosis and nlrp3 inflammasome activation in il-4-stimulated human bronchial epithelial cells in an in vitro pediatric asthma model. |
2023-07-24 |
2023-08-14 |
human |
| Paramita Basu, Camelia Maier, Dayna L Averitt, Arpita Bas. NLR family pyrin domain containing 3 (NLRP3) inflammasomes and peripheral neuropathic pain - Emphasis on microRNAs (miRNAs) as important regulators. European journal of pharmacology. 2023-07-14. PMID:37451423. |
here we provide a detailed review of the mechanisms whereby nlrp3 inflammasomes contribute to neuropathic pain via (1) neuroinflammation, (2) apoptosis, (3) pyroptosis, (4) proinflammatory cytokine release, (5) mitochondrial dysfunction, and (6) oxidative stress. |
2023-07-14 |
2023-08-14 |
Not clear |
| Guodong Cai, Hilda M Guerrero-Netro, Jianchun Bian, Isabelle P Oswald, Christopher Price, Imourana Alassane-Kpemb. Real-life exposure to Fusarium toxins deoxynivalenol and zearalenone triggers apoptosis and activates NLRP3 inflammasome in bovine primary theca cells. Mycotoxin research. 2023-07-09. PMID:37423938. |
real-life exposure to fusarium toxins deoxynivalenol and zearalenone triggers apoptosis and activates nlrp3 inflammasome in bovine primary theca cells. |
2023-07-09 |
2023-08-14 |
cattle |
| Eui-Hwan Choi, Sun-Ji Par. TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target. Experimental & molecular medicine. 2023-07-02. PMID:37394581. |
txnip activates endoplasmic reticulum (er) stress-mediated nucleotide-binding oligomerization domain (nod)-like receptor protein-3 (nlrp3) inflammasome complex formation, triggers mitochondrial stress-induced apoptosis, and stimulates inflammatory cell death (pyroptosis). |
2023-07-02 |
2023-08-14 |
Not clear |
| Yixian Wang, Chunhong Xin, Xiaokun Li, Xiaoxia Chang, Ru Jian. NLRP3 participates in the differentiation and apoptosis of PMA‑treated leukemia cells. Molecular medicine reports. vol 28. issue 2. 2023-06-23. PMID:37350394. |
nlrp3 participates in the differentiation and apoptosis of pma‑treated leukemia cells. |
2023-06-23 |
2023-08-14 |
Not clear |
| Yixian Wang, Chunhong Xin, Xiaokun Li, Xiaoxia Chang, Ru Jian. NLRP3 participates in the differentiation and apoptosis of PMA‑treated leukemia cells. Molecular medicine reports. vol 28. issue 2. 2023-06-23. PMID:37350394. |
it was found that the upregulation of nlrp3 expression induced using phorbol 12‑myristate 13‑acetate played a role in promoting the differentiation and maturation of leukemia cells into monocytes/macrophages, and it was directly involved in the apoptosis of leukemia cells and the differentiation and maturation of cd11b |
2023-06-23 |
2023-08-14 |
Not clear |
| Shanshan Wei, Wanjun Ma, Yuanying Yang, Taoli Sun, Chuanhao Jiang, Jian Liu, Bikui Zhang, Wenqun L. Trastuzumab potentiates doxorubicin-induced cardiotoxicity via activating the NLRP3 inflammasome in vivo and in vitro. Biochemical pharmacology. 2023-06-18. PMID:37331637. |
inhibiting the activation of nlrp3 inflammasome by nlrp3 silencing significantly reduced cell apoptosis and ros production in dox combined tra-treated pnrc. |
2023-06-18 |
2023-08-14 |
mouse |
| Shanshan Wei, Wanjun Ma, Yuanying Yang, Taoli Sun, Chuanhao Jiang, Jian Liu, Bikui Zhang, Wenqun L. Trastuzumab potentiates doxorubicin-induced cardiotoxicity via activating the NLRP3 inflammasome in vivo and in vitro. Biochemical pharmacology. 2023-06-18. PMID:37331637. |
compared with the wild type mice, the systolic dysfunction, myocardial hypertrophy, cardiomyocyte apoptosis and oxidative stress induced by dox combined tra were alleviated in nlrp3 gene knockout mice. |
2023-06-18 |
2023-08-14 |
mouse |
| Shanshan Wei, Wanjun Ma, Yuanying Yang, Taoli Sun, Chuanhao Jiang, Jian Liu, Bikui Zhang, Wenqun L. Trastuzumab potentiates doxorubicin-induced cardiotoxicity via activating the NLRP3 inflammasome in vivo and in vitro. Biochemical pharmacology. 2023-06-18. PMID:37331637. |
our data revealed that the co-activation of nlrp3 inflammasome by tra promoted the inflammation, oxidative stress and cardiomyocytes apoptosis in dox combined tra-induced cardiotoxicity model both in vivo and in vitro. |
2023-06-18 |
2023-08-14 |
mouse |
| Jing Luo, Jialei Chen, Changhong Yang, Junyi Tan, Jing Zhao, Ning Jiang, Yong Zha. Corrigendum to "6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1/FAF1 complex dissociation-mediated autophagy" [Int. Immunopharmacol. 100 (2021) 108146]. International immunopharmacology. 2023-06-12. PMID:37308372. |
corrigendum to "6-gingerol protects against cerebral ischemia/reperfusion injury by inhibiting nlrp3 inflammasome and apoptosis via trpv1/faf1 complex dissociation-mediated autophagy" [int. |
2023-06-12 |
2023-08-14 |
Not clear |
| Ting Mei, Linchuan Ma, Fanzhen Kon. Sodium aescinate improve behavioral performance by inhibiting dorsal raphe nucleus NLRP3 inflammasome in Post-traumatic stress disorder Rat Model. Biochemical and biophysical research communications. vol 671. 2023-06-11. PMID:37302291. |
we found that ptsd was associated with significant activation of the nlrp3 inflammasome in drn, whereas administration of sa significantly inhibited drn nlrp3 inflammasome activation and reduced drn apoptosis level. |
2023-06-11 |
2023-08-14 |
rat |
| Boru Hou, Dengfeng Wang, Cheng Jiang, Gang Wang, Dong Wang, Guizhong Yan, Xiumei Guo, Lixia Zhao, Zhuangzhuang Wan, Chenlong Fan, Wencheng Cao, Haijun Re. Neuroprotective Effects of Vinpocetine against Ischemia-Reperfusion Injury via Inhibiting NLRP3 Inflammasome Signaling Pathway. Neuroscience. 2023-06-08. PMID:37290685. |
then, based on this optimal dose, we observed the effects of vinpocetine on apoptosis, microglial proliferation and nlrp3 inflammasome. |
2023-06-08 |
2023-08-14 |
mouse |
| Jing Qiu, Jun Guo, Liang Liu, Xin Liu, Xianhui Sun, Huisheng Che. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282474. |
taken together, these findings show that silencing vav1 attenuates inflammation and neuronal apoptosis in rats subjected to cerebral ischemia/reperfusion through inhibiting the activation of microglia and nlrp3 inflammasome. |
2023-06-07 |
2023-08-14 |
rat |
| Yinli Cao, Yazhou Sun, Qingyang Cui, Xiaojing He, Zhenzhen L. [Artesunate alleviates hypoxic-ischemic brain damage in neonatal rats by inhibiting NLRP3 inflammasome activation and inflammatory cytokine secretion]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 5. 2023-05-30. PMID:37248835. |
results compared with the model group, the neurological deficit score was decreased; the pathological damage of brain tissues was relieved; the brain water content was significantly reduced; the apoptosis number of hippocampal neurons was decreased significantly; the levels of il-1β, il-6 and tnf-α in brain tissues and peripheral blood were significantly reduced; the protein expression levels of nlrp3, asc and caspase-1 were significantly lowered in the middle-dose and high-dose artesunate groups and the dexamethasone group. |
2023-05-30 |
2023-08-14 |
rat |