| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo Wang, Minfeng Shi, Chuanjin Yu, Hong Pan, Haiqing Shen, Yatao Du, Yi Zhang, Bin Liu, Di Xi, Jianzhong Sheng, Hefeng Huang, Guolian Din. NLRP3 Inflammasome-dependent Pathway is Involved in the Pathogenesis of Polycystic Ovary Syndrome. Reproductive sciences (Thousand Oaks, Calif.). 2023-10-10. PMID:37815748. |
following nlrp3 overexpression in kgn cells, the genes involved in n-glycan processing, steroidogenesis, oocyte maturation, autophagy, and apoptosis were upregulated. |
2023-10-10 |
2023-10-15 |
mouse |
| Bo Wang, Minfeng Shi, Chuanjin Yu, Hong Pan, Haiqing Shen, Yatao Du, Yi Zhang, Bin Liu, Di Xi, Jianzhong Sheng, Hefeng Huang, Guolian Din. NLRP3 Inflammasome-dependent Pathway is Involved in the Pathogenesis of Polycystic Ovary Syndrome. Reproductive sciences (Thousand Oaks, Calif.). 2023-10-10. PMID:37815748. |
taken together, the nlrp3 inflammasome-dependent pathway is involved in the pathogenesis of pcos not only by mediating pyroptosis, but also by regulating glycan synthesis, sex hormone synthesis, autophagy, and apoptosis in gcs. |
2023-10-10 |
2023-10-15 |
mouse |
| Computational And Mathematical Methods In Medicin. Retracted: miR-223-3p Regulates NLRP3 to Inhibit Proliferation and Promote Apoptosis of ONG Cells. Computational and mathematical methods in medicine. vol 2023. 2023-10-09. PMID:37811265. |
retracted: mir-223-3p regulates nlrp3 to inhibit proliferation and promote apoptosis of ong cells. |
2023-10-09 |
2023-10-15 |
Not clear |
| Yuanxu Li, Gaolong Zhong, Ting He, Jinwen Quan, Siying Liu, Zhonghua Liu, Zhaoxin Tang, Wenlan Y. Effect of arsenic and copper in kidney of mice: Crosstalk between Nrf2/ Keap1 pathway in apoptosis and pyroptosis. Ecotoxicology and environmental safety. vol 266. 2023-10-06. PMID:37801897. |
meanwhile, exposure induced kidney cell pyroptosis and apoptosis by promoting the expression of nlrp3 inflammasomes and caspase-3, which peaked in mice co-treated with as and cu. |
2023-10-06 |
2023-10-15 |
mouse |
| Hongwei Zhang, Jian Liao, Litong Jin, Yan Li. NLRP3 inflammasome involves in the pathophysiology of sepsis-induced myocardial dysfunction by multiple mechanisms. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-23. PMID:37741253. |
nlrp3 inflammasome and its related signaling pathways might affect the regulation of inflammation, autophagy, apoptosis, and pyroptosis in simd. |
2023-09-23 |
2023-10-07 |
Not clear |
| Alireza Shadab, Mohamad Mahjoor, Mohammad Abbasi-Kolli, Hamed Afkhami, Parisa Moeinian, Amir-Reza Safdaria. Divergent functions of NLRP3 inflammasomes in cancer: a review. Cell communication and signaling : CCS. vol 21. issue 1. 2023-09-15. PMID:37715239. |
one of the most recently identified signaling pathways, whose activation seems to affect many metabolic disorders, is the "inflammasome" a multiprotein complex composed of nlrp3 (nucleotide-binding domain and leucine-rich repeat protein 3), asc (apoptosis associated speck-like protein containing a card), and procaspase-1. |
2023-09-15 |
2023-10-07 |
Not clear |
| Xiao-Hong Xiang, Jing Wei, Xiao-Fang Wang, Qin Xu, Chong-Lin Yu, Chang-Long He, Tao Long, Ming-Song Guo, Xue Chen, Xiao-Gang Zhou, Jian-Ming Wu, Da-Lian Qin, An-Guo Wu, Yong Tang, Hong-Bin L. Lychee seed polyphenol ameliorates DR via inhibiting inflammasome/apoptosis and angiogenesis in hRECs and db/db mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-13. PMID:37703661. |
mechanistic studies revealed that lsp inhibits the nlrp3 inflammasome, reduces cell apoptosis in retinal tissue, increases tight junction protein (tj) expression, and reduces vascular endothelial growth factor (vegf) and ve-cadherin in vivo and in vitro. |
2023-09-13 |
2023-10-07 |
mouse |
| Liang Li, Xiao-Fang Wei, Zhi-Yong Yang, Rui Zhu, Deng-Lai Li, Guo-Jun Shang, Hao-Tong Wang, Si-Tong Meng, Yin-Tao Wang, Si-Ying Liu, Li-Fang W. Alleviative effect of poly-β-hydroxybutyrate on lipopolysaccharide-induced oxidative stress, inflammation and cell apoptosis in Cyprinus carpio. International journal of biological macromolecules. 2023-09-10. PMID:37690640. |
summary, this study suggested that appropriate level of dietary phb alleviated lps-induced oxidative stress, inflammation, apoptosis and the activation of nlrp3 inflammasome in common carp. |
2023-09-10 |
2023-10-07 |
cat |
| Haoyue Guan, Wenxue Ma, Qiong Wu, Jingzeng Cai, Ziwei Zhan. Exploring the Toxic Effects of ZEA on IPEC-J2 Cells from the Inflammatory Response and Apoptosis. Animals : an open access journal from MDPI. vol 13. issue 17. 2023-09-09. PMID:37684994. |
zea also caused apoptosis in porcine small intestine cells, resulting in a significant reduction in protein and/or mrna expression of apoptosis-related pathway factors such as p53, caspase 3, caspase 9, bax, and cyt-c, which in turn caused a significant decrease in protein and/or mrna expression of inflammatory-related factors such as il-1β, il-2, cox-2, nf-κd, nlrp3, il-6, and il -18, which in turn caused a significant increase in protein and/or mrna expression levels. |
2023-09-09 |
2023-10-07 |
cat |
| Bingling Dai, Hanbing Cao, Yu Hu, Zhengyan Gong, Xiaoyue Huang, Yanbin Chen, Feng Liu, Xiujuan Peng, Yanmin Zhang, Xinjun Le. Role of NLRP3 inflammasome activation in HCC cell progression. Heliyon. vol 9. issue 9. 2023-09-08. PMID:37681160. |
our results revealed that nlrp3 inflammasome activation inhibited the proliferation of bel-7402 and smmc-7721 cells, arrested the cell cycle at the g1 phase, and suppressed cell migration, while apoptosis remained unaffected. |
2023-09-08 |
2023-10-07 |
Not clear |
| Cuicui Zhuang, Jinhui Zhao, Shiyao Zhang, Muhammad Shahi. Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells. Microbial pathogenesis. 2023-09-08. PMID:37683833. |
lactic dehydrogenase activities, interleukin (il)-10, il-1β, il-18 and tumor necrosis factor-α concentrations, total apoptosis indexes, and protein expressions of p-cdc25c, p-cdk1, cleaved caspase 9, cleaved caspase 3, cleaved parp, p-nf-κb, nlrp3, asc, caspase 1, gasdermin d n-terminal, il-1β and il-18 were significantly increased in e. coli infected bmecs. |
2023-09-08 |
2023-10-07 |
cattle |
| Di Jia, Jiahui Han, Jimin Cai, Zhirong Huan, Yan Wang, Xin G. Mesenchymal stem cells overexpressing PBX1 alleviates haemorrhagic shock-induced kidney damage by inhibiting NF-κB activation. Biochimica et biophysica acta. Molecular cell research. 2023-09-06. PMID:37673222. |
furthermore, administration with rbmscs overexpressing pbx1 inhibited hs-induced nod-like receptor family pyrin domain containing 3 (nlrp3) inflammasome activation and the release of proinflammatory cytokines, and further attenuated apoptosis. |
2023-09-06 |
2023-10-07 |
human |
| Di Jia, Jiahui Han, Jimin Cai, Zhirong Huan, Yan Wang, Xin G. Mesenchymal stem cells overexpressing PBX1 alleviates haemorrhagic shock-induced kidney damage by inhibiting NF-κB activation. Biochimica et biophysica acta. Molecular cell research. 2023-09-06. PMID:37673222. |
hbmscs overexpressing pbx1 also exhibited protective effects on hk-2 cells exposed to hypoxia, as shown by the increase in cell viability, the mitigation of apoptosis, the decrease in inflammation, and the inhibition of nf-κb and nlrp3 inflammasome activation. |
2023-09-06 |
2023-10-07 |
human |
| K Bibha, T M Akhigbe, M A Hamed, R E Akhigb. Metabolic Derangement by Arsenic: a Review of the Mechanisms. Biological trace element research. 2023-09-05. PMID:37670201. |
in addition, arsenic activates mapks, modulates p53/ bcl-2 signaling, suppresses mdm-2 and parp, activates nlrp3 inflammasome and caspase-mediated apoptosis, and induces er stress, and ox-mtdna-dependent mitophagy and autophagy. |
2023-09-05 |
2023-10-07 |
Not clear |
| Daru Guo, Kang Cheng, Chao Song, Fei Liu, Weiye Cai, Jingwen Chen, Yongliang Mei, Daqian Zhou, Silong Gao, Guoyou Wang, Zongchao Li. Mechanisms of inhibition of nucleus pulposus cells pyroptosis through SDF1/CXCR4-NFkB-NLRP3 axis in the treatment of intervertebral disc degeneration by Duhuo Jisheng Decoction. International immunopharmacology. vol 124. issue Pt A. 2023-08-30. PMID:37647678. |
through bioinformatics, we found that nlrp3, gsdmd, il-1βand other hub proteins of pyroptosis were highly expressed in ivdd sd rats, and network pharmacology discovered that dhjsd may control cellular senescence, apoptosis, and pyroptosis in order to treat ivdd. |
2023-08-30 |
2023-09-07 |
rat |
| Antoine Fayand, Margaux Cescato, Laurent Le Corre, Alexandre Terré, Margaux Wacheux, Yixiang Y J Zhu, Armelle Melet, Thomas R J Moreau, Bahram Bodaghi, Fabrice Bonnet, Didier Bronnimann, Laurence Cuisset, Raquel Faria, Gilles Grateau, Pascal Pillet, Catharina M Mulders-Manders, Benedicte Neven, Pierre Quartier, Olivier Richer, Léa Savey, Marie-Elise Truchetet, Bénédicte F Py, Guilaine Boursier, Jean-Philippe Herbeuval, Sophie Georgin-Lavialle, Mathieu P Roder. Pathogenic variants in the NLRP3 LRR domain at position 861 are responsible for a boost-dependent atypical CAPS phenotype. The Journal of allergy and clinical immunology. 2023-08-26. PMID:37506976. |
cryopyrin-associated periodic syndrome (caps) is associated with nlrp3 pathogenic variants, mostly located in the nacht (neuronal apoptosis inhibitor protein, mhc class 2 transcription activator, incompatibility locus protein from podospora anserina, telomerase-associated protein) domain. |
2023-08-26 |
2023-09-07 |
Not clear |
| Renxu Chang, Hongdou Jia, Zhihao Dong, Qiushi Xu, Lei Liu, Zolzaya Majigsuren, Tugsjargal Batbaatar, Chuang Xu, Qing Yang, Xudong Su. Free Fatty Acids Induce Apoptosis of Mammary Epithelial Cells of Ketotic Dairy Cows via the Mito-ROS/NLRP3 Signaling Pathway. Journal of agricultural and food chemistry. 2023-08-16. PMID:37585786. |
the pyrin domain 3 (nlrp3) pathway involving the mitochondrial reactive oxygen species (mito-ros)-induced nucleotide-binding oligomerization domain-like receptor has been recognized as a key mechanism in this inflammatory response and cell apoptosis. |
2023-08-16 |
2023-09-07 |
Not clear |
| Renxu Chang, Hongdou Jia, Zhihao Dong, Qiushi Xu, Lei Liu, Zolzaya Majigsuren, Tugsjargal Batbaatar, Chuang Xu, Qing Yang, Xudong Su. Free Fatty Acids Induce Apoptosis of Mammary Epithelial Cells of Ketotic Dairy Cows via the Mito-ROS/NLRP3 Signaling Pathway. Journal of agricultural and food chemistry. 2023-08-16. PMID:37585786. |
however, nlrp3 inhibitor mcc950 pretreatment or mito-ros scavenging by mitotempo attenuated apoptosis in ffa-induced mac-t cells by inhibiting the nlrp3 inflammasome pathway. |
2023-08-16 |
2023-09-07 |
Not clear |
| Yan Chen, Xiankun Cao, Bin Pan, Han Du, Baixing Li, Xiao Yang, Xuzhuo Chen, Xin Wang, Tangjun Zhou, An Qin, Changqing Zhao, Jie Zha. Verapamil attenuates intervertebral disc degeneration by suppressing ROS overproduction and pyroptosis via targeting the Nrf2/TXNIP/NLRP3 axis in four-week puncture-induced rat models both in vivo and in vitro. International immunopharmacology. vol 123. 2023-08-14. PMID:37579541. |
administration of verapamil, a classic clinical drug, mitigated the tbhp-induced overproduction of reactive oxygen species and activation of the nlrp3 inflammasome, thus protecting cells from pyroptosis, apoptosis, and extracellular matrix degradation. |
2023-08-14 |
2023-09-07 |
rat |
| Mahammad Ghouse Shaik, Swanand Vinayak Joshi, Ravikumar Akunuri, Preeti Rana, Ziaur Rahman, Anusha Polomoni, Venkata Madhavi Yaddanapudi, Manoj P Dandekar, Nanduri Sriniva. Small molecule inhibitors of NLRP3 inflammasome and GSK-3β in the management of traumatic brain injury: A review. European journal of medicinal chemistry. vol 259. 2023-08-13. PMID:37573828. |
the activation of nlrp3 post-tbi increases the production of pro-inflammatory cytokines and caspase-1, which are major drivers of neuroinflammation and apoptosis. |
2023-08-13 |
2023-08-16 |
Not clear |