| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paramita Basu, Camelia Maier, Dayna L Averitt, Arpita Bas. NLR family pyrin domain containing 3 (NLRP3) inflammasomes and peripheral neuropathic pain - Emphasis on microRNAs (miRNAs) as important regulators. European journal of pharmacology. 2023-07-14. PMID:37451423. |
here we provide a detailed review of the mechanisms whereby nlrp3 inflammasomes contribute to neuropathic pain via (1) neuroinflammation, (2) apoptosis, (3) pyroptosis, (4) proinflammatory cytokine release, (5) mitochondrial dysfunction, and (6) oxidative stress. |
2023-07-14 |
2023-08-14 |
Not clear |
| Guodong Cai, Hilda M Guerrero-Netro, Jianchun Bian, Isabelle P Oswald, Christopher Price, Imourana Alassane-Kpemb. Real-life exposure to Fusarium toxins deoxynivalenol and zearalenone triggers apoptosis and activates NLRP3 inflammasome in bovine primary theca cells. Mycotoxin research. 2023-07-09. PMID:37423938. |
real-life exposure to fusarium toxins deoxynivalenol and zearalenone triggers apoptosis and activates nlrp3 inflammasome in bovine primary theca cells. |
2023-07-09 |
2023-08-14 |
cattle |
| Eui-Hwan Choi, Sun-Ji Par. TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target. Experimental & molecular medicine. 2023-07-02. PMID:37394581. |
txnip activates endoplasmic reticulum (er) stress-mediated nucleotide-binding oligomerization domain (nod)-like receptor protein-3 (nlrp3) inflammasome complex formation, triggers mitochondrial stress-induced apoptosis, and stimulates inflammatory cell death (pyroptosis). |
2023-07-02 |
2023-08-14 |
Not clear |
| Yixian Wang, Chunhong Xin, Xiaokun Li, Xiaoxia Chang, Ru Jian. NLRP3 participates in the differentiation and apoptosis of PMA‑treated leukemia cells. Molecular medicine reports. vol 28. issue 2. 2023-06-23. PMID:37350394. |
nlrp3 participates in the differentiation and apoptosis of pma‑treated leukemia cells. |
2023-06-23 |
2023-08-14 |
Not clear |
| Yixian Wang, Chunhong Xin, Xiaokun Li, Xiaoxia Chang, Ru Jian. NLRP3 participates in the differentiation and apoptosis of PMA‑treated leukemia cells. Molecular medicine reports. vol 28. issue 2. 2023-06-23. PMID:37350394. |
it was found that the upregulation of nlrp3 expression induced using phorbol 12‑myristate 13‑acetate played a role in promoting the differentiation and maturation of leukemia cells into monocytes/macrophages, and it was directly involved in the apoptosis of leukemia cells and the differentiation and maturation of cd11b |
2023-06-23 |
2023-08-14 |
Not clear |
| Shanshan Wei, Wanjun Ma, Yuanying Yang, Taoli Sun, Chuanhao Jiang, Jian Liu, Bikui Zhang, Wenqun L. Trastuzumab potentiates doxorubicin-induced cardiotoxicity via activating the NLRP3 inflammasome in vivo and in vitro. Biochemical pharmacology. 2023-06-18. PMID:37331637. |
inhibiting the activation of nlrp3 inflammasome by nlrp3 silencing significantly reduced cell apoptosis and ros production in dox combined tra-treated pnrc. |
2023-06-18 |
2023-08-14 |
mouse |
| Shanshan Wei, Wanjun Ma, Yuanying Yang, Taoli Sun, Chuanhao Jiang, Jian Liu, Bikui Zhang, Wenqun L. Trastuzumab potentiates doxorubicin-induced cardiotoxicity via activating the NLRP3 inflammasome in vivo and in vitro. Biochemical pharmacology. 2023-06-18. PMID:37331637. |
compared with the wild type mice, the systolic dysfunction, myocardial hypertrophy, cardiomyocyte apoptosis and oxidative stress induced by dox combined tra were alleviated in nlrp3 gene knockout mice. |
2023-06-18 |
2023-08-14 |
mouse |
| Shanshan Wei, Wanjun Ma, Yuanying Yang, Taoli Sun, Chuanhao Jiang, Jian Liu, Bikui Zhang, Wenqun L. Trastuzumab potentiates doxorubicin-induced cardiotoxicity via activating the NLRP3 inflammasome in vivo and in vitro. Biochemical pharmacology. 2023-06-18. PMID:37331637. |
our data revealed that the co-activation of nlrp3 inflammasome by tra promoted the inflammation, oxidative stress and cardiomyocytes apoptosis in dox combined tra-induced cardiotoxicity model both in vivo and in vitro. |
2023-06-18 |
2023-08-14 |
mouse |
| Jing Luo, Jialei Chen, Changhong Yang, Junyi Tan, Jing Zhao, Ning Jiang, Yong Zha. Corrigendum to "6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1/FAF1 complex dissociation-mediated autophagy" [Int. Immunopharmacol. 100 (2021) 108146]. International immunopharmacology. 2023-06-12. PMID:37308372. |
corrigendum to "6-gingerol protects against cerebral ischemia/reperfusion injury by inhibiting nlrp3 inflammasome and apoptosis via trpv1/faf1 complex dissociation-mediated autophagy" [int. |
2023-06-12 |
2023-08-14 |
Not clear |
| Ting Mei, Linchuan Ma, Fanzhen Kon. Sodium aescinate improve behavioral performance by inhibiting dorsal raphe nucleus NLRP3 inflammasome in Post-traumatic stress disorder Rat Model. Biochemical and biophysical research communications. vol 671. 2023-06-11. PMID:37302291. |
we found that ptsd was associated with significant activation of the nlrp3 inflammasome in drn, whereas administration of sa significantly inhibited drn nlrp3 inflammasome activation and reduced drn apoptosis level. |
2023-06-11 |
2023-08-14 |
rat |
| Boru Hou, Dengfeng Wang, Cheng Jiang, Gang Wang, Dong Wang, Guizhong Yan, Xiumei Guo, Lixia Zhao, Zhuangzhuang Wan, Chenlong Fan, Wencheng Cao, Haijun Re. Neuroprotective Effects of Vinpocetine against Ischemia-Reperfusion Injury via Inhibiting NLRP3 Inflammasome Signaling Pathway. Neuroscience. 2023-06-08. PMID:37290685. |
then, based on this optimal dose, we observed the effects of vinpocetine on apoptosis, microglial proliferation and nlrp3 inflammasome. |
2023-06-08 |
2023-08-14 |
mouse |
| Jing Qiu, Jun Guo, Liang Liu, Xin Liu, Xianhui Sun, Huisheng Che. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282474. |
taken together, these findings show that silencing vav1 attenuates inflammation and neuronal apoptosis in rats subjected to cerebral ischemia/reperfusion through inhibiting the activation of microglia and nlrp3 inflammasome. |
2023-06-07 |
2023-08-14 |
rat |
| Yinli Cao, Yazhou Sun, Qingyang Cui, Xiaojing He, Zhenzhen L. [Artesunate alleviates hypoxic-ischemic brain damage in neonatal rats by inhibiting NLRP3 inflammasome activation and inflammatory cytokine secretion]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 5. 2023-05-30. PMID:37248835. |
results compared with the model group, the neurological deficit score was decreased; the pathological damage of brain tissues was relieved; the brain water content was significantly reduced; the apoptosis number of hippocampal neurons was decreased significantly; the levels of il-1β, il-6 and tnf-α in brain tissues and peripheral blood were significantly reduced; the protein expression levels of nlrp3, asc and caspase-1 were significantly lowered in the middle-dose and high-dose artesunate groups and the dexamethasone group. |
2023-05-30 |
2023-08-14 |
rat |
| Nini Chen, Peiyu Chen, Yanhe Zhou, Sidong Chen, Sitang Gong, Ming Fu, Lanlan Gen. HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome. Vaccines. vol 11. issue 5. 2023-05-27. PMID:37243097. |
the nlrp3 inflammasome plays a key role in host innate immune responses by activating caspase1 to facilitate il-1β and il-18 secretion and n-gsdmd-driven apoptosis, while nlrp3 inflammasome overactivation plays an important role in the development of various inflammatory diseases. |
2023-05-27 |
2023-08-14 |
human |
| Jiaxuan Wu, Shengya Fang, Pengfei Feng, Chunjiang Cai, Leying Zhang, Ling Yan. Changes in expression levels of Nod-like receptors in the spleen of ewes. Animal reproduction. vol 20. issue 1. 2023-05-25. PMID:37228386. |
expression of nlr family, including nod1, nod2, class ii transactivator (ciita), nlr family apoptosis inhibitory protein (naip), nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1 (nlrp1), nlrp3 and nlrp7, was analyzed using quantitative real-time pcr, western blot and immunohistochemistry analysis. |
2023-05-25 |
2023-08-14 |
Not clear |
| Huijie Zhao, Yiming Zhang, Yanting Zhang, Chaoran Chen, Huiyang Liu, Yihan Yang, Honggang Wan. The role of NLRP3 inflammasome in hepatocellular carcinoma. Frontiers in pharmacology. vol 14. 2023-05-09. PMID:37153780. |
so far, the best studied and most characteristic inflammasome is the nlr-family pyrin domain-containing protein 3(nlrp3) inflammasome, which is composed of nlrp3, apoptosis associated speck like protein (asc) and pro-caspase-1. |
2023-05-09 |
2023-08-14 |
Not clear |
| Baoshan Hu, Shan Lin, Shengrong Lin, Gang Ru. Ginkgetin Alleviates Intervertebral Disc Degeneration by Inhibiting Apoptosis, Inflammation, and Disturbance of Extracellular Matrix Synthesis and Catabolism via Inactivation of NLRP3 Inflammasome. Immunological investigations. 2023-05-08. PMID:37154418. |
ginkgetin alleviates intervertebral disc degeneration by inhibiting apoptosis, inflammation, and disturbance of extracellular matrix synthesis and catabolism via inactivation of nlrp3 inflammasome. |
2023-05-08 |
2023-08-14 |
Not clear |
| Yu Zhang, Chong Li, Zhifang Wang, Tingting Wang, Yahui Zhou, Lili Zhen. Blocking CXC Motif Chemokine Ligand 2 Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Apoptosis and NLRP3 Inflammasome Activation. Biological & pharmaceutical bulletin. vol 46. issue 5. 2023-04-30. PMID:37121693. |
blocking cxc motif chemokine ligand 2 ameliorates diabetic peripheral neuropathy via inhibiting apoptosis and nlrp3 inflammasome activation. |
2023-04-30 |
2023-08-14 |
rat |
| Yu Zhang, Chong Li, Zhifang Wang, Tingting Wang, Yahui Zhou, Lili Zhen. Blocking CXC Motif Chemokine Ligand 2 Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Apoptosis and NLRP3 Inflammasome Activation. Biological & pharmaceutical bulletin. vol 46. issue 5. 2023-04-30. PMID:37121693. |
in conclusion, these results indicated that cxcl2 knockdown exhibited amelioration of hyperglycemia-induced dpn by inhibiting cell apoptosis and nlrp3 inflammasome activation, suggesting that targeting cxcl2 might be a potential strategy for dpn treatment. |
2023-04-30 |
2023-08-14 |
rat |
| Yuanshui Liu, Hang Yang, Fei Zhu, Yanhong Ouyang, Pinhua Pa. Inhibition of STAT3 phosphorylation by colchicine regulates NLRP3 activation to alleviate sepsis-induced acute lung injury. Inflammopharmacology. 2023-04-28. PMID:37115345. |
colchicine significantly attenuated ali in mice caused by sepsis by alleviating respiratory dysfunction and pulmonary edema in mice, inhibiting nlrp3 inflammasome formation, and reducing oxidative stress, pyroptosis, and apoptosis of murine alveolar macrophage (j774a.1) cells. |
2023-04-28 |
2023-08-14 |
mouse |