| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenfeng Liu, Feng Zhang, Bing Quan, Fan Yao, Rongxin Chen, Zhenggang Ren, Xin Yi. NLRP3/IL-1β induced myeloid-derived suppressor cells recruitment and PD-L1 upregulation promotes oxaliplatin resistance of hepatocellular carcinoma. MedComm. vol 4. issue 6. 2023-12-20. PMID:38116060. |
to further understand its impact on drug resistance, we knocked down nlrp3 and observed that it sensitized hcc cells to the growth-inhibitory effects of oxaliplatin and induced cell apoptosis. |
2023-12-20 |
2023-12-23 |
mouse |
| Yunying Qian, Guiying Qian, Haiyan Ni, Danying Zhu, Weiqun Gu, Ximei Ca. Exploratory study on the mechanism of necrotic effect of nourishing cells in the context of genital tract infection in premature rupture of membranes. Medicine. vol 102. issue 50. 2023-12-20. PMID:38115314. |
prom is associated with a significant upregulation of placental nourishing cell apoptosis and necrotic factors, including caspase-1, caspase-3, nlrp3, and il-1β proteins. |
2023-12-20 |
2023-12-23 |
Not clear |
| Zeynep Dal, Başak Ar. The role of curcumin on apoptosis and NLRP3 inflammasome-dependent pyroptosis on colorectal cancer in vitro. Turkish journal of medical sciences. vol 53. issue 4. 2023-12-01. PMID:38031951. |
the role of curcumin on apoptosis and nlrp3 inflammasome-dependent pyroptosis on colorectal cancer in vitro. |
2023-12-01 |
2023-12-10 |
Not clear |
| Sen Zhou, Yang Liu, Binbin Xue, Peigen Yua. Low-dose Esketamine suppresses NLRP3-mediated apoptotic and pyroptotic cell death in microglial cells to ameliorate LPS-induced depression via ablating GSK-3β. Behavioural brain research. vol 459. 2023-11-30. PMID:38029844. |
next, by conducting mechanical experiments, we verified that low-dose esketamine downregulated gsk-3β to inactivate nlrp3 inflammasome, and the effects of low-dose esketamine on cell pyroptosis, neuroinflammation and apoptosis in the lps-treated microglial cells were all abrogated by overexpressing gsk-3β and nlrp3. |
2023-11-30 |
2023-12-10 |
mouse |
| Qingmei Gong, Yanbo Wang, Xiaowei Wang, Haiyan Pan, Ci Ya. Baicalein promotes the microglia M2 polarization and suppresses apoptosis by targeting HMOX1/PDE4D to alleviate Alzheimer's disease. Immunobiology. vol 228. issue 6. 2023-11-25. PMID:38006681. |
in app/ps1 mice, it was found that baicalein decreased the aβ plaque deposition in brain, attenuated nlrp3 inflammasome activation and neuronal apoptosis in app/ps1 mice. |
2023-11-25 |
2023-11-28 |
mouse |
| Meng Yuan, Asli F Ceylan, Rifeng Gao, Hong Zhu, Yingmei Zhang, Jun Re. Selective inhibition of the NLRP3 inflammasome protects against acute ethanol-induced cardiotoxicity in an FBXL2-dependent manner. Acta biochimica et biophysica Sinica. 2023-11-23. PMID:37994158. |
levels of nlrp3 inflammasome, mitophagy and apoptosis are evaluated by western blot analysis and immunofluorescence techniques. |
2023-11-23 |
2023-11-29 |
mouse |
| Meng Yuan, Asli F Ceylan, Rifeng Gao, Hong Zhu, Yingmei Zhang, Jun Re. Selective inhibition of the NLRP3 inflammasome protects against acute ethanol-induced cardiotoxicity in an FBXL2-dependent manner. Acta biochimica et biophysica Sinica. 2023-11-23. PMID:37994158. |
levels of nlrp3 inflammasome and apoptosis are elevated, and mitophagy flux is blocked (elevated pink1-parkin and lc3b along with diminished p62 and rab7) in mice receiving acute ethanol challenge. |
2023-11-23 |
2023-11-29 |
mouse |
| Meng Yuan, Asli F Ceylan, Rifeng Gao, Hong Zhu, Yingmei Zhang, Jun Re. Selective inhibition of the NLRP3 inflammasome protects against acute ethanol-induced cardiotoxicity in an FBXL2-dependent manner. Acta biochimica et biophysica Sinica. 2023-11-23. PMID:37994158. |
although mcc950 does not elicit a notable effect on myocardial function, apoptosis or inflammasome activation in the absence of ethanol exposure, it effectively rescues acute ethanol cardiotoxicity, as manifested by restored myocardial and cardiomyocyte functional homeostasis, suppressed nlrp3 inflammasome activation and apoptosis, and improved mitophagy flux. |
2023-11-23 |
2023-11-29 |
mouse |
| Soumya Ranjan Mishra, Bishnu Prasad Behera, Vineet Kumar Singh, Kewal Kumar Mahapatra, Deepak Mundkinajeddu, Deeksha Bhat, Aruna Mukti Minz, Gautam Sethi, Thomas Efferth, Surajit Das, Sujit Kumar Bhuti. Anticancer activity of Bacopa monnieri through apoptosis induction and mitophagy-dependent NLRP3 inflammasome inhibition in oral squamous cell carcinoma. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 123. 2023-11-11. PMID:37951147. |
anticancer activity of bacopa monnieri through apoptosis induction and mitophagy-dependent nlrp3 inflammasome inhibition in oral squamous cell carcinoma. |
2023-11-11 |
2023-11-20 |
human |
| Yi Xu, Yanling Yang, Xi Chen, Danling Jiang, Fei Zhang, Yao Guo, Bin Hu, Guohai Xu, Shengliang Peng, Lidong Wu, Jialing H. NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors. Translational neurodegeneration. vol 12. issue 1. 2023-11-02. PMID:37915104. |
we also explore the intrinsic relationship between the nlrp3 inflammasome and cognitive impairment, which involves immune cell activation, cell apoptosis, oxidative stress, mitochondrial autophagy, and neuroinflammation. |
2023-11-02 |
2023-11-08 |
Not clear |
| Fei Li, Hongxiang Zhu, Zijuan Chang, Ying L. Gentiopicroside alleviates acute myocardial infarction injury in rats by disrupting Nrf2/NLRP3 signaling. Experimental biology and medicine (Maywood, N.J.). 2023-10-18. PMID:37850391. |
reactive oxygen species (ros) and cell apoptosis were assessed, while nrf2 and the expression of the nlrp3 inflammatory body signal pathway were evaluated using western blot and immunofluorescence techniques. |
2023-10-18 |
2023-11-08 |
rat |
| Mary Speir, Hazel Tye, Timothy A Gottschalk, Daniel S Simpson, Tirta M Djajawi, Pankaj Deo, Rebecca L Ambrose, Stephanie A Conos, Jack Emery, Gilu Abraham, Ashlyn Pascoe, Sebastian A Hughes, Ashley Weir, Edwin D Hawkins, Isabella Kong, Marco J Herold, Jaclyn S Pearson, Najoua Lalaoui, Thomas Naderer, James E Vince, Kate E Lawlo. A1 is induced by pathogen ligands to limit myeloid cell death and NLRP3 inflammasome activation. EMBO reports. 2023-10-17. PMID:37846472. |
we show that, due to its tight transcriptional and post-translational regulation, a1 acts as a molecular rheostat to regulate bax/bak-dependent apoptosis and the subsequent nlrp3 inflammasome-dependent and inflammasome-independent maturation of the inflammatory cytokine il-1β. |
2023-10-17 |
2023-11-08 |
mouse |
| Hui Xu, Jiangtao Dong, Yang Li, Lei Zhang, Jiangwen Yin, Chao Zhu, Xu Wang, Kunhao Ren, Hao Zhang, Dong Zha. Neuritin has a neuroprotective role in the rat model of acute ischemia stroke by inhibiting neuronal apoptosis and NLRP3 inflammasome. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 32. issue 12. 2023-10-13. PMID:37832268. |
neuritin has a neuroprotective role in the rat model of acute ischemia stroke by inhibiting neuronal apoptosis and nlrp3 inflammasome. |
2023-10-13 |
2023-10-15 |
rat |
| Bo Wang, Minfeng Shi, Chuanjin Yu, Hong Pan, Haiqing Shen, Yatao Du, Yi Zhang, Bin Liu, Di Xi, Jianzhong Sheng, Hefeng Huang, Guolian Din. NLRP3 Inflammasome-dependent Pathway is Involved in the Pathogenesis of Polycystic Ovary Syndrome. Reproductive sciences (Thousand Oaks, Calif.). 2023-10-10. PMID:37815748. |
following nlrp3 overexpression in kgn cells, the genes involved in n-glycan processing, steroidogenesis, oocyte maturation, autophagy, and apoptosis were upregulated. |
2023-10-10 |
2023-10-15 |
mouse |
| Bo Wang, Minfeng Shi, Chuanjin Yu, Hong Pan, Haiqing Shen, Yatao Du, Yi Zhang, Bin Liu, Di Xi, Jianzhong Sheng, Hefeng Huang, Guolian Din. NLRP3 Inflammasome-dependent Pathway is Involved in the Pathogenesis of Polycystic Ovary Syndrome. Reproductive sciences (Thousand Oaks, Calif.). 2023-10-10. PMID:37815748. |
taken together, the nlrp3 inflammasome-dependent pathway is involved in the pathogenesis of pcos not only by mediating pyroptosis, but also by regulating glycan synthesis, sex hormone synthesis, autophagy, and apoptosis in gcs. |
2023-10-10 |
2023-10-15 |
mouse |
| Computational And Mathematical Methods In Medicin. Retracted: miR-223-3p Regulates NLRP3 to Inhibit Proliferation and Promote Apoptosis of ONG Cells. Computational and mathematical methods in medicine. vol 2023. 2023-10-09. PMID:37811265. |
retracted: mir-223-3p regulates nlrp3 to inhibit proliferation and promote apoptosis of ong cells. |
2023-10-09 |
2023-10-15 |
Not clear |
| Yuanxu Li, Gaolong Zhong, Ting He, Jinwen Quan, Siying Liu, Zhonghua Liu, Zhaoxin Tang, Wenlan Y. Effect of arsenic and copper in kidney of mice: Crosstalk between Nrf2/ Keap1 pathway in apoptosis and pyroptosis. Ecotoxicology and environmental safety. vol 266. 2023-10-06. PMID:37801897. |
meanwhile, exposure induced kidney cell pyroptosis and apoptosis by promoting the expression of nlrp3 inflammasomes and caspase-3, which peaked in mice co-treated with as and cu. |
2023-10-06 |
2023-10-15 |
mouse |
| Hongwei Zhang, Jian Liao, Litong Jin, Yan Li. NLRP3 inflammasome involves in the pathophysiology of sepsis-induced myocardial dysfunction by multiple mechanisms. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-23. PMID:37741253. |
nlrp3 inflammasome and its related signaling pathways might affect the regulation of inflammation, autophagy, apoptosis, and pyroptosis in simd. |
2023-09-23 |
2023-10-07 |
Not clear |
| Alireza Shadab, Mohamad Mahjoor, Mohammad Abbasi-Kolli, Hamed Afkhami, Parisa Moeinian, Amir-Reza Safdaria. Divergent functions of NLRP3 inflammasomes in cancer: a review. Cell communication and signaling : CCS. vol 21. issue 1. 2023-09-15. PMID:37715239. |
one of the most recently identified signaling pathways, whose activation seems to affect many metabolic disorders, is the "inflammasome" a multiprotein complex composed of nlrp3 (nucleotide-binding domain and leucine-rich repeat protein 3), asc (apoptosis associated speck-like protein containing a card), and procaspase-1. |
2023-09-15 |
2023-10-07 |
Not clear |
| Xiao-Hong Xiang, Jing Wei, Xiao-Fang Wang, Qin Xu, Chong-Lin Yu, Chang-Long He, Tao Long, Ming-Song Guo, Xue Chen, Xiao-Gang Zhou, Jian-Ming Wu, Da-Lian Qin, An-Guo Wu, Yong Tang, Hong-Bin L. Lychee seed polyphenol ameliorates DR via inhibiting inflammasome/apoptosis and angiogenesis in hRECs and db/db mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-13. PMID:37703661. |
mechanistic studies revealed that lsp inhibits the nlrp3 inflammasome, reduces cell apoptosis in retinal tissue, increases tight junction protein (tj) expression, and reduces vascular endothelial growth factor (vegf) and ve-cadherin in vivo and in vitro. |
2023-09-13 |
2023-10-07 |
mouse |