| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ngoc Minh-Hong Hoang, Hai Duc Nguyen, Wonhee Jo, Min-Sun Ki. Role of prolactin in the protective effect of amisulpride against 1,2-Diacetylbenzene's neurotoxicity. Environmental toxicology and pharmacology. 2024-03-17. PMID:38493881. |
additionally, amisulpride inhibited dab-triggered nlrp3 inflammasome activation and apoptosis. |
2024-03-17 |
2024-03-20 |
Not clear |
| Shuaichen Liu, Lan Hong, Song Zhang, Yuxin Tian, Yuchen Wang, Duanduan Zhao, Jingheng Lv, Jingjing Zhuang, Hongyan Xu, Guangjun Xi. Sporisorium reilianum polysaccharides improve DSS-induced ulcerative colitis by regulating intestinal barrier function and metabolites. International journal of biological macromolecules. 2024-03-15. PMID:38490380. |
epithelial cell apoptosis was inhibited by increased bcl-2 and decreased bax expression nlrp3, asc, and caspase-1 protein levels decreased. |
2024-03-15 |
2024-03-18 |
mouse |
| Yingying Lai, Ningning Yang, Xuankuai Chen, Xianhui Ma, Zhuliu Chen, Chengji Dong, Gaoxiang Yu, Yingying Huang, Donghao Shi, Pin Fang, Kejian Fu, Renhao Jiang, Cong Mao, Jian Ding, Weiyang Ga. Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap. Phytotherapy research : PTR. 2024-03-09. PMID:38459660. |
dihydrocapsaicin suppresses the sting-mediated accumulation of ros and nlrp3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap. |
2024-03-09 |
2024-03-11 |
Not clear |
| Yingying Lai, Ningning Yang, Xuankuai Chen, Xianhui Ma, Zhuliu Chen, Chengji Dong, Gaoxiang Yu, Yingying Huang, Donghao Shi, Pin Fang, Kejian Fu, Renhao Jiang, Cong Mao, Jian Ding, Weiyang Ga. Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap. Phytotherapy research : PTR. 2024-03-09. PMID:38459660. |
the expressions of angiogenesis, apoptosis, nlr family pyrin domain containing 3 (nlrp3) inflammasome, oxidative stress, and molecules related to cyclic guanosine monophosphate (gmp)-adenosine monophosphate synthase (cgas)-interferon gene stimulant (sting) pathway were assessed using western blotting, immunofluorescence, tunel staining, and dihydroethidium (dhe) staining. |
2024-03-09 |
2024-03-11 |
Not clear |
| Yingying Lai, Ningning Yang, Xuankuai Chen, Xianhui Ma, Zhuliu Chen, Chengji Dong, Gaoxiang Yu, Yingying Huang, Donghao Shi, Pin Fang, Kejian Fu, Renhao Jiang, Cong Mao, Jian Ding, Weiyang Ga. Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap. Phytotherapy research : PTR. 2024-03-09. PMID:38459660. |
our finding revealed that dhc promoted the perforator flap survival, which involves the cgas-sting pathway, oxidative stress, nlrp3 inflammasome, apoptosis, and angiogenesis. |
2024-03-09 |
2024-03-11 |
Not clear |
| Yingying Lai, Ningning Yang, Xuankuai Chen, Xianhui Ma, Zhuliu Chen, Chengji Dong, Gaoxiang Yu, Yingying Huang, Donghao Shi, Pin Fang, Kejian Fu, Renhao Jiang, Cong Mao, Jian Ding, Weiyang Ga. Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap. Phytotherapy research : PTR. 2024-03-09. PMID:38459660. |
dhc induced oxidative stress resistance and suppressed the nlrp3 inflammasome, preventing apoptosis in vascular endothelial cells. |
2024-03-09 |
2024-03-11 |
Not clear |
| Fatemeh Mirzaei, Ebrahim Abbasi, Amir Mirzaei, Nashmin Fayazi Hosseini, Nima Naseri, Iraj Khodadadi, Cyrus Jalili, Nesrine Majdou. Toxicity and Hepatoprotective Effects of ZnO Nanoparticles on Normal and High-Fat Diet-Fed Rat Livers: Mechanism of Action. Biological trace element research. 2024-03-05. PMID:38441796. |
the oxidative stress, nlrp3 inflammasome, inflammatory, and apoptosis pathways were measured. |
2024-03-05 |
2024-03-07 |
rat |
| Fatemeh Mirzaei, Ebrahim Abbasi, Amir Mirzaei, Nashmin Fayazi Hosseini, Nima Naseri, Iraj Khodadadi, Cyrus Jalili, Nesrine Majdou. Toxicity and Hepatoprotective Effects of ZnO Nanoparticles on Normal and High-Fat Diet-Fed Rat Livers: Mechanism of Action. Biological trace element research. 2024-03-05. PMID:38441796. |
antioxidant enzyme gene expression and activity were significantly augmented, while apoptosis, nlrp3 inflammasome, and inflammation pathways were significantly reduced by 5 mg/kg zno nps. |
2024-03-05 |
2024-03-07 |
rat |
| Li Liu, YingFeng Wei, NingSheng Xie, Hong Cai, Ye Li. Mitochondria-targeted reactive oxygen species blockor SS-31 blocks hepatic stellate cell activation and alleviates hepatic fibrosis by regulating NLRP3 inflammasomes. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 2. 2024-03-02. PMID:38430023. |
after tgf-β1 induction, hsc proliferation increased, apoptosis decreased, and col1a1, α-sma, and nlrp3 inflammasome protein expression increased. |
2024-03-02 |
2024-03-04 |
mouse |
| Li Liu, YingFeng Wei, NingSheng Xie, Hong Cai, Ye Li. Mitochondria-targeted reactive oxygen species blockor SS-31 blocks hepatic stellate cell activation and alleviates hepatic fibrosis by regulating NLRP3 inflammasomes. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 2. 2024-03-02. PMID:38430023. |
after ss-31 treatment, mitochondrial ros expression decreased, mmp recovered, atp level increased, hsc proliferation decreased, apoptosis increased, and the expressions of col1a1, α-sma, and nlrp3 inflammasome decreased. |
2024-03-02 |
2024-03-04 |
mouse |
| Xin Fang, Yaoxuan Ji, Shuang Li, Lei Wang, Bo He, Bo Li, Boshen Liang, Hongke Yin, Haotian Chen, Duojie Dingda, Bing Wu, Fabao Ga. Paeoniflorin attenuates cuproptosis and ameliorates left ventricular remodeling after AMI in hypobaric hypoxia environments. Journal of natural medicines. 2024-03-01. PMID:38427210. |
it also attenuated apoptosis, inflammation, and fibrosis by modulating bcl-2, bax, nlrp3, and oxidative stress markers. |
2024-03-01 |
2024-03-03 |
rat |
| Linxian Zhao, Haina Zhang, Peng Jiang, Guangmeng X. Isoliquiritin counteracts cadmium-induced intestinal damage in mice through enhancing intestinal barrier function and inhibiting apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-02-24. PMID:38401882. |
furthermore, iso could significantly suppress cd-induced intestinal apoptosis and activation of nlrp3 inflammasome. |
2024-02-24 |
2024-02-27 |
mouse |
| Linxian Zhao, Haina Zhang, Peng Jiang, Guangmeng X. Isoliquiritin counteracts cadmium-induced intestinal damage in mice through enhancing intestinal barrier function and inhibiting apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-02-24. PMID:38401882. |
interestingly, inhibiting the activation of nlrp3 by nigericin completely blocking the effect of iso on apoptosis. |
2024-02-24 |
2024-02-27 |
mouse |
| Linxian Zhao, Haina Zhang, Peng Jiang, Guangmeng X. Isoliquiritin counteracts cadmium-induced intestinal damage in mice through enhancing intestinal barrier function and inhibiting apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-02-24. PMID:38401882. |
taken together, these findings suggest that iso reduces cd-induced intestinal damage by increasing the goblet cells, improving intestinal barrier, suppressing nlrp3 inflammasome activation and inhibiting apoptosis, which may offer a novel strategy against the toxic effects of heavy metals. |
2024-02-24 |
2024-02-27 |
mouse |
| Kristy T Rodríguez-Ramírez, María Norte-Muñoz, Fernando Lucas-Ruiz, Alejandro Gallego-Ortega, Francesco Calzaferri, David García-Bernal, Carlos M Martínez, Caridad Galindo-Romero, Cristóbal de Los Ríos, Manuel Vidal-Sanz, Marta Agudo-Barrius. Retinal response to systemic inflammation differs between sexes and neurons. Frontiers in immunology. vol 15. 2024-02-22. PMID:38384465. |
here, we investigate the effect of systemic inflammation induced by intraperitoneal administration of lipopolysaccharide (lps) on the retina of male and female mice and determine whether antagonism of the nlrp3 inflammasome and the extrinsic pathway of apoptosis have protective effects on the retina. |
2024-02-22 |
2024-02-24 |
mouse |
| Dandan Chu, Mengyang Zhao, Shisong Rong, Wonho Jhe, Xiaolu Cai, Yi Xiao, Wei Zhang, Xingchen Geng, Zhanrong Li, Xingcai Zhang, Jingguo L. Dual-Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease. Nano-micro letters. vol 16. issue 1. 2024-02-19. PMID:38372846. |
the in vitro and in vivo results demonstrate the dan is endowed with superior biological activity in scavenging excessive ros, inhibiting nlrp3 inflammasome activation, decreasing proinflammatory cytokines expression, and suppressing cell apoptosis. |
2024-02-19 |
2024-02-21 |
Not clear |
| Qiaoyun Bai, Ruobai Liu, Changlin Quan, Xue Han, Dandan Wang, Chongyang Wang, Zhiguang Wang, Li Li, Liangchang Li, Hongmei Piao, Yilan Song, Guanghai Ya. DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma. Frontiers in immunology. vol 14. 2024-01-26. PMID:38274803. |
this study aims to investigate the role and mechanism of dek in asthmatic airway inflammation and in regulating pink1-parkin-mediated mitophagy, nlrp3 inflammasome activation, and apoptosis. |
2024-01-26 |
2024-01-28 |
mouse |
| Qiaoyun Bai, Ruobai Liu, Changlin Quan, Xue Han, Dandan Wang, Chongyang Wang, Zhiguang Wang, Li Li, Liangchang Li, Hongmei Piao, Yilan Song, Guanghai Ya. DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma. Frontiers in immunology. vol 14. 2024-01-26. PMID:38274803. |
pink1-parkin mitophagy, nlrp3 inflammasome, and apoptosis were examined after gene silencing or treatment with specific inhibitors (mitotempo, mcc950, and ac-devd-cho) in house dust mite (hdm) or recombinant dek (rmdek)-induced wt and dek-/- asthmatic mice and beas-2b cells. |
2024-01-26 |
2024-01-28 |
mouse |
| Qiaoyun Bai, Ruobai Liu, Changlin Quan, Xue Han, Dandan Wang, Chongyang Wang, Zhiguang Wang, Li Li, Liangchang Li, Hongmei Piao, Yilan Song, Guanghai Ya. DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma. Frontiers in immunology. vol 14. 2024-01-26. PMID:38274803. |
moreover, rmdek also increased drp1 expression, pink1-parkin-mediated mitophagy, nlrp3 inflammasome activation, and apoptosis. |
2024-01-26 |
2024-01-28 |
mouse |
| Yulin Zhang, Hongxian Wu, Chaozhi Xu, Shanqian Li, Yue Hu, Zongyi Zhang, Guixian Wu, Yuling Liu, Lin Yang, Yue Huang, Wenjun Lu, Lina H. (-)-Epigallocatechin gallate alleviates chronic unpredictable mild stress-induced depressive symptoms in mice by regulating the mTOR autophagy pathway and inhibiting NLRP3 inflammasome activation. Food science & nutrition. vol 12. issue 1. 2024-01-25. PMID:38268911. |
then, elisa, western blot and qt-pcr tests were used to assess the expression of the key components of the nlrp3 inflammasome and its downstream inflammatory effectors (e.g., il-1β, il-18), autophagy markers (beclin-1, lc3, p62) and apoptosis markers (bax, bcl-2) in mouse brain tissues. |
2024-01-25 |
2024-01-27 |
mouse |