| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingxin Pei, Ke Deng, Yanling Che. Role and mechanism of endoplasmic reticulum stress and NLRP3 inflammasome in acute kidney injury. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 49. issue 3. 2024-07-06. PMID:38970510. |
additionally, the nlrp3 inflammasome can mediate the recognition of endogenous and exogenous danger signal molecules by the host, subsequently activating caspase-1, pro-inflammatory cytokines such as il-1β and il-18, inducing inflammatory responses, and promoting apoptosis of renal cells. |
2024-07-06 |
2024-07-11 |
Not clear |
| Rajath Ramachandran, Abdul Manan, Jei Kim, Sangdun Cho. NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders. Experimental & molecular medicine. 2024-06-30. PMID:38945951. |
to understand the diverse behavior of nlrp3 activation and its significance in the development of lifestyle-related diseases, one must delve into the study of the immune response and apoptosis mediated by the release of proinflammatory cytokines. |
2024-06-30 |
2024-07-03 |
Not clear |
| Hanlong He, Huiren Su, Xinjian Chen, Xiaohong Chen, Shaoze Yan. Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes. Prostaglandins & other lipid mediators. 2024-06-27. PMID:38936540. |
interference with gpr4 inactivates nlrp3 inflammasome signaling by inhibiting lpar1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes. |
2024-06-27 |
2024-06-30 |
Not clear |
| Hanlong He, Huiren Su, Xinjian Chen, Xiaohong Chen, Shaoze Yan. Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes. Prostaglandins & other lipid mediators. 2024-06-27. PMID:38936540. |
western blot was employed to detect the expression of proteins related to apoptosis and nlrp3 inflammasome signaling. |
2024-06-27 |
2024-06-30 |
Not clear |
| Hanlong He, Huiren Su, Xinjian Chen, Xiaohong Chen, Shaoze Yan. Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes. Prostaglandins & other lipid mediators. 2024-06-27. PMID:38936540. |
to be concluded, gpr4 deficiency inactivates nlrp3 inflammasome signaling by inhibiting lpar1 expression to ameliorate ogd/r -induced inflammation and apoptosis of cardiomyocytes. |
2024-06-27 |
2024-06-30 |
Not clear |
| Yidan Liang, Wenqiao Fu, Yin Tang, Hongjiang Ye, Yanglingxi Wang, Chao Sun, Yi Xiang, Weiming Xiong, Min Cui, Yuanlin Chen, Ting Wang, Yongbing Den. Selective Activation of G Protein-Coupled Estrogen Receptor 1 (GPER1) Reduces ER Stress and Pyroptosis via AMPK Signaling Pathway in Experimental Subarachnoid Hemorrhage. Molecular neurobiology. 2024-06-27. PMID:38935231. |
endoplasmic reticulum (er) stress-induced apoptosis and nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3(nlrp3)-associated pyroptosis can contribute to the escalation of neuroinflammatory responses, leading to increased brain damage. |
2024-06-27 |
2024-06-29 |
mouse |
| Qing-Xiang Zheng, Qing-Lin Liu, Wen-Na Sun, Xin-Yu Jiang, Tao Zen. Biphasic effects of ethanol consumption on N,N-dimethylformamide-induced liver injury in mice. Toxicology. vol 506. 2024-06-26. PMID:38924947. |
mechanistically, acute ethanol consumption suppressed dmf-induced activation of the nlr family pyrin domain-containing protein 3 (nlrp3) inflammasome, while long-term moderate ethanol consumption promoted hepatocyte apoptosis in the mouse liver. |
2024-06-26 |
2024-06-29 |
mouse |
| Heliang Ni, Xiangdong Hu, Nannan Yang, Xiaoyang Liu, Wenyang Cai, Rui Zhong, Tiancheng Wang, Mingxi Yu, Shuang Tan. Roundup Toxicological research. vol 40. issue 3. 2024-06-24. PMID:38911547. |
in summary, our findings indicated that the premature senescence of granulosa cells caused by mitochondrial ros-triggered nlrp3 inflammasome activation might contribute to the ovarian toxicity of roundup, in addition to its known effects on steroidogenesis and apoptosis. |
2024-06-24 |
2024-06-26 |
mouse |
| Jiawei Chen, Xiandong Zhu, Ziqiong Wang, Michael Rützler, Qiaohong Lu, Hongjie Xu, Roland Andersson, Yinwei Dai, Zouwen Shen, Giuseppe Calamita, Shangjing Xie, Yongheng Bai, Bicheng Che. Inhibition of aquaporin-9 ameliorates severe acute pancreatitis and associated lung injury by NLRP3 and Nrf2/HO-1 pathways. International immunopharmacology. vol 137. 2024-06-21. PMID:38906007. |
moreover, we demonstrate that rg100204 reduced apoptosis in the lungs of rat sap animals, and reduces nf-κb signaling, nlrp3, expression, while profoundly increasing the nrf2-dependent anti oxidative stress response. |
2024-06-21 |
2024-06-24 |
mouse |
| Nada Hashim, Rasha Babiker, Riham Mohammed, Mohammed Mustahsen Rehman, Nallan Csk Chaitanya, Bakri Gobar. NLRP3 Inflammasome in Autoinflammatory Diseases and Periodontitis Advance in the Management. Journal of pharmacy & bioallied sciences. vol 16. issue Suppl 2. 2024-06-17. PMID:38882867. |
by boosting cytokines that promote inflammation in the periodontal ligament fibroblasts and triggering apoptosis in osteoblasts, the nlrp3 inflammasome regulates immune cell activity. |
2024-06-17 |
2024-06-19 |
Not clear |
| Yingying Qian, Ning Zhao, Ming Wang, Zhiguo Zou, Kewei Xi. P2X7 receptor deficiency attenuates cisplatin-induced kidney injury via inhibiting NLRP3 inflammasome activation. Biochemical pharmacology. 2024-06-16. PMID:38880358. |
compared with wild-type mice, p2x7r -/- mice showed decreased expression of nlrp3, apoptosis-associated speck-like protein containing a caspase recruitment domain (asc), cleaved caspase-1, and cleaved il-1β in kidney tissue after cisplatin administration, and the apoptosis of renal tubular epithelial cells were also decreased. |
2024-06-16 |
2024-06-19 |
mouse |
| Wei Zhang, Menglong Zou, Jia Fu, Yin Xu, Ying Zh. Autophagy: A potential target for natural products in the treatment of ulcerative colitis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 176. 2024-06-12. PMID:38865850. |
a growing number of studies have established that autophagy can interplay with endoplasmic reticulum stress, gut microbiota, apoptosis, and the nlrp3 inflammasome, all of which contribute to the pathogenesis of uc. |
2024-06-12 |
2024-06-15 |
Not clear |
| Qian Wu, Rui Li, Yifei You, Wei Cheng, Yan Li, Yan Feng, Yuqin Fan, Yan Wan. Lung microbiota participated in fibrous microplastics (MPs) aggravating OVA-induced asthma disease in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-06-08. PMID:38851522. |
in addition, mp fibers exposure induced lung epithelial cells apoptosis, disruption of epithelial barrier integrity and activation of nlrp3 related signaling pathways. |
2024-06-08 |
2024-06-11 |
mouse |
| Esra Adiyeke, Nurten Bakan, Ayca Uvez, Devrim Oz Arslan, Sima Kilic, Berkcan Koc, Samed Ozer, Ozlem Saatci, Elif İlkay Armuta. THE EFFECT OF N- ACETYLCYSTEINE ON THE NEUROTOXICITY OF SEVOFLURANE IN DEVELOPING HIPPOCAMPUS CELLS. Neurotoxicology. 2024-06-06. PMID:38843996. |
protein levels of nrf-2, nlrp3, il-1β, caspase-1, beclin 1, p62, lc3a, and apoptosis markers were assessed. |
2024-06-06 |
2024-06-10 |
rat |
| Qi Zhang, Xi-Rui Yang, Yao Den. Iguratimod Alleviates Experimental Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation. Cell biochemistry and biophysics. 2024-06-05. PMID:38839699. |
apoptosis and nlrp3 inflammasome-related proteins were detected by western blotting. |
2024-06-05 |
2024-06-08 |
mouse |
| Qi Zhang, Xi-Rui Yang, Yao Den. Iguratimod Alleviates Experimental Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation. Cell biochemistry and biophysics. 2024-06-05. PMID:38839699. |
in vitro, results corroborated that t-614 could protect hsg cells from ifn-α-induced cell apoptosis and inflammation by inhibiting nlrp3 inflammasome activation. |
2024-06-05 |
2024-06-08 |
mouse |
| Huizhen Wei, Mengru Sun, Ruixuan Wang, Hairong Zeng, Bei Zhao, Shenyi Ji. Puerarin mitigated LPS-ATP or HG-primed endothelial cells damage and diabetes-associated cardiovascular disease via ROS-NLRP3 signalling. Journal of cellular and molecular medicine. vol 28. issue 10. 2024-05-22. PMID:38774996. |
in the study, pue ameliorated lipopolysaccharide-adenosine triphosphate (lps-atp) or hg-primed cytotoxicity and apoptosis, while inhibited reactive oxygen species (ros)-mediated nlr family pyrin domain containing 3 (nlrp3) inflammasome in huvecs, as evidenced by significantly decreased ros level, nox4, caspase-1 activity and expression of nlrp3, gsdmd, cleaved caspase-1, il-1β and il-18. |
2024-05-22 |
2024-05-27 |
Not clear |
| Jaili Li, Ting Luo, Yao Zhao, Dou Wang, Yuanxiang Jin, Zufang Wu, Guiling Yang, Xingjiang Q. Cardioprotective potentials of myricetin on doxorubicin-induced cardiotoxicity based on biochemical and transcriptomic analysis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-05-22. PMID:38776683. |
myr effectively suppressed nlrp3 and asc gene expression levels to inhibit pyroptosis while regulating caspase1 and bax levels to reduce cardiac cell apoptosis. |
2024-05-22 |
2024-05-27 |
mouse |
| Shuang Gao, Na Li, Zhongjing Lin, Yisheng Zhong, Yanuo Wang, Xi She. Inhibition of NLRP3 inflammasome by MCC950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in Müller glia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 10. 2024-05-16. PMID:38752538. |
inhibition of nlrp3 inflammasome by mcc950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in müller glia. |
2024-05-16 |
2024-05-27 |
mouse |
| Shuang Gao, Na Li, Zhongjing Lin, Yisheng Zhong, Yanuo Wang, Xi She. Inhibition of NLRP3 inflammasome by MCC950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in Müller glia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 10. 2024-05-16. PMID:38752538. |
here, we identified the effect of a potent, selective nlrp3 inhibitor, mcc950, on autophagy and apoptosis under hypoxia. |
2024-05-16 |
2024-05-27 |
mouse |