| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenwen Zhang, Minghao Shen, Peng Chu, Tao Wang, Jie Ji, Xianhui Ning, Shaowu Yin, Kai Zhan. Molecular characterization of CIRBP from Takifugu fasciatus and its potential roles in cold-induced liver damage. International journal of biological macromolecules. 2024-10-11. PMID:39393746. |
cold exposure markedly induced histomorphological liver injury and triggered endogenous apoptosis and nlrp3 inflammatory response. |
2024-10-11 |
2024-10-14 |
Not clear |
| Guangli Xu, Chao Tian, Yanru Li, Lei Fang, Jing Wang, Zhuqing Jing, Simeng Li, Ping Che. Inhibition of BCAT1 expression improves recurrent miscarriage by regulating cellular dysfunction and inflammation of trophoblasts. Cell and tissue research. 2024-10-02. PMID:39356334. |
the results demonstrated that inhibition of bcat1 reduced trophoblast apoptosis, suppressed the release of proinflammatory cytokines, and prevented nlrp3 inflammasome activation in response to lps. |
2024-10-02 |
2024-10-04 |
mouse |
| Ze-Yang Qiu, Kai-Na Shi, Hui-Hua Li, Bo Zhan. CBR-470-1 protects against cardiomyocyte death in ischaemia/reperfusion injury by activating the Nrf2-GPX4 cascade. Toxicology and applied pharmacology. 2024-09-29. PMID:39343043. |
mechanistically, cbr-470-1 upregulated nrf2 expression, which increased the expression levels of antioxidant enzymes (nqo1, sod1, prdx1, and gclc) and antiferroptotic proteins (slc7a11 and gpx4) and downregulated the protein expression of p53 and nlrp3, leading to the inhibition of ros production and inflammation and subsequent cardiomyocyte death (apoptosis, ferroptosis and pyroptosis). |
2024-09-29 |
2024-10-02 |
mouse |
| Ze-Yang Qiu, Kai-Na Shi, Hui-Hua Li, Bo Zhan. CBR-470-1 protects against cardiomyocyte death in ischaemia/reperfusion injury by activating the Nrf2-GPX4 cascade. Toxicology and applied pharmacology. 2024-09-29. PMID:39343043. |
in summary, cbr-470-1 prevented i/r-mediated cardiac injury possibly through inhibiting cardiomyocyte apoptosis, ferroptosis and pyroptosis via nrf2-mediated inhibition of p53 and nlrp3 and activation of the slc7a11/gpx4 pathway. |
2024-09-29 |
2024-10-02 |
mouse |
| Yi Gao, Huangen Li, Yongkang Que, Weiwen Chen, Shi-Ying Huang, Wenjie Liu, Xiaotong Y. Lycium barbarum polysaccharides (LBP) suppresses hypoxia/reoxygenation (H/R)-induced rat H9C2 cardiomyocytes pyroptosis via Nrf2/HO-1 signaling pathway. International journal of biological macromolecules. 2024-09-25. PMID:39322131. |
the nrf2 sirna2 caused the following events in h/r model: (1) the increases of the apoptosis rate, ldh activity, the levels of inflammatory factors (il-1β and il-18), the levels of acs, nlrp3, and caspase-1 (mrnas and proteins); and (2) the decreases of the cell survival rate, the mrna levels of nrf2 and ho-1, and the protein levels of cytoplasm-nrf2, nucleus-nrf2, and ho-1. |
2024-09-25 |
2024-09-28 |
rat |
| Dingyu Chen, Lixia Wu, Xi Liu, Qinrong Wang, Shuqin Gui, Liya Bao, Zhengrong Wang, Xiaofeng He, Yan Zhao, Jianjiang Zhou, Yuan Xi. Helicobacter pylori CagA mediated mitophagy to attenuate the NLRP3 inflammasome activation and enhance the survival of infected cells. Scientific reports. vol 14. issue 1. 2024-09-17. PMID:39289452. |
inhibition of mitophagy led to an increase in nlrp3 inflammasome activation and apoptosis and a decrease in the viability of h. pylori-infected cells. |
2024-09-17 |
2024-09-20 |
Not clear |
| Kun Wang, Yang Zhou, Cong Wen, Linqin Du, Lan Li, Yangyang Cui, Hao Luo, Yanxu Liu, Lang Zeng, Shikang Li, Lijuan Xiong, Rongchuan Yu. Protective effects of tetramethylpyrazine on myocardial ischemia/reperfusion injury involve NLRP3 inflammasome suppression by autophagy activation. Biochemical pharmacology. 2024-09-16. PMID:39284501. |
in this study, a certain concentration of tmp was introduced into i/r mice or h9c2 cells after oxygen-glucose deprivation/reoxygenation (ogd/r) treatment to observe the effects of tmp on cardiomyocyte activity, cytotoxicity, apoptosis, autophagy, pyroptosis, and nlrp3 inflammasome activation. |
2024-09-16 |
2024-09-19 |
mouse |
| Fatemah A Alherz, Asmaa Saleh, Mona Y Alsheikh, Hany M Borg, Ahmed M Kabel, Maaly A Abd Elmaabou. Shikonin mitigates cyclophosphamide-induced cardiotoxicity in mice: the role of sirtuin-1, NLRP3 inflammasome, autophagy, and apoptosis. The Journal of pharmacy and pharmacology. 2024-09-08. PMID:39245439. |
shikonin mitigates cyclophosphamide-induced cardiotoxicity in mice: the role of sirtuin-1, nlrp3 inflammasome, autophagy, and apoptosis. |
2024-09-08 |
2024-09-11 |
mouse |
| Jingyi Wang, Ming Li, Wenda Wu, HuiJing Zhang, Yue Yang, Muhammad Usman, Ben Aernouts, Juan J Loor, Chuang X. Inflammatory Signaling via PEIZO1 Engages and Enhances the LPS-Mediated Apoptosis during Clinical Mastitis. Journal of agricultural and food chemistry. 2024-09-04. PMID:39229907. |
notably, the effects of piezo1 artificial activator yoda1 increased apoptosis and nlrp3 expression, effects mitigated by piezo1 silencing or nlrp3 inhibition. |
2024-09-04 |
2024-09-06 |
mouse |
| Michela Luciano, Helene Sieberer, Peter W Krenn, Hieu-Hoa Dang, Julia Vetter, Theresa Neuper, Diana Amend, Constantin Blöchl, Christian X Weichenberger, Anna Eglseer, Michael S Unger, Ancuela Andosch, Philip Steiner, Daniel Neureiter, Renate Bauer, Laura Hummer, Suzana Tesanovic, Stephanie Binder, Dominik P Elmer, Helen Strandt, Susanne Schaller, Dirk Strunk, Lisa Pleyer, Richard Greil, Stephan Winkler, Tanja N Hartmann, Dirk Schmidt-Arras, Christian G Huber, Fritz Aberger, Jutta Horejs-Hoec. Targeting NLRP3 inhibits AML progression by inducing PERK/eIF2-mediated apoptosis. Cell communication and signaling : CCS. vol 22. issue 1. 2024-09-03. PMID:39223663. |
targeting nlrp3 inhibits aml progression by inducing perk/eif2-mediated apoptosis. |
2024-09-03 |
2024-09-05 |
Not clear |
| Xiaoyan Tian, Chuanqiang Zhang, Daojuan Wang, Xiaowei Li, Qiang Wan. Ginseng polysaccharide promotes the apoptosis of colon cancer cells via activating the NLRP3 inflammasome. Immunopharmacology and immunotoxicology. 2024-09-02. PMID:39219032. |
ginseng polysaccharide promotes the apoptosis of colon cancer cells via activating the nlrp3 inflammasome. |
2024-09-02 |
2024-09-04 |
Not clear |
| Huaijuan Liu, Peijun Zhang, Jingwen Yu, Jiwei Wang, Jiezhong Yu, Minfang Gu. [Fasudil improves cognitive function in APP/PS1 transgenic mice by promoting mitophagy and inhibiting NLRP3 inflammasome activation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 40. issue 8. 2024-08-31. PMID:39215667. |
terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling assay (tunel) staining was used to detect neuronal apoptosis; the expression of p62 and nlrp3 was detected by immunofluorescence histochemical staining; real time fluorescence quantitative pcr was used to detect the mrna expression levels of phosphatase and tensin homolog deleted on chromosome ten (pten) -induced putative kinase 1 (pink1), parkin and nlrp3; western blot analysis was used to detect the expression of pink1, parkin, p62, microtubule-associated protein 1 light chain 3 (lc3), nlrp3, adapter protein apoptosis-associated speck-like protein (asc) and interleukin-18 (il-18). |
2024-08-31 |
2024-09-04 |
mouse |
| Yifeng Dai, Xijin Xu, Xia Huo, Joost H N Schuitemaker, Marijke M Faa. Differential effect of lead and cadmium on mitochondrial function and NLRP3 inflammasome activation in human trophoblast. The Journal of physiology. 2024-08-28. PMID:39197088. |
then, we evaluated cell viability, apoptosis, mitochondrial dna copy number (mtdnacn), mitochondrial membrane potential (ΔΨ), nlrp3 inflammasome proteins and interleukin (il)-1β secretion. |
2024-08-28 |
2024-08-31 |
human |
| Aiguo Zhang, Xuefei Wang, Mingming Fan, Yibo Guan, Yuchen Jiang, Shuangxing Jin, Lingling Liu, Heping Huangfu, Chao Son. Lycopene alleviates zearalenone-induced oxidative stress, apoptosis, and NLRP3 inflammasome activation in mice kidneys. Toxicon : official journal of the International Society on Toxinology. vol 249. 2024-08-25. PMID:39181415. |
lycopene alleviates zearalenone-induced oxidative stress, apoptosis, and nlrp3 inflammasome activation in mice kidneys. |
2024-08-25 |
2024-08-28 |
mouse |
| Aiguo Zhang, Xuefei Wang, Mingming Fan, Yibo Guan, Yuchen Jiang, Shuangxing Jin, Lingling Liu, Heping Huangfu, Chao Son. Lycopene alleviates zearalenone-induced oxidative stress, apoptosis, and NLRP3 inflammasome activation in mice kidneys. Toxicon : official journal of the International Society on Toxinology. vol 249. 2024-08-25. PMID:39181415. |
lycopene supplementation could alleviate zen-induced renal toxicity by inhibiting oxidative stress, apoptosis, and nlrp3 inflammasome activation. |
2024-08-25 |
2024-08-28 |
mouse |
| Zeqian Wang, Yanzhe Duan, Yige Wu, Cungen Ma, Yuqing Yan, Lijuan Son. [Research progress on the pyroptosis mediated by the NLRP3 inflammasome in the pathology of ischemic stroke]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 40. issue 7. 2024-08-23. PMID:39179409. |
pyroptosis, which is characterized by both apoptosis and necrosis, is mediated by activation of inflammasomes, such as nod-like receptor family, pyrin domain containing 3 (nlrp3). |
2024-08-23 |
2024-08-27 |
human |
| Xiao-Li Wang, Yun-Xia Gao, Qiong-Zhen Yuan, Ming Zhan. NLRP3 and autophagy in retinal ganglion cell inflammation in age-related macular degeneration: potential therapeutic implications. International journal of ophthalmology. vol 17. issue 8. 2024-08-19. PMID:39156786. |
the nlrp3 inflammasome was a protein complex that, upon activation, produces caspase-1, mediating the apoptosis of retinal cells and promoting the occurrence and development of retinal degenerative diseases. |
2024-08-19 |
2024-08-21 |
Not clear |
| Guang-Nan Jin, Yu Wang, Yi-Ming Liu, Yu-Nan Lu, Jing-Mei Lu, Jing-He Wang, Jing-Wen Ma, Yan-Zhu Quan, Hong-Yan Gao, Yue-Xian Cui, Xiang Xu, Lian-Xun Pia. Arctiin Mitigates Neuronal Injury by Modulating the P2X7R/NLPR3 Inflammasome Signaling Pathway. Inflammation. 2024-08-17. PMID:39154088. |
arc attenuated neuroinflammatory responses and neuronal apoptosis by inhibiting the overactivation of the p2x7 receptor (p2x7r)/nod-like receptor family pyrin domain-containing 3 (nlrp3) inflammasome signaling pathway, similar to the effect of a438079 (p2x7r antagonist). |
2024-08-17 |
2024-08-20 |
mouse |
| Jinjin Wang, Xingzhi Jing, Xiaoyang Liu, Feifei Chen, Zhongpeng Ge, Xiaodong Liu, Heng Yang, Yifei Guo, Xingang Cu. Naringin safeguards vertebral endplate chondrocytes from apoptosis and NLRP3 inflammasome activation through SIRT3-mediated mitophagy. International immunopharmacology. vol 140. 2024-08-09. PMID:39121608. |
naringin safeguards vertebral endplate chondrocytes from apoptosis and nlrp3 inflammasome activation through sirt3-mediated mitophagy. |
2024-08-09 |
2024-08-13 |
Not clear |
| Jianbing Hao, Xinyu Guo, Siyu Wang, Xiaojun Guo, Kun Yuan, Ruihong Chen, Lirong Ha. LincRNA-p21/AIF-1/CMPK2/NLRP3 pathway promoted inflammation, autophagy and apoptosis of human tubular epithelial cell induced by urate via exosomes. Scientific reports. vol 14. issue 1. 2024-08-05. PMID:39103417. |
furthermore, manipulating the activity of lincrna-p21, aif-1, cmpk2, and nlrp3 through overexpression or interference vectors regulated the level of inflammation, autophagy, and apoptosis in hk2 cells. |
2024-08-05 |
2024-08-08 |
human |