| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ximena V Qadir, Weina Chen, Chang Han, Kyoungsub Song, Jinqiang Zhang, Tong W. miR-223 Deficiency Protects against Fas-Induced Hepatocyte Apoptosis and Liver Injury through Targeting Insulin-Like Growth Factor 1 Receptor. The American journal of pathology. vol 185. issue 12. 2016-05-02. PMID:26598234. |
transfection of mir-223 ko hepatocytes with mir-223 mimic enhanced jo2-induced activation of caspase-3, caspase-8, and caspase-9, whereas transfection of wt hepatocytes with the mir-223 inhibitor attenuated jo2-induced apoptosis. |
2016-05-02 |
2023-08-13 |
mouse |
| Weina Chen, Chang Han, Jinqiang Zhang, Kyoungsub Song, Ying Wang, Tong W. miR-150 Deficiency Protects against FAS-Induced Acute Liver Injury in Mice through Regulation of AKT. PloS one. vol 10. issue 7. 2016-04-28. PMID:26196694. |
the primary hepatocytes isolated from mir-150 ko mice also showed protection against fas-induced apoptosis in vitro (characterized by less prominent parp cleavage, less nuclear fragmentation and less caspase activation) in comparison to hepatocytes from wild type mice. |
2016-04-28 |
2023-08-13 |
mouse |
| Taketo Inoue, Michiko Aoyama-Ishikawa, Shingo Kamoshida, Satoshi Nishino, Maki Sasano, Nobuki Oka, Hayato Yamashita, Motoki Kai, Atsunori Nakao, Joji Kotani, Makoto Usam. Endogenous interleukin 18 regulates testicular germ cell apoptosis during endotoxemia. Reproduction (Cambridge, England). vol 150. issue 2. 2016-04-01. PMID:25934945. |
during the acute phase of endotoxemia, apoptosis (as indicated by caspase-3 cleavage) was increased in wt mice but not in il18 ko mice. |
2016-04-01 |
2023-08-13 |
mouse |
| Taketo Inoue, Michiko Aoyama-Ishikawa, Shingo Kamoshida, Satoshi Nishino, Maki Sasano, Nobuki Oka, Hayato Yamashita, Motoki Kai, Atsunori Nakao, Joji Kotani, Makoto Usam. Endogenous interleukin 18 regulates testicular germ cell apoptosis during endotoxemia. Reproduction (Cambridge, England). vol 150. issue 2. 2016-04-01. PMID:25934945. |
during the recovery phase of endotoxemia, apoptosis was observed in the il18 ko mice but not in the wt mice. |
2016-04-01 |
2023-08-13 |
mouse |
| Asif Manzoor Khan, Alicia A Babcock, Hamid Saeed, Christa Løth Myhre, Moustapha Kassem, Bente Finse. Telomere dysfunction reduces microglial numbers without fully inducing an aging phenotype. Neurobiology of aging. vol 36. issue 6. 2016-03-17. PMID:25892207. |
terc ko mice also showed increased cellular apoptosis and impaired spatial learning. |
2016-03-17 |
2023-08-13 |
mouse |
| Norihiko Takemoto, Satoshi Serada, Minoru Fujimoto, Hiromi Honda, Tomoharu Ohkawara, Tsuyoshi Takahashi, Shintaro Nomura, Hidenori Inohara, Tetsuji Nak. Leucine-rich α-2-glycoprotein promotes TGFβ1-mediated growth suppression in the Lewis lung carcinoma cell lines. Oncotarget. vol 6. issue 13. 2016-03-15. PMID:25826092. |
furthermore, administration of a tgfβr1 inhibitor (sb431542) significantly enhanced the growth of llc tumors in wt mice compared with lrg ko mice via inhibition of apoptosis. |
2016-03-15 |
2023-08-13 |
mouse |
| Valvanera Fernández-Laso, Cristina Sastre, Jesús Egido, Jose L Martín-Ventura, Luis M Blanco-Coli. [Atorvastatin inhibits the atherosclerotic lesion induced by tumor necrosis factor-like weak inducer of apoptosis in apolipoprotein E deficient mice]. Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis. vol 27. issue 1. 2016-02-15. PMID:25027757. |
interaction of tumor necrosis factor-like weak inducer of apoptosis (tweak) with its receptor fn14 accelerates atherosclerotic plaque development in apoe deficient mice (apoe ko). |
2016-02-15 |
2023-08-13 |
mouse |
| Mee-Hyun Lee, Do Young Lim, Myoung Ok Kim, Sung-Young Lee, Seung Ho Shin, Jae Young Kim, Sung-Hyun Kim, Dong Joon Kim, Sung Keun Jung, Ke Yao, Joydeb Kumar Kundu, Hye Suk Lee, Cheol-Jung Lee, Sally E Dickinson, David Alberts, G Timothy Bowden, Steven Stratton, Clara Curiel, Janine Einspahr, Ann M Bode, Young-Joon Surh, Yong-Yeon Cho, Zigang Don. Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17. Carcinogenesis. vol 36. issue 11. 2016-02-03. PMID:26271098. |
moreover, ssl-induced apoptosis was abolished in skin from caspase-7 ko mice. |
2016-02-03 |
2023-08-13 |
mouse |
| Jie Wang, Mi-Young Song, Joo Young Lee, Keun Sang Kwon, Byung-Hyun Par. The NLRP3 inflammasome is dispensable for ER stress-induced pancreatic β-cell damage in Akita mice. Biochemical and biophysical research communications. vol 466. issue 3. 2016-01-11. PMID:26361146. |
tunicamycin-exposed islets from nlrp3 ko mice exhibited similar levels of er stress and apoptosis induction as islets from wt (ins2(+/+); nlrp3(+/+)) mice. |
2016-01-11 |
2023-08-13 |
mouse |
| Marcin Wysoczynski, Mitesh Solanki, Sylwia Borkowska, Patrick van Hoose, Kenneth R Brittian, Sumanth D Prabhu, Mariusz Z Ratajczak, Gregg Rokos. Complement component 3 is necessary to preserve myocardium and myocardial function in chronic myocardial infarction. Stem cells (Dayton, Ohio). vol 32. issue 9. 2015-12-08. PMID:24806427. |
morphometric analysis 28 days post-mi showed c3 ko mice had more scar tissue with less viable myocardium within the infarct zone which correlated with decreased c-kit(pos) cardiac stem/progenitor cells (cpsc), decreased proliferating ki67(pos) cspcs and decreased formation of new brdu(pos) /α-sarcomeric actin(pos) myocytes, and increased apoptosis compared to wt. |
2015-12-08 |
2023-08-13 |
mouse |
| Marcin Wysoczynski, Mitesh Solanki, Sylwia Borkowska, Patrick van Hoose, Kenneth R Brittian, Sumanth D Prabhu, Mariusz Z Ratajczak, Gregg Rokos. Complement component 3 is necessary to preserve myocardium and myocardial function in chronic myocardial infarction. Stem cells (Dayton, Ohio). vol 32. issue 9. 2015-12-08. PMID:24806427. |
decreased cspcs and increased apoptosis were evident 7 days post-mi in c3 ko hearts. |
2015-12-08 |
2023-08-13 |
mouse |
| Weina Chen, Chang Han, Jinqiang Zhang, Kyoungsub Song, Ying Wang, Tong W. Deletion of Mir155 prevents Fas-induced liver injury through up-regulation of Mcl-1. The American journal of pathology. vol 185. issue 4. 2015-12-07. PMID:25794705. |
the mir155 ko mice showed lower alanine aminotransferase and aspartate aminotransferase levels, less liver tissue damage, fewer apoptotic hepatocytes, and lower liver tissue caspase 3/7, 8, and 9 activities compared with the wt mice, indicating that mir155 deletion prevents fas-induced hepatocyte apoptosis and liver injury. |
2015-12-07 |
2023-08-13 |
mouse |
| Weina Chen, Chang Han, Jinqiang Zhang, Kyoungsub Song, Ying Wang, Tong W. Deletion of Mir155 prevents Fas-induced liver injury through up-regulation of Mcl-1. The American journal of pathology. vol 185. issue 4. 2015-12-07. PMID:25794705. |
hepatocytes isolated from mir155 ko mice also showed resistance to fas-induced apoptosis, in vitro. |
2015-12-07 |
2023-08-13 |
mouse |
| Weina Chen, Chang Han, Jinqiang Zhang, Kyoungsub Song, Ying Wang, Tong W. Deletion of Mir155 prevents Fas-induced liver injury through up-regulation of Mcl-1. The American journal of pathology. vol 185. issue 4. 2015-12-07. PMID:25794705. |
finally, restoration of mir155 expression in mir155 ko mice abolished the protection against fas-induced hepatocyte apoptosis. |
2015-12-07 |
2023-08-13 |
mouse |
| Andrew S Mitchell, Ian C Smith, Daniel Gamu, Stefan Donath, A Russell Tupling, Joe Quadrilater. Functional, morphological, and apoptotic alterations in skeletal muscle of ARC deficient mice. Apoptosis : an international journal on programmed cell death. vol 20. issue 3. 2015-11-16. PMID:25596718. |
however, cytosolic fractions of red muscle from arc ko mice had higher apoptosis inducing factor content, suggesting increased mitochondrial-mediated, caspase-independent apoptotic signaling. |
2015-11-16 |
2023-08-13 |
mouse |
| Chao Gao, Yi Liu, Qiujun Yu, Qiang Yang, Bing Li, Lu Sun, Wenjun Yan, Xiaoqing Cai, Erhe Gao, Lize Xiong, Haichang Wang, Ling Ta. TNF-α antagonism ameliorates myocardial ischemia-reperfusion injury in mice by upregulating adiponectin. American journal of physiology. Heart and circulatory physiology. vol 308. issue 12. 2015-09-21. PMID:25888509. |
etanercept still increased cardiac function and reduced infarct size and apoptosis in both apn ko and apn receptors knockdown mice. |
2015-09-21 |
2023-08-13 |
mouse |
| Eri Kawakami, Akinori Tokunaga, Manabu Ozawa, Reiko Sakamoto, Nobuaki Yoshid. The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators. Mechanisms of development. vol 135. 2015-09-11. PMID:25463925. |
previously, two other histone h3k36 demethylases (jmjd5 or fbxl10) were analyzed based on the phenotypes of the corresponding knockout (ko) mice; the results of those studies implicated h3k36 demethylases in cell proliferation, apoptosis, and senescence (fukuda et al., 2011; ishimura et al., 2012). |
2015-09-11 |
2023-08-13 |
mouse |
| Jiao Liu, Osama Abdel-Razek, Zhiyong Liu, Fengqi Hu, Qingshan Zhou, Robert N Cooney, Guirong Wan. Role of surfactant proteins A and D in sepsis-induced acute kidney injury. Shock (Augusta, Ga.). vol 43. issue 1. 2015-08-12. PMID:25255378. |
molecular analysis revealed levels of bcl-2 (an inhibitor of apoptosis) were lower and levels of caspase 3 (a biomarker of apoptosis) were higher in the kidney of septic sp-a/sp-d ko mice (p < 0.01, versus septic wt mice). |
2015-08-12 |
2023-08-13 |
mouse |
| Jaideep Behari, Huanan Li, Shiguang Liu, Maja Stefanovic-Racic, Laura Alonso, Christopher P O'Donnell, Sruti Shiva, Srikanth Singamsetty, Yoshio Watanabe, Vijay P Singh, Qing Li. β-catenin links hepatic metabolic zonation with lipid metabolism and diet-induced obesity in mice. The American journal of pathology. vol 184. issue 12. 2015-08-12. PMID:25300578. |
in contrast, hfd-fed ko mice had increased lobular inflammation and hepatocyte apoptosis. |
2015-08-12 |
2023-08-13 |
mouse |
| Ying Hu, Qi Zhan, Hui-Xin Liu, Thinh Chau, Yuyuan Li, Yu-Jui Wan, Yu-Jui Yvonne Wa. Accelerated partial hepatectomy-induced liver cell proliferation is associated with liver injury in Nur77 knockout mice. The American journal of pathology. vol 184. issue 12. 2015-08-12. PMID:25307349. |
despite accelerated regeneration, nur77 ko livers paradoxically incurred necrosis, hepatocyte apoptosis, elevated serum alanine aminotransferase activity, and kupffer cell accumulation. |
2015-08-12 |
2023-08-13 |
mouse |