| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ho-Keun Kwon, Gi-Cheon Kim, Ji Sun Hwang, Young Kim, Chang-Suk Chae, Jong Hee Nam, Chang-Duk Jun, Dipayan Rudra, Charles D Surh, Sin-Hyeog I. Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program. Scientific reports. vol 6. 2016-12-26. PMID:26777750. |
nfat1 ko t cells displayed a reduced expression of apoptosis associated bcl-2/bh3 family members. |
2016-12-26 |
2023-08-13 |
mouse |
| Ho-Keun Kwon, Gi-Cheon Kim, Ji Sun Hwang, Young Kim, Chang-Suk Chae, Jong Hee Nam, Chang-Duk Jun, Dipayan Rudra, Charles D Surh, Sin-Hyeog I. Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program. Scientific reports. vol 6. 2016-12-26. PMID:26777750. |
recipient rag2(-/-) mice transferred with nfat1 ko t cells showed more severe chs sensitivity due to a defect in activation induced hapten-reactive t cell apoptosis. |
2016-12-26 |
2023-08-13 |
mouse |
| Qi Yuan, Ke-Yu Deng, Le Sun, Shaopeng Chi, Zhiguang Yang, Jun Wang, Hong-Bo Xin, Xiaoqun Wang, Guangju J. Calstabin 2: An important regulator for learning and memory in mice. Scientific reports. vol 6. 2016-12-23. PMID:26888649. |
finally, we demonstrated that the increase in cytoplasmic calcium activated ca(2+) dependent potassium currents and led to neuronal apoptosis in ko hippocampal neurons. |
2016-12-23 |
2023-08-13 |
mouse |
| Shinpei Kadowaki, Tetsuro Shishido, Toshiki Sasaki, Takayuki Sugai, Taro Narumi, Yuki Honda, Yoichiro Otaki, Daisuke Kinoshita, Tetsuya Takahashi, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Takuya Miyamoto, Tetsu Watanabe, Akihiko Ishigami, Yasuchika Takeishi, Isao Kubot. Deficiency of Senescence Marker Protein 30 Exacerbates Cardiac Injury after Ischemia/Reperfusion. International journal of molecular sciences. vol 17. issue 4. 2016-12-16. PMID:27077846. |
after i/r, cardiomyocyte apoptosis and the ratio of infarct area/area at risk were higher, left ventricular fractional shortening was lower, and reactive oxygen species (ros) generation was enhanced in smp30 ko mice. |
2016-12-16 |
2023-08-13 |
mouse |
| Peter S Hegan, Surjit K Chandhoke, Christina Barone, Marie Egan, Martin Bähler, Mark S Mooseke. Mice lacking myosin IXb, an inflammatory bowel disease susceptibility gene, have impaired intestinal barrier function and superficial ulceration in the ileum. Cytoskeleton (Hoboken, N.J.). vol 73. issue 4. 2016-12-15. PMID:26972322. |
myo9b knock out (ko) mice exhibit impaired weight gain and fecal occult blood (indicator of gastrointestinal bleeding), and increased intestinal epithelial cell apoptosis could be detected along the entire intestinal axis. |
2016-12-15 |
2023-08-13 |
mouse |
| Chenyang Zhao, Tianhe Li, Bingxing Han, Wenhui Yue, Linlin Shi, Hongyun Wang, Yuting Guo, Zhongbing L. DDAH1 deficiency promotes intracellular oxidative stress and cell apoptosis via a miR-21-dependent pathway in mouse embryonic fibroblasts. Free radical biology & medicine. vol 92. 2016-12-13. PMID:26806551. |
in the present study, we assessed the potential role of the adma-ddah1-mir-21 pathway in the regulation of the cellular redox state and apoptosis using wild-type (wt) and ddah1-knockout (ko) immortalized mouse embryonic fibroblasts (mefs). |
2016-12-13 |
2023-08-13 |
mouse |
| Lung-Yi Lee, Calvin Harberg, Kristina A Matkowskyj, Shelly Cook, Drew Roenneburg, Sabine Werner, Jeffrey Johnson, David P Fole. Overactivation of the nuclear factor (erythroid-derived 2)-like 2-antioxidant response element pathway in hepatocytes decreases hepatic ischemia/reperfusion injury in mice. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 22. issue 1. 2016-10-28. PMID:26285140. |
as compared to wt animals after ischemia/reperfusion (ir), nrf2 ko mice had increased hepatocellular injury with increased serum alanine aminotransferase and aspartate aminotransferase, suzuki score, apoptosis, an increased inflammatory infiltrate, and enhanced inflammatory cytokine expression. |
2016-10-28 |
2023-08-13 |
mouse |
| Mikhail A Kolpakov, Khadija Rafiq, Xinji Guo, Bahman Hooshdaran, Tao Wang, Liudmila Vlasenko, Yulia V Bashkirova, Xiaoxiao Zhang, Xiongwen Chen, Sahar Iftikhar, Joseph R Libonati, Satya P Kunapuli, Abdelkarim Sabr. Protease-activated receptor 4 deficiency offers cardioprotection after acute ischemia reperfusion injury. Journal of molecular and cellular cardiology. vol 90. 2016-10-11. PMID:26643815. |
par4 ko mice also showed reduced cardiomyocyte apoptosis and putative signaling shifts in survival pathways in response to ir. |
2016-10-11 |
2023-08-13 |
mouse |
| Zhiyong Liu, Qiao Shi, Jiao Liu, Osama Abdel-Razek, Yongan Xu, Robert N Cooney, Guirong Wan. Innate Immune Molecule Surfactant Protein D Attenuates Sepsis-induced Acute Pancreatic Injury through Modulating Apoptosis and NF-κB-mediated Inflammation. Scientific reports. vol 5. 2016-10-06. PMID:26634656. |
apoptosis and neutrophil infiltration were increased in the pancreas of septic ko mice (p < 0.05, vs septic wt mice), with lower bcl-2 and higher caspase-3 levels in septic ko mice (p < 0.05). |
2016-10-06 |
2023-08-13 |
mouse |
| Hailong Li, Yicheng Xie, Nannan Zhang, Yang Yu, Qiao Zhang, Shinghua Din. Disruption of IP₃R2-mediated Ca²⁺ signaling pathway in astrocytes ameliorates neuronal death and brain damage while reducing behavioral deficits after focal ischemic stroke. Cell calcium. vol 58. issue 6. 2016-09-21. PMID:26433454. |
ip3r2 ko mice also exhibited less neuronal apoptosis, reactive astrogliosis, and tissue loss than wt mice. |
2016-09-21 |
2023-08-13 |
mouse |
| Fangyuan Zou, Rurong Mao, Liyan Yang, Shengchao Lin, Kecheng Lei, Yuanhong Zheng, Yue Ding, Peng Zhang, Guoxiang Cai, Xin Liang, Jianwen Li. Targeted deletion of miR-139-5p activates MAPK, NF-κB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer. The FEBS journal. vol 283. issue 8. 2016-08-30. PMID:26859226. |
we show that mir-139-5p knockout (ko) mice are highly susceptible to colitis and colon cancer, accompanied by elevated proliferation and decreased apoptosis, as well as an increased production of inflammatory cytokines, chemokines and tumorigenic factors. |
2016-08-30 |
2023-08-13 |
mouse |
| Zhiqiang Wang, He Huang, Wangwei He, Bin Kong, He Hu, Yang Fan, Jiafen Liao, Lei Wang, Yang Mei, Wanli Liu, Xiaoju Xiong, Jianye Peng, Yali Xiao, Dan Huang, Dajun Quan, Qi Li, Liang Xiong, Peng Zhong, Guangji Wan. Regulator of G-protein signaling 5 protects cardiomyocytes against apoptosis during in vitro cardiac ischemia-reperfusion in mice by inhibiting both JNK1/2 and P38 signaling pathways. Biochemical and biophysical research communications. vol 473. issue 2. 2016-08-29. PMID:27021681. |
our results revealed that compared with either wt or ko mice, tg mice showed inhibition of cardiomyocyte apoptosis as indicated by a greater increase of b cell lymphoma/lewkmia-2 (bcl-2), and an obvious reduction in the positive expression of the terminal deoxynucleotidyl transferase-mediated dutp nick end labeling (tunel), bcl-2 associated x protein (bax), and active caspase-3. |
2016-08-29 |
2023-08-13 |
mouse |
| Nagaraja Nagre, Shaohua Wang, Thomas Kellett, Ragu Kanagasabai, Jing Deng, Miyuki Nishi, Konstantin Shilo, Richard A Oeckler, Jack C Yalowich, Hiroshi Takeshima, John Christman, Rolf D Hubmayr, Xiaoli Zha. TRIM72 modulates caveolar endocytosis in repair of lung cells. American journal of physiology. Lung cellular and molecular physiology. vol 310. issue 5. 2016-08-01. PMID:26637632. |
apoptosis was accompanied by accentuation of gross lung injury manifestations in the trim72(ko) and cav1(ko) mice. |
2016-08-01 |
2023-08-13 |
mouse |
| Na Yin, Xiaoxiang Zheng, Jun Zhou, Hongmei Liu, Kaixun Huan. Knockdown of 15-kDa selenoprotein (Sep15) increases hLE cells' susceptibility to tunicamycin-induced apoptosis. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 20. issue 8. 2016-06-28. PMID:26531105. |
in this work, we investigated the effect of sep15 gene knockdown on apoptosis in human lens epithelial (hle) cells, trying to understand the relevance of sep15 to cataract formation in the sep15 knockout (ko) mice. |
2016-06-28 |
2023-08-13 |
mouse |
| Tatiana Hurtado de Mendoza, Fei Liu, Inder M Verm. Antiapoptotic Role for Lifeguard in T Cell Mediated Immune Response. PloS one. vol 10. issue 11. 2016-06-24. PMID:26565411. |
lfg ko and wt t cells were equally sensitive to the fas antibody jo-2 in ex vivo cultures, and blocking extrinsic pathways of cell death in vivo with fas l or caspase 8 inhibitors did not rescue the increased apoptosis in lfg ko t cells. |
2016-06-24 |
2023-08-13 |
mouse |
| Reynolds K Brobey, Dwight German, Patricia K Sonsalla, Prem Gurnani, Johanne Pastor, C-C Hsieh, John Papaconstantinou, Philip P Foster, Makoto Kuro-o, Kevin P Rosenblat. Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways. PloS one. vol 10. issue 10. 2016-06-03. PMID:26452228. |
here, we tested the hypothesis that the reactive oxygen species (ros)-sensitive apoptosis signal-regulating kinase 1 (ask1)/p38 mapk pathway regulates stress levels in the brain of these mice and showed that: 1) the ratio of free ask1 to thioredoxin (trx)-bound ask1 is relatively lower in the transgenic brain whereas the reverse is true for the klotho knockout mice; 2) the reduced p38 activation level in the transgene corresponds to higher level of ask1-bound trx, while the ko mice showed elevated p38 activation and lower level of-bound trx; and 3) that 14-3-3ζ is hyper phosphorylated (ser-58) in the transgene which correlated with increased monomer forms. |
2016-06-03 |
2023-08-13 |
mouse |
| Deepak Jain, Gesine Weber, Daniel Eberhard, Amir E Mehana, Jan Eglinger, Alena Welters, Barbara Bartosinska, Kay Jeruschke, Jürgen Weiss, Günter Päth, Hiroyoshi Ariga, Jochen Seufert, Eckhard Lammer. DJ-1 Protects Pancreatic Beta Cells from Cytokine- and Streptozotocin-Mediated Cell Death. PloS one. vol 10. issue 9. 2016-05-27. PMID:26422139. |
rates of beta cell apoptosis upon mlds treatment were twofold higher in dj-1 ko mice compared to wild type mice, and in vitro inflammatory cytokines led to twice as much beta cell death in pancreatic islets from dj-1 ko mice versus those of wild type mice. |
2016-05-27 |
2023-08-13 |
mouse |
| Masakazu Hashimoto, Tatsuya Sato, Yuko Muroyama, Lisa Fujimura, Masahiko Hatano, Tetsuichiro Sait. Nepro is localized in the nucleolus and essential for preimplantation development in mice. Development, growth & differentiation. vol 57. issue 7. 2016-05-25. PMID:26178919. |
nepro ko embryos were morphologically indistinguishable from wild type (wt) embryos until the morula stage but failed in blastocyst formation, and many cells of the ko embryos resulted in apoptosis. |
2016-05-25 |
2023-08-13 |
mouse |
| Deling Yin, Xiaohua Yang, Hui Li, Huimin Fan, Xiaoli Zhang, Yimin Feng, Charles Stuart, Dan Hu, Yi Caudle, Nanchang Xie, Zhongmin Liu, Gene LeSag. β-Arrestin 2 Promotes Hepatocyte Apoptosis by Inhibiting Akt Protein. The Journal of biological chemistry. vol 291. issue 2. 2016-05-18. PMID:26582201. |
inhibition of gsk3β following bdl decreases hepatic apoptosis and decreased p-p38 in wt mice but not in arrb2 ko mice. |
2016-05-18 |
2023-08-13 |
mouse |
| Dae-Hwan Nam, Jung-Hwa Han, Tae-Jin Lee, Tetsuro Shishido, Jae Hyang Lim, Geun-Young Kim, Chang-Hoon Wo. CHOP deficiency prevents methylglyoxal-induced myocyte apoptosis and cardiac dysfunction. Journal of molecular and cellular cardiology. vol 85. 2016-05-17. PMID:26027784. |
in contrast, myocyte apoptosis, inflammation, and cardiac dysfunction were significantly diminished in chop ko compared with littermate naïve controls. |
2016-05-17 |
2023-08-13 |
mouse |