| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Prasanth Viswanathan, Justine R Bersonda, Jackson Gill, Alyssandra Navarro, Allison C Farrar, Daniel Dunham, Karl W Boehme, Mark Manzan. The Mitochondrial Ubiquitin Ligase MARCHF5 Cooperates with MCL1 to Inhibit Apoptosis in KSHV-Transformed Primary Effusion Lymphoma Cell Lines. bioRxiv : the preprint server for biology. 2024-10-10. PMID:39386614. |
crispr knockout (ko) of marchf5 in pel cell lines resulted in a significant increase in apoptosis despite the presence of mcl1. |
2024-10-10 |
2024-10-12 |
Not clear |
| Lise Margrethe Sjøgaard-Frich, Morten Sølling Henriksen, Shi Min Lam, Frida Jolande Birkbak, Dominika Czaplinska, Mette Flinck, Stine F Pederse. NHE1 regulation in NAFLD in vitro contributes to hepatocyte injury and HSC crosstalk. The Journal of endocrinology. 2024-08-16. PMID:39150073. |
nhe1 ko in hepatocytes did not alter lipid droplet accumulation but reduced inflammatory signaling (p38 mapk activity), lipotoxicity (4-hne accumulation) and apoptosis (parp cleavage). |
2024-08-16 |
2024-08-18 |
Not clear |
| Xue Li, Chengyun Hu, Shanshan Luo, Feibiao Dai, Chuanyao Li, Wanjun Zhou, Jiawu Wang, Hao Chen, Zhen Wang, Tengfei Long, Lai Jiang, Chaoliang Tan. Cav3.2 deletion attenuates nonalcoholic fatty liver disease in mice. Gene. 2024-08-08. PMID:39116959. |
we provided evidence that cav3.2 ko inhibited hfd-induced hepatic oxidative stress, inflammation and hepatocyte apoptosis. |
2024-08-08 |
2024-08-12 |
mouse |
| Xue Li, Chengyun Hu, Shanshan Luo, Feibiao Dai, Chuanyao Li, Wanjun Zhou, Jiawu Wang, Hao Chen, Zhen Wang, Tengfei Long, Lai Jiang, Chaoliang Tan. Cav3.2 deletion attenuates nonalcoholic fatty liver disease in mice. Gene. 2024-08-08. PMID:39116959. |
in addition, cav3.2 ko also attenuated hepatic lipid accumulation, oxidative stress, inflammation and hepatocyte apoptosis in palmitic acid/oleic acid (paoa)-treated primary hepatocytes. |
2024-08-08 |
2024-08-12 |
mouse |
| Matteo Cassandri, Antonella Porrazzo, Silvia Pomella, Beatrice Noce, Clemens Zwergel, Francesca Antonella Aiello, Francesca Vulcano, Luisa Milazzo, Simona Camero, Deborah Pajalunga, Massimo Spada, Valeria Manzi, Giovanni Luca Gravina, Silvia Codenotti, Michela Piccione, Miriam Tomaciello, Michele Signore, Giovanni Barillari, Cinzia Marchese, Alessandro Fanzani, Biagio De Angelis, Concetta Quintarelli, Christopher R Vakoc, Eleanor Y Chen, Francesca Megiorni, Franco Locatelli, Sergio Valente, Antonello Mai, Rossella Rota, Francesco Marampo. HDAC3 genetic and pharmacologic inhibition radiosensitizes fusion positive rhabdomyosarcoma by promoting DNA double-strand breaks. Cell death discovery. vol 10. issue 1. 2024-08-06. PMID:39107280. |
thus, we dissected the effects of hdac3 depletion using crispr/cas9-dependent hdac3 knock-out (ko) in fp-rms cells, which resulted in endoplasmatic reticulum stress activation, erk inactivation, parp1- and caspase-dependent apoptosis and reduced stemness when combined with irradiation compared to single treatments. |
2024-08-06 |
2024-08-09 |
human |
| Milton H Hamblin, Austin C Boese, Rabi Murad, Jean-Pyo Le. MMP-3 Knockout Induces Global Transcriptional Changes and Reduces Cerebral Infarction in Both Male and Female Models of Ischemic Stroke. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000490. |
functional pathway analysis revealed that inflammation, integrin cell surface signaling, endothelial- and epithelial-mesenchymal transition (endmt/emt), and apoptosis gene signatures were decreased in mmp-3 ko stroke brains. |
2024-07-13 |
2024-07-15 |
mouse |
| Wen-Lei Yang, Wei-Feng Zhang, Yin Wang, Yue Lou, Yu Cai, Jun Zh. Origin recognition complex 6 overexpression promotes growth of glioma cells. Cell death & disease. vol 15. issue 7. 2024-07-06. PMID:38971772. |
in primary and immortalized (a172) glioma cells, depleting orc6 using specific shrna or cas9-sgrna knockout (ko) significantly decreased cell viability and proliferation, disrupted cell cycle progression and mobility, and triggered apoptosis. |
2024-07-06 |
2024-07-11 |
mouse |
| Wen-Lei Yang, Wei-Feng Zhang, Yin Wang, Yue Lou, Yu Cai, Jun Zh. Origin recognition complex 6 overexpression promotes growth of glioma cells. Cell death & disease. vol 15. issue 7. 2024-07-06. PMID:38971772. |
orc6 depletion, inhibited proliferation, decreased expression of cyclin a2/b2/top2a, and increased apoptosis were detected within these orc6 ko intracranial glioma xenografts. |
2024-07-06 |
2024-07-11 |
mouse |
| Zhenghui Tang, Zhongyang Liang, Bin Zhang, Xiaohui Xu, Peng Li, Lejun Li, Lin-Yu Lu, Yidan Li. MRE11 is essential for the long-term viability of undifferentiated spermatogonia. Cell proliferation. 2024-06-19. PMID:38894566. |
in addition, mre11 ko, but not nbs1 ko, undifferentiated spermatogonia are rapidly exhausted due to dsb accumulation, proliferation defects, and elevated apoptosis. |
2024-06-19 |
2024-06-21 |
Not clear |
| Matthieu Lewis, Valérie Prouzet-Mauléon, Florence Lichou, Elodie Richard, Richard Iggo, Béatrice Turcq, François-Xavier Maho. A genome-scale CRISPR knock-out screen in chronic myeloid leukemia identifies novel drug resistance mechanisms along with intrinsic apoptosis and MAPK signaling. Cancer medicine. vol 9. issue 18. 2024-06-04. PMID:38831555. |
specifically, reestablishing apoptosis in bim knock-out (ko) cells with bh3 mimetics, or inhibiting mapk signaling in spred2 ko cells with mek inhibitors restores sensitivity to imatinib. |
2024-06-04 |
2024-06-06 |
Not clear |
| Kazuhiro Nishiyama, Joji Horikoshi, Toko Maehara, Miyuu Tanaka, Takashi Tanida, Koichi Kawada, Susumu Takeshita, Naoshige Ono, Takeshi Izawa, Mitsuru Kuwamura, Yasu-Taka Azum. Deficiency of interleukin-19 exacerbates acute lung injury induced by intratracheal treatment of hydrochloric acid. Journal of pharmacological sciences. vol 155. issue 3. 2024-05-26. PMID:38797538. |
little apoptosis was detected in lung injury in wt mice, whereas apoptosis was observed in exacerbated area of lung injury in il-19 ko mice. |
2024-05-26 |
2024-05-31 |
mouse |
| Yingying Chen, Hui Liu, Chaomeng Wang, Weixin Chen, Liyan Li, Junshu Wu, Guanrou Wang, Guang Sheng Ling, Rong F. The histone demethylase JMJD1C regulates CPS1 expression and promotes the proliferation of paroxysmal nocturnal haemoglobinuria clones through cell metabolic reprogramming. British journal of haematology. 2024-04-23. PMID:38650379. |
knocking down jmjd1c in k562 ko cells upregulated cps1 and h3k36me3 expression, decreased cell proliferation and increased cell apoptosis. |
2024-04-23 |
2024-04-26 |
mouse |
| Jun He, Xuyang Hou, Junyong Wu, Kunpeng Wang, Xiaoyan Qi, Zuxing Wei, Yin Sun, Cong Wang, Hongliang Yao, Kuijie Li. Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of Prdx1. International journal of biological sciences. vol 20. issue 5. 2024-03-14. PMID:38481805. |
we found that ko or inhibition of hspb1 promoted acinar cell death through apoptosis and ferroptosis but not necroptosis or autophagy by increasing reactive oxygen species (ros) and lipid ros levels. |
2024-03-14 |
2024-03-16 |
mouse |
| Lifei Hou, Yi-Cheng Sin, Yue Chen, Koichi Yuk. Integrin CD11c regulates B cell homeostasis. Frontiers in immunology. vol 15. 2024-02-21. PMID:38380335. |
we found that cd11c ko recirculating and mature b cells was significantly fewer compared with wild type, associated with exaggerated proliferation and apoptosis. |
2024-02-21 |
2024-02-23 |
mouse |
| Lingxia Wang, Xixi Zhang, Haiwei Zhang, Kaili Lu, Ming Li, Xiaoming Li, Yangjing Ou, Xiaoming Zhao, Xiaoxia Wu, Xuanhui Wu, Jianling Liu, Mingyan Xing, Han Liu, Yue Zhang, Yongchang Tan, Fang Li, Xiaoxue Deng, Jiangshan Deng, Xiaojie Zhang, Jinbao Li, Yuwu Zhao, Qiurong Ding, Haikun Wang, Xiuzhe Wang, Yan Luo, Ben Zhou, Haibing Zhan. Excessive apoptosis of Rip1-deficient T cells leads to premature aging. EMBO reports. 2023-11-15. PMID:37965894. |
consistent with this, blocking apoptosis by co-deletion of fadd in rip1-deficient t cells significantly rescues lymphopenia, the imbalance between naïve and memory t cells, and aging-like phenotypes, and prolongs life span in t-cell-specific rip1 ko mice. |
2023-11-15 |
2023-11-20 |
mouse |
| Shan Hu, Min Huang, Shuai Mao, Manqi Yang, Hao Ju, Zheyu Liu, Mian Cheng, Gang W. Serinc2 deficiency exacerbates sepsis-induced cardiomyopathy by enhancing necroptosis and apoptosis. Biochemical pharmacology. 2023-11-02. PMID:37918695. |
serinc2 knockout (ko) exacerbated sepsis-induced myocardial inflammation, necroptosis, apoptosis, myocardial damage, and contractility impairment. |
2023-11-02 |
2023-11-08 |
rat |
| Tong Zhu, Yingao Li, Lilin Zhu, Jinyuan Xu, Zijun Feng, Hao Chen, Si Shi, Caiying Liu, Qingjian Ou, Furong Gao, Jieping Zhang, Caixia Jin, Jingying Xu, Jiao Li, Jingfa Zhang, Yanlong Bi, Guo-Tong Xu, Juan Wang, Haibin Tian, Lixia L. GMFB/AKT/TGF-β3 in Müller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model. Glia. 2023-10-31. PMID:37904673. |
compared to the wild type (wt) group, gmfb knockout (ko) significantly improved visual function, attenuated gliosis, reduced the apoptosis of neurons, and decreased the mrna levels of tumor necrosis factor α (tnf-α) and interleukin-1β (il-1β) in diabetic retinas. |
2023-10-31 |
2023-11-08 |
rat |
| Tong Zhu, Yingao Li, Lilin Zhu, Jinyuan Xu, Zijun Feng, Hao Chen, Si Shi, Caiying Liu, Qingjian Ou, Furong Gao, Jieping Zhang, Caixia Jin, Jingying Xu, Jiao Li, Jingfa Zhang, Yanlong Bi, Guo-Tong Xu, Juan Wang, Haibin Tian, Lixia L. GMFB/AKT/TGF-β3 in Müller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model. Glia. 2023-10-31. PMID:37904673. |
the protection of gmfb ko in primary müller cells against high glucose (hg)-induced photoreceptor apoptosis was partially counteracted by tgf-β3 antibody and administration of tgfbr1/2 inhibitors. |
2023-10-31 |
2023-11-08 |
rat |
| Yan Liu, Yi-Hui Shao, Jun-Meng Zhang, Ying Wang, Mei Zhou, Hui-Qin Li, Cong-Cong Zhang, Pei-Jie Yu, Shi-Juan Gao, Xue-Rui Wang, Li-Xin Jia, Chun-Mei Piao, Jie Du, Yu-Lin L. Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression. Signal transduction and targeted therapy. vol 8. issue 1. 2023-10-12. PMID:37828006. |
additionally, card9 ko suppressed cardiomyocyte apoptosis in the border region and attenuated matrix metalloproteinase (mmp) expression. |
2023-10-12 |
2023-10-15 |
mouse |
| Jiangman Gao, Wei Guo, Rong Li, Jie Qiao, Xiaoyu Lon. The impact of fibronectin knockout on invasion and migration of endometrial cell in adenomyosis. Heliyon. vol 9. issue 9. 2023-10-09. PMID:37809570. |
cell proliferation was markedly suppressed in the fn knockout (ko) group compared with the control group, while apoptosis significantly increased. |
2023-10-09 |
2023-10-15 |
Not clear |