| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Changuk Kim, Woori Kwak, Dong-Hoon Won, Jina Kim, Da-Bin Hwang, Nahyun Kim, Minhwa Kang, Young Jeon, Yong Il Park, Jun Won Park, Jun-Won Yu. Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through regulation of the Igfl-MAPK pathway axis. Cell biology and toxicology. 2023-08-21. PMID:37603122. |
in rna-seq analysis comparing wt and dact2 ko mice after cisplatin treatment, genes related to "apoptosis" and "activation of mitogen-activated protein kinase (mapk) activity" were among the downregulated degs in ko mice. |
2023-08-21 |
2023-09-07 |
mouse |
| Changuk Kim, Woori Kwak, Dong-Hoon Won, Jina Kim, Da-Bin Hwang, Nahyun Kim, Minhwa Kang, Young Jeon, Yong Il Park, Jun Won Park, Jun-Won Yu. Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through regulation of the Igfl-MAPK pathway axis. Cell biology and toxicology. 2023-08-21. PMID:37603122. |
these results were corroborated in western blotting of proteins related to apoptosis and proapoptotic mapk pathway; the expression of which was found to be lower in cisplatin-treated ko mice. |
2023-08-21 |
2023-09-07 |
mouse |
| Xueying Zhang, Rui Gao, Changteng Zhang, Yi Teng, Hai Chen, Qi Li, Changliang Liu, Jiahui Wu, Liuxing Wei, Liyun Deng, Lining Wu, Shixin Ye-Lehmann, Xiaobo Mao, Jin Liu, Tao Zhu, Chan Che. Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice. Signal transduction and targeted therapy. vol 8. issue 1. 2023-08-06. PMID:37544956. |
importantly, compared to the wild-type (wt) mice, tlr3 knockout (ko) mice and tlr3-specific neuronal knockdown mice both displayed improved cognitive function, reduced levels of inflammatory cytokines and neuronal apoptosis and attenuated injury to hippocampal neuroplasticity. |
2023-08-06 |
2023-08-14 |
mouse |
| Yeongseok Oh, Maho Kasu, Constence J Bottoms, Jenna C Douglas, Nikola Sekulovski, Kanako Hayashi, James A MacLean I. Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice†. Biology of reproduction. 2023-07-20. PMID:37471646. |
fertility analysis showed a low fecundity in rhox8 ko adult males, with disrupted spermatogenic cycles, increased germ cell apoptosis, and reduced sperm count and motility. |
2023-07-20 |
2023-08-14 |
mouse |
| Qiwen Yu, Sanyang Chen, Jiye Li, Hongwei Tang, Jihua Shi, Wenzhi Guo, Shuijun Zhan. Mitogen activated protein kinase phosphatase 5 alleviates liver ischemia-reperfusion injury by inhibiting TAK1/JNK/p38 pathway. Scientific reports. vol 13. issue 1. 2023-07-10. PMID:37429895. |
mkp5 ko or knockdown significantly increased liver injury, as demonstrated by elevated serum transaminases, hepatocyte necrosis, infiltrating inflammatory cells, secretion of pro-inflammatory cytokines, apoptosis, oxidative stress. |
2023-07-10 |
2023-08-14 |
mouse |
| Qicai Han, Penghui Yan, Ruipeng Song, Feifei Liu, Qing Tia. HOXC13-driven TIMM13 overexpression promotes osteosarcoma cell growth. Cell death & disease. vol 14. issue 7. 2023-07-05. PMID:37407582. |
timm13 ko also induced akt-mtor inactivation, atp depletion, oxidative injury, and apoptosis in the in situ os tumors. |
2023-07-05 |
2023-08-14 |
mouse |
| Brian M Castellano, Danming Tang, Scot Marsters, Cynthia Lam, Peter Liu, Christopher M Rose, Wendy Sandoval, Avi Ashkenazi, Brad Snedecor, Shahram Misagh. Activation of the PERK branch of the unfolded protein response during production reduces specific productivity in CHO cells via downregulation of PDGFRa and IRE1a signaling. Biotechnology progress. 2023-05-10. PMID:37161726. |
perk knockout (ko) cell lines displayed reduced growth and viability due to higher rates of apoptosis despite having stabilized pdgfra levels. |
2023-05-10 |
2023-08-14 |
Not clear |
| Brian M Castellano, Danming Tang, Scot Marsters, Cynthia Lam, Peter Liu, Christopher M Rose, Wendy Sandoval, Avi Ashkenazi, Brad Snedecor, Shahram Misagh. Activation of the PERK branch of the unfolded protein response during production reduces specific productivity in CHO cells via downregulation of PDGFRa and IRE1a signaling. Biotechnology progress. 2023-05-10. PMID:37161726. |
knocking out perk in an apoptosis impaired (bax/bak double ko) antibody-expressing cell line prevented apoptotic cell death and revealed that apoptosis was likely triggered by increased er stress and reactive oxygen species levels in the perk ko hosts. |
2023-05-10 |
2023-08-14 |
Not clear |
| Di Ye, Yongqi Feng, Heng Pan, Xiyi Lu, Zhen Wang, Menglong Wang, Jianfang Liu, Yao Xu, Jishou Zhang, Mengmeng Zhao, Shuwan Xu, Jing Ye, Jun Wa. Kielin/chordin-like protein deficiency causes cardiac aging in male mice. Journal of molecular medicine (Berlin, Germany). 2023-05-06. PMID:37149518. |
kcp ko aggravated the imbalance of oxidants and antioxidants and increased the expression of proinflammatory cytokines and cardiomyocyte apoptosis in aged mice. |
2023-05-06 |
2023-08-14 |
mouse |
| Di Ye, Yongqi Feng, Heng Pan, Xiyi Lu, Zhen Wang, Menglong Wang, Jianfang Liu, Yao Xu, Jishou Zhang, Mengmeng Zhao, Shuwan Xu, Jing Ye, Jun Wa. Kielin/chordin-like protein deficiency causes cardiac aging in male mice. Journal of molecular medicine (Berlin, Germany). 2023-05-06. PMID:37149518. |
our study demonstrated that kcp ko aggravated cardiac aging in mice by increasing the levels of oxidative stress, inflammation, and cardiomyocyte apoptosis. |
2023-05-06 |
2023-08-14 |
mouse |
| Di Ye, Yongqi Feng, Heng Pan, Xiyi Lu, Zhen Wang, Menglong Wang, Jianfang Liu, Yao Xu, Jishou Zhang, Mengmeng Zhao, Shuwan Xu, Jing Ye, Jun Wa. Kielin/chordin-like protein deficiency causes cardiac aging in male mice. Journal of molecular medicine (Berlin, Germany). 2023-05-06. PMID:37149518. |
kcp ko aggravated cardiac aging by increasing the levels of oxidative stress, inflammation, and cardiomyocyte apoptosis. |
2023-05-06 |
2023-08-14 |
mouse |
| Yingchen Xia, Chunyan He, Zhi Hu, Zhichao Wu, Yin Hui, Yuan-Yuan Liu, Chuanyong Mu, Jianhua Zh. The mitochondrial protein YME1 Like 1 is important for non-small cell lung cancer cell growth. International journal of biological sciences. vol 19. issue 6. 2023-04-17. PMID:37063426. |
in nsclc cells, shrna-mediated silence of yme1l or dcas9/sgrna-induced knockout (ko) of yme1l robustly suppressed cell growth and migration, and provoking apoptosis. |
2023-04-17 |
2023-08-14 |
human |
| Shixuan Wang, Aimin Liu, Yunchao Su, Zheng Don. Deficiency of the Planar Cell Polarity Protein Intu Delays Kidney Repair and Suppresses Renal Fibrosis after Acute Kidney Injury. The American journal of pathology. vol 193. issue 3. 2023-03-07. PMID:36586478. |
mechanistically, intu ko kidneys had less senescence but higher levels of cell proliferation and apoptosis during kidney repair after renal iri. |
2023-03-07 |
2024-02-12 |
mouse |
| Shu-Ping Li, Li Ou, Yan Zhang, Fang-Rong Shen, You-Guo Che. A first-in-class POLRMT specific inhibitor IMT1 suppresses endometrial carcinoma cell growth. Cell death & disease. vol 14. issue 2. 2023-02-23. PMID:36823110. |
similarly, polrmt depletion, through shrna-induced silencing or crispr/cas9-caused knockout (ko), inhibited primary endometrial carcinoma cell proliferation and motility, and induced mitochondrial dysfunction and apoptosis. |
2023-02-23 |
2023-08-14 |
mouse |
| Jiaying Li, Xiaoxiao Shi, Zhixin Chen, Jiatong Xu, Ruohuan Zhao, Yuhao Liu, Yubing Wen, Limeng Che. Aldehyde dehydrogenase 2 alleviates mitochondrial dysfunction by promoting PGC-1α-mediated biogenesis in acute kidney injury. Cell death & disease. vol 14. issue 1. 2023-01-20. PMID:36670098. |
aldh2 knockout (ko) mice exhibited exacerbated kidney impairment and apoptosis of tubular epithelial cells after cisplatin injection. |
2023-01-20 |
2023-08-14 |
mouse |
| Jianxin Mao, Di Wang, Dong Wang, Qi Wu, Qiliang Shang, Chu Gao, Huanbo Wang, Han Wang, Mu Du, Pandi Peng, Haoruo Jia, Xiaolong Xu, Jie Wang, Liu Yang, Zhuojing Lu. SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis. Experimental & molecular medicine. 2023-01-18. PMID:36653443. |
overexpression of sirt5 effectively alleviated, whereas knockdown of sirt5 aggravated, the apoptosis and dysfunction of np cells under mechanical stress, consistent with the more severe idd phenotype of sirt5 ko mice than wild-type mice that underwent lumbar spine instability (lsi) surgery. |
2023-01-18 |
2023-08-14 |
mouse |
| Yu Liu, Rui Liu, Lei Huang, Gang Zuo, Jiaxing Dai, Ling Gao, Hui Shi, Yuanjian Fang, Qin Lu, Takeshi Okada, Zhifei Wang, Xiao Hu, Cameron Lenahan, Jiping Tang, Jie Xiao, John H Zhan. Inhibition of Prostaglandin E2 Receptor EP3 Attenuates Oxidative Stress and Neuronal Apoptosis Partially by Modulating p38MAPK/FOXO3/Mul1/Mfn2 Pathway after Subarachnoid Hemorrhage in Rats. Oxidative medicine and cellular longevity. vol 2022. 2022-12-19. PMID:36531208. |
the inhibition of ep3 with l798106 or ep3 ko crispr ameliorated the neurological impairments, brain tissue oxidative stress, and neuronal apoptosis after sah. |
2022-12-19 |
2023-08-14 |
rat |
| Jingjing Lu, Qin Liu, Lixia Zhu, Yuanyuan Liu, Xiaoren Zhu, Shiqing Peng, Minbin Chen, Ping L. Endothelial cell-specific molecule 1 drives cervical cancer progression. Cell death & disease. vol 13. issue 12. 2022-12-15. PMID:36522312. |
in established and primary cervical cancer cells, esm1 shrna or crispr/cas9-induced esm1 ko hindered cell proliferation, cell cycle progression, in vitro cell migration and invasion, and induced significant apoptosis. |
2022-12-15 |
2023-08-14 |
mouse |
| Jian Pan, Yuxin Xie, Huiling Li, Xiaozhou Li, Junxiang Chen, Xiangfeng Liu, Jun Zhou, Xianming Tang, Zhibiao He, Zhenyu Peng, Hongliang Zhang, Yijian Li, Xudong Xiang, Yunchang Yuan, Dongshan Zhan. mmu-lncRNA 121686/hsa-lncRNA 520657 induced by METTL3 drive the progression of AKI by targeting miR-328-5p/HtrA3 signaling axis. Molecular therapy : the journal of the American Society of Gene Therapy. vol 30. issue 12. 2022-12-15. PMID:35869629. |
we reported that pt（proximal tubule）-mettl3-knockout (ko) noticeably suppressed ischemic-induced aki via inhibition of renal cell apoptosis. |
2022-12-15 |
2023-12-17 |
mouse |
| Jing Jin, Xiaofeng Li, Mei Ye, Feng Qiao, Hao Chen, Kin Lam Fo. Defb19 regulates the migration of germ cell and is involved in male fertility. Cell & bioscience. vol 12. issue 1. 2022-11-22. PMID:36414976. |
a marked increase in apoptosis and a significant decrease in the sperm count were observed in the ko mice. |
2022-11-22 |
2023-08-14 |
mouse |