| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Matthys, H Dooms, P Rottiers, T Mitera, L Overgergh, G Leclercq, A Billiau, J Groote. Induction of IL-15 by TCR/CD3 aggregation depends on IFN-gamma and protects against apoptosis of immature thymocytes in vivo. Clinical and experimental immunology. vol 130. issue 3. 2003-03-03. PMID:12452826. |
the loss of il-15 mrna induction in ifn-gammar ko mice was associated with increased thymocyte apoptosis. |
2003-03-03 |
2023-08-12 |
mouse |
| P Matthys, H Dooms, P Rottiers, T Mitera, L Overgergh, G Leclercq, A Billiau, J Groote. Induction of IL-15 by TCR/CD3 aggregation depends on IFN-gamma and protects against apoptosis of immature thymocytes in vivo. Clinical and experimental immunology. vol 130. issue 3. 2003-03-03. PMID:12452826. |
pretreatment of wild-type mice with neutralizing anti-il-15 ab increased the anti-cd3-triggered thymocyte apoptosis, thus mimicking the sensitive phenotype of ifn-gammar ko mice. |
2003-03-03 |
2023-08-12 |
mouse |
| P Matthys, H Dooms, P Rottiers, T Mitera, L Overgergh, G Leclercq, A Billiau, J Groote. Induction of IL-15 by TCR/CD3 aggregation depends on IFN-gamma and protects against apoptosis of immature thymocytes in vivo. Clinical and experimental immunology. vol 130. issue 3. 2003-03-03. PMID:12452826. |
inversely, anti-cd3-induced apoptosis in ifn-gammar ko mice was suppressed by administration of recombinant il-15. |
2003-03-03 |
2023-08-12 |
mouse |
| P Matthys, H Dooms, P Rottiers, T Mitera, L Overgergh, G Leclercq, A Billiau, J Groote. Induction of IL-15 by TCR/CD3 aggregation depends on IFN-gamma and protects against apoptosis of immature thymocytes in vivo. Clinical and experimental immunology. vol 130. issue 3. 2003-03-03. PMID:12452826. |
in ifn-gammar ko mice and in wild-type mice that were treated with anti-il-15, augmented apoptosis affected mainly cd4+cd8+ immature thymocytes. |
2003-03-03 |
2023-08-12 |
mouse |
| Andrea S Cupp, Lino Tessarollo, Michael K Skinne. Testis developmental phenotypes in neurotropin receptor trkA and trkC null mutations: role in formation of seminiferous cords and germ cell survival. Biology of reproduction. vol 66. issue 6. 2003-01-14. PMID:12021070. |
apoptosis was evaluated in testes of wild-type, trkc gene ko, and trka gene ko mice to determine if the alteration in germ cell numbers at each developmental age was influenced by different patterns of germ cell survival or apoptosis. |
2003-01-14 |
2023-08-12 |
mouse |
| Andrea S Cupp, Lino Tessarollo, Michael K Skinne. Testis developmental phenotypes in neurotropin receptor trkA and trkC null mutations: role in formation of seminiferous cords and germ cell survival. Biology of reproduction. vol 66. issue 6. 2003-01-14. PMID:12021070. |
interestingly, trka gene ko mice that survived to postnatal day 19 had a 10-fold increase in germ cell apoptosis when compared to germ cells in wild-type mice. |
2003-01-14 |
2023-08-12 |
mouse |
| Yu-Hua Tseng, Kohjiro Ueki, Kristina M Kriauciunas, C Ronald Kah. Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin. The Journal of biological chemistry. vol 277. issue 35. 2002-10-17. PMID:12082100. |
in response to 16 h of serum deprivation, irs-1-deficient cells showed a significant decrease in response to igf-1 protection from apoptosis, whereas no changes were observed in the irs-2, irs-3, or irs-4 ko cells. |
2002-10-17 |
2023-08-12 |
Not clear |
| Xiao-Dong Chen, Songtao Shi, Tianshun Xu, Pamela Gehron Robey, Marian F Youn. Age-related osteoporosis in biglycan-deficient mice is related to defects in bone marrow stromal cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 17. issue 2. 2002-08-02. PMID:11811564. |
the combination of decreased proliferation and increased apoptosis, if it occurred in vivo, would lead to a deficiency in the generation of mature osteoblasts and would be sufficient to account for the osteopenia developed in the bgn ko mice. |
2002-08-02 |
2023-08-12 |
mouse |
| Yunfent Zhao, Terry D Oberley, Luksana Chaiswing, Shu-mei Lin, Charles J Epstein, Ting-Ting Huang, Daret St Clai. Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model. Oncogene. vol 21. issue 24. 2002-06-19. PMID:12032821. |
moreover, p53 levels further increased in the mitochondria of dmba/tpa treated mice, and this increase was much greater in the mnsod ko than in the wild type mice, suggesting a link between mnsod deficiency and mitochondrial-mediated apoptosis. |
2002-06-19 |
2023-08-12 |
mouse |
| Yunfent Zhao, Terry D Oberley, Luksana Chaiswing, Shu-mei Lin, Charles J Epstein, Ting-Ting Huang, Daret St Clai. Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model. Oncogene. vol 21. issue 24. 2002-06-19. PMID:12032821. |
taken together, these results suggest that: (1) mnsod deficiency enhanced tpa-induced oxidative stress and ap-1 and p53 levels, consistent with the increase in both proliferation and apoptosis events in the mnsod ko mice, and (2) increased apoptosis may negate increased proliferation in the mnsod deficient mice during an early stage of tumor development. |
2002-06-19 |
2023-08-12 |
mouse |
| F Sam, D B Sawyer, Z Xie, D L Chang, S Ngoy, D A Brenner, D A Siwik, K Singh, C S Apstein, W S Colucc. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Circulation research. vol 89. issue 4. 2001-08-30. PMID:11509452. |
improved contractile function and reduced apoptosis were associated with reduced mortality rate in ko mice at 4 months after mi. |
2001-08-30 |
2023-08-12 |
mouse |
| M Landay, S K Oster, F Khosravi, L E Grove, X Yin, J Sedivy, L Z Penn, E V Prochowni. Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family. Cell death and differentiation. vol 7. issue 8. 2000-10-20. PMID:10918443. |
c-myc nullizygous fibroblasts (ko cells) were used to compare the abilities of c-myc, n-myc and l-myc oncoproteins to accelerate growth, promote apoptosis, revert morphology, and regulate the expression of previously described c-myc target genes. |
2000-10-20 |
2023-08-12 |
Not clear |
| M Landay, S K Oster, F Khosravi, L E Grove, X Yin, J Sedivy, L Z Penn, E V Prochowni. Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family. Cell death and differentiation. vol 7. issue 8. 2000-10-20. PMID:10918443. |
they also accelerated apoptosis following serum deprivation, reverted the abnormal ko cell morphology, and modulated the expression of previously described c-myc target genes. |
2000-10-20 |
2023-08-12 |
Not clear |
| D K Dalton, L Haynes, C Q Chu, S L Swain, S Wittme. Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells. The Journal of experimental medicine. vol 192. issue 1. 2000-08-15. PMID:10880532. |
in bcg-infected interferon (ifn)-gamma knockout (ko) mice, the activated cd4 t cell population did not undergo apoptosis. |
2000-08-15 |
2023-08-12 |
mouse |
| D K Dalton, L Haynes, C Q Chu, S L Swain, S Wittme. Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells. The Journal of experimental medicine. vol 192. issue 1. 2000-08-15. PMID:10880532. |
addition of ifn-gamma to cultured splenocytes from bcg-infected ifn-gamma ko mice induced apoptosis of activated cd4 t cells. |
2000-08-15 |
2023-08-12 |
mouse |
| C Q Chu, S Wittmer, D K Dalto. Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. The Journal of experimental medicine. vol 192. issue 1. 2000-08-15. PMID:10880533. |
cd4(+)cd44(hi) t cells in the spleen and central nervous system of ifn-gamma ko mice during eae showed markedly increased in vivo proliferation and significantly decreased ex vivo apoptosis compared with those of wild-type mice. |
2000-08-15 |
2023-08-12 |
mouse |
| X C Li, Y Li, I Dodge, A D Wells, X X Zheng, L A Turka, T B Stro. Induction of allograft tolerance in the absence of Fas-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 163. issue 5. 1999-09-14. PMID:10452986. |
as il-2 ko mice have a profound defect in fas-mediated apoptosis, we hypothesized that fas-mediated apoptosis of alloreactive t cells may be critical in the acquisition of allograft tolerance. |
1999-09-14 |
2023-08-12 |
mouse |
| Y Nomur. A transient brain ischemia- and bacterial endotoxin-induced glial iNOS expression and NO-induced neuronal apoptosis. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022234. |
koningic acid (ko), a chemical modifier and enzyme inhibitor of glyceraldehyde-3 phosphate dehydrogenase (gapdh), induced the apoptosis too. |
1999-02-25 |
2023-08-12 |
rat |
| G P Schielke, G Y Yang, B D Shivers, A L Bet. Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 18. issue 2. 1998-02-26. PMID:9469161. |
because il-1 beta converting enzyme (ice) is required for the conversion of proil-1 beta to its biologically active form, and has homology with proteins that regulate apoptosis in invertebrates, we studied the effect of cerebral ischemia on brain injury in mutant mice deficient in the ice gene (ice knockout [ko] mice). |
1998-02-26 |
2023-08-12 |
mouse |