| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Angus J Cameron, Katarzyna J Procyk, Michael Leitges, Peter J Parke. PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival. International journal of cancer. vol 123. issue 4. 2008-07-15. PMID:18508315. |
derivation of pkcalpha wt and ko mouse embryo fibroblast cell lines confirms a role for pkcalpha in protecting cells from apoptosis induced by serum deprivation. |
2008-07-15 |
2023-08-12 |
mouse |
| LiJuan Yao, Alexander I Agoulnik, Paul S Cooke, Daryl D Meling, O David Sherwoo. Relaxin acts on stromal cells to promote epithelial and stromal proliferation and inhibit apoptosis in the mouse cervix and vagina. Endocrinology. vol 149. issue 5. 2008-06-10. PMID:18218691. |
relaxin markedly increased proliferation and decreased apoptosis of epithelial and stromal cells in tissue recombinants containing wt stroma (p < 0.01) but had no effect on tissue recombinants prepared with ko stroma, regardless of whether epithelium was derived from wt or ko mice. |
2008-06-10 |
2023-08-12 |
mouse |
| Ho-Joon Lee, Hideo Sakamoto, Hongwei Luo, Malgorzata E Skaznik-Wikiel, Anne M Friel, Teruko Niikura, Jacqueline C Tilly, Yuichi Niikura, Rachael Klein, Aaron K Styer, Lawrence R Zukerberg, Jonathan L Tilly, Bo R Rued. Loss of CABLES1, a cyclin-dependent kinase-interacting protein that inhibits cell cycle progression, results in germline expansion at the expense of oocyte quality in adult female mice. Cell cycle (Georgetown, Tex.). vol 6. issue 21. 2007-12-31. PMID:17912041. |
these data support recent reports that adult female mice can generate new oocytes and follicles but the enhancement of postnatal oogenesis by cables1 ko appears offset by a reduction in oocyte quality, as reflected by increased elimination of these additional germ cells via apoptosis. |
2007-12-31 |
2023-08-12 |
mouse |
| Meijing Wang, Wenjun Zhang, Paul Crisostomo, Troy Markel, Kirstan K Meldrum, Xin Y Fu, Daniel R Meldru. Endothelial STAT3 plays a critical role in generalized myocardial proinflammatory and proapoptotic signaling. American journal of physiology. Heart and circulatory physiology. vol 293. issue 4. 2007-11-21. PMID:17675575. |
in addition, although no significant apoptosis was observed in wild-type and ko hearts, our results showed more expression of myocardial caspase-8 and more apoptosis in the myocardium around the capillary in stat3ko mice subjected to i/r. |
2007-11-21 |
2023-08-12 |
mouse |
| Takehiko Shibata, Kisaburo Nagata, Yoshiro Kobayash. Cutting edge: a critical role of nitric [corrected] oxide in preventing inflammation upon apoptotic cell clearance. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 6. 2007-11-05. PMID:17785773. |
in this study, we showed that, upon induction of apoptosis in the thymus by x-ray, inducible no synthase knockout (ko) mice exhibited higher levels of neutrophil infiltration and production of mip-2 and keratinocyte-derived chemokine (kc) in the thymus than wild-type (wt) mice. |
2007-11-05 |
2023-08-12 |
mouse |
| Kuk-Wha Lee, Laura J Cobb, Vladislava Paharkova-Vatchkova, Bingrong Liu, Jeffrey Milbrandt, Pinchas Cohe. Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3. Carcinogenesis. vol 28. issue 8. 2007-10-19. PMID:17434920. |
nur77 is a major component of igfbp-3-induced apoptosis as shown by utilizing mouse embryonic fibroblasts (mefs) derived from nur77 wild-type and knockout (ko) mice. |
2007-10-19 |
2023-08-12 |
mouse |
| Lin Yan, Dorothy E Vatner, J Patrick O'Connor, Andreas Ivessa, Hui Ge, Wei Chen, Shinichi Hirotani, Yoshihiro Ishikawa, Junichi Sadoshima, Stephen F Vatne. Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell. vol 130. issue 2. 2007-09-13. PMID:17662940. |
old ac5 ko mice are also protected from aging-induced cardiomyopathy, e.g., hypertrophy, apoptosis, fibrosis, and reduced cardiac function. |
2007-09-13 |
2023-08-12 |
mouse |
| Stefano Menini, Lorena Amadio, Giovanna Oddi, Carlo Ricci, Carlo Pesce, Francesco Pugliese, Marco Giorgio, Enrica Migliaccio, PierGiuseppe Pelicci, Carla Iacobini, Giuseppe Puglies. Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress. Diabetes. vol 55. issue 6. 2007-07-23. PMID:16731826. |
glomerular content of fibronectin and collagen iv was also lower in diabetic ko versus wild-type mice, whereas apoptosis was detected only in diabetic wild-type mice. |
2007-07-23 |
2023-08-12 |
mouse |
| Dru S Dace, Peter W Chen, Jerry Y Niederkor. CD8+ T cells circumvent immune privilege in the eye and mediate intraocular tumor rejection by a TNF-alpha-dependent mechanism. Journal of immunology (Baltimore, Md. : 1950). vol 178. issue 10. 2007-06-13. PMID:17475837. |
we discovered that cd8+ t cells used tnf-alpha to mediate tumor rejection, because ad5e1 tumor cells were highly sensitive to tnf-alpha-induced apoptosis and cd8+ t cells from tnf-alpha ko mice did not protect scid mice from progressive ad5e1 tumor growth. |
2007-06-13 |
2023-08-12 |
mouse |
| Yukihiro Tambe, Atsuko Yoshioka-Yamashita, Ken-ichi Mukaisho, Seiki Haraguchi, Tokuhiro Chano, Takahiro Isono, Takao Kawai, Yasuhiko Suzuki, Ryoji Kushima, Takanori Hattori, Motohito Goto, Shuichi Yamada, Makoto Kiso, Yumiko Saga, Hirokazu Inou. Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs. Carcinogenesis. vol 28. issue 4. 2007-05-10. PMID:17088259. |
in this study, we investigated the tumor suppressor function of drs and the correlation between drs-mediated apoptosis and tumor suppression by generating a gene-knockout (ko) mouse. |
2007-05-10 |
2023-08-12 |
mouse |
| Yukihiro Tambe, Atsuko Yoshioka-Yamashita, Ken-ichi Mukaisho, Seiki Haraguchi, Tokuhiro Chano, Takahiro Isono, Takao Kawai, Yasuhiko Suzuki, Ryoji Kushima, Takanori Hattori, Motohito Goto, Shuichi Yamada, Makoto Kiso, Yumiko Saga, Hirokazu Inou. Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs. Carcinogenesis. vol 28. issue 4. 2007-05-10. PMID:17088259. |
reintroduction of drs into a tumor cell line derived from the tumor of a drs ko mouse led to the suppression of tumor formation in nude mice, which was accompanied by enhanced apoptosis and the activation of caspase-9 and -3. |
2007-05-10 |
2023-08-12 |
mouse |
| Maria Maddalena Lino, Suzana Atanasoski, Mirna Kvajo, Bérengère Fayard, Eliza Moreno, Hans Rudolf Brenner, Ueli Suter, Denis Monar. Mice lacking protease nexin-1 show delayed structural and functional recovery after sciatic nerve crush. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 14. 2007-05-02. PMID:17409231. |
compared with the wild type, a significant delay in synapse reinnervation was detected in pn-1 knock-out (ko) animals, which was associated with both reduced proliferation and increased apoptosis of schwann cells. |
2007-05-02 |
2023-08-12 |
mouse |
| H A Arafat, E Lada, A K Katakam, N Ami. Osteopontin deficiency impacts the pancreatic TH1/TH2 cytokine profile following multiple low dose streptozotocin-induced diabetes. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 114. issue 10. 2007-04-03. PMID:17177137. |
mild lymphocytic infiltrate and apoptosis were detected in the wt diabetic islets, while no signs of inflammation were detected in the ko group. |
2007-04-03 |
2023-08-12 |
mouse |
| Yasutsugu Ishiba, Tomomi Higashide, Naoki Mori, Akira Kobayashi, Shinya Kubota, Margaret J McLaren, Hiromasa Satoh, Fulton Wong, George Inan. Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function. Experimental eye research. vol 84. issue 3. 2007-03-28. PMID:17174953. |
the ko model developed a slowly progressive retinal degeneration, characterized by mottling in the fundus, mild thinning of the photoreceptor layer, and increase in apoptosis as early as 6 months, dramatic acceleration at approximately 17 months, and virtual obliteration of the photoreceptors by 20 months. |
2007-03-28 |
2023-08-12 |
mouse |
| Yiwen Li, Genzou Takemura, Hideshi Okada, Shusaku Miyata, Hiromitsu Kanamori, Rumi Maruyama, Masayasu Esaki, Longhu Li, Atsushi Ogino, Takamasa Ohno, Takehito Kondo, Munehiro Nakagawa, Shinya Minatoguchi, Takako Fujiwara, Hisayoshi Fujiwar. ANG II type 1A receptor signaling causes unfavorable scar dynamics in the postinfarct heart. American journal of physiology. Heart and circulatory physiology. vol 292. issue 2. 2007-03-20. PMID:17028164. |
one week post-mi, the incidence of apoptosis among granulation tissue cells was fewer (3.3 +/- 0.4 vs. 4.4 +/- 0.5% in wt, p < 0.05), whereas vessel proliferation was higher in at(1a)ko hearts, which likely explains the later abundance of cells within the scar tissue. |
2007-03-20 |
2023-08-12 |
mouse |
| Kenji Nakazato, Hisakata Yamada, Toshiki Yajima, Yoshiko Kagimoto, Hiroyuki Kuwano, Yasunobu Yoshika. Enforced expression of Bcl-2 partially restores cell numbers but not functions of TCRgammadelta intestinal intraepithelial T lymphocytes in IL-15-deficient mice. Journal of immunology (Baltimore, Md. : 1950). vol 178. issue 2. 2007-02-22. PMID:17202336. |
in situ apoptosis of tcrgammadelta i-iel was decreased in bcl-2 transgenic (tg) x il-15 ko mice compared with il-15 ko mice. |
2007-02-22 |
2023-08-12 |
mouse |
| Hjalmar Kurzen, Sarah Brenne. Significance of autoimmunity to non-desmoglein targets in pemphigus. Autoimmunity. vol 39. issue 7. 2007-02-20. PMID:17101498. |
on the other hand, fundamental doubt has been raised towards this monopathogenic view by several independent factors: (1) pemphigus lesions can be induced in dsg3-knockout (ko) mice; (2) pemphigus sera contain multiple autoantibodies against different adhesion molecules and also cholinergic receptors; (3) experimental inhibition of pv igg induced acantholysis can be obtained by interference with different signaling cascades regulating both calcium homeostasis and apoptosis; and (4) cholinergic agonists exhibit anti-acantholytic activity both in vitro and in vivo. |
2007-02-20 |
2023-08-12 |
mouse |
| Vishwanie S Budhram-Mahadeo, Samantha Bowen, Sonia Lee, Christina Perez-Sanchez, Elizabeth Ensor, Peter J Morris, David S Latchma. Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. Nucleic acids research. vol 34. issue 22. 2007-01-25. PMID:17145718. |
furthermore, neurons from brn-3b knock-out (ko) mice were resistant to apoptosis and this correlated with reduced bax expression upon induction of p53 in neurons lacking brn-3b compared with controls. |
2007-01-25 |
2023-08-12 |
mouse |
| Sanjay Pradhan, Joseph Genebriera, Warren L Denning, Kumar Felix, Craig A Elmets, Laura Timare. CD4 T cell-induced, bid-dependent apoptosis of cutaneous dendritic cells regulates T cell expansion and immune responses. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 9. 2006-12-13. PMID:17056520. |
significant resistance to apoptosis by ot-2 cd4 cells was also observed for bid knockout (ko) lcs in vitro. |
2006-12-13 |
2023-08-12 |
mouse |
| Boyi Gan, Xu Peng, Tamas Nagy, Ana Alcaraz, Hua Gu, Jun-Lin Gua. Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. The Journal of cell biology. vol 175. issue 1. 2006-11-28. PMID:17015619. |
furthermore, fip200 ko embryos exhibited significant apoptosis in heart and liver. |
2006-11-28 |
2023-08-12 |
mouse |