| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Winnie W S Kum, Bernard C Lo, Hong B Yu, B Brett Finla. Protective role of Akt2 in Salmonella enterica serovar typhimurium-induced gastroenterocolitis. Infection and immunity. vol 79. issue 7. 2011-09-02. PMID:21555401. |
additionally, enhanced levels of annexin v(+) and terminal transferase dutp nick end labeling-positive (tunel(+)) apoptotic cells in the intestines of infected akt2 ko mice were also observed, indicating that akt2 plays an essential role in protection against apoptosis. |
2011-09-02 |
2023-08-12 |
mouse |
| Brian J Leibowitz, Wei Qiu, Hongtao Liu, Tao Cheng, Lin Zhang, Jian Y. Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21. Molecular cancer research : MCR. vol 9. issue 5. 2011-08-30. PMID:21450905. |
to better understand these two arms of p53 response in radiation-induced gi damage, we compared animal survival, as well as apoptosis, proliferation, cell-cycle progression, dna damage, and regeneration in the crypts of wt, p53 knockout (ko), puma ko, p21 ko, and p21/puma double ko (dko) mice in a whole body irradiation model. |
2011-08-30 |
2023-08-12 |
mouse |
| Brian J Leibowitz, Wei Qiu, Hongtao Liu, Tao Cheng, Lin Zhang, Jian Y. Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21. Molecular cancer research : MCR. vol 9. issue 5. 2011-08-30. PMID:21450905. |
puma deficiency alone enhanced survival and crypt regeneration by blocking apoptosis but failed to rescue delayed nonapoptotic crypt death or shortened survival in p21 ko mice. |
2011-08-30 |
2023-08-12 |
mouse |
| Xiu Hua Liu, Zhen Ying Zhang, Kristin Brevik Andersson, Cathrine Husberg, Ulla H Enger, Morten G Ræder, Geir Christensen, William E Louc. Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosis. Cell calcium. vol 49. issue 4. 2011-08-23. PMID:20965565. |
indeed, tunel staining revealed an increased fraction of cardiomyocytes undergoing apoptosis in serca2 ko. |
2011-08-23 |
2023-08-12 |
mouse |
| b' Urszula Ra\\xc5\\xbany, \\xc5\\x81ukasz W\\xc4\\x85tor, Anna Polus, Beata Kie\\xc4\\x87-Wilk, Yu-Jui Yvonne Wan, Grzegorz Dyduch, Romana Tomaszewska, Aldona Dembi\\xc5\\x84ska-Kie\\xc4\\x8. Modulatory effect of high saturated fat diet-induced metabolic disturbances on angiogenic response in hepatocyte RXR\\xce\\xb1 knockout mice. Pharmacological reports : PR. vol 62. issue 6. 2011-08-10. PMID:21273665.' |
summing up, hf diet feeding of hrxrα ko mice resulted in dyslipidemia and hyperleptinemia as well as impaired angiogenic response, and cell apoptosis. |
2011-08-10 |
2023-08-12 |
mouse |
| JoEllen Welsh, Lindsay N Zinser, Laurel Mianecki-Morton, Jamie Martin, Susan E Waltz, Howard James, Glendon M Zinse. Age-related changes in the epithelial and stromal compartments of the mammary gland in normocalcemic mice lacking the vitamin D3 receptor. PloS one. vol 6. issue 1. 2011-08-02. PMID:21298063. |
activation of caspase-3 and increased bax expression in mammary tissue of vdr ko mice suggests that enhanced apoptosis may contribute to loss of ductal branching. |
2011-08-02 |
2023-08-12 |
mouse |
| Sangita Choudhury, Soochan Bae, Qingen Ke, Ji Yoo Lee, Jacob Kim, Peter M Kan. Mitochondria to nucleus translocation of AIF in mice lacking Hsp70 during ischemia/reperfusion. Basic research in cardiology. vol 106. issue 3. 2011-07-13. PMID:21387140. |
although hsp70 ko and wt mice demonstrated similar amounts of aif released from mitochondria after i/r surgery, hsp70 ko mice showed a significantly greater increase in apoptosis, larger infarct size, and decreased cardiac output. |
2011-07-13 |
2023-08-12 |
mouse |
| Sangita Choudhury, Soochan Bae, Qingen Ke, Ji Yoo Lee, Jacob Kim, Peter M Kan. Mitochondria to nucleus translocation of AIF in mice lacking Hsp70 during ischemia/reperfusion. Basic research in cardiology. vol 106. issue 3. 2011-07-13. PMID:21387140. |
treatment with 4-an (4-amino-1,8-napthalimide, 3 mg/kg), a potent inhibitor of parp-1, which is a critical regulator of aif-induced apoptosis, significantly blocked the release of aif from mitochondria and the translocation of aif into the nuclei after i/r in both wt and hsp70 ko mice. |
2011-07-13 |
2023-08-12 |
mouse |
| Sangita Choudhury, Soochan Bae, Qingen Ke, Ji Yoo Lee, Jacob Kim, Peter M Kan. Mitochondria to nucleus translocation of AIF in mice lacking Hsp70 during ischemia/reperfusion. Basic research in cardiology. vol 106. issue 3. 2011-07-13. PMID:21387140. |
in addition, 4-an treatment resulted in a significant inhibition of apoptosis, a reduction of infarct size, and attenuated cardiac dysfunction in both wt and hsp70 ko mice after i/r. |
2011-07-13 |
2023-08-12 |
mouse |
| Ling Chen, Jin Zhang, Xuejiao Hu, Kenneth D Philipson, Steven M Schar. The Na+/Ca2+ exchanger-1 mediates left ventricular dysfunction in mice with chronic intermittent hypoxia. Journal of applied physiology (Bethesda, Md. : 1985). vol 109. issue 6. 2011-03-25. PMID:20947716. |
compared with hc, cih exposure was associated with apoptosis (terminal deoxynucleotidyl transferase dutp-mediated nick-end labeling and caspase-3) in wt, but not ko, mice. |
2011-03-25 |
2023-08-12 |
mouse |
| Stephen J Mnich, Patrick M Blanner, Liangbiao G Hu, Alexander F Shaffer, Fernando A Happa, Shawn O'Neil, Okechukwu Ukairo, Dave Weiss, Eric Welsh, Chad Storer, Gabriel Mbalaviele, Hidenori Ichijo, Joseph B Monahan, Medora M Hardy, Hiroyuki Ed. Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis. International immunopharmacology. vol 10. issue 10. 2011-02-15. PMID:20609399. |
in this report, we show that apoptosis signal-regulating kinase 1(-/-) (ask1 ko) mice were resistant to inflammatory arthritis induced in the k/bxn serum transfer model of rheumatoid arthritis (ra). |
2011-02-15 |
2023-08-12 |
mouse |
| Sheila J Semaan, Elaine K Murray, Matthew C Poling, Sangeeta Dhamija, Nancy G Forger, Alexander S Kauffma. BAX-dependent and BAX-independent regulation of Kiss1 neuron development in mice. Endocrinology. vol 151. issue 12. 2011-01-04. PMID:20926580. |
the role of bax-mediated apoptosis in generating this sex difference was tested in adult bax knockout (ko) and wild-type mice. |
2011-01-04 |
2023-08-12 |
mouse |
| Sheila J Semaan, Elaine K Murray, Matthew C Poling, Sangeeta Dhamija, Nancy G Forger, Alexander S Kauffma. BAX-dependent and BAX-independent regulation of Kiss1 neuron development in mice. Endocrinology. vol 151. issue 12. 2011-01-04. PMID:20926580. |
in the arc, kiss1 cell number was markedly increased in bax ko mice of both sexes, indicating that although bax-dependent apoptosis does not generate the sex difference in either kiss1 or th expression in avpv/pen, bax does importantly regulate kiss1 cell number in the arc. |
2011-01-04 |
2023-08-12 |
mouse |
| Vanessa M Hubbard, Rut Valdor, Bindi Patel, Rajat Singh, Ana Maria Cuervo, Fernando Macia. Macroautophagy regulates energy metabolism during effector T cell activation. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 12. 2011-01-04. PMID:21059894. |
using a conditional ko mouse model where atg7, a critical gene for macroautophagy, is specifically deleted in t cells, we have found that macroautophagy-deficient effector th cells have defective il-2 and ifn-γ production and reduced proliferation after stimulation, with no significant increase in apoptosis. |
2011-01-04 |
2023-08-12 |
mouse |
| Smitha R Georgy, Charles N Pagel, David M Wong, Sutharshani Sivagurunathan, Lay H Loh, Damian E Myers, Morley D Hollenberg, Robert N Pike, Eleanor J Macki. Proteinase-activated receptor-2 (PAR2) and mouse osteoblasts: regulation of cell function and lack of specificity of PAR2-activating peptides. Clinical and experimental pharmacology & physiology. vol 37. issue 3. 2010-12-14. PMID:19769607. |
when grown in serum-containing medium, ko cells increased in number more rapidly than wt cells, an effect that could be attributed to decreased apoptosis rather than increased proliferation. |
2010-12-14 |
2023-08-12 |
mouse |
| Smitha R Georgy, Charles N Pagel, David M Wong, Sutharshani Sivagurunathan, Lay H Loh, Damian E Myers, Morley D Hollenberg, Robert N Pike, Eleanor J Macki. Proteinase-activated receptor-2 (PAR2) and mouse osteoblasts: regulation of cell function and lack of specificity of PAR2-activating peptides. Clinical and experimental pharmacology & physiology. vol 37. issue 3. 2010-12-14. PMID:19769607. |
similarly, the par(2)aps inhibited serum deprivation-induced apoptosis and parathyroid hormone-, 1,25-dihydroxyvitamin d(3)- or interleukin-11-induced mineralization in wt and ko cells. |
2010-12-14 |
2023-08-12 |
mouse |
| Julie Jortay, Maximin Senou, Aurélie Delaigle, Laurence Noel, Tohru Funahashi, Norikazu Maeda, Marie C Many, Sonia M Brichar. Local induction of adiponectin reduces lipopolysaccharide-triggered skeletal muscle damage. Endocrinology. vol 151. issue 10. 2010-11-04. PMID:20702578. |
to test this paradigm, we examined whether muscles of apn-knockout (ko) mice exhibit a higher degree of oxidative stress and apoptosis than wild-type mice when challenged by ip lps and whether these abnormalities may be corrected by local administration of apn. |
2010-11-04 |
2023-08-12 |
mouse |
| Hyo-Jung Kwon, Jong-Hwan Lim, Jong-Tak Han, Sae-Bhom Lee, Won-Kee Yoon, Ki-Hoan Nam, In-Pyo Choi, Dae-Yong Kim, Young-Suk Won, Hyoung-Chin Ki. The role of vitamin D3 upregulated protein 1 in thioacetamide-induced mouse hepatotoxicity. Toxicology and applied pharmacology. vol 248. issue 3. 2010-10-25. PMID:20713078. |
in addition, induction of apoptosis was decreased in vdup1 ko mice, with the alteration of caspase-3 and -9 activities, bax-to-bcl-2 expression ratios, and mitogen activated protein kinase (mapk) signaling pathway. |
2010-10-25 |
2023-08-12 |
mouse |
| Erik J Zmuda, Ling Qi, Michael X Zhu, Raghavendra G Mirmira, Marc R Montminy, Tsonwin Ha. The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Molecular endocrinology (Baltimore, Md.). vol 24. issue 7. 2010-09-23. PMID:20519332. |
at 12 wk on high-fat diet, no beta-cell apoptosis was observed, and the wt and ko mice had comparable beta-cell areas. |
2010-09-23 |
2023-08-12 |
mouse |
| J M Dean, X Wang, A M Kaindl, P Gressens, B Fleiss, H Hagberg, C Mallar. Microglial MyD88 signaling regulates acute neuronal toxicity of LPS-stimulated microglia in vitro. Brain, behavior, and immunity. vol 24. issue 5. 2010-09-13. PMID:19903519. |
primary neuronal cultures were supplemented with the 14 or 24 h mcm, and the degree of neuronal apoptosis examined after exposure for 24 h. results showed a rapid and sustained elevation in multiple inflammatory mediators in the mcm of wt microglia exposed to lps, which was largely inhibited in myd88 ko microglia. |
2010-09-13 |
2023-08-12 |
mouse |