| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Satoshi Okumura, Takayuki Fujita, Wenqian Cai, Meihua Jin, Iyuki Namekata, Yasumasa Mototani, Huiling Jin, Yoshiki Ohnuki, Yayoi Tsuneoka, Reiko Kurotani, Kenji Suita, Yuko Kawakami, Shogo Hamaguchi, Takaya Abe, Hiroshi Kiyonari, Takashi Tsunematsu, Yunzhe Bai, Sayaka Suzuki, Yuko Hidaka, Masanari Umemura, Yasuhiro Ichikawa, Utako Yokoyama, Motohiko Sato, Fumio Ishikawa, Hiroko Izumi-Nakaseko, Satomi Adachi-Akahane, Hikaru Tanaka, Yoshihiro Ishikaw. Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses. The Journal of clinical investigation. vol 124. issue 6. 2014-08-18. PMID:24892712. |
compared with wt mice, aortic banding induced a similar degree of cardiac hypertrophy in epac1 ko; however, lack of epac1 prevented subsequent cardiac dysfunction as a result of decreased cardiac myocyte apoptosis and fibrosis. |
2014-08-18 |
2023-08-13 |
mouse |
| Yogesh M Kulkarni, Changxing Liu, Qi Qi, Yanmei Zhu, David J Klinke, Jun Li. Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis. The Analyst. vol 138. issue 22. 2014-08-15. PMID:24091439. |
differential proteomic analysis of caveolin-1 ko cells reveals sh2b3 and clec12b as novel interaction partners of caveolin-1 and capns1 as a potential mediator of caveolin-1-induced apoptosis. |
2014-08-15 |
2023-08-12 |
mouse |
| Jooyeon Kim, Kwang Min Lee, Chul-Seung Park, Woo Jin Par. Ablation of cereblon attenuates myocardial ischemia-reperfusion injury. Biochemical and biophysical research communications. vol 447. issue 4. 2014-08-13. PMID:24755080. |
apoptosis was also significantly reduced in the ko mice compared with that in wt mice, as shown by the reduced numbers of tunel-positive cells. |
2014-08-13 |
2023-08-13 |
mouse |
| Wei Wang, Aie Zhou, Xuemei Zhang, Yun Xiang, Yifei Huang, Lei Wang, Shuai Zhang, Yusi Liu, Yibing Yin, Yujuan H. Interleukin 17A promotes pneumococcal clearance by recruiting neutrophils and inducing apoptosis through a p38 mitogen-activated protein kinase-dependent mechanism in acute otitis media. Infection and immunity. vol 82. issue 6. 2014-06-30. PMID:24664502. |
using il-17a knockout (ko) mice, we found that il-17a boosted neutrophil recruitment to the mec and afterwards induced apoptosis, which was identified to be conducive to bacterial clearance. |
2014-06-30 |
2023-08-12 |
mouse |
| Anil K Jain, Neera Tewari-Singh, Swetha Inturi, David J Orlicky, Carl W White, Rajesh Agarwa. Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries. Toxicology. vol 320. 2014-06-23. PMID:24631667. |
nm exposure caused a significant increase in skin bi-fold thickness, epidermal thickness, microvesication, dna damage and apoptosis in wt mice compared to mpo ko mice. |
2014-06-23 |
2023-08-12 |
mouse |
| Seong Jeong Park, Hong Namkoong, Junsang Doh, Jong-Cheol Choi, Bo-Gie Yang, Yunji Park, Young Chul Sun. Negative role of inducible PD-1 on survival of activated dendritic cells. Journal of leukocyte biology. vol 95. issue 4. 2014-05-20. PMID:24319287. |
dcs, in spleen of lps-injected pd-1 ko mice, were more resistant to lps-mediated apoptosis in vivo than wt controls. |
2014-05-20 |
2023-08-12 |
mouse |
| Zhe Tang, Lan Ni, Sara Javidiparsijani, Fengqi Hu, Louis A Gatto, Robert Cooney, Guirong Wan. Enhanced liver autophagic activity improves survival of septic mice lacking surfactant proteins A and D. The Tohoku journal of experimental medicine. vol 231. issue 2. 2014-04-30. PMID:24126241. |
furthermore, differential responses to sepsis between sp-a/d ko and wt mice were found in six signaling pathways related to autophagy and apoptosis. |
2014-04-30 |
2023-08-12 |
mouse |
| Michael Li-Hsuan Huang, Sutharshani Sivagurunathan, Samantha Ting, Patric J Jansson, Christopher J D Austin, Matthew Kelly, Christopher Semsarian, Daohai Zhang, Des R Richardso. Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2α phosphorylation, and the induction of downstream targets. The American journal of pathology. vol 183. issue 3. 2014-03-12. PMID:23886890. |
indeed, expression of a panel of autophagy and apoptosis markers was enhanced in ko mice. |
2014-03-12 |
2023-08-12 |
mouse |
| Kuan-Ming Lu, Sylvia M Evans, Shinji Hirano, Fu-Chin Li. Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 1. 2014-03-12. PMID:24351932. |
striatonigral axonal projections were also impaired, and abnormal apoptosis was observed in isl1 ko striatum. |
2014-03-12 |
2023-08-12 |
mouse |
| Tomohiro Tanaka, Tomoko Wakabayashi, Hiroaki Oizumi, Shu Nishio, Takashi Sato, Akihiro Harada, Daisuke Fujii, Yuko Matsuo, Tadafumi Hashimoto, Takeshi Iwatsub. CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 4. 2014-03-11. PMID:24453327. |
failure of muscular innervation in col25a1 ko mice led to excessive apoptosis during development, resulting in almost complete and exclusive loss of spinal motoneurons and immaturity in skeletal muscle development. |
2014-03-11 |
2023-08-12 |
mouse |
| Tomohiro Tanaka, Tomoko Wakabayashi, Hiroaki Oizumi, Shu Nishio, Takashi Sato, Akihiro Harada, Daisuke Fujii, Yuko Matsuo, Tadafumi Hashimoto, Takeshi Iwatsub. CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 4. 2014-03-11. PMID:24453327. |
bax deletion in col25a1 ko mice rescued motoneurons from apoptosis, although motor axons remained halted around the muscle entry site. |
2014-03-11 |
2023-08-12 |
mouse |
| Fei Fang, George Chu Liu, Xiaohua Zhou, Stuart Yang, Heather Naomi Reich, Vanessa Williams, Amanda Hu, Janice Pan, Ana Konvalinka, Gavin Yadram Oudit, James William Scholey, Rohan Joh. Loss of ACE2 exacerbates murine renal ischemia-reperfusion injury. PloS one. vol 8. issue 8. 2014-03-03. PMID:23951161. |
changes in inflammatory cell infiltrates and cytokine expression were also associated with greater apoptosis and oxidative stress in ace2 ko mice compared to wt mice. |
2014-03-03 |
2023-08-12 |
mouse |
| Ratanesh Kumar Seth, Suvarthi Das, Ashutosh Kumar, Anindya Chanda, Maria B Kadiiska, Gregory Michelotti, Jose Manautou, Anna Mae Diehl, Saurabh Chatterje. CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis. Toxicology and applied pharmacology. vol 274. issue 1. 2014-02-24. PMID:24211274. |
apoptosis as evidenced by tunel assay and levels of cleaved caspase-3 was significantly lower in leptin and pfp/rag2 ko mice and highly correlated with protection from nash. |
2014-02-24 |
2023-08-12 |
mouse |
| Jung-Ran Noh, Jung Hwan Hwang, Yong-Hoon Kim, Kyoung-Shim Kim, Gil-Tae Gang, Sang-Woo Kim, Don-Kyu Kim, Minho Shong, In-Kyu Lee, Hueng-Sik Choi, Chul-Ho Le. The orphan nuclear receptor small heterodimer partner negatively regulates pancreatic beta cell survival and hyperglycemia in multiple low-dose streptozotocin-induced type 1 diabetic mice. The international journal of biochemistry & cell biology. vol 45. issue 8. 2014-02-11. PMID:23680671. |
in quantification for beta cell apoptosis at day 1 post stz treatment, the shp ko mice showed significantly increased anti-apoptotic gene expression and decreased release of apoptotic markers cytochrome c, smac/diablo, and only a few apoptotic beta cells were found in shp ko pancreas through inactivation of caspase-3, compared to those of wt. |
2014-02-11 |
2023-08-12 |
mouse |
| Weihua Zhou, Wenyi Wei, Yi Su. Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases. Cell research. vol 23. issue 5. 2013-11-26. PMID:23528706. |
in this review, we will provide a brief introduction to the ubiquitin-proteasome system (ups) and the scf e3 ubiquitin ligases, followed by a comprehensive overview on the existing tg and knockout (ko) mouse models of the scf e3s, and discuss the role of each component in mouse embryogenesis, cell proliferation, apoptosis, carcinogenesis, as well as other pathogenic processes associated with human diseases. |
2013-11-26 |
2023-08-12 |
mouse |
| Xiaoyong Lei, Robert N Bone, Tomader Ali, Mary Wohltmann, Ying Gai, Karen J Goodwin, Alan E Bohrer, John Turk, Sasanka Ramanadha. Genetic modulation of islet β-cell iPLA₂β expression provides evidence for its impact on β-cell apoptosis and autophagy. Islets. vol 5. issue 1. 2013-11-14. PMID:23411472. |
surprisingly, β-cells apoptosis while reduced in the ko is higher than in the wt group. |
2013-11-14 |
2023-08-12 |
mouse |
| Makoto Naoi, Wakako Maruyama, Keiko Inaba-Hasegaw. Type A and B monoamine oxidase in age-related neurodegenerative disorders: their distinct roles in neuronal death and survival. Current topics in medicinal chemistry. vol 12. issue 20. 2013-11-13. PMID:23231395. |
mao-a is a target of an endogenous neurotoxin, nmethyl( r)salsolinol, and mao-a knockdown (ko) with short interfering (si)rna protects neuronal death from apoptosis. |
2013-11-13 |
2023-08-12 |
Not clear |
| Soochan Bae, Sylvia S Singh, Hyeon Yu, Ji Yoo Lee, Byung Ryul Cho, Peter M Kan. Vitamin D signaling pathway plays an important role in the development of heart failure after myocardial infarction. Journal of applied physiology (Bethesda, Md. : 1985). vol 114. issue 8. 2013-10-17. PMID:23429874. |
vdr ko mice also demonstrated a significant increase in heart failure biomarkers, apoptosis, inflammation, and fibrosis. |
2013-10-17 |
2023-08-12 |
mouse |
| Lang Wang, Yanyun Lu, Hongjing Guan, Dingsheng Jiang, Yu Guan, Xin Zhang, Hiroyasu Nakano, Yan Zhou, Yan Zhang, Li Yang, Hongliang L. Tumor necrosis factor receptor-associated factor 5 is an essential mediator of ischemic brain infarction. Journal of neurochemistry. vol 126. issue 3. 2013-09-20. PMID:23413803. |
a low neuronal apoptosis level, an attenuated blood-brain barrier (bbb) disruption and an inhibited inflammatory response were exhibited in traf5 ko mice. |
2013-09-20 |
2023-08-12 |
mouse |
| Vladimir Petrovic, Dmitry Malin, Vincent L Cryn. αB-crystallin promotes oncogenic transformation and inhibits caspase activation in cells primed for apoptosis by Rb inactivation. Breast cancer research and treatment. vol 138. issue 2. 2013-09-17. PMID:23471649. |
αb-crystallin (-/-) ko mefs stably expressing dn p53 and e1a were more sensitive to chemotherapy-induced caspase-3 activation and apoptosis than the corresponding wt mefs, despite comparable induction of procaspases by e1a. |
2013-09-17 |
2023-08-12 |
Not clear |