| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seung-Hoon Yeo, Jung-Ran Noh, Yong-Hoon Kim, Gil-Tae Gang, Sang-Woo Kim, Kyoung-Shim Kim, Jung Hwan Hwang, Minho Shong, Chul-Ho Le. Increased vulnerability to β-cell destruction and diabetes in mice lacking NAD(P)H:quinone oxidoreductase 1. Toxicology letters. vol 219. issue 1. 2013-05-23. PMID:23458895. |
at the same time, mlds-treated ko mice showed significantly increased apoptotic markers in β-cells, including cleaved caspase 3, smac/diablo and aif (apoptosis inducing factor) in the cytoplasm. |
2013-05-23 |
2023-08-12 |
mouse |
| Kari Nejak-Bowen, Alexander Kikuchi, Satdarshan P S Mong. Beta-catenin-NF-κB interactions in murine hepatocytes: a complex to die for. Hepatology (Baltimore, Md.). vol 57. issue 2. 2013-04-04. PMID:22941935. |
to elucidate how β-catenin may be regulating hepatocyte survival, we investigated the susceptibility of β-catenin conditional knockout (ko) mice and their wild-type (wt) littermates to fas and tumor necrosis factor-α (tnf-α), two common pathways of hepatocyte apoptosis. |
2013-04-04 |
2023-08-12 |
mouse |
| Takaaki Takeda, Hiroaki Okuyama, Yasuko Nishizawa, Shuhei Tomita, Masahiro Inou. Hypoxia inducible factor-1α is necessary for invasive phenotype in Vegf-deleted islet cell tumors. Scientific reports. vol 2. 2013-03-17. PMID:22768384. |
double ko mice of vegf and hypoxia inducible factor-1α (hif-1α) showed increased life span and suppressed tumor growth due to increased apoptosis. |
2013-03-17 |
2023-08-12 |
mouse |
| Jatinder K Juss, Richard P Hayhoe, Charles E Owen, Ian Bruce, Sarah R Walmsley, Andrew S Cowburn, Suhasini Kulkarni, Keith B Boyle, Len Stephens, Phillip T Hawkins, Edwin R Chilvers, Alison M Condliff. Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival. PloS one. vol 7. issue 9. 2013-03-05. PMID:23029326. |
likewise, isolated blood neutrophils derived from double knockout pi3k p110δ(ko)γ(ko) mice underwent normal time-dependent constitutive apoptosis and displayed identical gm-csf mediated survival to wild type cells, but were sensitized to pharmacological inhibition of the remaining pi3k isoforms. |
2013-03-05 |
2023-08-12 |
mouse |
| Dawei Zhang, Li Jin, Davis L Reames, Francis H Shen, Adam L Shimer, Xudong L. Intervertebral disc degeneration and ectopic bone formation in apolipoprotein E knockout mice. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 31. issue 2. 2013-02-28. PMID:22915292. |
apoptosis was increased in the apoe ko np tissue. |
2013-02-28 |
2023-08-12 |
mouse |
| Xiaoqing He, Qiang M. Redox regulation by nuclear factor erythroid 2-related factor 2: gatekeeping for the basal and diabetes-induced expression of thioredoxin-interacting protein. Molecular pharmacology. vol 82. issue 5. 2013-02-12. PMID:22869588. |
knockout (ko) of nrf2 induced oxidative stress and apoptosis in ko heart; diabetes further increased oxidative damage. |
2013-02-12 |
2023-08-12 |
mouse |
| Casey Trimmer, Federica Sotgia, Michael P Lisanti, Franco Capozz. Cav1 inhibits benign skin tumor development in a two-stage carcinogenesis model by suppressing epidermal proliferation. American journal of translational research. vol 5. issue 1. 2013-02-08. PMID:23390568. |
treatment of wild-type (wt) and cav1 ko mice with dmba alone shows that both groups have similar rates of apoptosis. |
2013-02-08 |
2023-08-12 |
mouse |
| Cerrone R Foster, QinQin Zha, Laura L Daniel, Mahipal Singh, Krishna Sing. Lack of ataxia telangiectasia mutated kinase induces structural and functional changes in the heart: role in β-adrenergic receptor-stimulated apoptosis. Experimental physiology. vol 97. issue 4. 2013-02-01. PMID:22179422. |
here we analysed basal myocardial structure and function in atm knockout (ko) mice and tested the hypothesis that atm modulates β-ar-stimulated myocyte apoptosis. |
2013-02-01 |
2023-08-12 |
mouse |
| Cerrone R Foster, QinQin Zha, Laura L Daniel, Mahipal Singh, Krishna Sing. Lack of ataxia telangiectasia mutated kinase induces structural and functional changes in the heart: role in β-adrenergic receptor-stimulated apoptosis. Experimental physiology. vol 97. issue 4. 2013-02-01. PMID:22179422. |
left ventricular (lv) structure and function, myocyte apoptosis, fibrosis and expression of fibrosis-, hypertrophy- and apoptosis-related proteins were examined in wild-type (wt) and ko mice with or without l-isoprenaline treatment for 24 h. body and heart weights were lower in ko mice. |
2013-02-01 |
2023-08-12 |
mouse |
| Y Zhao, X Xiong, L Jia, Y Su. Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell death & disease. vol 3. 2013-01-14. PMID:22951983. |
biologically, autophagy is a survival signal to tumor cells, and blockage of autophagy via sirna knockdown, gene ko and small molecule inhibitor remarkably enhanced mln4924-induced apoptosis. |
2013-01-14 |
2023-08-12 |
human |
| Chiaki Kajiwara, Shiho Kondo, Shizuha Uda, Lei Dai, Tomoko Ichiyanagi, Tomoki Chiba, Satoshi Ishido, Takehiko Koji, Heiichiro Udon. Spermatogenesis arrest caused by conditional deletion of Hsp90α in adult mice. Biology open. vol 1. issue 10. 2012-12-06. PMID:23213375. |
it was recently shown that many spermatocytes underwent apoptosis in the testes of hsp90α ko mice. |
2012-12-06 |
2023-08-12 |
mouse |
| Manika Das, Somak Das, Istvan Lekli, Dipak K Da. Caveolin induces cardioprotection through epigenetic regulation. Journal of cellular and molecular medicine. vol 16. issue 4. 2012-10-26. PMID:21707918. |
cardioprotective property of cav-1 was further confirmed by reduced ventricular function, increased cardiomyocyte apoptosis, increased expression of junas kinase (jnk) and bax and decreased expression of phospho-adenosine monophosphate-activated protein kinase (ampk), phospho-akt and b cell lymphoma-2 (bcl-2) in cav-1 ko preconditioned heart. |
2012-10-26 |
2023-08-12 |
mouse |
| Soojeong Jang, Yunsook Lim, Giuseppe Valacchi, Sungbin Sorn, Hyon Park, Na-Young Park, Myoungsook Le. Preventive effects of protopanaxadiol and protopanaxatriol ginsenosides on liver inflammation and apoptosis in hyperlipidemic apoE KO mice. Genes & nutrition. vol 7. issue 2. 2012-10-02. PMID:21853335. |
preventive effects of protopanaxadiol and protopanaxatriol ginsenosides on liver inflammation and apoptosis in hyperlipidemic apoe ko mice. |
2012-10-02 |
2023-08-12 |
mouse |
| Soojeong Jang, Yunsook Lim, Giuseppe Valacchi, Sungbin Sorn, Hyon Park, Na-Young Park, Myoungsook Le. Preventive effects of protopanaxadiol and protopanaxatriol ginsenosides on liver inflammation and apoptosis in hyperlipidemic apoE KO mice. Genes & nutrition. vol 7. issue 2. 2012-10-02. PMID:21853335. |
the aim of this study was to evaluate the protective effects of different pd and pt combination ratios on liver inflammation and apoptosis in hyperlipidemic apo e ko mice. |
2012-10-02 |
2023-08-12 |
mouse |
| Soojeong Jang, Yunsook Lim, Giuseppe Valacchi, Sungbin Sorn, Hyon Park, Na-Young Park, Myoungsook Le. Preventive effects of protopanaxadiol and protopanaxatriol ginsenosides on liver inflammation and apoptosis in hyperlipidemic apoE KO mice. Genes & nutrition. vol 7. issue 2. 2012-10-02. PMID:21853335. |
different combinational treatment of pd and pt extracts might ameliorate the liver inflammation and apoptosis in hyperlipidemic apo e ko mice, which is atherosclerotic animal model. |
2012-10-02 |
2023-08-12 |
mouse |
| Cem Demirci, Sara Ernst, Juan C Alvarez-Perez, Taylor Rosa, Shelley Valle, Varsha Shridhar, Gabriella P Casinelli, Laura C Alonso, Rupangi C Vasavada, Adolfo García-Ocan. Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus. Diabetes. vol 61. issue 5. 2012-06-28. PMID:22427375. |
importantly, pancmet ko mice displayed decreased β-cell replication and increased β-cell apoptosis at gestational day (gd)15. |
2012-06-28 |
2023-08-12 |
mouse |
| Baowei Jiao, Hong Ma, Maxim N Shokhirev, Alexander Drung, Qin Yang, JongDae Shin, Shaolei Lu, Meg Byron, Sundeep Kalantry, Arthur M Mercurio, Jeanne B Lawrence, Alexander Hoffmann, Ingolf Bac. Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell. vol 149. issue 3. 2012-06-22. PMID:22541433. |
we find that knockout (ko) of rnf12 in female mammary glands inhibits alveolar differentiation and milk production upon pregnancy, with alveolar cells that lack rlim undergoing apoptosis as they begin to differentiate. |
2012-06-22 |
2023-08-12 |
mouse |
| Eui-Man Jung, Beum-Soo An, Kyung-Chul Choi, Eui-Bae Jeun. Apoptosis- and endoplasmic reticulum stress-related genes were regulated by estrogen and progesterone in the uteri of calbindin-D(9k) and -D(28k) knockout mice. Journal of cellular biochemistry. vol 113. issue 1. 2012-06-15. PMID:21882229. |
the aim of the present study was to evaluate the regulation of apoptosis in the uteri of cabp-9k, cabp-28k, and cabp-9k/28k knockout (ko) mice. |
2012-06-15 |
2023-08-12 |
mouse |
| Lemeng Zhang, Jon S Cardinal, Runalia Bahar, John Evankovich, Hai Huang, Gary Nace, Timothy R Billiar, Matthew R Rosengart, Pinhua Pan, Allan Tsun. Interferon regulatory factor-1 regulates the autophagic response in LPS-stimulated macrophages through nitric oxide. Molecular medicine (Cambridge, Mass.). vol 18. 2012-06-01. PMID:22105605. |
in vivo, tissue macrophages obtained from lps-stimulated irf-1 knockout (ko) mice demonstrated increased autophagy and decreased apoptosis compared to those isolated from irf-1 wild-type (wt) mice. |
2012-06-01 |
2023-08-12 |
mouse |
| Lemeng Zhang, Jon S Cardinal, Runalia Bahar, John Evankovich, Hai Huang, Gary Nace, Timothy R Billiar, Matthew R Rosengart, Pinhua Pan, Allan Tsun. Interferon regulatory factor-1 regulates the autophagic response in LPS-stimulated macrophages through nitric oxide. Molecular medicine (Cambridge, Mass.). vol 18. 2012-06-01. PMID:22105605. |
in vitro, lps-stimulated peritoneal macrophages obtained from irf-1 ko mice experienced increased autophagy and decreased apoptosis. |
2012-06-01 |
2023-08-12 |
mouse |