| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lemeng Zhang, Jon S Cardinal, Runalia Bahar, John Evankovich, Hai Huang, Gary Nace, Timothy R Billiar, Matthew R Rosengart, Pinhua Pan, Allan Tsun. Interferon regulatory factor-1 regulates the autophagic response in LPS-stimulated macrophages through nitric oxide. Molecular medicine (Cambridge, Mass.). vol 18. 2012-06-01. PMID:22105605. |
in vivo, tissue macrophages obtained from lps-stimulated irf-1 knockout (ko) mice demonstrated increased autophagy and decreased apoptosis compared to those isolated from irf-1 wild-type (wt) mice. |
2012-06-01 |
2023-08-12 |
mouse |
| Lemeng Zhang, Jon S Cardinal, Runalia Bahar, John Evankovich, Hai Huang, Gary Nace, Timothy R Billiar, Matthew R Rosengart, Pinhua Pan, Allan Tsun. Interferon regulatory factor-1 regulates the autophagic response in LPS-stimulated macrophages through nitric oxide. Molecular medicine (Cambridge, Mass.). vol 18. 2012-06-01. PMID:22105605. |
in vitro, lps-stimulated peritoneal macrophages obtained from irf-1 ko mice experienced increased autophagy and decreased apoptosis. |
2012-06-01 |
2023-08-12 |
mouse |
| Jun Cheng, Lin Xu, Dongwu Lai, Arnaud Guilbert, Hyun Joung Lim, Thitima Keskanokwong, Yanggan Wan. CaMKII inhibition in heart failure, beneficial, harmful, or both. American journal of physiology. Heart and circulatory physiology. vol 302. issue 7. 2012-05-15. PMID:22287581. |
in addition, an increase in myofilament sensitivity to ca(2+) and the slow skeletal muscle troponin i-to-cardiac troponin i ratio and interstitial fibrosis and a decrease in na/ca exchange function and myocyte apoptosis were observed in ko hf lv. |
2012-05-15 |
2023-08-12 |
mouse |
| Carolina Ferreira Oliveira, Daniel Manzoni-de-Almeida, Paula Seixas Mello, Caio Cotta Natale, Helton da Costa Santiago, Luíza da Silva Miranda, Fernanda Oliveira Ferraz, Liliane Martins dos Santos, Mauro Martins Teixeira, Rosa Maria Esteves Arantes, Leda Quercia Vieir. Characterization of chronic cutaneous lesions from TNF-receptor-1-deficient mice infected by Leishmania major. Clinical & developmental immunology. vol 2012. 2012-04-24. PMID:22203861. |
we investigated the cell composition, cytokine production, and apoptosis in lesions from l. major-infected tnfr1 ko and wild-type (wt) mice. |
2012-04-24 |
2023-08-12 |
mouse |
| Carolina Ferreira Oliveira, Daniel Manzoni-de-Almeida, Paula Seixas Mello, Caio Cotta Natale, Helton da Costa Santiago, Luíza da Silva Miranda, Fernanda Oliveira Ferraz, Liliane Martins dos Santos, Mauro Martins Teixeira, Rosa Maria Esteves Arantes, Leda Quercia Vieir. Characterization of chronic cutaneous lesions from TNF-receptor-1-deficient mice infected by Leishmania major. Clinical & developmental immunology. vol 2012. 2012-04-24. PMID:22203861. |
our studies showed that persistent lesions in l. major-infected tnfr1 ko mice may be mediated by continuous migration of cells to the site of inflammation due to the presence of chemokines and also by lower levels of apoptosis. |
2012-04-24 |
2023-08-12 |
mouse |
| Noriyoshi Usui, Keisuke Watanabe, Katsuhiko Ono, Koichi Tomita, Nobuaki Tamamaki, Kazuhiro Ikenaka, Hirohide Takebayash. Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formation. Development (Cambridge, England). vol 139. issue 6. 2012-04-16. PMID:22318233. |
the significance of motoneuron-derived ntf3 was analyzed using ntf3 conditional knockout (cko) embryos, in which we observed increased apoptosis and abnormal projection of the central branch innervating motoneuron, the phenotypes being apparently comparable with that of olig2 ko embryos. |
2012-04-16 |
2023-08-12 |
mouse |
| Yurai Okaji, Yoshihiko Tashiro, Ismael Gritli, Chiemi Nishida, Aki Sato, Yoko Ueno, Sandra Del Canto Gonzalez, Makiko Ohki-Koizumi, Haruyo Akiyama, Hiromitsu Nakauchi, Koichi Hattori, Beate Heissi. Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis. Experimental hematology. vol 40. issue 2. 2012-02-27. PMID:22056679. |
erythroid differentiation was attenuated in male plg ko mice and resulted in erythroblastic accumulation within the spleen and bone marrow, with increased apoptosis in the former, erythrocytosis, and splenomegaly, whereas similar erythropoietic defect was less prominent in female plg ko mice. |
2012-02-27 |
2023-08-12 |
mouse |
| Yi Wang, Xuemei Shi, Jian Qi, Xiaojie Li, Karen Uray, Xinfu Gua. SIRT1 inhibits the mouse intestinal motility and epithelial proliferation. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 2. 2012-02-16. PMID:22038824. |
the sirt1 ko mice showed enhanced crypt proliferation and suppressed villous apoptosis, resulting in increased intestinal villous height. |
2012-02-16 |
2023-08-12 |
mouse |
| David H Lee, Jesse M Wolstein, Basu Pudasaini, Matthew Plotki. INK4a deletion results in improved kidney regeneration and decreased capillary rarefaction after ischemia-reperfusion injury. American journal of physiology. Renal physiology. vol 302. issue 1. 2012-02-09. PMID:21957175. |
ko mice displayed decreased tubular cell apoptosis, increased cell proliferation, and lower creatinine levels after injury. |
2012-02-09 |
2023-08-12 |
mouse |
| Jinjiang Pang, Xiangbin Xu, Michael R Getman, Xi Shi, Stephen L Belmonte, Heidi Michaloski, Amy Mohan, Burns C Blaxall, Bradford C Ber. G protein coupled receptor kinase 2 interacting protein 1 (GIT1) is a novel regulator of mitochondrial biogenesis in heart. Journal of molecular and cellular cardiology. vol 51. issue 5. 2012-01-27. PMID:21756914. |
concordant with these mitochondrial observations, git1 ko mice showed enhanced cardiomyocyte apoptosis and cardiac dysfunction. |
2012-01-27 |
2023-08-12 |
mouse |
| Heekyong Bae, Jun-Lin Gua. Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents. Molecular cancer research : MCR. vol 9. issue 9. 2012-01-12. PMID:21807966. |
the persistent dna damage correlated to increased apoptosis and reduced survival of fip200 knockout (ko) mefs after treatments with camptothecin (cpt), a topoisomerase i inhibitor and chemotherapeutic agent. |
2012-01-12 |
2023-08-12 |
mouse |
| Christophe Stenger, Thomas Naves, Mireille Verdier, Marie-Helene Ratinau. The cell death response to the ROS inducer, cobalt chloride, in neuroblastoma cell lines according to p53 status. International journal of oncology. vol 39. issue 3. 2012-01-11. PMID:21687937. |
finally, cocl2 induced time-dependent canonical p53 mitochondrial apoptosis in the wt p53 cell line, and caspase-independent cell death in cells with a mutated or ko p53. |
2012-01-11 |
2023-08-12 |
Not clear |
| Leonardo A de Almeida, Natalia B Carvalho, Fernanda S Oliveira, Thais L S Lacerda, Anilton C Vasconcelos, Lucas Nogueira, Andre Bafica, Aristóbolo M Silva, Sergio C Oliveir. MyD88 and STING signaling pathways are required for IRF3-mediated IFN-β induction in response to Brucella abortus infection. PloS one. vol 6. issue 8. 2011-12-27. PMID:21829705. |
this resistance phenotype is accompanied by increased ifn-γ and no production by ifn-αβr ko spleen cells and reduced apoptosis. |
2011-12-27 |
2023-08-12 |
mouse |
| Sarita Garg, Jessica R Nichols, Nilufer Esen, Shuliang Liu, Nirmal K Phulwani, Mohsin Md Syed, William H Wood, Yongqing Zhang, Kevin G Becker, Amy Aldrich, Tammy Kielia. MyD88 expression by CNS-resident cells is pivotal for eliciting protective immunity in brain abscesses. ASN neuro. vol 1. issue 2. 2011-12-06. PMID:19570030. |
microarray analysis of infected myd88 ko compared with wt mice revealed a preponderance of differentially regulated genes involved in apoptotic pathways, suggesting that the extensive tissue damage characteristic of brain abscesses from myd88 ko mice could result from dysregulated apoptosis. |
2011-12-06 |
2023-08-12 |
mouse |
| Surekha Rani Panjala, Youde Jiang, Timothy S Kern, Steven A Thomas, Jena J Steinl. Increased tumor necrosis factor-α, cleaved caspase 3 levels and insulin receptor substrate-1 phosphorylation in the β₁-adrenergic receptor knockout mouse. Molecular vision. vol 17. 2011-12-06. PMID:21850156. |
to investigate the role of β1-adrenergic receptors on insulin like growth factor (igf)-1 receptor signaling and apoptosis in the retina using β1-adrenergic receptor knockout (ko) mice. |
2011-12-06 |
2023-08-12 |
mouse |
| Sonomi Maruyama, Rei Shibata, Koji Ohashi, Taiki Ohashi, Hiroyuki Daida, Kenneth Walsh, Toyoaki Murohara, Noriyuki Ouch. Adiponectin ameliorates doxorubicin-induced cardiotoxicity through Akt protein-dependent mechanism. The Journal of biological chemistry. vol 286. issue 37. 2011-11-22. PMID:21784858. |
systemic delivery of adenoviral vector expressing adiponectin improved left ventricle dysfunction and myocardial apoptosis following dox injection in wt and apn-ko mice but not in akt1 heterozygous ko mice. |
2011-11-22 |
2023-08-12 |
mouse |
| Yuri Ikeda-Matsuo, Hayato Tanji, Shuh Narumiya, Yasuharu Sasak. Inhibition of prostaglandin E2 EP3 receptors improves stroke injury via anti-inflammatory and anti-apoptotic mechanisms. Journal of neuroimmunology. vol 238. issue 1-2. 2011-11-22. PMID:21803432. |
furthermore, neuronal apoptosis in the ischemic cortex investigated by terminal dutp nick-end labeling (tunel) and caspase-3 immunostaining were ameliorated in ep3 antagonist-treated mice or ep3 ko mice as compared with vehicle-treated mice or wild-type (wt) mice, respectively. |
2011-11-22 |
2023-08-12 |
mouse |
| György Haskó, Balázs Csóka, Balázs Koscsó, Rachna Chandra, Pál Pacher, Linda F Thompson, Edwin A Deitch, Zoltán Spolarics, László Virág, Pál Gergely, Rolando H Rolandelli, Zoltán H Német. Ecto-5'-nucleotidase (CD73) decreases mortality and organ injury in sepsis. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 8. 2011-11-15. PMID:21918191. |
cd73 ko mice had increased apoptosis in the thymus, as evidenced by increased cleavage of caspase-3 and poly(adp-ribose) polymerase and increased activation of nf-κb. |
2011-11-15 |
2023-08-12 |
mouse |
| Jacqueline Heger, Björn Warga, Bettina Meyering, Yaser Abdallah, Klaus-Dieter Schlüter, Hans Michael Piper, Gerhild Eule. TGFβ receptor activation enhances cardiac apoptosis via SMAD activation and concomitant NO release. Journal of cellular physiology. vol 226. issue 10. 2011-10-13. PMID:21792926. |
the consequent assumption that endothelial nos is involved in tgfβ-induced no formation and apoptosis was supported by increased phosphorylation of enos at serine 1177 and by the fact that tgfβ did not increase no release in enos ko mice. |
2011-10-13 |
2023-08-12 |
mouse |
| Xiao-Ming Gao, Yang Liu, David White, Yidan Su, Brian G Drew, Clinton R Bruce, Helen Kiriazis, Qi Xu, Nicole Jennings, Alex Bobik, Mark A Febbraio, Bronwyn A Kingwell, Richard Bucala, Günter Fingerle-Rowson, Anthony M Dart, Eric F Morand, Xiao-Jun D. Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: a predominant role of anti-inflammation. Journal of molecular and cellular cardiology. vol 50. issue 6. 2011-09-26. PMID:21215754. |
following a prolonged cardiac i/r (60 min/24h) mif ko mice had a significant reduction in both infarct size (26±3% vs. 45±4%, p<0.05) and cardiomyocyte apoptosis (1.4±0.2% vs. 5.4±0.4%, p<0.05) and preserved contractile function compared with wt. |
2011-09-26 |
2023-08-12 |
mouse |