| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Iris A Camacho, Narendra Singh, Venkatesh L Hegde, Mitzi Nagarkatti, Prakash S Nagarkatt. Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin leads to aryl hydrocarbon receptor-dependent nuclear translocation of NF-kappaB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells. Journal of immunology (Baltimore, Md. : 1950). vol 175. issue 1. 2005-08-31. PMID:15972635. |
cross-talk between the two pathways was not necessary for apoptosis inasmuch as tcdd-treated bid ko mice showed thymic atrophy and increased apoptosis, similar to the wild-type mice. |
2005-08-31 |
2023-08-12 |
mouse |
| Gusheng Wu, Zi-Hua Lu, Xin Xie, Robert W Ledee. Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: rescue by GM1 and LIGA20. Glycoconjugate journal. vol 21. issue 6. 2005-05-10. PMID:15514479. |
in this study we demonstrate that glutamate has the same effect as k(+) on cgn from these ganglioside-deficient knockout (ko) mice and that apoptosis in both cases is averted by exogenous gm1. |
2005-05-10 |
2023-08-12 |
mouse |
| Dyana K Dalton, Susan Wittme. Nitric-oxide-dependent and independent mechanisms of protection from CNS inflammation during Th1-mediated autoimmunity: evidence from EAE in iNOS KO mice. Journal of neuroimmunology. vol 160. issue 1-2. 2005-04-28. PMID:15710464. |
apoptosis of cns-infiltrating cd4(+) t cells was impaired in inos ko mice at peak of disease; consequently, these mice had more cns-infiltrating cd4(+) t cells. |
2005-04-28 |
2023-08-12 |
mouse |
| Dyana K Dalton, Susan Wittme. Nitric-oxide-dependent and independent mechanisms of protection from CNS inflammation during Th1-mediated autoimmunity: evidence from EAE in iNOS KO mice. Journal of neuroimmunology. vol 160. issue 1-2. 2005-04-28. PMID:15710464. |
subsequently, inos ko mice up-regulated apoptosis of cns-cd4(+) t cells. |
2005-04-28 |
2023-08-12 |
mouse |
| Yunfeng Zhao, Luksana Chaiswing, Terry D Oberley, Ines Batinic-Haberle, William St Clair, Charles J Epstein, Daret St Clai. A mechanism-based antioxidant approach for the reduction of skin carcinogenesis. Cancer research. vol 65. issue 4. 2005-04-04. PMID:15735027. |
however, reduction of mnsod by heterozygous knockout of the mnsod gene (mnsod ko) did not lead to an increase in tumor incidence, because a reduction of mnsod enhanced both cell proliferation and apoptosis. |
2005-04-04 |
2023-08-12 |
mouse |
| Yunfeng Zhao, Luksana Chaiswing, Terry D Oberley, Ines Batinic-Haberle, William St Clair, Charles J Epstein, Daret St Clai. A mechanism-based antioxidant approach for the reduction of skin carcinogenesis. Cancer research. vol 65. issue 4. 2005-04-04. PMID:15735027. |
the present study extends our previous studies in the mnsod ko mice and shows that apoptosis in mouse epidermis occurred prior to cell proliferation (6 versus 24 hours) when treated with tumor promoter 12-o-tetradecanoylphorbol-13-acetate (tpa). |
2005-04-04 |
2023-08-12 |
mouse |
| Masaru Niki, Antonio Di Cristofano, Mingming Zhao, Hiroaki Honda, Hisamaru Hirai, Linda Van Aelst, Carlos Cordon-Cardo, Pier Paolo Pandolf. Role of Dok-1 and Dok-2 in leukemia suppression. The Journal of experimental medicine. vol 200. issue 12. 2005-03-24. PMID:15611295. |
strikingly, all dok-1/dok-2 double ko mutants spontaneously developed transplantable cml-like myeloproliferative disease due to increased cellular proliferation and reduced apoptosis. |
2005-03-24 |
2023-08-12 |
mouse |
| Marina Afanasyeva, Dimitrios Georgakopoulos, Diego F Belardi, Djahida Bedja, Delisa Fairweather, Yan Wang, Ziya Kaya, Kathleen L Gabrielson, E Rene Rodriguez, Patrizio Caturegli, David A Kass, Noel R Ros. Impaired up-regulation of CD25 on CD4+ T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart failure. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 1. 2005-03-10. PMID:15611472. |
cardiac dysfunction in the ko mice is associated with the expansion of activated (cd44(high)) cd3+ t cells due to reduced apoptosis of cd4+, but not cd8+, t cells. |
2005-03-10 |
2023-08-12 |
mouse |
| Robert J McKallip, Michael Fisher, Ursula Gunthert, Andras K Szakal, Prakash S Nagarkatti, Mitzi Nagarkatt. Role of CD44 and its v7 isoform in staphylococcal enterotoxin B-induced toxic shock: CD44 deficiency on hepatic mononuclear cells leads to reduced activation-induced apoptosis that results in increased liver damage. Infection and immunity. vol 73. issue 1. 2005-01-12. PMID:15618140. |
furthermore, liver mononuclear cells from cd44 ko mice were resistant to seb-induced apoptosis, and cdna microarray analysis revealed that seb activation of such cells led to the induction of several antiapoptotic genes and repression of proapoptotic genes. |
2005-01-12 |
2023-08-12 |
mouse |
| Britta Siegmund, Joseph A Sennello, Hans A Lehr, Arvind Batra, Inka Fedke, Martin Zeitz, Giamila Fantuzz. Development of intestinal inflammation in double IL-10- and leptin-deficient mice. Journal of leukocyte biology. vol 76. issue 4. 2004-11-09. PMID:15240754. |
conversely, rates of apoptosis were higher in lamina propria lymphocytes obtained from the colon of il-10 ko ob/ob compared with il-10 ko mice. |
2004-11-09 |
2023-08-12 |
mouse |
| Antonio Ciaramella, Anna Cavone, Marilina B Santucci, Sanjay K Garg, Nunzia Sanarico, Marialuisa Bocchino, Domenico Galati, Angelo Martino, Giovanni Auricchio, Melania D'Orazio, Graham R Stewart, Olivier Neyrolles, Douglas B Young, Vittorio Colizzi, Maurizio Frazian. Induction of apoptosis and release of interleukin-1 beta by cell wall-associated 19-kDa lipoprotein during the course of mycobacterial infection. The Journal of infectious diseases. vol 190. issue 6. 2004-10-07. PMID:15319868. |
purified mycobacterial 19-kda lipoprotein, 19-kda lipoprotein-expressing m. smegmatis (m. smegmatis 19+), 19-kda lipoprotein knockout (ko) m. tuberculosis, and 19-kda lipoprotein ko m. bovis bacille calmette-guerin (bcg) strains were analyzed for their ability to induce apoptosis in mdms. |
2004-10-07 |
2023-08-12 |
human |
| Antonio Ciaramella, Anna Cavone, Marilina B Santucci, Sanjay K Garg, Nunzia Sanarico, Marialuisa Bocchino, Domenico Galati, Angelo Martino, Giovanni Auricchio, Melania D'Orazio, Graham R Stewart, Olivier Neyrolles, Douglas B Young, Vittorio Colizzi, Maurizio Frazian. Induction of apoptosis and release of interleukin-1 beta by cell wall-associated 19-kDa lipoprotein during the course of mycobacterial infection. The Journal of infectious diseases. vol 190. issue 6. 2004-10-07. PMID:15319868. |
m. tuberculosis and bcg ko strains had significantly decreased abilities to induce apoptosis. |
2004-10-07 |
2023-08-12 |
human |
| Lisa E Morrison, Ross J Whittaker, Robert E Klepper, Eric F Wawrousek, Christopher C Glembotsk. Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model. American journal of physiology. Heart and circulatory physiology. vol 286. issue 3. 2004-04-01. PMID:14592939. |
isolated perfused ko mouse hearts displayed normal contractility; however, when compared with wt, after i/r, ko mouse hearts exhibited a twofold reduction in contractile recovery, as well as increased necrosis and apoptosis. |
2004-04-01 |
2023-08-12 |
mouse |
| Kah M Lim, Wee S Yeo, Vincent T K Cho. Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle. International journal of cancer. vol 109. issue 1. 2004-03-12. PMID:14735464. |
compared to wild-type murine embryonic fibroblasts, antisense treatment of nfkappab and tnfr1 ko cells resulted in markedly more pronounced cell death, whereas antisense-treated tnfalpha and tnfr2 knockouts exhibited less prominent apoptosis. |
2004-03-12 |
2023-08-12 |
mouse |
| Joji Kotani, Nicholas J Avallone, Edward Lin, Masahiro Goshima, Kishor Gandhi, Stephen F Lowry, Steve E Calvan. Fas-mediated neutrophil apoptosis and associated A1 protein expression during systemic inflammation are regulated independently of both tumor necrosis factor receptors. Shock (Augusta, Ga.). vol 19. issue 3. 2003-10-15. PMID:12630518. |
j+c-induced apoptosis was inhibited similarly in all the lps-injected wt and ko mice. |
2003-10-15 |
2023-08-12 |
mouse |
| Yong Song, Yi Shi, Alden H Harken, Xianzhong Men. Induction of type II alveolar epithelial cells apoptosis in mouse by lipopolysaccharide does not require TNF-alpha. Chinese medical journal. vol 116. issue 4. 2003-08-21. PMID:12875736. |
to examine whether lipopolysaccharide (lps)-induced apoptosis correlates with tnf-alpha release by type ii alveolar epithelial cells (aec ii), whether tnf-alpha knockout (tnf ko) abrogates the induction of apoptosis by lps and whether tnf-alpha is sufficient to induce apoptosis in this cell type. |
2003-08-21 |
2023-08-12 |
mouse |
| H Koike, T Kanda, H Sumino, T Yokoyama, M Arai, M Motooka, T Suzuki, J Tamura, I Kobayash. Reduction of viral myocarditis in mice lacking perforin. Research communications in molecular pathology and pharmacology. vol 110. issue 3-4. 2003-06-03. PMID:12760490. |
to investigate whether mice lacking perforin have enhanced severity of viral myocarditis and acceleration of myocardial apoptosis, perforin knockout (ko) mice were infected with encephalomyocarditis virus. |
2003-06-03 |
2023-08-12 |
mouse |
| JoEllen Welsh, Jennifer A Wietzke, Glendon M Zinser, Sarah Smyczek, Saara Romu, Emily Tribble, Jennifer C Welsh, Belinda Byrne, Carmen J Narvae. Impact of the Vitamin D3 receptor on growth-regulatory pathways in mammary gland and breast cancer. The Journal of steroid biochemistry and molecular biology. vol 83. issue 1-5. 2003-05-23. PMID:12650704. |
in addition, involution after weaning, a process driven by epithelial cell apoptosis, proceeds at a slower rate in vdr ko mice compared to wt mice. |
2003-05-23 |
2023-08-12 |
mouse |
| Juan Arredondo, Vu Thuong Nguyen, Alexander I Chernyavsky, Dani Bercovich, Avi Orr-Urtreger, Douglas E Vetter, Sergei A Grand. Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis. Life sciences. vol 72. issue 18-19. 2003-04-04. PMID:12628457. |
we studied in vitro effects of functional inactivation of alpha7 receptor on the expression of apoptosis regulators in keratinocytes (kc) lacking alpha7 nachr, and extracellular matrix regulators in the skin of alpha7 knockout (ko) mice. |
2003-04-04 |
2023-08-12 |
mouse |
| Robert J McKallip, Yoon Do, Michael T Fisher, John L Robertson, Prakash S Nagarkatti, Mitzi Nagarkatt. Role of CD44 in activation-induced cell death: CD44-deficient mice exhibit enhanced T cell response to conventional and superantigens. International immunology. vol 14. issue 9. 2003-04-02. PMID:12202399. |
in a model examining in vitro aicd, splenocytes from cd44 ko mice showed resistance to tcr-mediated apoptosis when compared to splenocytes from cd44 wild-type mice. |
2003-04-02 |
2023-08-12 |
mouse |