| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Boyi Gan, Xu Peng, Tamas Nagy, Ana Alcaraz, Hua Gu, Jun-Lin Gua. Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. The Journal of cell biology. vol 175. issue 1. 2006-11-28. PMID:17015619. |
consistent with this, fip200 ko mouse embryo fibroblasts and liver cells showed increased apoptosis and reduced c-jun n-terminal kinase phosphorylation in response to tumor necrosis factor (tnf) alpha stimulation, which might be mediated by fip200 interaction with apoptosis signal-regulating kinase 1 (ask1) and tnf receptor-associated factor 2 (traf2), regulation of traf2-ask1 interaction, and ask1 phosphorylation. |
2006-11-28 |
2023-08-12 |
mouse |
| Laura Faulconer, Iris Camacho, Mitzi Nagarkatti, Prakash S Nagarkatt. Superantigen-primed T cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) replicate poorly following recall encounter. Archives of toxicology. vol 80. issue 3. 2006-09-08. PMID:16189661. |
using ahr knockout (ko) mice, we found ahr involvement in the regulation of defective cell division and apoptosis induced by tcdd. |
2006-09-08 |
2023-08-12 |
mouse |
| b' Zolt\\xc3\\xa1n H N\\xc3\\xa9meth, Bal\\xc3\\xa1zs Cs\\xc3\\xb3ka, Jeanette Wilmanski, Dazhong Xu, Qi Lu, Catherine Ledent, Edwin A Deitch, P\\xc3\\xa1l Pacher, Zolt\\xc3\\xa1n Spolarics, Gy\\xc3\\xb6rgy Hask\\xc3\\xb. Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis. Journal of immunology (Baltimore, Md. : 1950). vol 176. issue 9. 2006-06-06. PMID:16622031.' |
apoptosis was attenuated in the spleen of a(2a) ko mice indicating preserved lymphocyte function. |
2006-06-06 |
2023-08-12 |
mouse |
| Manling Zhang, Sun-Mi Park, Yue Wang, Ramila Shah, Ni Liu, Andrea E Murmann, Chyung-Ru Wang, Marcus E Peter, Philip G Ashton-Rickard. Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules. Immunity. vol 24. issue 4. 2006-05-26. PMID:16618603. |
infection with either lymphocytic choriomeningitis virus (lcmv) or listeria monocytogenes (lm) revealed increased apoptosis and diminished survival of spi6 knockout (ko) ctls, which was cell autonomous and could be corrected by grb deficiency. |
2006-05-26 |
2023-08-12 |
mouse |
| Manling Zhang, Sun-Mi Park, Yue Wang, Ramila Shah, Ni Liu, Andrea E Murmann, Chyung-Ru Wang, Marcus E Peter, Philip G Ashton-Rickard. Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules. Immunity. vol 24. issue 4. 2006-05-26. PMID:16618603. |
spi6 ko ctls revealed a breakdown in the integrity of cytotoxic granules, increased cytoplasmic grb, and ensuing apoptosis. |
2006-05-26 |
2023-08-12 |
mouse |
| Timothy D O'Connell, Philip M Swigart, M C Rodrigo, Shinji Ishizaka, Shuji Joho, Lynne Turnbull, Laurence H Tecott, Anthony J Baker, Elyse Foster, William Grossman, Paul C Simpso. Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. The Journal of clinical investigation. vol 116. issue 4. 2006-05-16. PMID:16585965. |
however, ko hearts after tac had increased interstitial fibrosis, increased apoptosis, and failed induction of the fetal hypertrophic genes. |
2006-05-16 |
2023-08-12 |
mouse |
| Timothy D O'Connell, Philip M Swigart, M C Rodrigo, Shinji Ishizaka, Shuji Joho, Lynne Turnbull, Laurence H Tecott, Anthony J Baker, Elyse Foster, William Grossman, Paul C Simpso. Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. The Journal of clinical investigation. vol 116. issue 4. 2006-05-16. PMID:16585965. |
before tac, isolated ko myocytes were more susceptible to apoptosis after oxidative and beta-ar stimulation, and beta-ars were desensitized. |
2006-05-16 |
2023-08-12 |
mouse |
| Demet Tekin, Lei Xi, Rakesh C Kukrej. Genetic deletion of fas receptors or Fas ligands does not reduce infarct size after acute global ischemia-reperfusion in isolated mouse heart. Cell biochemistry and biophysics. vol 44. issue 1. 2006-04-05. PMID:16456239. |
in conclusion, contrary to our original hypothesis, the present study in the gene ko mice suggests that the fas ligand- and fas receptor-mediated death receptor pathway of apoptosis is not the primary determinant of myocardial infarct size and ventricular dysfunction caused by acute global i-r injury in the isolated perfused mouse heart. |
2006-04-05 |
2023-08-12 |
mouse |
| Chikako Harada, Kazuaki Nakamura, Kazuhiko Namekata, Akinori Okumura, Yoshinori Mitamura, Yoko Iizuka, Kenji Kashiwagi, Kazuhiko Yoshida, Shigeaki Ohno, Atsushi Matsuzawa, Kohichi Tanaka, Hidenori Ichijo, Takayuki Harad. Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo. The American journal of pathology. vol 168. issue 1. 2006-03-23. PMID:16400028. |
in the present study, we used ask1 knockout (ko) mice to examine the possibility that ask1 is involved in the neural cell apoptosis that occurs during retinal development and ischemic injury. |
2006-03-23 |
2023-08-12 |
mouse |
| Chikako Harada, Kazuaki Nakamura, Kazuhiko Namekata, Akinori Okumura, Yoshinori Mitamura, Yoko Iizuka, Kenji Kashiwagi, Kazuhiko Yoshida, Shigeaki Ohno, Atsushi Matsuzawa, Kohichi Tanaka, Hidenori Ichijo, Takayuki Harad. Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo. The American journal of pathology. vol 168. issue 1. 2006-03-23. PMID:16400028. |
interestingly, ischemia-induced phosphorylation of p38 mitogen-activated protein kinase (p38), which mediates rgc apoptosis, was almost completely suppressed in ask1 ko mice. |
2006-03-23 |
2023-08-12 |
mouse |
| Chikako Harada, Kazuaki Nakamura, Kazuhiko Namekata, Akinori Okumura, Yoshinori Mitamura, Yoko Iizuka, Kenji Kashiwagi, Kazuhiko Yoshida, Shigeaki Ohno, Atsushi Matsuzawa, Kohichi Tanaka, Hidenori Ichijo, Takayuki Harad. Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo. The American journal of pathology. vol 168. issue 1. 2006-03-23. PMID:16400028. |
furthermore, cultured rgcs from ask1 ko mice were resistant to h(2)o(2)-induced apoptosis. |
2006-03-23 |
2023-08-12 |
mouse |
| Gusheng Wu, Zi-Hua Lu, Jianfeng Wang, Yvette Wang, Xin Xie, Markus F Meyenhofer, Robert W Ledee. Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 47. 2006-03-07. PMID:16306414. |
nissl staining and terminal deoxynucleotidyl transferase-mediated biotinylated utp nick end labeling assay revealed substantial deterioration of pyramidal neurons attributable to apoptosis in the ko hippocampus, especially the ca3 region. |
2006-03-07 |
2023-08-12 |
mouse |
| Zhi Liu, Minglang Zhao, Ning Li, Luis A Diaz, Tanya N Mayada. Differential roles for beta2 integrins in experimental autoimmune bullous pemphigoid. Blood. vol 107. issue 3. 2006-03-02. PMID:16234355. |
however, more neutrophils accumulated in the skin of mac-1 ko mice compared with wt mice at early time points (2-4 hours), which was associated with an increase in their survival as determined by apoptosis markers. |
2006-03-02 |
2023-08-12 |
mouse |
| Caius G Radu, Donghui Cheng, Amar Nijagal, Mireille Riedinger, Jami McLaughlin, Li V Yang, James Johnson, Owen N Witt. Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor. Molecular and cellular biology. vol 26. issue 2. 2006-02-13. PMID:16382156. |
furthermore, tdag8 ko thymocytes showed normal apoptosis following in vivo and in vitro gc treatment. |
2006-02-13 |
2023-08-12 |
mouse |
| Francisca Diaz, Christine K Thomas, Sofia Garcia, Dayami Hernandez, Carlos T Morae. Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency. Human molecular genetics. vol 14. issue 18. 2006-02-10. PMID:16103131. |
surprisingly, even though cox activity in cox10 ko muscles was <5% of control muscle at 2.5 months, these muscles were still able to contract at 80-100% of control maximal forces and showed only a 10% increase in fatigability, and no signs of oxidative damage or apoptosis were detected. |
2006-02-10 |
2023-08-12 |
mouse |
| Rahul Sharma, Harini Bagavant, Wael N Jarjour, Sun-Sang J Sung, Shyr-Te J. The role of Fas in the immune system biology of IL-2R alpha knockout mice: interplay among regulatory T cells, inflammation, hemopoiesis, and apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 175. issue 3. 2005-10-26. PMID:16034141. |
our age-dependent, lifelong analysis of il-2ralpha ko and dm mice supports a cd4+cd25+ treg cell-based mechanism for the abnormal immune system biology observed in il-2ralpha ko mice and provides a global view of the interplays among treg cells, multiorgan inflammation, hemopoiesis, and apoptosis. |
2005-10-26 |
2023-08-12 |
mouse |
| Meredith N Mann-Chandler, Mohit Kashyap, Harry V Wright, Farnaz Norozian, Brian O Barnstein, Sébastien Gingras, Evan Parganas, John J Rya. IFN-gamma induces apoptosis in developing mast cells. Journal of immunology (Baltimore, Md. : 1950). vol 175. issue 5. 2005-10-14. PMID:16116187. |
bone marrow cells from socs-1 knockout (ko) mice failed to give rise to viable mast cells after culture in il-3 plus stem cell factor, with profound apoptosis occurring as the cultures matured. |
2005-10-14 |
2023-08-12 |
mouse |
| Joao T Marques, Dominique Rebouillat, Chilakamarti V Ramana, Junko Murakami, Jason E Hill, Andrei Gudkov, Robert H Silverman, George R Stark, Bryan R G William. Down-regulation of p53 by double-stranded RNA modulates the antiviral response. Journal of virology. vol 79. issue 17. 2005-09-29. PMID:16103161. |
moreover, in wt cells the onset of dsrna-induced apoptosis begins after p53 levels are down-regulated, whereas p53 ko cells, which lack the early-g(1) arrest, rapidly undergo apoptosis. |
2005-09-29 |
2023-08-12 |
human |
| Yukitaka Shizukuda, Satoaki Matoba, Omar Y Mian, Tammy Nguyen, Paul M Hwan. Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice. Molecular and cellular biochemistry. vol 273. issue 1-2. 2005-09-13. PMID:16013437. |
apoptosis of cardiac myocytes as measured by the tunel and ligase reactions were significantly increased at 24 h after dox treatment in wt mice but not in p53 ko mice. |
2005-09-13 |
2023-08-12 |
mouse |
| Iris A Camacho, Narendra Singh, Venkatesh L Hegde, Mitzi Nagarkatti, Prakash S Nagarkatt. Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin leads to aryl hydrocarbon receptor-dependent nuclear translocation of NF-kappaB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells. Journal of immunology (Baltimore, Md. : 1950). vol 175. issue 1. 2005-08-31. PMID:15972635. |
ahr knockout (ko) mice were resistant to tcdd-induced thymic atrophy and apoptosis when compared with the ahr wild-type mice. |
2005-08-31 |
2023-08-12 |
mouse |