| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Larissa G de Vicente, Vitor R Muñoz, Ana P Pinto, Rafael L Rovina, Alisson L da Rocha, Bruno B Marafon, Maria Eduarda de A Tavares, Giovana R Teixeira, Gustavo D Ferrari, Luciane C Alberici, Fabiani G Frantz, Fernando M Simabuco, Eduardo R Ropelle, Leandro P de Moura, Dennys E Cintra, José R Pauli, Adelino S R da Silv. TLR4 deletion increases basal energy expenditure and attenuates heart apoptosis and ER stress but mitigates the training-induced cardiac function and performance improvement. Life sciences. vol 285. 2021-11-15. PMID:34592238. |
the tlr4 ko mice had higher energy expenditure and heart rate in the control state but lower activation of apoptosis and er stress pathways. |
2021-11-15 |
2023-08-13 |
mouse |
| Christina Nadolny, Xinmu Zhang, Qiwen Chen, Syed F Hashmi, Winifer Ali, Christopher Hemme, Nagib Ahsan, Yuan Chen, Ruitang Den. Dysregulation and activities of ubiquitin specific peptidase 2b in the pathogenesis of hepatocellular carcinoma. American journal of cancer research. vol 11. issue 10. 2021-11-13. PMID:34765291. |
unbiased proteomic analysis of usp2-knockout (ko) and parental hepg2 cells resulted in identification of usp2-regulated downstream target proteins involved in cell proliferation, apoptosis, and tumorigenesis, including serine/threonine kinase 4 (stk4), epidermal growth factor receptor (egfr), dipeptidyl peptidase 4 (dpp4) and fatty acid binding protein 1 (fabp1). |
2021-11-13 |
2023-08-13 |
mouse |
| Yuan Liu, Shi Xu, Haijun Zhang, Kaoliang Qian, Jiachen Huang, Xianger Gu, Yan Li, Yi Fan, Jun H. Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis. Cell death & disease. vol 12. issue 5. 2021-10-14. PMID:33953172. |
unlike in vivo studies, we found that primary chondrocytes from α7-nachrs knockout (ko) mice showed decreased lc3 levels under normal conditions and were more sensitive toward mia-induced apoptosis. |
2021-10-14 |
2023-08-13 |
mouse |
| Yong Sook Kim, Hyang Hee Cho, Dong Im Cho, Hye-Yun Jeong, Soo Yeon Lim, Ju Hee Jun, Mi Ra Kim, Bo Gyeong Kang, Meeyoung Cho, Hye-Jin Kang, Wan Seok Kang, Goo Taeg Oh, Youngkeun Ah. The adipokine Retnla deficiency increases responsiveness to cardiac repair through adiponectin-rich bone marrow cells. Cell death & disease. vol 12. issue 4. 2021-10-13. PMID:33753732. |
angiogenesis was substantially increased in the ko mice, and cardiomyocyte apoptosis was markedly suppressed in the ko mice. |
2021-10-13 |
2023-08-13 |
mouse |
| Dong-Hyun Kim, Jung Sun Park, Hoon-In Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Ki. The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD. Cell death & disease. vol 12. issue 4. 2021-10-13. PMID:33767132. |
here, using farnesoid x receptor (fxr) knockout (ko) mice, we determined whether fxr prevents the progression of aki to ckd after renal ischemic-reperfusion (such as i/r) injury through the regulation of renal autophagy and apoptosis. |
2021-10-13 |
2023-08-13 |
mouse |
| Silas A Culver, Safia Akhtar, Callie Rountree-Jablin, Susanna R Keller, Helen P Cathro, John J Gildea, Helmy M Sirag. Knockout of Nephron ATP6AP2 Impairs Proximal Tubule Function and Prevents High-Fat Diet-Induced Obesity in Male Mice. Endocrinology. vol 162. issue 12. 2021-10-08. PMID:34534267. |
atp6ap2 ko showed greater levels of proximal tubule apoptosis and histologic evidence of proximal tubule injury. |
2021-10-08 |
2023-08-13 |
mouse |
| Tianshi Sun, Qing Liu, Yifan Wang, Youwen Deng, Dongshan Zhan. MBD2 mediates renal cell apoptosis via activation of Tox4 during rhabdomyolysis-induced acute kidney injury. Journal of cellular and molecular medicine. vol 25. issue 10. 2021-10-04. PMID:33764669. |
mbd2 inhibition via mbd2 small interfering rna and mbd2-knockout (ko) attenuated rm-induced aki and renal cell apoptosis. |
2021-10-04 |
2023-08-13 |
mouse |
| Carol A Casey, Amanda J Macke, Ryan R Gough, Artem N Pachikov, Mary E Morris, Paul G Thomes, Jacy L Kubik, Melissa S Holzapfel, Armen Petrosya. Alcohol-Induced Liver Injury: Down-regulation and Redistribution of Rab3D Results in Atypical Protein Trafficking. Hepatology communications. 2021-09-29. PMID:34494400. |
in rab3d ko mice, hepatocytes experience endoplasmic reticulum (er) stress, and etoh administration activates apoptosis. |
2021-09-29 |
2023-08-13 |
mouse |
| Handan Emisoglu-Kulahli, Seref Gul, Hande Morgil, Onur Ozcan, Fatih Aygenli, Saba Selvi, Ibrahim Halil Kavakli, Nuri Oztur. Transcriptome analysis of the circadian clock gene BMAL1 deletion with opposite carcinogenic effects. Functional & integrative genomics. vol 21. issue 1. 2021-09-27. PMID:33111200. |
in this study, an rna-seq approach was taken to uncover the differentially expressed genes (degs) and pathways after treating bmal1 knockout (ko) or wild-type (wt) mda-mb-231 cells with cisplatin and doxorubicin to initiate apoptosis. |
2021-09-27 |
2023-08-13 |
Not clear |
| Seiya Oura, Takayuki Koyano, Chisato Kodera, Yuki Horisawa-Takada, Makoto Matsuyama, Kei-Ichiro Ishiguro, Masahito Ikaw. KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice. PLoS genetics. vol 17. issue 5. 2021-09-22. PMID:33961623. |
phenotyping of zfp541 ko spermatocytes demonstrated xy chromosome asynapsis and recurrent dna damage in the late pachytene stage, leading to apoptosis. |
2021-09-22 |
2023-08-13 |
mouse |
| Hongtao Shen, Jing Li, Tyler Heisler-Taylor, Ryan Makin, Huan Yang, Timur A Mavlyutov, Bradley Gelfand, Colleen M Cebulla, Lian-Wang Gu. TMEM97 ablation aggravates oxidant-induced retinal degeneration. Cellular signalling. vol 86. 2021-08-30. PMID:34245862. |
in vitro, sodium iodate treatment of crispr-mediated tmem97 ko rpe cells resulted in diminished abundance of the master antioxidant transcription factor nrf2 and its target gene product sod2, the mitochondrial superoxide dismutase, as well as elevated ros and apoptosis markers. |
2021-08-30 |
2023-08-13 |
mouse |
| Kexiong Zhang, Lihui Wang, Hao Chen, Yao Shi, Yingying Liu, Jun Liu, Xiaojing Hong, Jun-Ping Li. Pulmonary alveolar stem cells undergo senescence, apoptosis and differentiation by p53-dependent and -independent mechanisms in telomerase deficient mice. Clinical and experimental pharmacology & physiology. vol 48. issue 5. 2021-08-27. PMID:33634502. |
the present study shows that pulmonary alveolar epithelial type 2 cells (aec2) (alveolar stem cells) undergo not only replicative senescence, but also apoptosis and differentiation in association with increased innate immune natural killer (nk) cells in telomerase knockout (ko) mice. |
2021-08-27 |
2023-08-13 |
mouse |
| Mariana Bonjiorno Martins, Arina Marina Perez, Vilhelm A Bohr, David M Wilson, Jörg Kobar. NEK1 deficiency affects mitochondrial functions and the transcriptome of key DNA repair pathways. Mutagenesis. vol 36. issue 3. 2021-08-12. PMID:33740813. |
our studies revealed that nek1 ko cells resulted in increased apoptosis and hypersensitivity to the alkylator methyl methanesulfonate, the radiomimetic bleomycin and uvc light, yet increased resistance to the crosslinker cisplatin. |
2021-08-12 |
2023-08-13 |
Not clear |
| Wei-Ning Kong, Wen Li, Chun Bai, Yuan Dong, Yuan Wu, Wei A. Augmenter of liver regeneration-mediated mitophagy protects against hepatic ischemia/reperfusion injury. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2021-08-05. PMID:34242470. |
mfn2 administration prevented the inhibition of mitophagy in alr-knockout (ko) cells, thus attenuated mitochondrial dysfunction and cell apoptosis. |
2021-08-05 |
2023-08-13 |
mouse |
| Anahita Shahraz, Jannis Wißfeld, Aurélien Ginolhac, Mona Mathews, Lasse Sinkkonen, Harald Neuman. Phagocytosis-related NADPH oxidase 2 subunit gp91phox contributes to neurodegeneration after repeated systemic challenge with lipopolysaccharides. Glia. vol 69. issue 1. 2021-07-28. PMID:32721081. |
transcriptome analysis by rna-seq of total brain tissue indicated increased lps-induced upregulation of genes belonging to the reactive oxygen species and reactive nitrogen species production, complement and lysosome activation as well as apoptosis and necroptosis in wt compared to nox-2 ko mice. |
2021-07-28 |
2023-08-13 |
mouse |
| Naoki Mizutani, Hayato Hikita, Yoshinobu Saito, Yuta Myojin, Katsuhiko Sato, Makiko Urabe, Tomohide Kurahashi, Yuto Shiode, Sadatsugu Sakane, Kazuhiro Murai, Yasutoshi Nozaki, Takahiro Kodama, Ryotaro Sakamori, Yuichi Yoshida, Tomohide Tatsumi, Tetsuo Takehar. Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis, and tumorigenesis. American journal of physiology. Gastrointestinal and liver physiology. vol 320. issue 6. 2021-07-26. PMID:33787344. |
p35-gab1 was also detected in the livers of mice with hepatocyte-specific mcl-1 knockout (ko), which causes persistent hepatocyte apoptosis. |
2021-07-26 |
2023-08-13 |
mouse |
| Naoki Mizutani, Hayato Hikita, Yoshinobu Saito, Yuta Myojin, Katsuhiko Sato, Makiko Urabe, Tomohide Kurahashi, Yuto Shiode, Sadatsugu Sakane, Kazuhiro Murai, Yasutoshi Nozaki, Takahiro Kodama, Ryotaro Sakamori, Yuichi Yoshida, Tomohide Tatsumi, Tetsuo Takehar. Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis, and tumorigenesis. American journal of physiology. Gastrointestinal and liver physiology. vol 320. issue 6. 2021-07-26. PMID:33787344. |
gab1 deficiency exacerbated hepatocyte apoptosis in mcl-1 ko mice with posttranscriptional downregulation of bcl-xl. |
2021-07-26 |
2023-08-13 |
mouse |
| Yong-Jun Ji, Yang Shao, Jie Zhang, Xu Zhang, Ping Qian. Bromodomain-containing protein 4 silencing by microRNA-765 produces anti-ovarian cancer cell activity. Aging. vol 13. issue 6. 2021-07-20. PMID:33686960. |
moreover, crispr/cas9-induced brd4 knockout (ko)inhibited proliferation and activated apoptosis in ovarian cancer cells. |
2021-07-20 |
2023-08-13 |
human |
| Li Sun, Ruili Han, Fei Guo, Hai Chen, Wen Wang, Zhiyang Chen, Wei Liu, Xude Sun, Changjun Ga. Antagonistic effects of IL-17 and Astragaloside IV on cortical neurogenesis and cognitive behavior after stroke in adult mice through Akt/GSK-3β pathway. Cell death discovery. vol 6. 2021-07-15. PMID:32818074. |
furthermore, il-17 ko mice and as-iv were used simultaneously to evaluate the mechanism of cell apoptosis and proliferation after stroke in vivo. |
2021-07-15 |
2023-08-13 |
mouse |
| Kang Han, Xiaofang Jin, Xin Guo, Guoli Cao, Siyu Tian, Yiming Song, Yuanyuan Zuo, Peng Yu, Guofen Gao, Yan-Zhong Chan. Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice. Free radical biology & medicine. vol 162. 2021-06-18. PMID:33248265. |
in contrast to the predicted neuroprotective role of nrf2 in oxidative stress-related diseases, we found that nrf2 ko remarkably improved the motor coordination of aged mice, which was associated with the reduced ros level and decreased apoptosis of dopaminergic neurons in substantia nigra (sn) of 18-month-old nrf2 ko mice. |
2021-06-18 |
2023-08-13 |
mouse |