| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Ye, Yuan Wang, Zhen Wang, Ling Liu, Zicong Yang, Di Ye, Menglong Wang, Yao Xu, Jishou Zhang, Mengmeng Zhao, Jianfang Liu, Yingzhong Lin, Qingwei Ji, Jun Wa. Interleukin-12p35 deficiency enhances mitochondrial dysfunction and aggravates cardiac remodeling in aging mice. Aging. vol 12. issue 1. 2021-01-08. PMID:31901899. |
furthermore, reduced mitochondrial complex (i-iv) activity and atp levels and increased apoptosis-inducing factor (aif)-related cardiomyocyte apoptosis were observed in aged il-12p35 ko mice compared with wild-type mice. |
2021-01-08 |
2023-08-13 |
mouse |
| Jing Ye, Yuan Wang, Zhen Wang, Ling Liu, Zicong Yang, Di Ye, Menglong Wang, Yao Xu, Jishou Zhang, Mengmeng Zhao, Jianfang Liu, Yingzhong Lin, Qingwei Ji, Jun Wa. Interleukin-12p35 deficiency enhances mitochondrial dysfunction and aggravates cardiac remodeling in aging mice. Aging. vol 12. issue 1. 2021-01-08. PMID:31901899. |
our results demonstrate that aging is aggravated by il-12p35 ko and that the mechanism may be related to exacerbation of mitochondrial dysfunction and aif-related cardiomyocyte apoptosis. |
2021-01-08 |
2023-08-13 |
mouse |
| Hu Huang, Anton Lenniko. CXCR5/NRF2 double knockout mice develop retinal degeneration phenotype at early adult age. Experimental eye research. vol 196. 2021-01-08. PMID:32387618. |
the adult dko mice underwent photoreceptor cell apoptosis compared to the single cxcr5 and nrf2 ko and the wt mice at an early adult age. |
2021-01-08 |
2023-08-13 |
mouse |
| Tsai-Chun Lai, Tzu-Lin Lee, Yu-Chun Chang, Yu-Chen Chen, Shu-Rung Lin, Shu-Wha Lin, Chi-Ming Pu, Jaw-Shiun Tsai, Yuh-Lien Che. MicroRNA-221/222 Mediates ADSC-Exosome-Induced Cardioprotection Against Ischemia/Reperfusion by Targeting PUMA and ETS-1. Frontiers in cell and developmental biology. vol 8. 2020-12-22. PMID:33344446. |
we also observed that cardiac i/r operation markedly increased cell apoptosis and hypertrophy in mir-221/222 knockout (ko) mice, while adsc-exo reduced the effects of i/r operation. |
2020-12-22 |
2023-08-13 |
mouse |
| Wenfei Zhang, Qian Sun, Lingling Jia, Ming L. Ketamine exerts a protective role in a cell-based model of major depressive disorder via the inhibition of apoptosis and inflammation and activation of the Krebs cycle. Bosnian journal of basic medical sciences. vol 20. issue 1. 2020-12-18. PMID:31215856. |
ketamine significantly increased the viability and decreased the apoptosis of pc12 cells in kt and ki vs. nc group, but not in ko group. |
2020-12-18 |
2023-08-13 |
Not clear |
| Aeyung Kim, Seo-Young Lee, Chang-Seob Seo, Sun-Ku Chun. Prunellae Spica Extract Suppresses Teratoma Formation of Pluripotent Stem Cells through p53-Mediated Apoptosis. Nutrients. vol 12. issue 3. 2020-12-14. PMID:32182802. |
in p53 knockout (ko) ipscs, the eps did not induce apoptosis, indicating that eps-mediated apoptosis of uscs was p53-dependent. |
2020-12-14 |
2023-08-13 |
Not clear |
| Yun Jeong Lee, Eun-Young Lee, Bo Hee Choi, Hyonchol Jang, Jae-Kyung Myung, Hye Jin Yo. The Role of Nuclear Receptor Subfamily 1 Group H Member 4 (NR1H4) in Colon Cancer Cell Survival through the Regulation of c-Myc Stability. Molecules and cells. vol 43. issue 5. 2020-11-11. PMID:32299194. |
we generated nr1h4 knockout (ko) colon cancer cells using clustered regularly interspaced short palindromic repeats (crispr)-crispr-associated protein-9 nuclease (cas9) technology and explored the effects of nr1h4 ko in colon cancer cell proliferation, survival, and apoptosis. |
2020-11-11 |
2023-08-13 |
Not clear |
| Yun Jeong Lee, Eun-Young Lee, Bo Hee Choi, Hyonchol Jang, Jae-Kyung Myung, Hye Jin Yo. The Role of Nuclear Receptor Subfamily 1 Group H Member 4 (NR1H4) in Colon Cancer Cell Survival through the Regulation of c-Myc Stability. Molecules and cells. vol 43. issue 5. 2020-11-11. PMID:32299194. |
moreover, nr1h4 ko enhanced the anti-cancer effects of doxorubicin and cisplatin, supporting the role of myc in the enhanced apoptosis observed in nr1h4 ko cells. |
2020-11-11 |
2023-08-13 |
Not clear |
| Takashi Ohnishi, Katsuhisa Yamada, Koji Iwasaki, Takeru Tsujimoto, Hideaki Higashi, Taichi Kimura, Norimasa Iwasaki, Hideki Sud. Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging. Scientific reports. vol 9. issue 1. 2020-11-09. PMID:31852919. |
apoptosis was suppressed in the ivd cells of casp-3 ko mice, but cellular senescence was enhanced. |
2020-11-09 |
2023-08-13 |
mouse |
| Zhihao Zhang, Zhugui Chen, Ruimeng Liu, Qingchun Liang, Zhiyong Peng, Shuang Yin, Jing Tang, Ting Gong, Youtan Li. Bcl-2 Proteins Regulate Mitophagy in Lipopolysaccharide-Induced Acute Lung Injury via PINK1/Parkin Signaling Pathway. Oxidative medicine and cellular longevity. vol 2020. 2020-10-19. PMID:32148654. |
atg5 knockout (ko) inhibited lps-induced cell apoptosis. |
2020-10-19 |
2023-08-13 |
mouse |
| T Feng, J Dzieran, X Yuan, A Dropmann, T Maass, A Teufel, S Marhenke, T Gaiser, F Rückert, I Kleiter, S Kanzler, M P Ebert, A Vogel, P Ten Dijke, S Dooley, N M Meindl-Beinke. Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice. Oncogenesis. vol 6. issue 1. 2020-10-01. PMID:28134936. |
smad7 ko mice presented with increased psmad2/3 levels and decreased apoptosis in the tumor tissue. |
2020-10-01 |
2023-08-13 |
mouse |
| Cunzhi Yu, Yu Li, Mingxia Liu, Man Gao, Chenggang Li, Hong Yan, Chunzhu Li, Lihan Sun, Liying Mo, Chunyong Wu, Xinming Qi, Jin Re. Critical Role of Hepatic Cyp450s in the Testis-Specific Toxicity of (5R)-5-Hydroxytriptolide in C57BL/6 Mice. Frontiers in pharmacology. vol 8. 2020-10-01. PMID:29209210. |
compared to wild type (wt) mice, after lldt-8 treatment, ko mice suffered severe testicular toxicity (decreased testicular weight, spermatocytes apoptosis) unlike wt mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Wenyi Liu, Xue Li, Xi Chen, Jieqiong Zhang, Linlin Luo, Qiumei Hu, Jiaxing Zhou, Jun Yan, Sen Lin, Jian Y. JIP1 Deficiency Protects Retinal Ganglion Cells From Apoptosis in a Rotenone-Induced Injury Model. Frontiers in cell and developmental biology. vol 7. 2020-10-01. PMID:31681759. |
here, we used jip1 gene knockout (ko) mice to investigate the importance of jip1-jnk signaling in the apoptosis of rgcs in a rotenone-induced injury model. |
2020-10-01 |
2023-08-13 |
mouse |
| Kamalakshi Deka, Archana Singh, Surajit Chakraborty, Rupak Mukhopadhyay, Sougata Sah. Protein arginylation regulates cellular stress response by stabilizing HSP70 and HSP40 transcripts. Cell death discovery. vol 2. 2020-09-30. PMID:27752365. |
our findings suggest that ate1 knock out (ko) cells are more susceptible to heat stress compared with its wild-type counterparts due to the induction of apoptosis in ko cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zhongyang Gao, Cuiting Min, Huimin Xie, Jing Qin, Xijing He, Songlin Zho. TNFR2 knockdown triggers apoptosis-induced proliferation in primarily cultured Schwann cells. Neuroscience research. vol 150. 2020-09-30. PMID:30731109. |
additionally, we established the sciatic nerve injury model on tnf-α knock-out (ko) mice, and found that the schwann cells of ko mice occurred significantly less apoptosis and proliferation than that of wild-type mice in the distal segments, which indicated tnf-α and its receptors were essential in the massive apoptosis and the apoptosis-induced proliferation of schwann cells after sciatic nerve injury. |
2020-09-30 |
2023-08-13 |
mouse |
| Jennifer Kreckel, Mohammed A Anany, Daniela Siegmund, Harald Wajan. TRAF2 Controls Death Receptor-Induced Caspase-8 Processing and Facilitates Proinflammatory Signaling. Frontiers in immunology. vol 10. 2020-09-29. PMID:31555268. |
to prevent negative selection effects arising from the increased cell death sensitivity of traf2-deficient cells, cell lines were used for the generation of the traf2 ko variants that were protected from dr-induced apoptosis downstream of caspase-8 activation. |
2020-09-29 |
2023-08-13 |
Not clear |
| Zhen-Qi Qin, Qi-Guang Li, Hong Yi, Shan-Shan Lu, Wei Huang, Zhuo-Xian Rong, Yao-Yun Tang, Zhi-Qiang Xia. Heterozygous p53-R280T Mutation Enhances the Oncogenicity of NPC Cells Through Activating PI3K-Akt Signaling Pathway. Frontiers in oncology. vol 10. 2020-09-28. PMID:32117754. |
in this study, we generated p53 knockout (ko) npc cell lines from cne2 cells carrying heterozygous p53 r280t (p53-r280t) mutation and c666-1 cells carrying wild-type p53 by crispr-cas9 gene editing system, and found that ko of heterozygous p53-r280t significantly decreased npc cell proliferation and increased npc cell apoptosis, whereas ko of wild-type p53 had opposite effects on npc cell proliferation and apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ruinan Lu, Qian Wang, Jianyong Li, Dengshun Mia. P27 deletion enhances hematopoiesis by paracrine action of IL22 secreted from bone marrow mesenchymal stem cells. American journal of translational research. vol 12. issue 3. 2020-09-28. PMID:32269712. |
to answer this question, we cultured the bm-mscs from wild-type (wt) or p27 knockout (ko) mice, analyzed their proliferation, apoptosis and osteogenesis and harvested their conditioned medium (cm); we also cultured the bone marrow cells (bmcs) with normal medium or cm from wt or ko bm-mscs and analyzed changes of hscs and hpcs and colony forming cells (cfcs). |
2020-09-28 |
2023-08-13 |
mouse |
| Jingjing Ding, Yanfei Cong, Fang Li, Bo Liu, Di Wu, Jianing Miao, Lili Wan. Muscle death participates in myofibrillar abnormalities in FHL1 knockout mice. Biochemical and biophysical research communications. vol 523. issue 1. 2020-09-10. PMID:31836140. |
p2rx7 induces cell death, such as autophagy, pyroptosis or apoptosis via cell-specific downstream signaling; however, the roles of p2rx7 in pyroptosis or apoptosis in myofibrillar abnormalities in fhl1 ko mice have not been well elucidated. |
2020-09-10 |
2023-08-13 |
mouse |
| Ji Eun Kim, So Yeon Bae, Shin Young Ahn, Young Joo Kwon, Gang Jee K. The role of nuclear factor erythroid-2-related factor 2 expression in radiocontrast-induced nephropathy. Scientific reports. vol 9. issue 1. 2020-09-09. PMID:30796317. |
significant increases in apoptosis and f4/80(+) inflammatory cell infiltration were demonstrated in ko mice compared to wt mice. |
2020-09-09 |
2023-08-13 |
mouse |