| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao Qu, Xuebing Yan, Cheng Kong, Yin Zhu, Hao Li, Dengdeng Pan, Xiaohui Zhang, Yongqiang Liu, Fang Yin, Huanlong Qi. c-Myb promotes growth and metastasis of colorectal cancer through c-fos-induced epithelial-mesenchymal transition. Cancer science. vol 110. issue 10. 2019-10-11. PMID:31338937. |
c-myb ko inhibits the proliferation, apoptosis resistance, invasion, metastasis, colony formation and in vivo tumorigenesis of crc cells. |
2019-10-11 |
2023-08-13 |
Not clear |
| Takehiko Oami, Eizo Watanabe, Masahiko Hatano, Youichi Teratake, Lisa Fujimura, Akemi Sakamoto, Chizuru Ito, Kiyotaka Toshimori, Paul E Swanson, Shigeto Od. Blocking Liver Autophagy Accelerates Apoptosis and Mitochondrial Injury in Hepatocytes and Reduces Time to Mortality in a Murine Sepsis Model. Shock (Augusta, Ga.). vol 50. issue 4. 2019-10-07. PMID:29076973. |
additionally, we confirmed a significant increase in autophagic vacuoles in the control mice relative to ko mice; in contrast, cell shrinkage and nuclear fragmentation (morphological characteristics of apoptosis) were preferentially seen in the ko mice by transmission electron microscopy. |
2019-10-07 |
2023-08-13 |
mouse |
| Jee Hyun Kim, Jihye Kim, Jaeyoung Chun, Changhyun Lee, Jong Pil Im, Joo Sung Ki. Role of iRhom2 in intestinal ischemia-reperfusion-mediated acute lung injury. Scientific reports. vol 8. issue 1. 2019-09-16. PMID:29491382. |
after intestinal i/r, lungs from irhom2 ko mice showed significantly lower myeloperoxidase (mpo) activity and markedly reduced cell apoptosis associated with a decreased level of active caspase 3 and decreased tunel staining compared with lungs from wt mice. |
2019-09-16 |
2023-08-13 |
mouse |
| Qiong Wu, Jin-Xian Chen, Yu Chen, Li-Li Cai, Xiao-Zhong Wang, Wu-Hua Guo, Jian-Feng Zhen. The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation. Cell death & disease. vol 9. issue 2. 2019-09-11. PMID:29445190. |
transgenic ccr10-knockout (ccr10 ko) in den-treated mice significantly increased hepatocellular apoptosis levels and significantly lowered compensatory hepatocellular proliferation but did not affect upstream tnf expression. |
2019-09-11 |
2023-08-13 |
mouse |
| Ying Wang, Weina Chen, Chang Han, Jinqiang Zhang, Kyoungsub Song, Hyunjoo Kwon, Srikanta Dash, Lu Yao, Tong W. Adult Hepatocytes Are Hedgehog-Responsive Cells in the Setting of Liver Injury: Evidence for Smoothened-Mediated Activation of NF-κB/Epidermal Growth Factor Receptor/Akt in Hepatocytes that Counteract Fas-Induced Apoptosis. The American journal of pathology. vol 188. issue 11. 2019-08-30. PMID:30366594. |
on the other hand, the smo ko hepatocytes were devoid of hh activation and were more susceptible to jo2-induced apoptosis. |
2019-08-30 |
2023-08-13 |
mouse |
| Vincent Abramowski, Olivier Etienne, Ramy Elsaid, Junjie Yang, Aurélie Berland, Laetitia Kermasson, Benoit Roch, Stefania Musilli, Jean-Paul Moussu, Karelia Lipson-Ruffert, Patrick Revy, Ana Cumano, François D Boussin, Jean-Pierre de Villarta. PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice. Cell death and differentiation. vol 25. issue 2. 2019-08-19. PMID:29077092. |
in contrast, we show here that mice defective for both xlf and paxx are embryonically lethal owing to a massive apoptosis of post-mitotic neurons, a situation reminiscent to xrcc4 or dna ligase iv ko conditions. |
2019-08-19 |
2023-08-13 |
mouse |
| Heng Liu, Dong Ming Li, Lan Yu Zhu, Le Jin Lai, Wan Yun Yan, Yus Huang Lu, Yi Wei, Yue Qi Huang, Mei Fang, Yuan Gang Su, Fang Yang, Wei Sh. [Research on the knockout of LMNA gene by CRISPR/Cas9 system in human cell lines]. Yi chuan = Hereditas. vol 41. issue 1. 2019-08-13. PMID:30686786. |
compared to the respective wild type cells, the lmna ko cell lines showed decrease in proliferation ability, increase in apoptosis, alteration in cellular morphology and uneven structures in the nucleus membrane. |
2019-08-13 |
2023-08-13 |
human |
| Zuochuan Ding, Dunfeng Du, Yang Yang, Min Yang, Yan Miao, Zhimiao Zou, Xiaoqian Zhang, Zeyang Li, Xue Zhang, Limin Zhang, Xinqiang Wang, Yuanyuan Zhao, Jipin Jiang, Fengchao Jiang, Ping Zho. Short-term use of MyD88 inhibitor TJ-M2010-5 prevents d-galactosamine/lipopolysaccharide-induced acute liver injury in mice. International immunopharmacology. vol 67. 2019-05-09. PMID:30583234. |
these pathological results demonstrated that tj-m2010-5 and myd88 ko reduced the infiltration of inflammatory cells and protected hepatocytes against apoptosis. |
2019-05-09 |
2023-08-13 |
mouse |
| Yong Tang, Hailin Tu, Guangna Liu, Guoxing Zheng, Mingchao Wang, Lin Li, Xueqiang Zhao, Xin Li. RNF31 Regulates Skin Homeostasis by Protecting Epidermal Keratinocytes from Cell Death. Journal of immunology (Baltimore, Md. : 1950). vol 200. issue 12. 2019-04-08. PMID:29728512. |
the inflammation was mainly triggered by tnf-α-induced apoptosis in rnf31 ko keratinocytes. |
2019-04-08 |
2023-08-13 |
mouse |
| Hein Min Latt, Hiroaki Matsushita, Miku Morino, Yuuri Koga, Hiroyuki Michiue, Teiichi Nishiki, Kazuhito Tomizawa, Hideki Matsu. Oxytocin Inhibits Corticosterone-induced Apoptosis in Primary Hippocampal Neurons. Neuroscience. vol 379. 2019-03-18. PMID:29596965. |
ot was unable to protect primary hippocampal neurons prepared from otr ko mice from cort-induced apoptosis. |
2019-03-18 |
2023-08-13 |
mouse |
| Lukas Hofmann, Dorothea Hose, Anne Grießhammer, Robert Blum, Frank Döring, Sulayman Dib-Hajj, Stephen Waxman, Claudia Sommer, Erhard Wischmeyer, Nurcan Üçeyle. Characterization of small fiber pathology in a mouse model of Fabry disease. eLife. vol 7. 2019-03-11. PMID:30328411. |
α-gal deficient mice (gla ko) age-dependently accumulate globotriaosylceramide (gb3) in dorsal root ganglion (drg) neurons paralleled by endoplasmic stress and apoptosis as contributors to skin denervation. |
2019-03-11 |
2023-08-13 |
mouse |
| Xian-Qiang Ni, Wei-Wei Lu, Jin-Sheng Zhang, Qing Zhu, Jin-Ling Ren, Yan-Rong Yu, Xiu-Ying Liu, Xiu-Jie Wang, Mei Han, Qing Jing, Jie Du, Chao-Shu Tang, Yong-Fen Q. Inhibition of endoplasmic reticulum stress by intermedin1-53 attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE KO Mice. Endocrine. vol 62. issue 1. 2019-02-18. PMID:29943223. |
imd infusion promoted the phosphorylation of adenosine 5'-monophosphate (amp)-activated protein kinase (ampk) in aortas in apoe ko mice, and the ampk inhibitor compound c abolished the protective effect of imd on vsmc ers and apoptosis induced by angii. |
2019-02-18 |
2023-08-13 |
mouse |
| Yan Li, Jingjing Jiang, Wei Liu, Hui Wang, Lei Zhao, Shengnan Liu, Peng Li, Shengjie Zhang, Chao Sun, Yuting Wu, Shuxian Yu, Xihua Li, Hui Zhang, Haifeng Qian, Duo Zhang, Feifan Guo, Qiwei Zhai, Qiurong Ding, Li Wang, Hao Yin. microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 46. 2019-01-23. PMID:30373812. |
here, we show that mir-378/378* ko mice cannot maintain normal muscle weight and have poor running performance, which is accompanied by impaired autophagy, accumulation of abnormal mitochondria, and excessive apoptosis in skeletal muscle, whereas mir-378 overexpression is able to enhance autophagy and repress apoptosis in skeletal muscle of mice. |
2019-01-23 |
2023-08-13 |
mouse |
| Yan Yan, Yulan Qing, John J Pink, Stanton L Gerso. Loss of Uracil DNA Glycosylase Selectively Resensitizes p53-Mutant and -Deficient Cells to 5-FdU. Molecular cancer research : MCR. vol 16. issue 2. 2019-01-11. PMID:29117941. |
however, in p53 ko cells, apoptosis is compromised in udg-expressing cells, but dramatically elevated in udg-depleted cells. |
2019-01-11 |
2023-08-13 |
human |
| Kristina Rode, Karola Weider, Oliver Siegfried Damm, Joachim Wistuba, Marion Langeheine, Ralph Breh. Loss of connexin 43 in Sertoli cells provokes postnatal spermatogonial arrest, reduced germ cell numbers and impaired spermatogenesis. Reproductive biology. vol 18. issue 4. 2019-01-10. PMID:30243528. |
apoptosis was analyzed in both, ko and wild type (wt) male littermates during postnatal development and in adulthood using tunel. |
2019-01-10 |
2023-08-13 |
mouse |
| Anqi Chen, Jixi Li, Lesheng Song, Chaoneng Ji, Marion Böing, Jinzhong Chen, Beate Brand-Saber. GGNBP2 is necessary for testis morphology and sperm development. Scientific reports. vol 7. issue 1. 2019-01-09. PMID:28592902. |
in addition, increased apoptosis was observed in the testes of ggnbp2 ko mice. |
2019-01-09 |
2023-08-13 |
mouse |
| Robert Fuchs, Anika Stracke, Viktoria Holzmann, Gerfried Luschin-Ebengreuth, Nathalie Meier-Allard, Nadine Ebner, Teresa Maria Lassacher, Markus Absenger-Novak, Eleonore Fröhlich, Matthias Schittmayer, Sara Cano Crespo, Manuel Palacin, Beate Rinner, Ruth Birner-Gruenberge. Prazosin induced lysosomal tubulation interferes with cytokinesis and the endocytic sorting of the tumour antigen CD98hc. Biochimica et biophysica acta. Molecular cell research. vol 1865. issue 9. 2018-12-11. PMID:29909287. |
cd98hc ko cells showed reduced endoreplication capacity and lower sensitivity towards prz induced apoptosis than wild type cells. |
2018-12-11 |
2023-08-13 |
human |
| Ying-Qian Han, Sheng-Li Ming, Hong-Tao Wu, Lei Zeng, Gen Ba, Jian Li, Wei-Fei Lu, Jie Han, Qia-Jun Du, Miao-Miao Sun, Guo-Yu Yang, Jiang Wang, Bei-Bei Ch. Myostatin knockout induces apoptosis in human cervical cancer cells via elevated reactive oxygen species generation. Redox biology. vol 19. 2018-12-11. PMID:30241032. |
a knockout (ko) of mstn created by clustered regularly interspaced short palindromic repeats (crispr)/crispr-associated protein (cas) 9 (crispr/cas9) induced mitochondria-dependent apoptosis in hela cells. |
2018-12-11 |
2023-08-13 |
human |
| Ying-Qian Han, Sheng-Li Ming, Hong-Tao Wu, Lei Zeng, Gen Ba, Jian Li, Wei-Fei Lu, Jie Han, Qia-Jun Du, Miao-Miao Sun, Guo-Yu Yang, Jiang Wang, Bei-Bei Ch. Myostatin knockout induces apoptosis in human cervical cancer cells via elevated reactive oxygen species generation. Redox biology. vol 19. 2018-12-11. PMID:30241032. |
importantly, apoptosis induced by mstn ko was partially rescued by antioxidants and etomoxir, thereby suggesting that the increased level of ros was functionally involved in mediating apoptosis. |
2018-12-11 |
2023-08-13 |
human |
| Helen Baixia Hao, Sarah E Webb, Jianbo Yue, Marc Moreau, Catherine Leclerc, Andrew L Mille. TRPC3 is required for the survival, pluripotency and neural differentiation of mouse embryonic stem cells (mESCs). Science China. Life sciences. vol 61. issue 3. 2018-11-27. PMID:29392682. |
crispr/cas9-mediated knockout (ko) of trpc3 induced apoptosis and the disruption of mitochondrial membrane potential both in undifferentiated mescs and in those undergoing neural differentiation. |
2018-11-27 |
2023-08-13 |
mouse |