| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhu Meng, Mei-Yan Song, Chuan-Fang Li, Jia-Qi Zha. shRNA interference of NLRP3 inflammasome alleviate ischemia reperfusion-induced myocardial damage through autophagy activation. Biochemical and biophysical research communications. vol 494. issue 3-4. 2017-11-21. PMID:29069583. |
nonetheless, the elevated levels of myocardial enzymes, inflammatory factors and cell apoptosis caused by i/r injury were vastly inhibited in nlrp3 ko rats. |
2017-11-21 |
2023-08-13 |
rat |
| Qian-Shi Zhang, Deepa S Kurpad, My G Mahoney, Marla J Steinbeck, Theresa A Freema. Inhibition of apoptosis signal-regulating kinase 1 alters the wound epidermis and enhances auricular cartilage regeneration. PloS one. vol 12. issue 10. 2017-10-30. PMID:29045420. |
herein, we report that knockout (ko) or inhibition of apoptosis signal-regulated kinase-1 (ask1), also known as mitogen-activated protein kinase kinase kinase 5 (map3k5), after full thickness ear punch in mice prolongs keratinocyte activation within the wound epidermis and promotes regeneration of auricular cartilage. |
2017-10-30 |
2023-08-13 |
mouse |
| Long Shi, Tongyu Meng, Zhilong Zhao, Jinsheng Han, Wei Zhang, Fei Gao, Jianhui Ca. CRISPR knock out CTLA-4 enhances the anti-tumor activity of cytotoxic T lymphocytes. Gene. vol 636. 2017-10-18. PMID:28888577. |
ctla-4 ko ctls robustly enhanced tumor cell death by 40% compared to the control and facilitated apoptosis and caspase activities in tumor cells. |
2017-10-18 |
2023-08-13 |
mouse |
| Megha Dubey, Sheela Nagarkoti, Deepika Awasthi, Abhishek K Singh, Tulika Chandra, J Kumaravelu, Manoj K Barthwal, Madhu Dikshi. Nitric oxide-mediated apoptosis of neutrophils through caspase-8 and caspase-3-dependent mechanism. Cell death & disease. vol 7. issue 9. 2017-10-04. PMID:27584786. |
no-mediated augmentation of caspase-8 and bid cleavage was significantly prevented in bmdn from neutrophil cytosolic factor-1 (ncf-1) knockout (ko) mice, implying the involvement of nox2 in no-induced apoptosis of pmns. |
2017-10-04 |
2023-08-13 |
mouse |
| Megha Dubey, Sheela Nagarkoti, Deepika Awasthi, Abhishek K Singh, Tulika Chandra, J Kumaravelu, Manoj K Barthwal, Madhu Dikshi. Nitric oxide-mediated apoptosis of neutrophils through caspase-8 and caspase-3-dependent mechanism. Cell death & disease. vol 7. issue 9. 2017-10-04. PMID:27584786. |
impaired apoptosis of bmdn from inos ko mice was due to reduced caspase-8 activity which subsequently prevented caspase-3 and -9 activation. |
2017-10-04 |
2023-08-13 |
mouse |
| Yoko Yoshihisa, Mati Ur Rehman, Takashi Kondo, Tadamichi Shimiz. Role of macrophage migration inhibitory factor in heat-induced apoptosis in keratinocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 11. 2017-09-21. PMID:27528627. |
here, we evaluated the effects of mif on hyperthermia (ht)-induced apoptosis in mif-deficient [knockout (ko)] and mif-transgenic (tg) mouse keratinocytes. |
2017-09-21 |
2023-08-13 |
mouse |
| Yang Sheng, Changfu Xu, Wenping Zen. TAB3 defect induces augmented cardioprotection loss from ischemic injury. Cell biology international. vol 41. issue 7. 2017-09-21. PMID:28462515. |
for in vitro studies, cardiomyocytes (cms) were isolated from both tab3 knockout (ko) and wild-type (wt) mice, and the apoptosis ratios were tested after a 48-h ischemic stimulation. |
2017-09-21 |
2023-08-13 |
mouse |
| Takeshi Matsui, Vanesa Nieto-Estévez, Sergii Kyrychenko, Jay W Schneider, Jenny Hsie. Retinoblastoma protein controls growth, survival and neuronal migration in human cerebral organoids. Development (Cambridge, England). vol 144. issue 6. 2017-09-11. PMID:28087635. |
knockout (ko) mice have shown that rb plays roles in cell migration, differentiation and apoptosis, in developing and adult brain. |
2017-09-11 |
2023-08-13 |
mouse |
| Victor H Leyva-Grado, Megan E Ermler, Michael Schotsaert, Ma G Gonzalez, Virginia Gillespie, Jean K Lim, Adolfo García-Sastr. Contribution of the Purinergic Receptor P2X7 to Development of Lung Immunopathology during Influenza Virus Infection. mBio. vol 8. issue 2. 2017-07-11. PMID:28351919. |
overall lung pathology and apoptosis were reduced in virus-infected ko mice. |
2017-07-11 |
2023-08-13 |
mouse |
| Per Flodby, Changgong Li, Yixin Liu, Hongjun Wang, Crystal N Marconett, Ite A Laird-Offringa, Parviz Minoo, Amy S Lee, Beiyun Zho. The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. American journal of respiratory cell and molecular biology. vol 55. issue 1. 2017-06-30. PMID:26816051. |
lung epithelial-specific grp78 ko disrupted lung morphogenesis, causing developmental arrest, increased alveolar epithelial type ii cell apoptosis, and decreased surfactant protein and type i cell marker expression in perinatal lungs. |
2017-06-30 |
2023-08-13 |
mouse |
| Rasha M S M Mohamed, Sachio Morimoto, Islam A A E-H Ibrahim, Dong-Yun Zhan, Cheng-Kun Du, Masaki Arioka, Tatsuya Yoshihara, Fumi Takahashi-Yanaga, Toshiyuki Sasagur. GSK-3β heterozygous knockout is cardioprotective in a knockin mouse model of familial dilated cardiomyopathy. American journal of physiology. Heart and circulatory physiology. vol 310. issue 11. 2017-06-29. PMID:27106044. |
gsk-3β(+/-) ko also prevented cardiac enlargement, myocardial fibrosis, and cardiomyocyte apoptosis and markedly reduced the expression of cardiac β-myosin heavy chain isoform, indicative of hf, in dcm mice with homozygous Δk210 ctnt ki mutation. |
2017-06-29 |
2023-08-13 |
mouse |
| Sakiko Suzuki, Ronny R Racine, Nathan A Manalo, Sharon B Cantor, Glen D Raffe. Impairment of fetal hematopoietic stem cell function in the absence of Fancd2. Experimental hematology. vol 48. 2017-06-06. PMID:27915139. |
fancd2 ko fetal liver cells display similar functional defects to fancd2 adult bone marrow cells, including reduced colony-forming units, increased mitomycin c sensitivity, increased lt-hsc apoptosis, and heavily impaired competitive repopulation, implying that these defects are intrinsic to the fetal liver and are not dependent on the accumulation of dna damage during aging. |
2017-06-06 |
2023-08-13 |
mouse |
| Sakiko Suzuki, Ronny R Racine, Nathan A Manalo, Sharon B Cantor, Glen D Raffe. Impairment of fetal hematopoietic stem cell function in the absence of Fancd2. Experimental hematology. vol 48. 2017-06-06. PMID:27915139. |
telomere shortening, an aging-related mechanism proposed to contribute to hsc apoptosis and bone marrow failure in fa, was not observed in fancd2 ko fetal livers. |
2017-06-06 |
2023-08-13 |
mouse |
| Keiko Omori, Eiji Kobayashi, Hirotake Komatsu, Jeffrey Rawson, Garima Agrawal, Mounika Parimi, Alina R Oancea, Luis Valiente, Kevin Ferreri, Ismail H Al-Abdullah, Fouad Kandeel, Masafumi Takahashi, Yoko Mulle. Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming. American journal of physiology. Endocrinology and metabolism. vol 310. issue 11. 2017-06-05. PMID:27117005. |
in this study, we examined mechanisms of pancreatic cold preservation and rewarming-induced injury by interrogating the proapoptotic gene bbc3/bbc3, also known as puma (p53 upregulated modulator of apoptosis), using three experimental models: 1) bioluminescence imaging of isolated luciferase-transgenic ("firefly") lewis rat islets, 2) cold preservation of en bloc-harvested pancreata from bbc3-knockout (ko) mice, and 3) cold preservation and rewarming of human pancreata and isolated islets. |
2017-06-05 |
2023-08-13 |
mouse |
| K Saito, M Nakatomi, H Ida-Yonemochi, H Ohshim. Osteopontin Is Essential for Type I Collagen Secretion in Reparative Dentin. Journal of dental research. vol 95. issue 9. 2017-05-29. PMID:27126446. |
a groove-shaped cavity was prepared on the mesial surface of the upper first molars of wild-type (wt) and opn knockout (ko) mice, and the samples were collected at intervals of 1 to 14 d. the demineralized sections were processed for immunohistochemistry for ki67, nestin, opn, dentin sialoprotein (dsp), integrin αvβ3, and type i collagen; in situ hybridization for opn, col1a1, and dentin sialophosphoprotein (dspp); and apoptosis assay. |
2017-05-29 |
2023-08-13 |
mouse |
| Mariia Lunova, Peggy Schwarz, Renwar Nuraldeen, Kateryna Levada, Deniz Kuscuoglu, Michael Stützle, Maja Vujić Spasić, Johannes Haybaeck, Piotr Ruchala, Milan Jirsa, Jean-Christophe Deschemin, Sophie Vaulont, Christian Trautwein, Pavel Strna. Hepcidin knockout mice spontaneously develop chronic pancreatitis owing to cytoplasmic iron overload in acinar cells. The Journal of pathology. vol 241. issue 1. 2017-05-09. PMID:27741349. |
as an underlying mechanism, 6-month-old hepcidin ko mice showed increased pancreatic oxidative stress, with elevated dna damage, apoptosis and activated nuclear factor-κb (nf-κb) signalling. |
2017-05-09 |
2023-08-13 |
mouse |
| Shylaja Hegde, Om Srivastav. Different gene knockout/transgenic mouse models manifesting persistent fetal vasculature: Are integrins to blame for this pathological condition? Life sciences. vol 171. 2017-04-06. PMID:28039002. |
based on similar cellular defects observed in different knockouts (ko)s such as altered migration, increased proliferation and decreased apoptosis and, the known role of integrins in the regulation of these cellular behaviors, we propose here that integrins may play a significant role in the pathophysiology of persistent fetal vasculature disease. |
2017-04-06 |
2023-08-13 |
mouse |
| Seung Taek Nam, Jung Hwan Hwang, Dae Hong Kim, Li Fang Lu, Ji Hong, Peng Zhang, I Na Yoon, Jae Sam Hwang, Hyo Kyun Chung, Minho Shong, Chul-Ho Lee, Ho Ki. NQO1-Knockout Mice Are Highly Sensitive to Clostridium Difficile Toxin A-Induced Enteritis. Journal of microbiology and biotechnology. vol 26. issue 8. 2017-03-20. PMID:27116994. |
the levels of fluid secretion, villus disruption, and epithelial cell apoptosis were also higher in toxin a-treated nqo1 ko mice compared with wt mice. |
2017-03-20 |
2023-08-13 |
mouse |
| Gretel G Pellegrini, Cynthya C Morales, Taylor C Wallace, Lilian I Plotkin, Teresita Bellid. Avenanthramides Prevent Osteoblast and Osteocyte Apoptosis and Induce Osteoclast Apoptosis in Vitro in an Nrf2-Independent Manner. Nutrients. vol 8. issue 7. 2017-03-13. PMID:27409635. |
avas prevented apoptosis of both wild type (wt) and nrf2 knockout (ko) osteoblasts, demonstrating that avas-induced survival does not require nrf2 expression. |
2017-03-13 |
2023-08-13 |
Not clear |
| Gretel G Pellegrini, Cynthya C Morales, Taylor C Wallace, Lilian I Plotkin, Teresita Bellid. Avenanthramides Prevent Osteoblast and Osteocyte Apoptosis and Induce Osteoclast Apoptosis in Vitro in an Nrf2-Independent Manner. Nutrients. vol 8. issue 7. 2017-03-13. PMID:27409635. |
although avas did not affect wt osteoclasts, ava 2p reversed the low apoptosis of ko osteoclasts. |
2017-03-13 |
2023-08-13 |
Not clear |