| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoo Yeon Kim, Janet Ren Chao, Chulho Kim, Boyoung Kim, Phuong Thi-Thanh Nguyen, Harry Jung, Jiwon Chang, Jun Ho Lee, Jun Gyo Su. Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet. Biochemical and biophysical research communications. vol 523. issue 3. 2020-09-08. PMID:31948760. |
reactive oxygen species (ros) and apoptosis rates were detected in the cochlea of the apoe ko male mice. |
2020-09-08 |
2023-08-13 |
mouse |
| Ciro Menale, Lisa J Robinson, Eleonora Palagano, Rosita Rigoni, Marco Erreni, Alejandro J Almarza, Dario Strina, Stefano Mantero, Michela Lizier, Antonella Forlino, Roberta Besio, Marta Monari, Paolo Vezzoni, Barbara Cassani, Harry C Blair, Anna Villa, Cristina Sobacch. Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 34. issue 11. 2020-09-03. PMID:31295380. |
accordingly, in vitro studies revealed that dpp3 ko osteoclasts had an inherent increased resorptive activity and ros production, which on the other hand made them prone to apoptosis. |
2020-09-03 |
2023-08-13 |
mouse |
| Changli Zhang, Madeline P Smith, George K Zhou, Alon Lai, Robert C Hoy, Victoria Mroz, Olivia M Torre, Damien M Laudier, Elizabeth W Bradley, Jennifer J Westendorf, James C Iatridis, Svenja Illien-Jünge. Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice. Cell death & disease. vol 10. issue 10. 2020-08-20. PMID:31582730. |
in mice, 3 days after ivd needle puncture injury, phlpp1 knockout (ko) promoted akt phosphorylation and cell proliferation, with less apoptosis. |
2020-08-20 |
2023-08-13 |
mouse |
| HanLin Ma, Le Su, XiaoYing He, JunYing Mia. Loss of HMBOX1 promotes LPS-induced apoptosis and inhibits LPS-induced autophagy of vascular endothelial cells in mouse. Apoptosis : an international journal on programmed cell death. vol 24. issue 11-12. 2020-08-03. PMID:31583496. |
there existed no differences in apoptosis and autophagy of aortic endothelial cells between wild type and ko mouse. |
2020-08-03 |
2023-08-13 |
mouse |
| HanLin Ma, Le Su, XiaoYing He, JunYing Mia. Loss of HMBOX1 promotes LPS-induced apoptosis and inhibits LPS-induced autophagy of vascular endothelial cells in mouse. Apoptosis : an international journal on programmed cell death. vol 24. issue 11-12. 2020-08-03. PMID:31583496. |
in conclusion, hmbox1 participated in the functional maintenance of mouse aortic endothelial cells, the aortic endothelial cells of hmbox1 ko mouse showed increased apoptosis and decreased autophagy with lps treatment. |
2020-08-03 |
2023-08-13 |
mouse |
| Rachel C West, Jennifer E Russ, Gerrit J Bouma, Quinton A Winge. BRCA1 regulates HMGA2 levels in the Swan71 trophoblast cell line. Molecular reproduction and development. vol 86. issue 11. 2020-07-07. PMID:31410930. |
finally, we found that the caspase activity was significantly higher in brca1 ko and mir-182 overexpressing cells suggesting an increased amount of apoptosis. |
2020-07-07 |
2023-08-13 |
human |
| Xudong Wang, Ying-Tang Gao, Dan Jiang, Yuzhou Wang, Hongyan Du, Jili Lv, Shu Jie L. Hv1-deficiency protects β cells from glucotoxicity through regulation of NOX4 level. Biochemical and biophysical research communications. vol 513. issue 2. 2020-04-27. PMID:30967259. |
following 48 h of treatment with 30 mm high glucose, hv1 ko β cells showed higher cell viability, lower cell apoptosis and a more stable insulin gene expression level compared to wt β cells. |
2020-04-27 |
2023-08-13 |
Not clear |
| Karim Bahmed, Chih-Ru Lin, Hannah Simborio, Loukmane Karim, Mark Aksoy, Steven Kelsen, Dhanendra Tomar, Muniswamy Madesh, John Elrod, Elise Messier, Robert Mason, Ellen M Unterwald, Toby K Eisenstein, Gerard J Criner, Beata Kosmide. The role of DJ-1 in human primary alveolar type II cell injury induced by e-cigarette aerosol. American journal of physiology. Lung cellular and molecular physiology. vol 317. issue 4. 2020-04-01. PMID:31313616. |
dj-1 knockout (ko) mice were more susceptible to atii cell apoptosis and lung injury induced by e-cigarette aerosol compared with wild-type mice. |
2020-04-01 |
2023-08-13 |
mouse |
| Karthik M Kodigepalli, Serena Bonifati, Nagaraja Tirumuru, Li W. SAMHD1 modulates in vitro proliferation of acute myeloid leukemia-derived THP-1 cells through the PI3K-Akt-p27 axis. Cell cycle (Georgetown, Tex.). vol 17. issue 9. 2019-12-17. PMID:29911928. |
we have reported that samhd1 knockout (ko) in the aml-derived thp-1 cells results in enhanced proliferation and reduced apoptosis, but the underlying mechanisms are unclear. |
2019-12-17 |
2023-08-13 |
mouse |
| Ariful Islam, Yoshiteru Kagawa, Hirofumi Miyazaki, Subrata Kumar Shil, Banlanjo A Umaru, Yuki Yasumoto, Yui Yamamoto, Yuji Owad. FABP7 Protects Astrocytes Against ROS Toxicity via Lipid Droplet Formation. Molecular neurobiology. vol 56. issue 8. 2019-12-17. PMID:30680690. |
consequently, activation of apoptosis signalling molecules, including p38 mitogen-activated protein kinase (mapk) and stress-activated protein kinase/c-jun n-terminal kinase (sapk/jnk), and increased expression of cleaved caspase 3 were observed in fabp7 ko astrocytes under ros stress. |
2019-12-17 |
2023-08-13 |
mouse |
| Erica C Pandolfi, Karen J Tonsfeldt, Hanne M Hoffmann, Pamela L Mello. Deletion of the Homeodomain Protein Six6 From GnRH Neurons Decreases GnRH Gene Expression, Resulting in Infertility. Endocrinology. vol 160. issue 9. 2019-12-11. PMID:31211355. |
here we find that global six6 knockout (ko) embryos show apoptosis of gnrh neurons beginning at embryonic day 14.5 with 90% loss of gnrh neurons by postnatal day 1. |
2019-12-11 |
2023-08-13 |
mouse |
| Eliene Albers, Mauro Sbroggiò, David Pladevall-Morera, Anna H Bizard, Alexandra Avram, Patricia Gonzalez, Javier Martin-Gonzalez, Ian D Hickson, Andres J Lopez-Contrera. Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality. Cell reports. vol 24. issue 12. 2019-12-09. PMID:30232008. |
however, despite the presence of chromosomal instability, extensive p53 activation, and increased apoptosis throughout the embryo, pich ko embryos survive until day 12.5 of embryonic development. |
2019-12-09 |
2023-08-13 |
mouse |
| Eliene Albers, Mauro Sbroggiò, David Pladevall-Morera, Anna H Bizard, Alexandra Avram, Patricia Gonzalez, Javier Martin-Gonzalez, Ian D Hickson, Andres J Lopez-Contrera. Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality. Cell reports. vol 24. issue 12. 2019-12-09. PMID:30232008. |
the absence of p53 failed to improve the viability of the pich ko embryos, suggesting that the observed developmental defects are not solely due to p53-induced apoptosis. |
2019-12-09 |
2023-08-13 |
mouse |
| Juan Du, Osama Abdel-Razek, Qiao Shi, Fengqi Hu, Guohua Ding, Robert N Cooney, Guirong Wan. Surfactant protein D attenuates acute lung and kidney injuries in pneumonia-induced sepsis through modulating apoptosis, inflammation and NF-κB signaling. Scientific reports. vol 8. issue 1. 2019-11-29. PMID:30337682. |
increased renal tubular apoptosis, nf-κb activation and proinflammatory cytokines in the kidney of ko mice were found when compared with wt and htg mice. |
2019-11-29 |
2023-08-13 |
mouse |
| Juan Du, Osama Abdel-Razek, Qiao Shi, Fengqi Hu, Guohua Ding, Robert N Cooney, Guirong Wan. Surfactant protein D attenuates acute lung and kidney injuries in pneumonia-induced sepsis through modulating apoptosis, inflammation and NF-κB signaling. Scientific reports. vol 8. issue 1. 2019-11-29. PMID:30337682. |
furthermore, in vitro primary proximal tubular epithelial cells from ko mice showed more apoptosis with higher level of activated caspase-3 than those from wt mice after lps treatment. |
2019-11-29 |
2023-08-13 |
mouse |
| Consuelo Amantini, Valerio Farfariello, Claudio Cardinali, Maria Beatrice Morelli, Oliviero Marinelli, Massimo Nabissi, Matteo Santoni, Laura Bonfili, Valentina Cecarini, Anna Maria Eleuteri, Giorgio Santon. The TRPV1 ion channel regulates thymocyte differentiation by modulating autophagy and proteasome activity. Oncotarget. vol 8. issue 53. 2019-11-20. PMID:29207602. |
in addition, positive selection of thymocytes triggered by anti-tcrβ/cd2 ab-mediated costimulation induces apoptosis in thymocytes from trpv1 ko as compared with wt mice. |
2019-11-20 |
2023-08-13 |
mouse |
| Zhilong Zhao, Long Shi, Wei Zhang, Jinsheng Han, Shaohui Zhang, Zexian Fu, Jianhui Ca. CRISPR knock out of programmed cell death protein 1 enhances anti-tumor activity of cytotoxic T lymphocytes. Oncotarget. vol 9. issue 4. 2019-11-20. PMID:29435173. |
results show that pd-1 ko ctls facilitate apoptosis and caspase activation of the co-cultured mm cells and enhanced mm cell death by 36% compared with the control. |
2019-11-20 |
2023-08-13 |
Not clear |
| Bin Wang, Yingying Zhang, Hongli Dong, Siyi Gong, Bin Wei, Man Luo, Hongyan Wang, Xiaohui Wu, Wei Liu, Xingshun Xu, Yufang Zheng, Miao Su. Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell death & disease. vol 9. issue 5. 2019-11-08. PMID:29725084. |
in conclusion, our results show that tctn3 ko disrupts the shh signaling pathway and neural tube patterning, resulting in abnormal embryonic development, cellular apoptosis, and prenatal death in mice. |
2019-11-08 |
2023-08-13 |
mouse |
| Fang-da Li, Hao Nie, Cui Tian, Hong-Xia Wang, Bao-Hua Sun, Hua-Liang Ren, Xu Zhang, Peng-Zhi Liao, Duan Liu, Hui-Hua Li, Yue-Hong Zhen. Ablation and Inhibition of the Immunoproteasome Catalytic Subunit LMP7 Attenuate Experimental Abdominal Aortic Aneurysm Formation in Mice. Journal of immunology (Baltimore, Md. : 1950). vol 202. issue 4. 2019-10-24. PMID:30642978. |
histological alterations, including aortic wall thickening, collagen deposition, elastin fragmentation, and vascular smooth muscle cell apoptosis in aaa tissue of apoe ko mice, were also significantly attenuated in lmp7/apoe dko mice. |
2019-10-24 |
2023-08-13 |
mouse |
| Qi Xiong, Qin Ru, Xiang Tian, Mei Zhou, Lin Chen, Yi Li, Chaoying L. Krill oil protects PC12 cells against methamphetamine-induced neurotoxicity by inhibiting apoptotic response and oxidative stress. Nutrition research (New York, N.Y.). vol 58. 2019-10-17. PMID:30340818. |
in this study, pc12 cells were exposed to both meth (3 mmol/l) and ko (0.1, 0.2, 0.4, 0.8 μg/ml) in vitro for 24 h, and the following parameters were measured to detect apoptosis and oxidative stress responses that were triggered by meth: cell viability, the oxidative enzyme system, no production, ros production, apoptosis, mitochondrial membrane potential and protein expression of cleaved caspase-3. |
2019-10-17 |
2023-08-13 |
human |