| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marine H Laporte, Christine Chatellard, Victoria Vauchez, Fiona J Hemming, Jean-Christophe Deloulme, Frédérique Vossier, Béatrice Blot, Sandrine Fraboulet, Rémy Sadou. Alix is required during development for normal growth of the mouse brain. Scientific reports. vol 7. 2018-11-09. PMID:28322231. |
indeed, embryonic surface expansion of the alix ko cortex is reduced because of the loss of neural progenitors during a transient phase of apoptosis occurring between e11.5 and e12.5. |
2018-11-09 |
2023-08-13 |
mouse |
| Mohammad Moshahid Khan, Weng-Lang Yang, Max Brenner, Alexandra Cerutti Bolognese, Ping Wan. Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress. Scientific reports. vol 7. 2018-10-22. PMID:28128330. |
effector pathways downstream from er stress - apoptosis, nf-κb (p65), proinflammatory cytokines (il-6, il-1β), neutrophil chemoattractants (mip-2, kc), neutrophil infiltration (mpo activity), lipid peroxidation (4-hne), and nitric oxide (inos) - were significantly increased in wt mice, but only mildly elevated in cirp ko mice. |
2018-10-22 |
2023-08-13 |
mouse |
| Leticia Gonzalez, Alexander S Qian, Usama Tahir, Pei Yu, Bernardo L Trigatt. Sphingosine-1-Phosphate Receptor 1, Expressed in Myeloid Cells, Slows Diet-Induced Atherosclerosis and Protects against Macrophage Apoptosis in Ldlr KO Mice. International journal of molecular sciences. vol 18. issue 12. 2018-07-20. PMID:29244772. |
sphingosine-1-phosphate receptor 1, expressed in myeloid cells, slows diet-induced atherosclerosis and protects against macrophage apoptosis in ldlr ko mice. |
2018-07-20 |
2023-08-13 |
mouse |
| Stellor Nlandu-Khodo, Romain Dissard, Udo Hasler, Matthias Schäfer, Haymo Pircher, Pidder Jansen-Durr, Karl Heinz Krause, Pierre-Yves Martin, Sophie de Seigneu. NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury. Scientific reports. vol 6. 2018-06-06. PMID:27924932. |
nox4 ko mice displayed decreased renal function and more severe tubular apoptosis, decreased bcl-2 expression and higher histologic damage scores compared to wt. |
2018-06-06 |
2023-08-13 |
mouse |
| Stellor Nlandu-Khodo, Romain Dissard, Udo Hasler, Matthias Schäfer, Haymo Pircher, Pidder Jansen-Durr, Karl Heinz Krause, Pierre-Yves Martin, Sophie de Seigneu. NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury. Scientific reports. vol 6. 2018-06-06. PMID:27924932. |
in vitro silencing of nox4 in cells showed an enhanced propensity to apoptosis, with reduced expression of nrf2, glutathione content and bcl-2 expression, similar to cells derived from nox4 ko mice. |
2018-06-06 |
2023-08-13 |
mouse |
| Wonyong Cho, Jie Young Song, Se Won Oh, Myung Gyu Kim, Yoon Sook Ko, Hee Yong Lee, Sang Kyung J. Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury. Journal of Korean medical science. vol 32. issue 10. 2018-05-14. PMID:28875605. |
the clearance of neutrophils was delayed in the bax knockout (ko)(bm) → wild-type (wt) chimera in which bone marrow derived cells are partially resistant to apoptosis, compared to wt(bm) → wt mice. |
2018-05-14 |
2023-08-13 |
mouse |
| Qingguo Li, Xin Liang, Yuwei Wang, Xianke Meng, Ye Xu, Sanjun Cai, Zhimin Wang, Jianwen Liu, Guoxiang Ca. miR-139-5p Inhibits the Epithelial-Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2. Scientific reports. vol 6. 2018-04-25. PMID:27244080. |
the functional roles of mir-139-5p in colon cancer were demonstrated by cck-8 proliferation assay, cell invasion and migration, cell apoptosis and in a ko mouse study. |
2018-04-25 |
2023-08-13 |
mouse |
| B Yeganeh, S Ghavami, Md N Rahim, T Klonisch, A J Halayko, K M Coomb. Autophagy activation is required for influenza A virus-induced apoptosis and replication. Biochimica et biophysica acta. Molecular cell research. vol 1865. issue 2. 2018-04-17. PMID:29108912. |
both bax knockout (ko) and bax/bak double knockout mefs displayed inhibition of virus-induced cytopathology and cell death and diminished virus-mediated caspase activation, suggesting that virus-induced apoptosis is bax/bak-dependent. |
2018-04-17 |
2023-08-13 |
mouse |
| Kevin Chen, Abbey Kardys, Yibu Chen, Stephen Flink, Boris Tabakoff, Jean C Shi. Altered gene expression in early postnatal monoamine oxidase A knockout mice. Brain research. vol 1669. 2018-04-12. PMID:28535982. |
many other genes involved in neurodevelopment, apoptosis, neurotransmission, and cognitive function were differentially expressed at p7 in mao a ko mice. |
2018-04-12 |
2023-08-13 |
mouse |
| Sabina Paglialunga, Genevieve Simnett, Holly Robson, Monica Hoang, Renjitha Pillai, Alicia M Arkell, Jeremy A Simpson, Arend Bonen, Mark Huising, Jamie W Joseph, Graham P Hollowa. The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 42. issue 6. 2018-04-11. PMID:28177704. |
an 8-week pair-fed high-fat diet did not further alter β-cell mass or apoptosis in ko rats, suggesting that dietary lipids per se, do not lead to a further impairment in glucose homeostasis. |
2018-04-11 |
2023-08-13 |
human |
| Shengbing Li, Cong Wang, Ke Li, Ling Li, Mingyuan Tian, Jing Xie, Mengliu Yang, Yanjun Jia, Junying He, Lin Gao, Guenther Boden, Hua Liu, Gangyi Yan. NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance. Scientific reports. vol 6. 2018-04-02. PMID:27229177. |
we demonstrated that a specific nampt knockdown increased plasma hdl-c levels, reduced the plaque area of the total aorta en face and the cross-sectional aortic sinus, decreased macrophage number and apoptosis, and promoted rct in hfd-fed apoe ko mice. |
2018-04-02 |
2023-08-13 |
mouse |
| Lauren J Maskell, Kashif Qamar, Aram A Babakr, Thomas A Hawkins, Richard J Heads, Vishwanie S Budhram-Mahade. Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart. Cell death & disease. vol 8. issue 6. 2018-03-07. PMID:28594399. |
bax, thereby increasing apoptosis and contribute to morphological defects such as non-compaction, ventricular wall/septal thinning and increased crypts/fissures, which may cause lethality of brn-3a ko mutants soon after birth. |
2018-03-07 |
2023-08-13 |
Not clear |
| Su-Hyung Lee, Jun-Won Park, Sang-Ho Woo, Du-Min Go, Hyo-Jung Kwon, Ja-June Jang, Dae-Yong Ki. Suppression of osteopontin inhibits chemically induced hepatic carcinogenesis by induction of apoptosis in mice. Oncotarget. vol 7. issue 52. 2018-02-22. PMID:27888617. |
apoptosis was significantly enhanced in opn ko mice, and was accompanied by the downregulation of epidermal growth factor receptor (egfr). |
2018-02-22 |
2023-08-13 |
mouse |
| Yaqing Li, Xiaoran Li, Xiaoli Li, Yali Zhong, Yasai Ji, Dandan Yu, Mingzhi Zhang, Jian-Guo Wen, Hongquan Zhang, Mariusz Adam Goscinski, Jahn M Nesland, Zhenhe Su. PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence. Oncotarget. vol 7. issue 33. 2018-01-30. PMID:27462778. |
pharmacological blockade of the glutaminolysis pathway resulted in massive tumor cells apoptosis and dysfunction of ros scavenge in the lncap pdha1 ko cells. |
2018-01-30 |
2023-08-13 |
human |
| Sudip Banerjee, Nukhet Aykin-Burns, Kimberly J Krager, Sumit K Shah, Stepan B Melnyk, Martin Hauer-Jensen, Snehalata A Pawa. Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction. Free radical biology & medicine. vol 99. 2018-01-02. PMID:27554969. |
we found that cebpd-knockout (ko) mouse embryonic fibroblasts (mefs) expressed elevated levels of ros, both at basal levels and after exposure to gamma radiation which correlated with increased apoptosis, and decreased clonogenic survival. |
2018-01-02 |
2023-08-13 |
mouse |
| Andreas Schwingshackl, Benjamin Lopez, Bin Teng, Charlean Luellen, Florian Lesage, John Belperio, Riccardo Olcese, Christopher M Water. Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins. American journal of physiology. Lung cellular and molecular physiology. vol 313. issue 6. 2017-12-06. PMID:28839101. |
we exposed wt and trek-1/trek-2/traak-deficient [triple knockout (ko)] mice to either room air, 72-h ho, mv [high and low tidal volume (tv)], or a combination of ho + mv and measured quasistatic lung compliance, bronchoalveolar lavage (bal) protein concentration, histologic lung injury scores (lis), cellular apoptosis, and cytokine levels. |
2017-12-06 |
2023-08-13 |
mouse |
| Andreas Schwingshackl, Benjamin Lopez, Bin Teng, Charlean Luellen, Florian Lesage, John Belperio, Riccardo Olcese, Christopher M Water. Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins. American journal of physiology. Lung cellular and molecular physiology. vol 313. issue 6. 2017-12-06. PMID:28839101. |
ho treatment increased lung injury in triple ko but not wt mice, including an elevated lis, bal protein concentration, and markers of apoptosis, decreased lung compliance, and a more proinflammatory cytokine phenotype. |
2017-12-06 |
2023-08-13 |
mouse |
| Fan Chen, Dandan Chen, Yubin Zhang, Liang Jin, Han Zhang, Miyang Wan, Tianshu Pan, Xiaochuan Wang, Yuheng Su, Yitao Xu, Junmei Y. Interleukin-6 deficiency attenuates angiotensin II-induced cardiac pathogenesis with increased myocyte hypertrophy. Biochemical and biophysical research communications. vol 494. issue 3-4. 2017-11-22. PMID:29079193. |
immunohistological and serum studies revealed that the extents of cardiac fibrosis, inflammation and apoptosis were reduced in il-6 ko heart during angii-stimulation, while cardiac hypertrophy was obviously induced. |
2017-11-22 |
2023-08-13 |
mouse |
| Yubin Wang, Joshua Hersheson, Dulce Lopez, Monia Hammer, Yan Liu, Ka-Hung Lee, Vanessa Pinto, Jeff Seinfeld, Sarah Wiethoff, Jiandong Sun, Rim Amouri, Faycal Hentati, Neema Baudry, Jennifer Tran, Andrew B Singleton, Marie Coutelier, Alexis Brice, Giovanni Stevanin, Alexandra Durr, Xiaoning Bi, Henry Houlden, Michel Baudr. Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Cell reports. vol 16. issue 1. 2017-11-21. PMID:27320912. |
calpain-1 knockout (ko) mice also exhibit a mild form of ataxia due to abnormal cerebellar development, including enhanced neuronal apoptosis, decreased number of cerebellar granule cells, and altered synaptic transmission. |
2017-11-21 |
2023-08-13 |
mouse |
| Yubin Wang, Joshua Hersheson, Dulce Lopez, Monia Hammer, Yan Liu, Ka-Hung Lee, Vanessa Pinto, Jeff Seinfeld, Sarah Wiethoff, Jiandong Sun, Rim Amouri, Faycal Hentati, Neema Baudry, Jennifer Tran, Andrew B Singleton, Marie Coutelier, Alexis Brice, Giovanni Stevanin, Alexandra Durr, Xiaoning Bi, Henry Houlden, Michel Baudr. Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Cell reports. vol 16. issue 1. 2017-11-21. PMID:27320912. |
injection of neonatal mice with the indirect akt activator, bisperoxovanadium, or crossing calpain-1 ko mice with phlpp1 ko mice prevented increased postnatal cerebellar granule cell apoptosis and restored granule cell density and motor coordination in adult mice. |
2017-11-21 |
2023-08-13 |
mouse |