| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Yang, Xian Liu, Hui Chen, Pengjun Wang, Songhui Yao, Bin Zhou, Ronghua Yin, Changyan Li, Chutse Wu, Xiaoming Yang, Miao Y. HPS protects the liver against steatosis, cell death, inflammation and fibrosis in mice with steatohepatitis. The FEBS journal. 2022-03-14. PMID:35285180. |
hfd- and mcd-induced hepatic steatosis, inflammation, apoptosis, and fibrosis were more pronounced in hps knockout (ko) mice than in the wild type (wt) mice. |
2022-03-14 |
2023-08-13 |
mouse |
| Upadhyayula S Srinivas, Norbert S C Tay, Patrick Jaynes, Akshaya Anbuselvan, Gokula K Ramachandran, Joanna D Wardyn, Michal M Hoppe, Phuong Mai Hoang, Yanfen Peng, Sherlly Lim, May Yin Lee, Praveen C Peethala, Omer An, Akshay Shendre, Bryce W Q Tan, Sherlyn Jemimah, Manikandan Lakshmanan, Longyu Hu, Rekha Jakhar, Karishma Sachaphibulkij, Lina H K Lim, Shazib Pervaiz, Karen Crasta, Henry Yang, Patrick Tan, Chao Liang, Lena Ho, Vartika Khanchandani, Dennis Kappei, Wei Peng Yong, David S P Tan, Matteo Bordi, Silvia Campello, Wai Leong Tam, Christian Frezza, Anand D Jeyasekhara. PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production. Oncogene. 2022-03-03. PMID:35236967. |
inhibition of plk1 in arid1a ko cells further uncouples oxygen consumption from atp production, with subsequent membrane depolarization and apoptosis. |
2022-03-03 |
2023-08-13 |
Not clear |
| Xiao Han, Yun-Long Zhang, Qiu-Yue Lin, Hui-Hua Li, Shu-Bin Gu. ATGL deficiency aggravates pressure overload-triggered myocardial hypertrophic remodeling associated with the proteasome-PTEN-mTOR-autophagy pathway. Cell biology and toxicology. 2022-02-26. PMID:35218467. |
tac in wt mice significantly reduced cardiac function and autophagy while enhancing left ventricular hypertrophy, interstitial fibrosis, inflammatory response, superoxide generation, and cardiomyocyte apoptosis, accompanied with upregulation of the proteasome activity, reduction of pten level and activation of akt-mtor signaling, and these effects were further aggravated in atgl ko mice. |
2022-02-26 |
2023-08-13 |
mouse |
| Konrad Kwaśniak, Justyna Czarnik-Kwaśniak, Khrystyna Malysheva, Katarzyna Pogoda, Olexandr Korchynskyi, Paweł Rybojad, Bożenna Karczmarek-Borowska, Jacek Tabarkiewic. LncCDH5-3:3 Regulates Apoptosis, Proliferation, and Aggressiveness in Human Lung Cancer Cells. Cells. vol 11. issue 3. 2022-02-15. PMID:35159188. |
moreover, knockout (ko) and overexpression, as well as molecular and biochemical techniques, were used to investigate the biological functions of lnccdh5-3:3 in nsclc cells, with a focus on the cells' proliferation and migration; (3) the finding that lnccdh5-3:3 silencing promotes apoptosis and probably regulates the cell cycle and e-cadherin expression in adenocarcinoma cell lines. |
2022-02-15 |
2023-08-13 |
human |
| Mark A Doll, Andrew R Ray, Raúl A Salazar-González, Parag P Shah, Alexis A Vega, Sophia M Sears, Austin M Krueger, Kyung U Hong, Levi J Beverly, David W Hei. Deletion of arylamine N-acetyltransferase 1 in MDA-MB-231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis. Molecular carcinogenesis. 2022-02-08. PMID:35133049. |
nat1 ko mda-mb-231 cells produced primary tumors smaller than those formed by parental cells, which was contributed by an increased rate of apoptosis in ko cells. |
2022-02-08 |
2023-08-13 |
mouse |
| Abilasha Gayani Jayathilake, Elif Kadife, Nyanbol Kuol, Rodney Brain Luwor, Kulmira Nurgali, Xiao Qun S. Krill oil supplementation reduces the growth of CT-26 orthotopic tumours in Balb/c mice. BMC complementary medicine and therapies. vol 22. issue 1. 2022-02-05. PMID:35120511. |
we have previously reported that the free fatty acid extract (ffae) of krill oil (ko) significantly inhibits the proliferation and migration, and induces apoptosis of colorectal cancer (crc) cells. |
2022-02-05 |
2023-08-13 |
mouse |
| Abilasha Gayani Jayathilake, Elif Kadife, Nyanbol Kuol, Rodney Brain Luwor, Kulmira Nurgali, Xiao Qun S. Krill oil supplementation reduces the growth of CT-26 orthotopic tumours in Balb/c mice. BMC complementary medicine and therapies. vol 22. issue 1. 2022-02-05. PMID:35120511. |
this study aimed to investigate the in vivo efficacy of various doses of ko supplementation on the inhibition of crc tumour growth, molecular markers of proliferation, angiogenesis, apoptosis, the epidermal growth factor receptor (egfr) and its downstream molecular signalling. |
2022-02-05 |
2023-08-13 |
mouse |
| Jialing Shen, Chunxue Yang, Misty Shuo Zhang, Don Wai-Ching Chin, For-Fan Chan, Cheuk-Ting Law, Gengchao Wang, Carol Lai-Hung Cheng, Mengnuo Chen, Rebecca Ting-Chi Wan, Mengjie Wu, Zhijian Kuang, Rakesh Sharma, Terence Kin Wah Lee, Irene Oi-Lin Ng, Carmen Chak-Lui Wong, Chun-Ming Won. Histone chaperone FACT complex coordinates with HIF to mediate an expeditious transcription program to adapt to poorly oxygenated cancers. Cell reports. vol 38. issue 5. 2022-02-02. PMID:35108543. |
metabolic tracing confirms that fact ko suppresses glycolytic flux and impairs lactate extrusion, leading to intracellular acidification and apoptosis in cancer cells. |
2022-02-02 |
2023-08-13 |
Not clear |
| Jaafar Al-Hasani, Carla Sens-Albert, Subhajit Ghosh, Felix A Trogisch, Taslima Nahar, Prisca A P Friede, Jan-Christian Reil, Markus Hecke. Zyxin protects from hypertension-induced cardiac dysfunction. Cellular and molecular life sciences : CMLS. vol 79. issue 2. 2022-01-25. PMID:35075545. |
hearts from hypertensive zyxin ko mice revealed increased apoptosis, fibrosis and an upregulation of active focal adhesion kinase as well as of integrins α5 and β1. |
2022-01-25 |
2023-08-13 |
mouse |
| Jaafar Al-Hasani, Carla Sens-Albert, Subhajit Ghosh, Felix A Trogisch, Taslima Nahar, Prisca A P Friede, Jan-Christian Reil, Markus Hecke. Zyxin protects from hypertension-induced cardiac dysfunction. Cellular and molecular life sciences : CMLS. vol 79. issue 2. 2022-01-25. PMID:35075545. |
while zyxin ko mice per se do not reveal a cardiac phenotype, this is unmasked upon induction of hypertension and owing to enhanced cardiomyocyte apoptosis and excessive fibrosis causes cardiac dysfunction. |
2022-01-25 |
2023-08-13 |
mouse |
| Xuechun Sun, Xiaodan Sun, Huali Meng, Junduo Wu, Xin Guo, Lei Du, Hao W. Krill Oil Inhibits NLRP3 Inflammasome Activation in the Prevention of the Pathological Injuries of Diabetic Cardiomyopathy. Nutrients. vol 14. issue 2. 2022-01-21. PMID:35057549. |
the diabetic mice developed pathological features, including cardiac fibrosis, apoptosis and inflammatory cell infiltration, the effects of which were remarkably prevented by ko. |
2022-01-21 |
2023-08-13 |
mouse |
| Eman Soliman, Sophia Bhalla, Ahmed E M Elhassanny, Anagha Malur, David Ogburn, Nancy Leffler, Achut G Malur, Mary Jane Thomasse. Myeloid ABCG1 Deficiency Enhances Apoptosis and Initiates Efferocytosis in Bronchoalveolar Lavage Cells of Murine Multi-Walled Carbon Nanotube-Induced Granuloma Model. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008476. |
mwcnt induced more apoptosis in bal cells of abcg1 ko mice. |
2022-01-11 |
2023-08-13 |
mouse |
| Eman Soliman, Sophia Bhalla, Ahmed E M Elhassanny, Anagha Malur, David Ogburn, Nancy Leffler, Achut G Malur, Mary Jane Thomasse. Myeloid ABCG1 Deficiency Enhances Apoptosis and Initiates Efferocytosis in Bronchoalveolar Lavage Cells of Murine Multi-Walled Carbon Nanotube-Induced Granuloma Model. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008476. |
initiation of apoptosis is most likely mediated by the extrinsic pathway since caspase 8 activity and fas expression are significantly higher in mwcnt instilled abcg1 ko mice compared to the wild type. |
2022-01-11 |
2023-08-13 |
mouse |
| Jianlan Zhao, Yinhui Dong, Xingyu Chen, Xiao Xiao, Bo Tan, Gong Chen, Jin Hu, Dashi Qi, Xiaomu Li, Rong Xi. p53 Inhibition Protects against Neuronal Ischemia/Reperfusion Injury by the p53/PRAS40/mTOR Pathway. Oxidative medicine and cellular longevity. vol 2021. 2021-12-13. PMID:34900085. |
we found that the infarction size, neuronal apoptosis, and autophagy were less severe in p53 ko mice and p53 ko neurons after cerebral i/r or ogd/r injury. |
2021-12-13 |
2023-08-13 |
mouse |
| Monica Hoang, Emelien Jentz, Sarah M Janssen, Daniela Nasteska, Federica Cuozzo, David J Hodson, A Russell Tupling, Guo-Hua Fong, Jamie W Josep. Isoform-specific Roles of Prolyl Hydroxylases in the Regulation of Pancreatic β-Cell Function. Endocrinology. vol 163. issue 1. 2021-12-11. PMID:34718519. |
islets from both β-phd1 ko and β-phd3 ko had elevated β-cell apoptosis and reduced β-cell mass. |
2021-12-11 |
2023-08-13 |
mouse |
| Ju Youn Beak, Hong Soon Kang, Wei Huang, Rishi Deshmukh, Seok Jae Hong, Nishi Kadakia, Amir Aghajanian, Kevin Gerrish, Anton Jetten, Brian Jense. The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy. The Journal of biological chemistry. vol 297. issue 6. 2021-12-11. PMID:34756888. |
the hearts of our novel cardiomyocyte-specific rorα ko mouse line demonstrated impaired contractile function, enhanced oxidative stress, increased apoptosis, and reduced autophagic flux relative to cre(-) littermates. |
2021-12-11 |
2023-08-13 |
mouse |
| Oktay Genel, Carmine M Pariante, Alessandra Borsin. The role of AQP4 in the pathogenesis of depression, and possible related mechanisms. Brain, behavior, and immunity. vol 98. 2021-12-09. PMID:34474133. |
in preclinical aqp4 ko studies, aqp4 expression is necessary to prevent the effect of stress and inflammation on reduced neurogenesis and gliogenesis, and increased apoptosis and depressive-like behaviours. |
2021-12-09 |
2023-08-13 |
Not clear |
| Darko Maric, Aleksandra Paterek, Marion Delaunay, Irene Pérez López, Miroslav Arambasic, Dario Divian. A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction. Cells. vol 10. issue 11. 2021-12-08. PMID:34831084. |
in line with these findings, cardiomyocyte-specific akap2 ko reduces bcl2 and vegfa expression, increases myocardial apoptosis and impairs the formation of new blood vessels in infarcted hearts. |
2021-12-08 |
2023-08-13 |
mouse |
| Kexiong Zhang, Lihui Wang, Xiaojing Hong, Hao Chen, Yao Shi, Yingying Liu, Jun Liu, Jun-Ping Li. Pulmonary Alveolar Stem Cell Senescence, Apoptosis, and Differentiation by p53-Dependent and -Independent Mechanisms in Telomerase-Deficient Mice. Cells. vol 10. issue 11. 2021-12-08. PMID:34831112. |
telomerase deficiency induced by telomerase rna component (terc) knockout (ko) accelerates not only replicative senescence but also altered differentiation and apoptosis of the pulmonary alveolar stem cells (aec2) in association with increased innate immune natural killer (nk) cells in |
2021-12-08 |
2023-08-13 |
mouse |
| George N Ioannou, Sum P Lee, Peter S Linsley, Vivian Gersuk, Matthew M Yeh, Yen-Ying Chen, Yi-Jen Peng, Moumita Dutta, Gabby Mascarinas, Bruk Molla, Julia Yue Cui, Christopher Savar. Pcsk9 Deletion Promotes Murine Nonalcoholic Steatohepatitis and Hepatic Carcinogenesis: Role of Cholesterol. Hepatology communications. 2021-11-24. PMID:34816633. |
pcsk9 ko mice developed crown-like structures of macrophages surrounding cholesterol crystal-containing lipid droplets and hepatocytes, exhibited higher levels of apoptosis, and developed significantly more hepatic inflammation and fibrosis consistent with fibrosing steatohepatitis, including 5-fold and 11-fold more fibrosis at 0.5% and 0.75% dietary cholesterol, respectively. |
2021-11-24 |
2023-08-13 |
mouse |