| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Phuong Thi Thanh Nguyen, Hayoung Song, Boyoung Kim, Yoo Yeon Kim, Chulho Kim, Jun Ho Lee, Jun Gyo Su. Age-related hearing loss was accelerated by apoptosis of spiral ganglion and stria vascularis cells in ApoE KO mice with hyperglycemia and hyperlipidemia. Frontiers in neurology. vol 13. 2022-11-21. PMID:36408520. |
age-related hearing loss was accelerated by apoptosis of spiral ganglion and stria vascularis cells in apoe ko mice with hyperglycemia and hyperlipidemia. |
2022-11-21 |
2023-08-14 |
mouse |
| Bao-Biao Zhuo, Lun-Qing Zhu, Chen Yao, Xi-Hua Wang, Shi-Xian Li, Rong Wang, Yuan Li, Zhuo-Yan Lin. ADCK1 is a potential therapeutic target of osteosarcoma. Cell death & disease. vol 13. issue 11. 2022-11-12. PMID:36371387. |
in primary and established os cells, adck1 shrna or crispr/cas9-induced adck1 knockout (ko) remarkably inhibited cell viability, proliferation and migration, and provoked apoptosis activation. |
2022-11-12 |
2023-08-14 |
mouse |
| Bao-Biao Zhuo, Lun-Qing Zhu, Chen Yao, Xi-Hua Wang, Shi-Xian Li, Rong Wang, Yuan Li, Zhuo-Yan Lin. ADCK1 is a potential therapeutic target of osteosarcoma. Cell death & disease. vol 13. issue 11. 2022-11-12. PMID:36371387. |
adck1 depletion, apoptosis activation and atp reduction were detected in pos-1 xenografts bearing adck1 shrna or adck1 ko construct. |
2022-11-12 |
2023-08-14 |
mouse |
| Didier Hodzic, Jun Wu, Karen Krchma, Andrea Jurisicova, Yonit Tsatskis, Yijie Liu, Peng Ji, Kyunghee Choi, Helen McNeil. The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts. PLoS biology. vol 20. issue 10. 2022-10-10. PMID:36215313. |
the erythroid lineage of nemp1 ko mice is overrepresented until the pronounced apoptosis of polychromatophilic erythroblasts. |
2022-10-10 |
2023-08-14 |
mouse |
| Jingru Zhu, Yitong Wang, Jingxia Li, Pankoj Kumar Das, Hanwen Zhang, Tenzin Passang, Jian Ming Li, Tamas Nagy, Khanjan Gandhi, Sruthi Ravindranathan, Cynthia R Giver, Mojibade Hassan, Yiwen Li, Alina Ulezko Antonova, Shuhua Wang, John D Roback, Edmund K Walle. Donor plasmacytoid dendritic cells limit graft-versus-host disease through vasoactive intestinal polypeptide expression. Blood. vol 140. issue 12. 2022-09-26. PMID:35443019. |
cotransplanting vip-knockout (ko) pdcs with hematopoietic stem cells and t cells in major histocompatibility complex mismatched allogeneic bmt led to lower survival, higher gvhd scores, and more colon crypt cell apoptosis than transplanting wild-type pdcs. |
2022-09-26 |
2023-11-20 |
human |
| Yang Liu, Hongzhao Shi, Yajie Hu, Ruizhi Yao, Peng Liu, Yuying Yang, Shize L. RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure. Cell stress & chaperones. 2022-09-23. PMID:36149580. |
compared with wild type (wt) mice, rbm3 and p65 phosphorylation were decreased in specific skeletal muscle ogt (ko) mice, whereas akt phosphorylation, glycolysis, and apoptosis were increased. |
2022-09-23 |
2023-08-14 |
mouse |
| Min Woo Kim, Ju-Hee Kang, Hyun Jin Jung, Se Yong Park, Jong-Ik Hwang, Je Kyung Seong, Yeo Sung Yoon, Seung Hyun O. Deficiency of Ninjurin1 attenuates LPS/D-galactosamine-induced acute liver failure by reducing TNF-α-induced apoptosis in hepatocytes. Journal of cellular and molecular medicine. 2022-09-07. PMID:36071453. |
also, ninj1 knock-down in l929 and aml12 cells and ninj1 ko in hepg2 cells ameliorated tnf-α-mediated apoptosis. |
2022-09-07 |
2023-08-14 |
mouse |
| Lanlan Jia, Zhengli Chen, Ting Pan, Yu Xia, Junbo He, Asad Jahangir, Xiaoli Wei, Wentao Liu, Riyi Shi, Chao Huang, Qihui Lu. TRIM67 Deficiency Exacerbates Hypothalamic Inflammation and Fat Accumulation in Obese Mice. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012700. |
we found exacerbated neuroinflammation and apoptosis in the hypothalamus of obese trim67 ko mice. |
2022-08-26 |
2023-08-14 |
mouse |
| Tingting Liu, Xiaolei Zhu, Chaoli Huang, Jiang Chen, Shu Shu, Guiquan Chen, Yun Xu, Yimin H. ERK inhibition reduces neuronal death and ameliorates inflammatory responses in forebrain-specific Ppp2cα knockout mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 9. 2022-08-23. PMID:35997299. |
we show that ppp2cα ko mice display robust neuronal apoptosis and inflammatory responses in the postnatal cortex. |
2022-08-23 |
2023-08-14 |
mouse |
| Lili Qu, Bingqian Lin, Wenping Zeng, Chunhong Fan, Haotian Wu, Yushu Ge, Qianqian Li, Canjun Li, Yanan Wei, Jing Xin, Xingbing Wang, Dan Liu, Chunlei Can. Lysosomal K EMBO reports. 2022-08-01. PMID:35913019. |
in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mouse model of parkinson's disease (pd), knockout (ko) of tmem175 mitigated motor impairment and dopaminergic (da) neuron loss, suggesting that tmem175-mediated apoptosis plays an important role in parkinson's disease (pd). |
2022-08-01 |
2023-08-14 |
mouse |
| Qingchun Yang, Jie Zhang, Qianyi Bao, Jialin Zhong, Xiaoqing Wang, Yixin Tao, Xuegang Xu, Kaiyang Lv, Yushu Wang, Baojie Li, Lin He, Xizhi Guo, Gang M. Foxp1 and Foxp4 deletion causes the loss of follicle stem cell niche and cyclic hair shedding by inducing inner bulge cell apoptosis. Stem cells (Dayton, Ohio). 2022-06-27. PMID:35759955. |
in addition, the double ko of foxp1/4 induced the apoptosis of k6-positive (k6+) inner bulge cells, a well-established stem cell (sc) niche, thus resulting in the destruction of the bulge sc niche and recurrent hair loss. |
2022-06-27 |
2023-08-14 |
mouse |
| Yuan Zhang, Shasha Zhang, Han Zhou, Xiangyu Ma, Leilei Wu, Mengyao Tian, Siyu Li, Xiaoyun Qian, Xia Gao, Renjie Cha. Dync1li1 is required for the survival of mammalian cochlear hair cells by regulating the transportation of autophagosomes. PLoS genetics. vol 18. issue 6. 2022-06-21. PMID:35727824. |
next, we used dync1li1 knockout (ko) mice to investigate its effects on hearing and found that deletion of dync1li1 leads to early onset of progressive hc loss via apoptosis and to subsequent hearing loss. |
2022-06-21 |
2023-08-14 |
mouse |
| Yuan Zhang, Shasha Zhang, Han Zhou, Xiangyu Ma, Leilei Wu, Mengyao Tian, Siyu Li, Xiaoyun Qian, Xia Gao, Renjie Cha. Dync1li1 is required for the survival of mammalian cochlear hair cells by regulating the transportation of autophagosomes. PLoS genetics. vol 18. issue 6. 2022-06-21. PMID:35727824. |
in addition, dync1li1 ko results in a thinner golgi apparatus and the accumulation of lc3+ autophagic vacuoles, which triggers hc apoptosis. |
2022-06-21 |
2023-08-14 |
mouse |
| Lee Elisha, Elina Abaev-Schneiderman, Ofir Cohn, Guy Shapira, Noam Shomron, Michal Feldman, Dan Lev. Structure-function conservation between the methyltransferases SETD3 and SETD6. Biochimie. 2022-05-13. PMID:35550916. |
accordingly, we show that the double ko cells displayed high apoptotic levels, suggesting that setd6 and setd3 inhibit apoptosis. |
2022-05-13 |
2023-08-13 |
Not clear |
| Saiaravind Sompalle, Catherine N Domingo, Parker Kim, Karlina Kegecik, Thomas Pucci, Lindsay Shockling, Liya Yin, Feng Dong, William Chilian, Vahgan Ohanya. Is HFpEF Caused by Coronary Microvascular Disease? FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556035. |
we hypothesized that inadequate metabolic dilation in the ko mice leads to chronic coronary insufficiency, i.e., inadequate myocardial blood flow, which would lead to cardiac apoptosis resulting in diffuse fibrosis, stiffening, and culminating in hfpef. |
2022-05-13 |
2023-08-13 |
mouse |
| Sarah Rose Anderson, Jacqueline M Roberts, Nathaniel Ghena, Emmalyn A Irvin, Joon Schwakopf, Isabelle B Cooperstein, Alejandra Bosco, Monica L Vette. Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence. eLife. vol 11. 2022-04-28. PMID:35481836. |
using early postnatal mouse retina, a cns region undergoing significant developmental remodeling, we performed scrnaseq on microglia from mice that are wild-type, lack neuronal apoptosis (bax ko), or are treated with csf1r inhibitor (plx3397). |
2022-04-28 |
2023-08-13 |
mouse |
| An-Guo Wu, Yuan-Yuan Yong, Yi-Ru Pan, Li Zhang, Jian-Ming Wu, Yue Zhang, Yong Tang, Jing Wei, Lu Yu, Betty Yuen-Kwan Law, Chong-Lin Yu, Jian Liu, Cai Lan, Ru-Xiang Xu, Xiao-Gang Zhou, Da-Lian Qi. Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals. Oxidative medicine and cellular longevity. vol 2022. 2022-04-14. PMID:35419162. |
recently, emerging evidence indicated the knockout (ko) of nrf2 aggravates the pathology of tbi, while the treatment of nrf2 activators inhibits neuronal apoptosis and neuroinflammatory responses via reducing oxidative damage. |
2022-04-14 |
2023-08-13 |
Not clear |
| Y-X Xie, M Zhang, C-R Zhang, F Che. Relationship between NogoA/NgR1/RhoA signaling pathway and the apoptosis of cerebral neurons after cerebral infarction in rats. European review for medical and pharmacological sciences. vol 26. issue 6. 2022-04-01. PMID:35363321. |
the authors state that they recently conducted animal experiments again to verify the state of apoptosis in the brain tissue of the ci + nogoa ko group. |
2022-04-01 |
2023-08-13 |
rat |
| Kunihiro Azuma, Tomoko Koumura, Ryo Iwamoto, Masaki Matsuoka, Ryo Terauchi, Shu Yasuda, Tomoyasu Shiraya, Sumiko Watanabe, Makoto Aihara, Hirotaka Imai, Takashi Uet. Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice. The Journal of biological chemistry. 2022-03-15. PMID:35288190. |
we also observed shrunken and uniformly condensed nuclei as well as caspase-3 activation in mgpx4 ko photoreceptors, suggesting that apoptosis was prevalent. |
2022-03-15 |
2023-08-13 |
mouse |
| Yang Yang, Xian Liu, Hui Chen, Pengjun Wang, Songhui Yao, Bin Zhou, Ronghua Yin, Changyan Li, Chutse Wu, Xiaoming Yang, Miao Y. HPS protects the liver against steatosis, cell death, inflammation and fibrosis in mice with steatohepatitis. The FEBS journal. 2022-03-14. PMID:35285180. |
hfd- and mcd-induced hepatic steatosis, inflammation, apoptosis, and fibrosis were more pronounced in hps knockout (ko) mice than in the wild type (wt) mice. |
2022-03-14 |
2023-08-13 |
mouse |