| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vita M Golubovskaya, Richard Finch, William G Canc. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. The Journal of biological chemistry. vol 280. issue 26. 2005-08-16. PMID:15855171. |
introduction of the fak plasmid into p53-null saos-2 cells was able to rescue these cells from apoptosis induced by expression of wild type p53. |
2005-08-16 |
2023-08-12 |
human |
| Vita M Golubovskaya, Richard Finch, William G Canc. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. The Journal of biological chemistry. vol 280. issue 26. 2005-08-16. PMID:15855171. |
the results of the fak and p53 interaction study strongly support the conclusion that fak can suppress p53-mediated apoptosis and inhibit transcriptional activity of p53. |
2005-08-16 |
2023-08-12 |
human |
| Maroesja J van Nimwegen, Saertje Verkoeijen, Liesbeth van Buren, Danny Burg, Bob van de Wate. Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation. Cancer research. vol 65. issue 11. 2005-07-28. PMID:15930288. |
in cell culture, doxycycline-mediated expression of frnk inhibited mtln3 cell spreading and migration in association with reduced formation of focal adhesions and phosphorylation of fak on tyr(397), but frnk did not cause apoptosis. |
2005-07-28 |
2023-08-12 |
rat |
| Elizabeth Tafolla, Shaohui Wang, Benita Wong, Jeffrey Leong, Yvonne L Kapil. JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53. The Journal of biological chemistry. vol 280. issue 20. 2005-07-08. PMID:15778501. |
jnk1 and jnk2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: jnk links fak and p53. |
2005-07-08 |
2023-08-12 |
Not clear |
| Asha Manohar, Swati Ghosh Shome, John Lamar, Lee Stirling, Vandana Iyer, Kevin Pumiglia, C Michael DiPersi. Alpha 3 beta 1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathway. Journal of cell science. vol 117. issue Pt 18. 2005-04-26. PMID:15280429. |
we also show that alpha 3 beta1-mediated adhesion activates focal adhesion kinase (fak) and extracellular signal-regulated kinase (erk), and that inhibition of either fak or erk signaling leads to apoptosis of keratinocytes attached to laminin-5. |
2005-04-26 |
2023-08-12 |
mouse |
| Ryoko Utsubo, Yoshiko Sonoda, Reiko Takahashi, Shiro Iijima, Eriko Aizu-Yokota, Tadashi Kasahar. Proteome analysis of focal adhesion kinase (FAK)-overexpressing cells. Biological & pharmaceutical bulletin. vol 27. issue 11. 2005-04-19. PMID:15516715. |
we established several focal adhesion kinase (fak) cdna-transfected cells and found that fak-transfected hl-60 (hl-60/fak) cells are resistant to apoptosis induced with hydrogen peroxide, etoposide and radiation compared with the parental hl-60 or the vector-transfected (hl-60/vect) cells. |
2005-04-19 |
2023-08-12 |
Not clear |
| Edward Kyu-Ho Han, Thomas Mcgonigal, Jieyi Wang, Vincent L Giranda, Yan Lu. Functional analysis of focal adhesion kinase (FAK) reduction by small inhibitory RNAs. Anticancer research. vol 24. issue 6. 2005-03-22. PMID:15736429. |
fak has been implicated in several cellular processes such as invasion, motility, proliferation and apoptosis. |
2005-03-22 |
2023-08-12 |
human |
| Edward Kyu-Ho Han, Thomas Mcgonigal, Jieyi Wang, Vincent L Giranda, Yan Lu. Functional analysis of focal adhesion kinase (FAK) reduction by small inhibitory RNAs. Anticancer research. vol 24. issue 6. 2005-03-22. PMID:15736429. |
although fak sirna reduced the fak protein levels by approximately 70% in several cancer cell lines, there was no clear evidence of apoptosis. |
2005-03-22 |
2023-08-12 |
human |
| Xu-Wen Liu, Marcus E Taube, Ki-Kyung Jung, Zhong Dong, Yong J Lee, Stefanie Roshy, Bonnie F Sloane, Rafael Fridman, Hyeong-Reh Choi Ki. Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: a potential oncogenic activity of tissue inhibitor of metalloproteinase-1. Cancer research. vol 65. issue 3. 2005-03-14. PMID:15705888. |
timp-1 inhibits intrinsic apoptosis by inducing timp-1 specific cell survival pathways involving focal adhesion kinase (fak). |
2005-03-14 |
2023-08-12 |
human |
| Xu-Wen Liu, Marcus E Taube, Ki-Kyung Jung, Zhong Dong, Yong J Lee, Stefanie Roshy, Bonnie F Sloane, Rafael Fridman, Hyeong-Reh Choi Ki. Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: a potential oncogenic activity of tissue inhibitor of metalloproteinase-1. Cancer research. vol 65. issue 3. 2005-03-14. PMID:15705888. |
importantly, inhibition of pi 3-kinase signaling by wortmannin and down-regulation of fak expression using sirna significantly diminish timp-1 protection of human breast epithelial cells against trail-induced extrinsic apoptosis. |
2005-03-14 |
2023-08-12 |
human |
| Xu-Wen Liu, Marcus E Taube, Ki-Kyung Jung, Zhong Dong, Yong J Lee, Stefanie Roshy, Bonnie F Sloane, Rafael Fridman, Hyeong-Reh Choi Ki. Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: a potential oncogenic activity of tissue inhibitor of metalloproteinase-1. Cancer research. vol 65. issue 3. 2005-03-14. PMID:15705888. |
taken together, these studies suggest that timp-1 may exert oncogenic activity in breast cancer through inhibition of both intrinsic and extrinsic apoptosis involving the fak survival signal transduction pathway. |
2005-03-14 |
2023-08-12 |
human |
| Chun-long Lin, Zhen-xiang Zhang, Yong-jian Xu, Wang Ni, Shi-xin Che. Focal adhesion kinase antisense oligodeoxynucleotides inhibit human pulmonary artery smooth muscle cells proliferation and promote human pulmonary artery smooth muscle cells apoptosis. Chinese medical journal. vol 118. issue 1. 2005-03-10. PMID:15642221. |
we investigated whether fak takes part in the intracellular signalling pathway involved in hpasmcs proliferation and apoptosis, by using antisense oligodeoxynucleotides (odns) to selectively suppress the expression of fak protein. |
2005-03-10 |
2023-08-12 |
human |
| Gordon W McLean, Noboru H Komiyama, Bryan Serrels, Hidefumi Asano, Louise Reynolds, Francesco Conti, Kairbaan Hodivala-Dilke, Daniel Metzger, Pierre Chambon, Seth G N Grant, Margaret C Fram. Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. Genes & development. vol 18. issue 24. 2005-03-02. PMID:15601818. |
our work provides the first experimental proof implicating fak in tumorigenesis, and this is associated with enhanced apoptosis. |
2005-03-02 |
2023-08-12 |
mouse |
| Yan Zhang, Hai Lu, Paul Dazin, Yvonne Kapil. Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase. The Journal of biological chemistry. vol 279. issue 46. 2005-01-21. PMID:15331608. |
apoptosis was increased by blocking fak with an antisense oligonucleotide and reduced by blocking p53. |
2005-01-21 |
2023-08-12 |
human |
| Martin P Playford, Michael D Schalle. The interplay between Src and integrins in normal and tumor biology. Oncogene. vol 23. issue 48. 2004-12-28. PMID:15489911. |
we will identify the key players in the integrin-mediated signaling pathways involved in cell motility and apoptosis, such as fak, paxillin and p130(cas), and discuss how src signaling affects the formation of focal adhesions and the extracellular matrix. |
2004-12-28 |
2023-08-12 |
human |
| J Adrian Lunn, Enrique Rozengur. Hyperosmotic stress induces rapid focal adhesion kinase phosphorylation at tyrosines 397 and 577. Role of Src family kinases and Rho family GTPases. The Journal of biological chemistry. vol 279. issue 43. 2004-12-14. PMID:15302877. |
furthermore, fak null fibroblasts compared with their fak containing controls show markedly increased sensitivity, manifest by subsequent apoptosis, to sustained hyperosmotic stress. |
2004-12-14 |
2023-08-12 |
Not clear |
| Yuji Tamagiku, Yoshiko Sonoda, Mari Kunisawa, Daiju Ichikawa, Yayoi Murakami, Eriko Aizu-Yokota, Tadashi Kasahar. Down-regulation of procaspase-8 expression by focal adhesion kinase protects HL-60 cells from TRAIL-induced apoptosis. Biochemical and biophysical research communications. vol 323. issue 2. 2004-11-16. PMID:15369772. |
the introduction of fak sirna in hl-60/fak cells sensitized them against trail-induced apoptosis, confirming that overexpressed fak downregulates procaspase-8 expression, which subsequently inhibits downstream apoptosis pathway in the hl-60/fak cells. |
2004-11-16 |
2023-08-12 |
Not clear |
| Elena Alimenti, Simona Tafuri, Antonio Scibelli, Danila D'Angelo, Laura Manna, Luigi Michele Pavone, M Antonietta Belisario, Norma Staian. Pro-apoptotic signaling pathway activated by echistatin in GD25 cells. Biochimica et biophysica acta. vol 1693. issue 1. 2004-09-21. PMID:15276326. |
the down-regulation of pp125(fak) preceded apoptosis and cell detachment induced by echistatin. |
2004-09-21 |
2023-08-12 |
Not clear |
| Hong Xia, Richard Seonghun Nho, Judy Kahm, Jill Kleidon, Craig A Henk. Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. The Journal of biological chemistry. vol 279. issue 31. 2004-09-10. PMID:15166238. |
in contrast, enforced activation of beta(1) integrin by anti-beta(1) integrin antibody, which protects fibroblasts from apoptosis, preserves fak phosphorylation. |
2004-09-10 |
2023-08-12 |
Not clear |
| Hong Xia, Richard Seonghun Nho, Judy Kahm, Jill Kleidon, Craig A Henk. Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. The Journal of biological chemistry. vol 279. issue 31. 2004-09-10. PMID:15166238. |
dominant negative fak augmented fibroblast apoptosis during collagen contraction, and this was associated with diminished akt activity. |
2004-09-10 |
2023-08-12 |
Not clear |