| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nikolaos A Chatzizacharias, Gregory P Kouraklis, Stamatios E Theochari. Clinical significance of FAK expression in human neoplasia. Histology and histopathology. vol 23. issue 5. 2008-03-06. PMID:18283648. |
fak was held responsible for cancer cells' uninhibited proliferation, protection from apoptosis, invasion, migration, adhesion and spreading, as well as tumor angiogenesis. |
2008-03-06 |
2023-08-12 |
human |
| Rainer Klocke, Lekbira Hasib, Sigrid Niko. Recently patented applications of homologous cellular and extracellular agents as therapeutics or targets for the prevention of restenosis post-angioplasty. Recent patents on cardiovascular drug discovery. vol 1. issue 1. 2008-02-15. PMID:18221074. |
such agents include c-jun, the focal adhesion kinase (fak) and its inhibitor fak-related non-kinase (frnk), estrogen receptors, variants of vascular endothelial growth factor (vegf) and fibroblast growth factor-2 (fgf-2) as well as some so far poorly characterized factors supposedly involved in the control of cell proliferation, inflammation and apoptosis. |
2008-02-15 |
2023-08-12 |
Not clear |
| Marie-Line Garron, James Arthos, Jean-François Guichou, Jonathan McNally, Claudia Cicala, Stefan T Arol. Structural basis for the interaction between focal adhesion kinase and CD4. Journal of molecular biology. vol 375. issue 5. 2008-02-14. PMID:18078954. |
in infected cells, hiv-1 nef may displace fak from cd4 to protect the cells from apoptosis. |
2008-02-14 |
2023-08-12 |
human |
| Chiung-Ho Liao, Shengmin Sang, Chi-Tang Ho, Jen-Kun Li. Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. Journal of cellular biochemistry. vol 96. issue 1. 2008-02-01. PMID:16052481. |
garcinol modulates tyrosine phosphorylation of fak and subsequently induces apoptosis through down-regulation of src, erk, and akt survival signaling in human colon cancer cells. |
2008-02-01 |
2023-08-12 |
human |
| Chiung-Ho Liao, Shengmin Sang, Chi-Tang Ho, Jen-Kun Li. Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. Journal of cellular biochemistry. vol 96. issue 1. 2008-02-01. PMID:16052481. |
focal adhesion kinase (fak) is the major signaling mediator of integrin-mediated cell-matrix contact-regulated cellular proliferation, migration, and apoptosis in adherent cells. |
2008-02-01 |
2023-08-12 |
human |
| Pachiyappan Kamarajan, Yvonne L Kapil. An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK. Apoptosis : an international journal on programmed cell death. vol 12. issue 12. 2008-01-30. PMID:17879163. |
overexpression of integrin alpha v or fak inhibited the increase in caspase-3 activation and apoptosis, whereas suppression of alpha v or fak triggered a further significant increase in apoptosis, indicating that the apoptosis was mediated by suppression of integrin alpha v levels and dephosphorylation of fak. |
2008-01-30 |
2023-08-12 |
human |
| Mark A Carlson, Amy K Prall, Jeremiah J Gum. RNA interference in human foreskin fibroblasts within the three-dimensional collagen matrix. Molecular and cellular biochemistry. vol 306. issue 1-2. 2008-01-29. PMID:17657589. |
consistent with prediction, knockdown of fak induced apoptosis in the fibroblast-populated collagen matrix. |
2008-01-29 |
2023-08-12 |
human |
| Edward Kyu-Ho Han, Thomas McGoniga. Role of focal adhesion kinase in human cancer: a potential target for drug discovery. Anti-cancer agents in medicinal chemistry. vol 7. issue 6. 2008-01-03. PMID:18045062. |
fak is involved in several cellular processes including invasion, motility, proliferation and apoptosis. |
2008-01-03 |
2023-08-12 |
human |
| Lillian I Plotkin, Stavros C Manolagas, Teresita Bellid. Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis. The Journal of biological chemistry. vol 282. issue 33. 2007-10-19. PMID:17581824. |
in addition, the focal adhesion kinase fak prevents dexamethasone-induced apoptosis, whereas the fak-related kinase pyk2 increases the basal levels of apoptosis. |
2007-10-19 |
2023-08-12 |
human |
| R Besch, C Berking, C Kammerbauer, K Degit. Inhibition of urokinase-type plasminogen activator receptor induces apoptosis in melanoma cells by activation of p53. Cell death and differentiation. vol 14. issue 4. 2007-07-24. PMID:17110957. |
however, inhibition of fak did not induce apoptosis. |
2007-07-24 |
2023-08-12 |
Not clear |
| Irene Mamali, Marianthi N Tatari, Ilina Micheva, Maria Lampropoulou, Vassilis J Marmara. Apoptosis in medfly hemocytes is regulated during pupariation through FAK, Src, ERK, PI-3K p85a, and Akt survival signaling. Journal of cellular biochemistry. vol 101. issue 2. 2007-07-24. PMID:17177294. |
apoptosis in medfly hemocytes is regulated during pupariation through fak, src, erk, pi-3k p85a, and akt survival signaling. |
2007-07-24 |
2023-08-12 |
Not clear |
| Irene Mamali, Marianthi N Tatari, Ilina Micheva, Maria Lampropoulou, Vassilis J Marmara. Apoptosis in medfly hemocytes is regulated during pupariation through FAK, Src, ERK, PI-3K p85a, and Akt survival signaling. Journal of cellular biochemistry. vol 101. issue 2. 2007-07-24. PMID:17177294. |
focal adhesion kinase (fak) and its downstream signaling targets are implicated in the process of apoptosis induced by external stimuli, in several mammalian systems. |
2007-07-24 |
2023-08-12 |
Not clear |
| Irene Mamali, Marianthi N Tatari, Ilina Micheva, Maria Lampropoulou, Vassilis J Marmara. Apoptosis in medfly hemocytes is regulated during pupariation through FAK, Src, ERK, PI-3K p85a, and Akt survival signaling. Journal of cellular biochemistry. vol 101. issue 2. 2007-07-24. PMID:17177294. |
in particular, we show using western blot, elisa and flow cytometry analysis, that fak expression silencing in transfected by fak double-stranded rna (dsrna) hemocytes, enhances twofold hemocyte apoptosis, by signaling through src, mek/erk, and pi-3k/akt signaling pathways. |
2007-07-24 |
2023-08-12 |
Not clear |
| Irene Mamali, Marianthi N Tatari, Ilina Micheva, Maria Lampropoulou, Vassilis J Marmara. Apoptosis in medfly hemocytes is regulated during pupariation through FAK, Src, ERK, PI-3K p85a, and Akt survival signaling. Journal of cellular biochemistry. vol 101. issue 2. 2007-07-24. PMID:17177294. |
pre-incubation of hemocytes, with specific inhibitors of fak downstream signaling molecules, demonstrated that all these inhibitors reduced hemocyte viability and enhanced the magnitude of apoptosis about threefold. |
2007-07-24 |
2023-08-12 |
Not clear |
| Irene Mamali, Marianthi N Tatari, Ilina Micheva, Maria Lampropoulou, Vassilis J Marmara. Apoptosis in medfly hemocytes is regulated during pupariation through FAK, Src, ERK, PI-3K p85a, and Akt survival signaling. Journal of cellular biochemistry. vol 101. issue 2. 2007-07-24. PMID:17177294. |
the novel aspect of this report is based on the fact that hemocytes attempt to suppress apoptosis, by increasing the expression/phosphorylation of fak and, hence its downstream targets signaling molecules src, erk, pi-3k p85a, and akt. |
2007-07-24 |
2023-08-12 |
Not clear |
| Kyung Mi Woo, Jihye Seo, Ruiyun Zhang, Peter X M. Suppression of apoptosis by enhanced protein adsorption on polymer/hydroxyapatite composite scaffolds. Biomaterials. vol 28. issue 16. 2007-07-18. PMID:17320948. |
furthermore, beta1 and beta3 integrins and phosphorylation of fak and akt proteins in the cells on the plla/hap scaffolds were significantly more abundent than those on plla scaffolds, which suggest that enhanced adsorption of serum adhesion proteins to plla/hap scaffolds protect the cells from apoptosis possibly through the integrin-fak-akt pathway. |
2007-07-18 |
2023-08-12 |
Not clear |
| Jill K Slack-Davis, Karen H Martin, Robert W Tilghman, Marcin Iwanicki, Ethan J Ung, Christopher Autry, Michael J Luzzio, Beth Cooper, John C Kath, W Gregory Roberts, J Thomas Parson. Cellular characterization of a novel focal adhesion kinase inhibitor. The Journal of biological chemistry. vol 282. issue 20. 2007-07-18. PMID:17395594. |
treatment of cells with concentrations of pf-573,228 that significantly decreased fak tyr(397) phosphorylation failed to inhibit cell growth or induce apoptosis. |
2007-07-18 |
2023-08-12 |
Not clear |
| Yi Fang, Xing Zhang, Ji-Ren Zhang, Wen-Qi Jian. [Correlation of GLC-82 lung carcinoma cell aggregation in suspension culture to the activation of protein kinases FAK, AKT, ERK, and SRC]. Ai zheng = Aizheng = Chinese journal of cancer. vol 24. issue 10. 2007-06-29. PMID:16219134. |
our previous study revealed that tyrosine kinase fak can partly mediate the aggregation of tumor cells in suspension culture, therefore, suppress cell apoptosis and promote cell proliferation. |
2007-06-29 |
2023-08-12 |
Not clear |
| Elizabeth A Beierle, Angelica Trujillo, Abhilasha Nagaram, Elena V Kurenova, Richard Finch, Xiaojie Ma, Jennifer Vella, William G Cance, Vita M Golubovskay. N-MYC regulates focal adhesion kinase expression in human neuroblastoma. The Journal of biological chemistry. vol 282. issue 17. 2007-06-14. PMID:17327229. |
finally down-regulation of fak expression in n-myc-inducible neuroblastoma cell lines with fak small interfering rna or a dominant-negative fak inhibitor (adfak-cd) significantly decreased viability and increased apoptosis in the n-myc(+) (tet(-)) cells compared with the isogenic n-myc(-) (tet(+)) cells, demonstrating the biological significance of fak overexpression in the n-myc-expressing cell lines. |
2007-06-14 |
2023-08-12 |
human |
| Danshan Huang, Michelle Khoe, Merone Befekadu, Sue Chung, Yasunori Takata, Dusko Ilic, Michael Bryer-As. Focal adhesion kinase mediates cell survival via NF-kappaB and ERK signaling pathways. American journal of physiology. Cell physiology. vol 292. issue 4. 2007-06-07. PMID:17135301. |
fak(-/-) fibroblasts were more vulnerable to tnf-alpha-induced apoptosis, as measured by terminal deoxynucleotidyl transferase positivity. |
2007-06-07 |
2023-08-12 |
Not clear |