| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danshan Huang, Michelle Khoe, Merone Befekadu, Sue Chung, Yasunori Takata, Dusko Ilic, Michael Bryer-As. Focal adhesion kinase mediates cell survival via NF-kappaB and ERK signaling pathways. American journal of physiology. Cell physiology. vol 292. issue 4. 2007-06-07. PMID:17135301. |
the specific role of fak to protect cells from apoptosis is regulated by activation and phosphorylation of nf-kappab and interaction between activated growth factor anti-apoptotic signaling pathways involving both phosphatidylinositol 3-kinase/akt and mapk/erk1/2. |
2007-06-07 |
2023-08-12 |
Not clear |
| Danshan Huang, Michelle Khoe, Merone Befekadu, Sue Chung, Yasunori Takata, Dusko Ilic, Michael Bryer-As. Focal adhesion kinase mediates cell survival via NF-kappaB and ERK signaling pathways. American journal of physiology. Cell physiology. vol 292. issue 4. 2007-06-07. PMID:17135301. |
thus we propose a novel role for fak in protection from cytokine-mediated apoptosis. |
2007-06-07 |
2023-08-12 |
Not clear |
| Jeffrey C Horowitz, David S Rogers, Vishal Sharma, Ragini Vittal, Eric S White, Zongbin Cui, Victor J Thannicka. Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts. Cellular signalling. vol 19. issue 4. 2007-04-18. PMID:17113264. |
tgf-beta1 is able to activate akt in cells expressing mutant fak or in cells treated with an rgd-containing peptide that interferes with integrin signalling, inhibits fak activation and induces anoikis (apoptosis induced by loss of adhesion signalling). |
2007-04-18 |
2023-08-12 |
human |
| Maoulana Andjilani, Jean-Pierre Droz, Mohamed Benahmed, Eric Tabon. Down-regulation of FAK and IAPs by laminin during cisplatin-induced apoptosis in testicular germ cell tumors. International journal of oncology. vol 28. issue 2. 2007-02-01. PMID:16391810. |
down-regulation of fak and iaps by laminin during cisplatin-induced apoptosis in testicular germ cell tumors. |
2007-02-01 |
2023-08-12 |
Not clear |
| Maoulana Andjilani, Jean-Pierre Droz, Mohamed Benahmed, Eric Tabon. Down-regulation of FAK and IAPs by laminin during cisplatin-induced apoptosis in testicular germ cell tumors. International journal of oncology. vol 28. issue 2. 2007-02-01. PMID:16391810. |
the purpose of this present study was to investigate the role of inhibitor of apoptosis proteins (iaps), their inhibitor, smac, and the focal adhesion kinase (fak) in the laminin enhancement of cisplatin-induced apoptosis in a testicular tumor germ cell line, nccit. |
2007-02-01 |
2023-08-12 |
Not clear |
| Stephana Carelli, Giorgia Zadra, Valentina Vaira, Monica Falleni, Luca Bottiglieri, Mario Nosotti, Anna Maria Di Giulio, Alfredo Gorio, Silvano Bosar. Up-regulation of focal adhesion kinase in non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands). vol 53. issue 3. 2007-01-16. PMID:16842883. |
focal adhesion kinase (fak) is a non-receptor tyrosine kinase linked to the integrin and growth factor receptor-signalling pathways that regulates a number of the biological processes involved in neoplastic transformation, invasion and metastases, such as cell adhesion, migration and apoptosis. |
2007-01-16 |
2023-08-12 |
human |
| Laureen E Connell, David M Helfma. Myosin light chain kinase plays a role in the regulation of epithelial cell survival. Journal of cell science. vol 119. issue Pt 11. 2007-01-12. PMID:16723733. |
in addition, this rescue of apoptosis is dependent on fak activity, suggesting the participation of an integrin-dependent signaling pathway. |
2007-01-12 |
2023-08-12 |
Not clear |
| S J Ryu, K A Cho, Y S Oh, S C Par. Role of Src-specific phosphorylation site on focal adhesion kinase for senescence-associated apoptosis resistance. Apoptosis : an international journal on programmed cell death. vol 11. issue 3. 2006-12-11. PMID:16523241. |
in addition, senescent cells whose fak expression was downregulated by sirna showed the increased level of apoptosis by staurosporine treatment via caspase-3 activation but not by hydrogen peroxide treatment. |
2006-12-11 |
2023-08-12 |
Not clear |
| S J Ryu, K A Cho, Y S Oh, S C Par. Role of Src-specific phosphorylation site on focal adhesion kinase for senescence-associated apoptosis resistance. Apoptosis : an international journal on programmed cell death. vol 11. issue 3. 2006-12-11. PMID:16523241. |
interestingly dephosphorylation at tyr577 of fak by pp2 treatment, src-family kinase inhibitor, induced the apoptosis by staurosporine in senescent cells but dephosphorylation at tyr397 by downregulation of caveolin-1 was not affected. |
2006-12-11 |
2023-08-12 |
Not clear |
| S J Ryu, K A Cho, Y S Oh, S C Par. Role of Src-specific phosphorylation site on focal adhesion kinase for senescence-associated apoptosis resistance. Apoptosis : an international journal on programmed cell death. vol 11. issue 3. 2006-12-11. PMID:16523241. |
these data suggest that fak might differently regulate apoptosis and focal adhesion formation through site-specific tyrosine phosphorylation in senescent cells. |
2006-12-11 |
2023-08-12 |
Not clear |
| Maroesja J van Nimwegen, Merei Huigsloot, Annamarie Camier, Ine B Tijdens, Bob van de Wate. Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells. Molecular pharmacology. vol 70. issue 4. 2006-11-29. PMID:16825486. |
in the present study, we examined the role of fak in the control of anticancer drug-induced apoptosis of mammary adenocarcinoma mtln3 cells. |
2006-11-29 |
2023-08-12 |
Not clear |
| Maroesja J van Nimwegen, Merei Huigsloot, Annamarie Camier, Ine B Tijdens, Bob van de Wate. Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells. Molecular pharmacology. vol 70. issue 4. 2006-11-29. PMID:16825486. |
phosphorylation of fak on tyrosine 397 decreased only during the onset of doxorubicin-induced apoptosis in a bcl-2 and caspase-independent manner. |
2006-11-29 |
2023-08-12 |
Not clear |
| Maroesja J van Nimwegen, Merei Huigsloot, Annamarie Camier, Ine B Tijdens, Bob van de Wate. Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells. Molecular pharmacology. vol 70. issue 4. 2006-11-29. PMID:16825486. |
altogether, these data fit with a model wherein fak is involved in the doxorubicin-induced activation of the pi-3 kinase/pkb signaling route, thereby suppressing the onset of apoptosis caused by doxorubicin. |
2006-11-29 |
2023-08-12 |
Not clear |
| S K Mitra, S-T Lim, A Chi, D D Schlaepfe. Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model. Oncogene. vol 25. issue 32. 2006-11-08. PMID:16547501. |
whereas fak shrna-expressing 4t1 cells formed tumors in mice with low levels of apoptosis, when mammary-injected, these cells did not exhibit lung metastasis after 21 days and caused only 40% lethality up to 60 days. |
2006-11-08 |
2023-08-12 |
mouse |
| Laura A DiMichele, Jason T Doherty, Mauricio Rojas, Hilary E Beggs, Louis F Reichardt, Christopher P Mack, Joan M Taylo. Myocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy. Circulation research. vol 99. issue 6. 2006-10-12. PMID:16902179. |
these studies show that loss of fak impairs normal compensatory hypertrophic remodeling without a concomitant increase in apoptosis in response to cardiac pressure overload and highlight the possibility that fak activation may be a common requirement for the initiation of this compensatory response. |
2006-10-12 |
2023-08-12 |
mouse |
| Marc D Basson, Matthew A Sanders, Ruben Gomez, James Hatfield, Richard Vanderheide, Vijayalakshmi Thamilselvan, Jianhu Zhang, Mary F Wals. Focal adhesion kinase protein levels in gut epithelial motility. American journal of physiology. Gastrointestinal and liver physiology. vol 291. issue 3. 2006-09-28. PMID:16899713. |
most studies of focal adhesion kinase (fak), a protein that regulates motility, proliferation, and apoptosis, have focused on rapid phosphorylation. |
2006-09-28 |
2023-08-12 |
human |
| Zhi-Min Wu, Xian-Hou Yuan, Pu-Cha Jiang, Zhi-Qiang Li, Tao W. Antisense oligonucleodes targeting the focal adhesion kinase inhibit proliferation, induce apoptosis and cooperate with cytotoxic drugs in human glioma cells. Journal of neuro-oncology. vol 77. issue 2. 2006-08-29. PMID:16314954. |
to examine the role of focal adhesion kinase in human glioma cells, we studied its effects on proliferation and apoptosis using fak antisense oligonucleotide. |
2006-08-29 |
2023-08-12 |
human |
| Zhi-Min Wu, Xian-Hou Yuan, Pu-Cha Jiang, Zhi-Qiang Li, Tao W. Antisense oligonucleodes targeting the focal adhesion kinase inhibit proliferation, induce apoptosis and cooperate with cytotoxic drugs in human glioma cells. Journal of neuro-oncology. vol 77. issue 2. 2006-08-29. PMID:16314954. |
it is possible that fak via mitochondrial and caspase-3 inhibits u251 mg cells apoptosis. |
2006-08-29 |
2023-08-12 |
human |
| Khadija Rafiq, Mikhail A Kolpakov, Malika Abdelfettah, Daniel N Streblow, Aviv Hassid, Louis J Dell'Italia, Abdelkarim Sabr. Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikis. The Journal of biological chemistry. vol 281. issue 28. 2006-08-21. PMID:16690621. |
expression of dominant negative shp2 mutant markedly attenuates fak tyrosine dephosphorylation induced by cat.g and protects myocytes to undergo apoptosis. |
2006-08-21 |
2023-08-12 |
rat |
| Khadija Rafiq, Mikhail A Kolpakov, Malika Abdelfettah, Daniel N Streblow, Aviv Hassid, Louis J Dell'Italia, Abdelkarim Sabr. Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikis. The Journal of biological chemistry. vol 281. issue 28. 2006-08-21. PMID:16690621. |
in contrast, increased shp2 expression exacerbates cat.g-induced fak tyrosine dephosphorylation and myocyte apoptosis. |
2006-08-21 |
2023-08-12 |
rat |