| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tianjiao E, Chengyu Xu, Xiapu Fan, Jiawei Liu, Jinpeng Zhao, Nan Bao, Yuan Zhao, Mohammed Hamdy Farouk, Yun Ji, Zhenlong Wu, Li Pan, Guixin Qi. Soybean Agglutinin Induced Apoptotic Effects by Down-Regulating ANXA2 Through FAK Pathway in IPEC-J2 Cells. Journal of animal physiology and animal nutrition. 2024-10-16. PMID:39410871. |
the results showed that sba induced the apoptosis through fak signal pathway and decreased the gene and protein expressions of anxa2 in ipec-j2. |
2024-10-16 |
2024-10-18 |
human |
| Tianjiao E, Chengyu Xu, Xiapu Fan, Jiawei Liu, Jinpeng Zhao, Nan Bao, Yuan Zhao, Mohammed Hamdy Farouk, Yun Ji, Zhenlong Wu, Li Pan, Guixin Qi. Soybean Agglutinin Induced Apoptotic Effects by Down-Regulating ANXA2 Through FAK Pathway in IPEC-J2 Cells. Journal of animal physiology and animal nutrition. 2024-10-16. PMID:39410871. |
the expression of anxa2 protein had a negative correlation with the apoptosis rates, and a positive correlation with the expression of fak protein and fak pathway downstream proteins. |
2024-10-16 |
2024-10-18 |
human |
| Tianjiao E, Chengyu Xu, Xiapu Fan, Jiawei Liu, Jinpeng Zhao, Nan Bao, Yuan Zhao, Mohammed Hamdy Farouk, Yun Ji, Zhenlong Wu, Li Pan, Guixin Qi. Soybean Agglutinin Induced Apoptotic Effects by Down-Regulating ANXA2 Through FAK Pathway in IPEC-J2 Cells. Journal of animal physiology and animal nutrition. 2024-10-16. PMID:39410871. |
in conclusion, sba induced apoptosis of ipec-j2 cells by downregulating the expression of anxa2, which activated the fak pathway. |
2024-10-16 |
2024-10-18 |
human |
| Fang Liu, Shaohua Wen, Manli Liu, Yong Min, Zhigang Zhang, Liqiao Shi, Kaimei Wang, Yunxia Deng, Ziwen Yang, Fei Yang, Shaoyong K. Heterocycle-functional steroidal derivatives: Design, synthesis, bioevaluation and SARs of steroidal pyrazolo[1,5-a]pyrimidines as potential ALK inhibitors. Bioorganic chemistry. vol 153. 2024-09-30. PMID:39348750. |
especially, compound 4c has certain inhibitory effects on the tyrosine protein kinases alk, cdk2/cycline1, fak, cdk5/p35, cdk9/cyclint1, cdk5/p25, pim2, cdk2/cyclina2, cdk1/cyclinb1, etc., and which displayed highest inhibitory effect on the kinases of alk with inhibition rate 40.63 % at the concentration of 10 μm, which induced cell death in a875 cells at least partly (initially), by apoptosis. |
2024-09-30 |
2024-10-03 |
human |
| Corrigendum to 'Adipocyte-specific FAK deletion promotes pancreatic β-cell apoptosis via adipose inflammatory response to exacerbate diabetes mellitus'. Clinical and translational medicine. vol 14. issue 9. 2024-09-24. PMID:39315822. |
corrigendum to 'adipocyte-specific fak deletion promotes pancreatic β-cell apoptosis via adipose inflammatory response to exacerbate diabetes mellitus'. |
2024-09-24 |
2024-09-26 |
Not clear |
| Chiara Pozzato, Gonçalo Outeiro-Pinho, Mirco Galiè, Giorgio Ramadori, Georgia Konstantinido. ERK5 suppression overcomes FAK inhibitor resistance in mutant KRAS-driven non-small cell lung cancer. EMBO molecular medicine. 2024-09-13. PMID:39271958. |
inhibition of erk5 and cdk5 synergistically suppressed fak function, decreased proliferation and induced apoptosis owing to exacerbated ros-induced dna damage. |
2024-09-13 |
2024-09-16 |
mouse |
| Metin Cetin, Ozge Saatci, Abdol-Hossein Rezaeian, Chintada Nageswara Rao, Chad Beneker, Kukkamudi Sreenivas, Harrison Taylor, Breanna Pederson, Ioulia Chatzistamou, Brian Buckley, Susan Lessner, Peggi Angel, Campbell McInnes, Ozgur Sahi. A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer. Cell chemical biology. 2024-07-23. PMID:39043186. |
this leads to better drug penetration, inhibits fak signaling, and induces ros/dna damage, g1 arrest, and apoptosis in chemoresistant triple-negative breast cancer (tnbc) cell lines, pdx organoids, and in vivo. |
2024-07-23 |
2024-07-26 |
Not clear |
| Piman Pocasap, Auemduan Prawan, Sarinya Kongpetch, Laddawan Senggunpra. Network pharmacology- and cell-based assessments identify the FAK/Src pathway as a molecular target for the antimetastatic effect of momordin Ic against cholangiocarcinoma. Heliyon. vol 10. issue 11. 2024-07-04. PMID:38961933. |
the results unveiled the potential involvement of mic in apoptosis and cell migration, pinpointing src and fak as key targets. |
2024-07-04 |
2024-07-10 |
Not clear |
| Fei Ding, Peng Zheng, Hong-Ting Fang, Yuan-Yuan Luo, Xi-Yue Yan, Hui-Jian Chen, You-E Ya. Adipocyte-specific FAK deletion promotes pancreatic β-cell apoptosis via adipose inflammatory response to exacerbate diabetes mellitus. Clinical and translational medicine. vol 14. issue 7. 2024-06-26. PMID:38925910. |
adipocyte-specific fak deletion promotes pancreatic β-cell apoptosis via adipose inflammatory response to exacerbate diabetes mellitus. |
2024-06-26 |
2024-06-29 |
Not clear |
| Juanjuan Xu, Manjun Lv, Xiaohong N. Marein Alleviates Doxorubicin-Induced Cardiotoxicity through FAK/AKT Pathway Modulation while Potentiating its Anticancer Activity. Cardiovascular toxicology. 2024-06-19. PMID:38896162. |
mechanistically, mar reduced inflammation, oxidative stress, and apoptosis in cardiomyocytes, potentially via activation of the focal adhesion kinase (fak)/akt pathway. |
2024-06-19 |
2024-06-21 |
mouse |
| Xiaochen Wang, Yifan Zhang, Kun Chi, Yuwei Ji, Keying Zhang, Ping Li, Zhangning Fu, Xu Wang, Shaoyuan Cui, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Hanyu Zhu, Quan Hon. IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin α5/FAK in diabetic kidney disease. Apoptosis : an international journal on programmed cell death. 2024-05-25. PMID:38796567. |
furthermore, igfbp2 facilitated apoptosis, which was characterized by increase in inflammation and oxidative stress, by binding with integrin α5 (itga5) of podocytes, and then activating the phosphorylation of focal adhesion kinase (fak)-mediated mitochondrial injury, including membrane potential decreasing, ros production increasing. |
2024-05-25 |
2024-05-31 |
mouse |
| Xiaochen Wang, Yifan Zhang, Kun Chi, Yuwei Ji, Keying Zhang, Ping Li, Zhangning Fu, Xu Wang, Shaoyuan Cui, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Hanyu Zhu, Quan Hon. IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin α5/FAK in diabetic kidney disease. Apoptosis : an international journal on programmed cell death. 2024-05-25. PMID:38796567. |
moreover, itga5 knockdown or fak inhibition attenuated the podocyte apoptosis caused by high glucose or igfbp2 overexpression. |
2024-05-25 |
2024-05-31 |
mouse |
| Mingming Xue, Lingyu Xing, Yilin Yang, Mian Shao, Fengqing Liao, Feixiang Xu, Yumei Chen, Sheng Wang, Bin Chen, Chenling Yao, Guorong Gu, Chaoyang Ton. A decrease in integrin α5β1/FAK is associated with increased apoptosis of aortic smooth muscle cells in acute type a aortic dissection. BMC cardiovascular disorders. vol 24. issue 1. 2024-03-27. PMID:38532364. |
human aortic smooth muscle cells (hasmcs) exhibit decreased proliferation and increased apoptosis, and integrin α5β1 and fak are important proangiogenic factors involved in regulating angiogenesis. |
2024-03-27 |
2024-03-29 |
human |
| Jiancong Wu, Xiaobi Huang, Xiaofang Li, Honglian Zhou, Xiaorao Chen, Yongyang Chen, Yudong Guo, Jian Huang, Hanqing Huang, Zhong Huang, Guoan Chen, Zhixiong Yang, Jian Zhang, Wenmei S. Suppression of the long non-coding RNA LINC01279 triggers autophagy and apoptosis in lung cancer by regulating FAK and SIN3A. Discover. Oncology. vol 15. issue 1. 2024-01-03. PMID:38168833. |
suppression of the long non-coding rna linc01279 triggers autophagy and apoptosis in lung cancer by regulating fak and sin3a. |
2024-01-03 |
2024-01-06 |
human |
| Anqi Huo, Xiangyang Xion. PAICS as a potential target for cancer therapy linking purine biosynthesis to cancer progression. Life sciences. 2023-09-06. PMID:37673296. |
evidence suggests that paics and its catalytic product, n-succinylcarboxamide-5-aminoimidazole ribonucleotide (saicar), could inhibit tumor cell apoptosis and promote the growth, epithelial-mesenchymal transition (emt), invasion, and metastasis by regulating signaling pathways such as pyruvate kinase m2 (pkm2), extracellular signal-related kinases 1 and 2 (erk1/2), focal adhesion kinase (fak) and so on. |
2023-09-06 |
2023-10-07 |
Not clear |
| Chao-Cheng Chen, Suyang Wang, Jr-Ming Yang, Chuan-Hsiang Huan. Targeting Ras signaling excitability in cancer cells through combined inhibition of FAK and PI3K. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398082. |
we found that the combination of fak and pi3k inhibitors synergistically suppressed the growth of select cervical and pancreatic cancer cell lines through increased apoptosis and decreased mitosis. |
2023-07-03 |
2023-08-14 |
human |
| Malcy Tarin, Fariba Némati, Didier Decaudin, Christine Canbezdi, Benjamin Marande, Lisseth Silva, Héloïse Derrien, Aart G Jochemsen, Sophie Gardrat, Sophie Piperno-Neumann, Manuel Rodrigues, Pascale Mariani, Nathalie Cassoux, Marc-Henri Stern, Sergio Roman-Roman, Samar Alsafad. FAK Inhibitor-Based Combinations with MEK or PKC Inhibitors Trigger Synergistic Antitumor Effects in Uveal Melanoma. Cancers. vol 15. issue 8. 2023-05-16. PMID:37190207. |
the combined inhibition of fak and mek or pkc had highly synergistic effects by reducing cell viability and inducing apoptosis. |
2023-05-16 |
2023-08-14 |
Not clear |
| Kainan Zhang, Xizhou An, Yao Zhu, Lan Huang, Xinyuan Yao, Xing Zeng, Shaoyan Liang, Jie Y. Netrin-1 inducing antiapoptotic effect of acute myeloid leukemia cells in a concentration-dependent manner through the Unc-5 netrin receptor B-focal adhesion kinase axis. Cancer biology & therapy. vol 24. issue 1. 2023-04-10. PMID:37038247. |
both fak and akt inhibitors abrogated the effects of netrin-1 on the proliferation and apoptosis of aml cells. |
2023-04-10 |
2023-08-14 |
Not clear |
| Mikiko Takebayashi Kano, Toshio Kokuryo, Taisuke Baba, Kimitoshi Yamazaki, Junpei Yamaguchi, Masaki Sunagawa, Atsushi Ogura, Nobuyuki Watanabe, Shunsuke Onoe, Kazushi Miyata, Takashi Mizuno, Kay Uehara, Tsuyoshi Igami, Yukihiro Yokoyama, Tomoki Ebata, Masato Nagin. Cyclodextrin Conjugated α-Bisabolol Suppresses FAK Phosphorylation and Induces Apoptosis in Pancreatic Cancer. Anticancer research. vol 43. issue 3. 2023-02-28. PMID:36854520. |
cyclodextrin conjugated α-bisabolol suppresses fak phosphorylation and induces apoptosis in pancreatic cancer. |
2023-02-28 |
2023-08-14 |
Not clear |
| Ya-Hui Chen, Jyun-Xue Wu, Shun-Fa Yang, Yi-Hsuan Hsia. Synergistic Combination of Luteolin and Asiatic Acid on Cervical Cancer In Vitro and In Vivo. Cancers. vol 15. issue 2. 2023-01-21. PMID:36672499. |
furthermore, lut combined with asa induced apoptosis and inhibited migration through downregulated pi3k/akt (pi3k, akt and p70s6k), jnk/p38 mapk and fak (integrin β1, paxillin and fak) signaling and upregulated erk signaling. |
2023-01-21 |
2023-08-14 |
Not clear |