| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Sonoda, S Watanabe, Y Matsumoto, E Aizu-Yokota, T Kasahar. FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line. The Journal of biological chemistry. vol 274. issue 15. 1999-05-03. PMID:10187851. |
fak is the upstream signal protein of the phosphatidylinositol 3-kinase-akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line. |
1999-05-03 |
2023-08-12 |
human |
| Y Sonoda, S Watanabe, Y Matsumoto, E Aizu-Yokota, T Kasahar. FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line. The Journal of biological chemistry. vol 274. issue 15. 1999-05-03. PMID:10187851. |
thus, it became apparent that fak is the upstream signal protein of the pi 3-kinase-akt survival pathway in hydrogen peroxide-induced apoptosis in t98g cells. |
1999-05-03 |
2023-08-12 |
human |
| Y M Fu, Z X Yu, B A Pelayo, V J Ferrans, G G Meadow. Focal adhesion kinase-dependent apoptosis of melanoma induced by tyrosine and phenylalanine deficiency. Cancer research. vol 59. issue 3. 1999-02-25. PMID:9973229. |
fak protein expression recovered within 60 min, and cell viability recovered within 24 h. genistein, a tyrosine kinase inhibitor that specifically inhibits tyr phosphorylation of fak, did not induce apoptosis in a375 melanoma cells at a concentration of 50 microm. |
1999-02-25 |
2023-08-12 |
human |
| L A Cary, J L Gua. Focal adhesion kinase in integrin-mediated signaling. Frontiers in bioscience : a journal and virtual library. vol 4. 1999-02-04. PMID:9889179. |
finally, fak's roles in the regulation of several integrin-mediated cellular events are discussed, including the promotion of cell migration, proliferation and spreading, and the prevention of cell apoptosis. |
1999-02-04 |
2023-08-12 |
Not clear |
| D Ilić, E A Almeida, D D Schlaepfer, P Dazin, S Aizawa, C H Damsk. Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. The Journal of cell biology. vol 143. issue 2. 1998-11-12. PMID:9786962. |
if fak or the correct ecm is absent, cells enter apoptosis through a p53-dependent pathway activated by protein kinase c lambda/iota and cytosolic phospholipase a2. |
1998-11-12 |
2023-08-12 |
Not clear |
| F Fukai, M Mashimo, K Akiyama, T Goto, S Tanuma, T Katayam. Modulation of apoptotic cell death by extracellular matrix proteins and a fibronectin-derived antiadhesive peptide. Experimental cell research. vol 242. issue 1. 1998-08-10. PMID:9665806. |
thus, the opposing effects of ecm proteins, including fibronectin and vitronectin, and peptide iii14-2 on huvec apoptosis appear to be due to the opposing effects of these factors on the signaling pathway which includes tyrosine phosphorylation of fak and bcl-2 expression. |
1998-08-10 |
2023-08-12 |
human |
| F G Gervais, N A Thornberry, S C Ruffolo, D W Nicholson, S Ro. Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide. The Journal of biological chemistry. vol 273. issue 27. 1998-08-06. PMID:9642276. |
we demonstrate that fak is cleaved by caspases at two distinct sites during apoptosis. |
1998-08-06 |
2023-08-12 |
Not clear |
| F G Gervais, N A Thornberry, S C Ruffolo, D W Nicholson, S Ro. Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide. The Journal of biological chemistry. vol 273. issue 27. 1998-08-06. PMID:9642276. |
the cleavage of fak during apoptosis separates the tyrosine kinase domain from the focal adhesion targeting (fat) domain. |
1998-08-06 |
2023-08-12 |
Not clear |
| F G Gervais, N A Thornberry, S C Ruffolo, D W Nicholson, S Ro. Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide. The Journal of biological chemistry. vol 273. issue 27. 1998-08-06. PMID:9642276. |
interestingly, rodent fak lacks an optimal caspase-3 consensus cleavage site although it is cleaved in murine cells undergoing apoptosis at an upstream site. |
1998-08-06 |
2023-08-12 |
Not clear |
| T Zhu, E L Goh, P E Lobi. Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription. The Journal of biological chemistry. vol 273. issue 17. 1998-05-22. PMID:9553131. |
the use of fak in the signal transduction pathway utilized by gh may be central to many of the pleiotropic effects of gh, including cytoskeletal reorganization, cell migration, chemotaxis, mitogenesis, and/or prevention of apoptosis and gene transcription. |
1998-05-22 |
2023-08-12 |
Not clear |
| Y Sonoda, T Kasahara, E Yokota-Aizu, M Ueno, S Watanab. A suppressive role of p125FAK protein tyrosine kinase in hydrogen peroxide-induced apoptosis of T98G cells. Biochemical and biophysical research communications. vol 241. issue 3. 1998-02-03. PMID:9434784. |
when t98g cells were incubated with fak antisense oligonucleotide, apoptosis was also accelerated. |
1998-02-03 |
2023-08-12 |
human |
| W Xiong, J T Parson. Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase. The Journal of cell biology. vol 139. issue 2. 1997-11-20. PMID:9334354. |
collectively, our results suggest that pyk2 and fak, albeit highly homologous in primary structure, appear to have different functions; fak is required for cell survival, whereas pyk2 induces apoptosis in fibroblasts. |
1997-11-20 |
2023-08-12 |
mouse |
| L P Wen, J A Fahrni, S Troie, J L Guan, K Orth, G D Rose. Cleavage of focal adhesion kinase by caspases during apoptosis. The Journal of biological chemistry. vol 272. issue 41. 1997-11-13. PMID:9325343. |
the interactions of integrins with the extracellular matrix activates focal adhesion kinase (fak) and suppresses apoptosis in diverse cell types. |
1997-11-13 |
2023-08-12 |
Not clear |
| L P Wen, J A Fahrni, S Troie, J L Guan, K Orth, G D Rose. Cleavage of focal adhesion kinase by caspases during apoptosis. The Journal of biological chemistry. vol 272. issue 41. 1997-11-13. PMID:9325343. |
in this study, we show that fak is sequentially cleaved into two different fragments early in apo-2l-induced apoptosis. |
1997-11-13 |
2023-08-12 |
Not clear |
| S M Frisch, K Vuori, E Ruoslahti, P Y Chan-Hu. Control of adhesion-dependent cell survival by focal adhesion kinase. The Journal of cell biology. vol 134. issue 3. 1996-09-12. PMID:8707856. |
the interactions of integrins with extracellular matrix proteins can activate focal adhesion kinase (fak) and suppress apoptosis in normal epithelial and endothelial cells; this subset of apoptosis has been termed "anoikis." |
1996-09-12 |
2023-08-12 |
mouse |
| D H Crouch, V J Fincham, M C Fram. Targeted proteolysis of the focal adhesion kinase pp125 FAK during c-MYC-induced apoptosis is suppressed by integrin signalling. Oncogene. vol 12. issue 12. 1996-09-04. PMID:8700528. |
targeted proteolysis of the focal adhesion kinase pp125 fak during c-myc-induced apoptosis is suppressed by integrin signalling. |
1996-09-04 |
2023-08-12 |
chicken |
| D H Crouch, V J Fincham, M C Fram. Targeted proteolysis of the focal adhesion kinase pp125 FAK during c-MYC-induced apoptosis is suppressed by integrin signalling. Oncogene. vol 12. issue 12. 1996-09-04. PMID:8700528. |
proteolysis of pp125 fak occurs in adherent cells prior to commitment to death, suggesting that it contributes to c-myc-induced apoptosis, rather than being a consequence of it. |
1996-09-04 |
2023-08-12 |
chicken |
| C Zhang, M P Lambert, C Bunch, K Barber, W S Wade, G A Krafft, W L Klei. Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in response to Alzheimer's A beta peptide. The Journal of biological chemistry. vol 269. issue 41. 1994-11-17. PMID:7929215. |
since tyrosine phosphorylation of fak is essential to its activity as a transduction component of integrin-, peptide-, and lysophosphatidic acid-mediated signaling, the data establish a link between a beta aggregates and signal transduction pathways implicated in diverse cell functions including neurite outgrowth, control of the cell cycle, and apoptosis. |
1994-11-17 |
2023-08-12 |
human |