| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bhumsoo Kim, Eva L Feldma. Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. The Journal of biological chemistry. vol 277. issue 30. 2002-08-22. PMID:12011046. |
treatment of the cells with zvad, a general caspase inhibitor, blocks the mannitol-induced fak and akt degradation as well as cell detachment and apoptosis. |
2002-08-22 |
2023-08-12 |
human |
| Bhumsoo Kim, Eva L Feldma. Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. The Journal of biological chemistry. vol 277. issue 30. 2002-08-22. PMID:12011046. |
these results suggest that one of the pathways of mannitol-mediated apoptosis is through the degradation of fak and akt and that igf-i protects the cells from apoptosis by blocking the activation of caspases, which may be responsible for the loss of fak and akt. |
2002-08-22 |
2023-08-12 |
human |
| Maria C Heidkamp, Allison L Bayer, Jared A Kalina, Diane M Eble, Allen M Samare. GFP-FRNK disrupts focal adhesions and induces anoikis in neonatal rat ventricular myocytes. Circulation research. vol 90. issue 12. 2002-07-16. PMID:12089066. |
furthermore, gfp-frnk resulted in the loss of detectable fak and paxillin in focal adhesions, which was accompanied by reduced levels of total paxillin and, ultimately, cell detachment and apoptosis. |
2002-07-16 |
2023-08-12 |
rat |
| Shinya Sakurai, Yoshiko Sonoda, Emiko Koguchi, Nobusada Shinoura, Hirofumi Hamada, Tadashi Kasahar. Mutated focal adhesion kinase induces apoptosis in a human glioma cell line, T98G. Biochemical and biophysical research communications. vol 293. issue 1. 2002-07-05. PMID:12054581. |
we have established that focal adhesion kinase (fak)-transfected hl-60 (hl-60/fak) cells were highly resistant to hydrogen peroxide and etoposide-induced apoptosis compared to vector-transfected cells. |
2002-07-05 |
2023-08-12 |
human |
| Shinya Sakurai, Yoshiko Sonoda, Emiko Koguchi, Nobusada Shinoura, Hirofumi Hamada, Tadashi Kasahar. Mutated focal adhesion kinase induces apoptosis in a human glioma cell line, T98G. Biochemical and biophysical research communications. vol 293. issue 1. 2002-07-05. PMID:12054581. |
we found that 397fak induced marked apoptosis with significant fak degradation. |
2002-07-05 |
2023-08-12 |
human |
| Shinya Sakurai, Yoshiko Sonoda, Emiko Koguchi, Nobusada Shinoura, Hirofumi Hamada, Tadashi Kasahar. Mutated focal adhesion kinase induces apoptosis in a human glioma cell line, T98G. Biochemical and biophysical research communications. vol 293. issue 1. 2002-07-05. PMID:12054581. |
these results indicated that 397fak induces apoptosis in t98g cells, by interrupting signals of fak leading to the survival pathway in t98g glioma cells. |
2002-07-05 |
2023-08-12 |
human |
| Hiromasa Sasaki, Fumikazu Kotsuji, Benjamin K Tsan. Caspase 3-mediated focal adhesion kinase processing in human ovarian cancer cells: possible regulation by X-linked inhibitor of apoptosis protein. Gynecologic oncology. vol 85. issue 2. 2002-06-11. PMID:11972398. |
we have examined the processing of focal adhesion kinase (fak), a component of integrin-mediated signal transduction, in a cisplatin-sensitive human ovarian epithelial cancer cell line (ov2008), to test the possible role of fak degradation in the control of apoptosis via regulation of cell attachment. |
2002-06-11 |
2023-08-12 |
human |
| Robert E Bellas, Elizabeth O Harrington, Kerri Lynn Sheahan, Julie Newton, Caroline Marcus, Sharon Round. FAK blunts adenosine-homocysteine-induced endothelial cell apoptosis: requirement for PI 3-kinase. American journal of physiology. Lung cellular and molecular physiology. vol 282. issue 5. 2002-05-09. PMID:11943680. |
fak blunts adenosine-homocysteine-induced endothelial cell apoptosis: requirement for pi 3-kinase. |
2002-05-09 |
2023-08-12 |
cattle |
| Robert E Bellas, Elizabeth O Harrington, Kerri Lynn Sheahan, Julie Newton, Caroline Marcus, Sharon Round. FAK blunts adenosine-homocysteine-induced endothelial cell apoptosis: requirement for PI 3-kinase. American journal of physiology. Lung cellular and molecular physiology. vol 282. issue 5. 2002-05-09. PMID:11943680. |
however, overexpression of focal adhesion kinase (fak) cdna blunted ado-hc-induced apoptosis. |
2002-05-09 |
2023-08-12 |
cattle |
| Robert E Bellas, Elizabeth O Harrington, Kerri Lynn Sheahan, Julie Newton, Caroline Marcus, Sharon Round. FAK blunts adenosine-homocysteine-induced endothelial cell apoptosis: requirement for PI 3-kinase. American journal of physiology. Lung cellular and molecular physiology. vol 282. issue 5. 2002-05-09. PMID:11943680. |
fak constructs lacking the central catalytic domain or containing a point mutation, rendering the catalytic domain enzymatically inactive, did not provide protection from apoptosis. |
2002-05-09 |
2023-08-12 |
cattle |
| Robert E Bellas, Elizabeth O Harrington, Kerri Lynn Sheahan, Julie Newton, Caroline Marcus, Sharon Round. FAK blunts adenosine-homocysteine-induced endothelial cell apoptosis: requirement for PI 3-kinase. American journal of physiology. Lung cellular and molecular physiology. vol 282. issue 5. 2002-05-09. PMID:11943680. |
a fak mutant in amino acid 395, deficient in phosphatidylinositol 3-kinase (pi 3-kinase) binding, was not able to blunt apoptosis. |
2002-05-09 |
2023-08-12 |
cattle |
| Robert E Bellas, Elizabeth O Harrington, Kerri Lynn Sheahan, Julie Newton, Caroline Marcus, Sharon Round. FAK blunts adenosine-homocysteine-induced endothelial cell apoptosis: requirement for PI 3-kinase. American journal of physiology. Lung cellular and molecular physiology. vol 282. issue 5. 2002-05-09. PMID:11943680. |
finally, overexpression of fak did not provide protection from apoptosis in the presence of ly-294002, a pi 3-kinase inhibitor. |
2002-05-09 |
2023-08-12 |
cattle |
| Robert E Bellas, Elizabeth O Harrington, Kerri Lynn Sheahan, Julie Newton, Caroline Marcus, Sharon Round. FAK blunts adenosine-homocysteine-induced endothelial cell apoptosis: requirement for PI 3-kinase. American journal of physiology. Lung cellular and molecular physiology. vol 282. issue 5. 2002-05-09. PMID:11943680. |
taken together, these data suggest that the survival signals mediated by overexpression of fak in response to ado-hc-induced apoptosis require a pi 3-kinase-dependent pathway. |
2002-05-09 |
2023-08-12 |
cattle |
| Patrick Laprise, Eve-Marie Poirier, Anne Vézina, Nathalie Rivard, Pierre H Vacho. Merosin-integrin promotion of skeletal myofiber cell survival: Differentiation state-distinct involvement of p60Fyn tyrosine kinase and p38alpha stress-activated MAP kinase. Journal of cellular physiology. vol 191. issue 1. 2002-04-15. PMID:11920683. |
herein, we report that: 1) of four members of the src family of tyrosine kinases studied (p60src, p53/56lyn, p59yes, or p60fyn), the expression and activity of p60fyn are found in myotubes exclusively; 2) a severe decrease of p60fyn activity correlates with myotube apoptosis/anoikis induced by pharmocological compounds (herbimycin a or pp2) which inhibit tyrosine kinases of the src family, by merosin deficiency and by beta1 integrin inhibition; 3) myoblast survival depends on fak and the mek/erk pathway, in contrast to myotubes; 4) the pi3-k pathway is not involved in either myoblast or myotube survival; and 5) p38alpha sapk stimulation and activity (but not that of p38beta) are required in the progression of myotube apoptosis/anoikis induced by p60fyn inhibition, merosin deficiency or beta1 integrin-inhibition; however, p38 is not involved in myoblast apoptosis. |
2002-04-15 |
2023-08-12 |
Not clear |
| I M Rasca. Focal adhesion kinase modulates B cell receptor-transduced apoptosis in WEHI 231 cells. Pflugers Archiv : European journal of physiology. vol 442. issue 6 Suppl 1. 2002-03-21. PMID:11678321. |
the nature of fak function in bcr-induced apoptosis of wehi 231 lymphoblastoid cells was studied by overexpressing a c-terminal non-catalytic domain of fak, termed focal adhesion targeted (fat) domain. |
2002-03-21 |
2023-08-12 |
Not clear |
| Sompol Permpongkosol, Jing-Ding Wang, Shiro Takahara, Kiyomi Matsumiya, Norio Nonomura, Kazuo Nishimura, Akira Tsujimura, Apichat Kongkanand, Akihiko Okuyam. Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis. International journal of cancer. vol 98. issue 2. 2002-03-07. PMID:11857403. |
anticarcinogenic effect of fty720 in human prostate carcinoma du145 cells: modulation of mitogenic signaling, fak, cell-cycle entry and apoptosis. |
2002-03-07 |
2023-08-12 |
human |
| R Abu-Ghazaleh, J Kabir, H Jia, M Lobo, I Zachar. Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells. The Biochemical journal. vol 360. issue Pt 1. 2001-12-18. PMID:11696015. |
in contrast, the specific ptdins 3-kinase inhibitor ly294002 induced apoptosis and markedly decreased p125(fak) expression and increased fak proteolysis but had little effect on y861 phosphorylation. |
2001-12-18 |
2023-08-12 |
human |
| M Ayaki, K Komatsu, M Mukai, K Murata, M Kameyama, S Ishiguro, J Miyoshi, M Tatsuta, H Nakamur. Reduced expression of focal adhesion kinase in liver metastases compared with matched primary human colorectal adenocarcinomas. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 7. issue 10. 2001-12-05. PMID:11595702. |
the focal adhesion kinase (fak) is implicated in integrin-mediated signal transduction pathways used in cell adhesion, cell motility, apoptosis, and anchorage-independent growth. |
2001-12-05 |
2023-08-12 |
human |
| K Iguchi, K Hirano, M Hamatake, R Ishid. Phosphatidylserine induces apoptosis in adherent cells. Apoptosis : an international journal on programmed cell death. vol 6. issue 4. 2001-11-01. PMID:11445668. |
these results suggested that ps causes apoptosis through actin disorganization, cell detachment and cleavage of fak. |
2001-11-01 |
2023-08-12 |
Not clear |
| B van de Water, F Houtepen, M Huigsloot, I B Tijden. Suppression of chemically induced apoptosis but not necrosis of renal proximal tubular epithelial (LLC-PK1) cells by focal adhesion kinase (FAK). Role of FAK in maintaining focal adhesion organization after acute renal cell injury. The Journal of biological chemistry. vol 276. issue 39. 2001-11-01. PMID:11447217. |
suppression of chemically induced apoptosis but not necrosis of renal proximal tubular epithelial (llc-pk1) cells by focal adhesion kinase (fak). |
2001-11-01 |
2023-08-12 |
Not clear |