| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lucia Beviglia, Vita Golubovskaya, LiHui Xu, XiHui Yang, Rolf J Craven, William G Canc. Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis. The Biochemical journal. vol 373. issue Pt 1. 2003-10-06. PMID:12659633. |
apoptosis was accompanied by dephosphorylation of fak tyr(397), degradation of the endogenous fak protein and activation of caspase-3. |
2003-10-06 |
2023-08-12 |
human |
| Lucia Beviglia, Vita Golubovskaya, LiHui Xu, XiHui Yang, Rolf J Craven, William G Canc. Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis. The Biochemical journal. vol 373. issue Pt 1. 2003-10-06. PMID:12659633. |
expression of fak-nt in non-malignant breast epithelial cells did not lead to rounding, loss of fak phosphorylation or apoptosis. |
2003-10-06 |
2023-08-12 |
human |
| Abdelkarim Sabri, Sasha G Alcott, Hasnae Elouardighi, Elena Pak, Claudia Derian, Patricia Andrade-Gordon, Kathleen Kinnally, Susan F Steinber. Neutrophil cathepsin G promotes detachment-induced cardiomyocyte apoptosis via a protease-activated receptor-independent mechanism. The Journal of biological chemistry. vol 278. issue 26. 2003-08-20. PMID:12707281. |
of note, prolonged incubation of cardiomyocytes with cathepsin g results in the activation of caspase-3, cleavage of fak and akt, sarcomeric disassembly, cell rounding, cell detachment from underlying matrix, and morphologic features of apoptosis. |
2003-08-20 |
2023-08-12 |
mouse |
| Jahangir Kabir, Melvin Lobo, Ian Zachar. Staurosporine induces endothelial cell apoptosis via focal adhesion kinase dephosphorylation and focal adhesion disassembly independent of focal adhesion kinase proteolysis. The Biochemical journal. vol 367. issue Pt 1. 2003-06-17. PMID:12084011. |
focal adhesion kinase (fak) is thought to play a key role in maintaining focal adhesion function and cell survival, whereas caspase-mediated fak proteolysis is implicated in focal adhesion disassembly during apoptosis. |
2003-06-17 |
2023-08-12 |
Not clear |
| Jahangir Kabir, Melvin Lobo, Ian Zachar. Staurosporine induces endothelial cell apoptosis via focal adhesion kinase dephosphorylation and focal adhesion disassembly independent of focal adhesion kinase proteolysis. The Biochemical journal. vol 367. issue Pt 1. 2003-06-17. PMID:12084011. |
we examined the relationship between changes in fak phosphorylation and proteolysis during apoptosis of primary porcine aortic endothelial cells (paec) induced by staurosporine, a widely used apoptogenic agent in diverse cell types. |
2003-06-17 |
2023-08-12 |
Not clear |
| Jahangir Kabir, Melvin Lobo, Ian Zachar. Staurosporine induces endothelial cell apoptosis via focal adhesion kinase dephosphorylation and focal adhesion disassembly independent of focal adhesion kinase proteolysis. The Biochemical journal. vol 367. issue Pt 1. 2003-06-17. PMID:12084011. |
staurosporine-induced paec apoptosis was detected after 1 h and was preceded by disruption and loss of fak localization to focal adhesions within a few minutes, whereas staurosporine-induced cleavage of fak occurred only after 8-24 h. staurosporine induced a very rapid dephosphorylation of fak at tyr(861) and tyr(397) and caused dissociation of phosphorylated fak from focal adhesions as early as 30 s. the effect of staurosporine was very potent with striking inhibition of tyr(861) and tyr(397) phosphorylation and focal adhesion disruption occurring in the range 10-100 nm. |
2003-06-17 |
2023-08-12 |
Not clear |
| Jahangir Kabir, Melvin Lobo, Ian Zachar. Staurosporine induces endothelial cell apoptosis via focal adhesion kinase dephosphorylation and focal adhesion disassembly independent of focal adhesion kinase proteolysis. The Biochemical journal. vol 367. issue Pt 1. 2003-06-17. PMID:12084011. |
cycloheximide, the protein synthesis inhibitor, induced paec apoptosis more slowly than staurosporine, but did not induce fak dephosphorylation or rapid focal adhesion disruption, and instead caused a slower loss of focal adhesions and a marked increase in fak proteolysis. |
2003-06-17 |
2023-08-12 |
Not clear |
| Jahangir Kabir, Melvin Lobo, Ian Zachar. Staurosporine induces endothelial cell apoptosis via focal adhesion kinase dephosphorylation and focal adhesion disassembly independent of focal adhesion kinase proteolysis. The Biochemical journal. vol 367. issue Pt 1. 2003-06-17. PMID:12084011. |
these studies show that fak dephosphorylation and focal adhesion disassembly are very early events mediating the onset of staurosporine-induced endothelial cell apoptosis and are dissociated from fak proteolysis. |
2003-06-17 |
2023-08-12 |
Not clear |
| Jahangir Kabir, Melvin Lobo, Ian Zachar. Staurosporine induces endothelial cell apoptosis via focal adhesion kinase dephosphorylation and focal adhesion disassembly independent of focal adhesion kinase proteolysis. The Biochemical journal. vol 367. issue Pt 1. 2003-06-17. PMID:12084011. |
cycloheximide induces apoptosis through a pathway involving fak proteolysis without dephosphorylation. |
2003-06-17 |
2023-08-12 |
Not clear |
| Carolina Rubel, Sonia Gómez, Gabriela C Fernández, Martín A Isturiz, Jorge Caamaño, Marina S Palerm. Fibrinogen-CD11b/CD18 interaction activates the NF-kappa B pathway and delays apoptosis in human neutrophils. European journal of immunology. vol 33. issue 5. 2003-06-12. PMID:12731070. |
we have demonstrated that soluble fibrinogen (sfbg) delays human neutrophil (pmn) apoptosis through a mechanism that involves cd11b interactions, and phosphorylation of focal adhesion kinase (fak) and extracellular signal-regulated kinase 1/2 (erk1/2). |
2003-06-12 |
2023-08-12 |
human |
| Ching-Hsin Ku, Martin Browne, Peter J Gregson, Jacques Corbeil, Dominique P Piolett. Large-scale gene expression analysis of osteoblasts cultured on three different Ti-6Al-4V surface treatments. Biomaterials. vol 23. issue 21. 2003-06-10. PMID:12194522. |
based on the genes studied, we could propose a general pathway for the cell reaction according to the surface treatments used: (1) metal ion release changes the time course of gene expression in the fak pathway; (2) once the accumulation of metal ions released from the ti surface exceeds a threshold value, cell growth is diminished and apoptosis may be activated; (3) ptk up-regulation is also induced by metal ion release; (4) the expression of bcl-2 family and bax may suggest that metal ions induce apoptosis. |
2003-06-10 |
2023-08-12 |
Not clear |
| Debra W Taylor, Michael W Lamé, Lynn S Nakayama, H J Segall, Dennis W Wilso. Effects of monocrotaline pyrrole and thrombin on pulmonary endothelial cell junction and matrix adhesion proteins. Toxicology. vol 184. issue 2-3. 2003-03-18. PMID:12499124. |
western blot analysis showed thrombin stimulated catalysis of zo-1 and fak while mctp pretreatment resulted in fak fragmentation similar to previous reports for apoptosis. |
2003-03-18 |
2023-08-12 |
Not clear |
| Tadashi Kasahara, Emiko Koguchi, Megumi Funakoshi, Eriko Aizu-Yokota, Yoshiko Sonod. Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation. Antioxidants & redox signaling. vol 4. issue 3. 2003-02-27. PMID:12215217. |
these results indicated that mitochondria pathway is required for ir-induced apoptosis, and fak overexpression prevents this pathway, thus rendering antiapoptotic states. |
2003-02-27 |
2023-08-12 |
Not clear |
| Sabrina Di Bartolomeo, Angelo Spined. Ordering ceramide-induced cell detachment and apoptosis in human neuroepithelioma. Neuroscience letters. vol 334. issue 3. 2003-01-28. PMID:12453617. |
however, the pan-caspase inhibitor benzyloxycarbonyl-val-ala-asp-fluoromethylketone (targeting not only caspase 3 but also caspases 1, 5, 7, 8 and 9) did not prevent ceramide-induced cell detachment, although apoptosis, caspase 3 processing, parp cleavage and fak downregulation were suppressed in floating cells. |
2003-01-28 |
2023-08-12 |
human |
| Vita Golubovskaya, Lucia Beviglia, Li-Hui Xu, H Shelton Earp, Rolf Craven, William Canc. Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. The Journal of biological chemistry. vol 277. issue 41. 2002-11-25. PMID:12167618. |
in low egfr-expressing bt474-pcdna3 vector control cells, inhibition of fak by the fak c-terminal domain caused detachment and apoptosis via pathways involving activation of caspase-3 and -8, cleavage of poly(adp-ribose) polymerase, and caspase-3-dependent degradation of akt. |
2002-11-25 |
2023-08-12 |
human |
| Vita Golubovskaya, Lucia Beviglia, Li-Hui Xu, H Shelton Earp, Rolf Craven, William Canc. Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. The Journal of biological chemistry. vol 277. issue 41. 2002-11-25. PMID:12167618. |
egfr overexpression did not inhibit detachment induced by the fak c-terminal domain, but did suppress apoptosis, activating akt and erk1/2 survival pathways and inhibiting cleavage of fak, caspase-3 and -8, and poly(adp-ribose) polymerase. |
2002-11-25 |
2023-08-12 |
human |
| Vita Golubovskaya, Lucia Beviglia, Li-Hui Xu, H Shelton Earp, Rolf Craven, William Canc. Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. The Journal of biological chemistry. vol 277. issue 41. 2002-11-25. PMID:12167618. |
in addition, inhibition of fak and egfr in another breast cancer cell line (bt20) endogenously overexpressing these kinases also induced apoptosis via the same mechanism as in the egfr-overexpressing bt474 cells. |
2002-11-25 |
2023-08-12 |
human |
| Vita Golubovskaya, Lucia Beviglia, Li-Hui Xu, H Shelton Earp, Rolf Craven, William Canc. Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. The Journal of biological chemistry. vol 277. issue 41. 2002-11-25. PMID:12167618. |
the results of this study indicate that dual inhibition of fak and egfr signaling pathways can cooperatively enhance apoptosis in breast cancers. |
2002-11-25 |
2023-08-12 |
human |
| Joshua D Rovin, Henry F Frierson, Wayne Ledinh, J Thomas Parsons, Reid B Adam. Expression of focal adhesion kinase in normal and pathologic human prostate tissues. The Prostate. vol 53. issue 2. 2002-10-29. PMID:12242727. |
focal adhesion kinase (fak) regulates multiple cellular processes including growth, differentiation, adhesion, motility, and apoptosis. |
2002-10-29 |
2023-08-12 |
human |
| Xiao-Jing Liu, Li Yang, Hong-Bin Wu, Ou Qiang, Ming-Hui Huang, Ying-Ping Wan. Apoptosis of rat hepatic stellate cells induced by anti-focal adhesion kinase antibody. World journal of gastroenterology. vol 8. issue 4. 2002-10-04. PMID:12174388. |
to explore the role of focal adhesion kinase (fak) in the apoptosis in culture-activated rat hepatic stellate cells (hscs) using a specific anti-fak antibody. |
2002-10-04 |
2023-08-12 |
rat |