| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong Xia, Richard Seonghun Nho, Judy Kahm, Jill Kleidon, Craig A Henk. Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. The Journal of biological chemistry. vol 279. issue 31. 2004-09-10. PMID:15166238. |
constitutively active fak augmented levels of p85 subunit of pi3k and akt phosphorylation, and fibroblasts were protected from apoptosis. |
2004-09-10 |
2023-08-12 |
Not clear |
| Yoshiko Sonoda, Naomi Aiba, Ryouko Utsubo, Emiko Koguchi, Maki Hasegawa, Tadashi Kasahar. Induction of antioxidant enzymes by FAK in a human leukemic cell line, HL-60. Biochimica et biophysica acta. vol 1683. issue 1-3. 2004-08-10. PMID:15238216. |
we have established several focal adhesion kinase (fak) cdna-transfected hl-60 (hl-60/fak) cells which were highly resistant to oxidative stress-induced apoptosis. |
2004-08-10 |
2023-08-12 |
human |
| Bhumsoo Kim, Cynthia M van Golen, Eva L Feldma. Degradation and dephosphorylation of focal adhesion kinase during okadaic acid-induced apoptosis in human neuroblastoma cells. Neoplasia (New York, N.Y.). vol 5. issue 5. 2004-07-12. PMID:14670178. |
focal adhesion kinase (fak) prevents apoptosis in many cell types. |
2004-07-12 |
2023-08-12 |
human |
| Bhumsoo Kim, Cynthia M van Golen, Eva L Feldma. Degradation and dephosphorylation of focal adhesion kinase during okadaic acid-induced apoptosis in human neuroblastoma cells. Neoplasia (New York, N.Y.). vol 5. issue 5. 2004-07-12. PMID:14670178. |
we have reported that tyrosine residues in fak are dephosphorylated and fak is degraded during mannitol-induced apoptosis in human neuroblastoma cells. |
2004-07-12 |
2023-08-12 |
human |
| Bhumsoo Kim, Cynthia M van Golen, Eva L Feldma. Degradation and dephosphorylation of focal adhesion kinase during okadaic acid-induced apoptosis in human neuroblastoma cells. Neoplasia (New York, N.Y.). vol 5. issue 5. 2004-07-12. PMID:14670178. |
therefore, agents resulting in the dephosphorylation of fak may be beneficial for therapeutic treatment, irrespective of fak protein levels, as this may result in apoptosis, which cannot be prevented by growth factor signaling. |
2004-07-12 |
2023-08-12 |
human |
| Elena Kurenova, Li-Hui Xu, Xihui Yang, Albert S Baldwin, Rolf J Craven, Steven K Hanks, Zheng-Gang Liu, William G Canc. Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Molecular and cellular biology. vol 24. issue 10. 2004-06-17. PMID:15121855. |
attenuation of fak expression in tumor cells results in apoptosis that is mediated by caspase 8- and fadd-dependent pathways, suggesting that death receptor pathways are involved in the process. |
2004-06-17 |
2023-08-12 |
human |
| Lan Sun, Wen-Li Liu, Han-Ying Sun, Yin-Li Zhou, Hui-Zhen Xu, Wu L. [Effect of Ligustrazine on the expression of vascular endothelial growth factor in bone marrow stromal cells of radiation injured mice]. Zhongguo shi yan xue ye xue za zhi. vol 12. issue 1. 2004-06-15. PMID:14989777. |
to evaluate the effect of ligustrazine on the expression of vegf in bone marrow stromal cells (bmscs) of radiation injured mice and to explore the effect of vegf on the recovery of hematopoiesis and the mechanism of signal transduction, the protein expression of vegf, focal adhesion kinase (fak) and mitogen-activated protein kinase (mapk) in bmscs were assayed by western blot, the cell cycle and apoptosis rate of bmscs were tested by flow cytometry. |
2004-06-15 |
2023-08-12 |
mouse |
| Tang-Long Shen, Jun-Lin Gua. Grb7 in intracellular signaling and its role in cell regulation. Frontiers in bioscience : a journal and virtual library. vol 9. 2004-06-07. PMID:14766359. |
recent studies have suggested that various isoforms of grb10 play important roles in mediating insulin/insulin-like growth factor regulation of cell proliferation and apoptosis, whereas grb7 mediates signaling pathways from fak and ephb1 receptor to regulate cell migration, which is also implicated in tumor progression. |
2004-06-07 |
2023-08-12 |
caenorhabditis_elegans |
| Hee Boong Park, Vita Golubovskaya, Lihui Xu, Xihui Yang, Jin Woo Lee, Sean Scully, Rolf Joseph Craven, William G Canc. Activated Src increases adhesion, survival and alpha2-integrin expression in human breast cancer cells. The Biochemical journal. vol 378. issue Pt 2. 2004-05-19. PMID:14629195. |
disruption of fak function by overexpression of the fak c-terminal domain [fak-cd, analogous to the frnk (fak-related non-kinase) protein] leads to loss of adhesion and apoptosis in tumour cells. |
2004-05-19 |
2023-08-12 |
human |
| Vita M Golubovskaya, Steven Gross, Aparna S Kaur, Richard I Wilson, Li-Hui Xu, Xi Hui Yang, William G Canc. Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. Molecular cancer research : MCR. vol 1. issue 10. 2004-04-02. PMID:12939401. |
adenovirus-containing fak-cd (ad-fak-cd), a dominant-negative, cooh-terminal portion of fak, was used to inhibit fak and cause apoptosis. |
2004-04-02 |
2023-08-12 |
Not clear |
| Vita M Golubovskaya, Steven Gross, Aparna S Kaur, Richard I Wilson, Li-Hui Xu, Xi Hui Yang, William G Canc. Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. Molecular cancer research : MCR. vol 1. issue 10. 2004-04-02. PMID:12939401. |
activation of caspase-3, down-regulation of fak, and src and akt activities were demonstrated in ad-fak-cd + pp2-treated colon cancer cells undergoing apoptosis. |
2004-04-02 |
2023-08-12 |
Not clear |
| Vita M Golubovskaya, Steven Gross, Aparna S Kaur, Richard I Wilson, Li-Hui Xu, Xi Hui Yang, William G Canc. Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. Molecular cancer research : MCR. vol 1. issue 10. 2004-04-02. PMID:12939401. |
the results suggest that fak and src are both important survival factors, playing a role in protecting colon cancer cell lines from ad-fak-cd-induced apoptosis. |
2004-04-02 |
2023-08-12 |
Not clear |
| Krikor Bijian, Tomoko Takano, Joan Papillon, Abdelkrim Khadir, Andrey V Cybulsk. Extracellular matrix regulates glomerular epithelial cell survival and proliferation. American journal of physiology. Renal physiology. vol 286. issue 2. 2004-02-24. PMID:14559718. |
compared with gec on plastic substratum, adhesion to collagen increased activation of focal adhesion kinase (fak), c-src, and erk and facilitated survival (prevented apoptosis). |
2004-02-24 |
2023-08-12 |
rat |
| Steven K Hanks, Larisa Ryzhova, Nah-Young Shin, Jan Brábe. Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. Frontiers in bioscience : a journal and virtual library. vol 8. 2004-02-11. PMID:12700132. |
cas phosphorylation, as well as phosphatidylinositol 3-kinase (pi3k) activation resulting from its binding to the fak tyr-397 site, have been implicated as downstream fak signaling events that confer a resistance to apoptosis. |
2004-02-11 |
2023-08-12 |
Not clear |
| Mark S Duxbury, Hiromichi Ito, Eric Benoit, Michael J Zinner, Stanley W Ashley, Edward E Whan. RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity. Biochemical and biophysical research communications. vol 311. issue 3. 2004-01-05. PMID:14623342. |
focal adhesion kinase (fak) is an important regulator of cellular signaling, migration, apoptosis, and cell cycle progression. |
2004-01-05 |
2023-08-12 |
mouse |
| Mark S Duxbury, Hiromichi Ito, Eric Benoit, Michael J Zinner, Stanley W Ashley, Edward E Whan. RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity. Biochemical and biophysical research communications. vol 311. issue 3. 2004-01-05. PMID:14623342. |
while not affecting cellular proliferation or apoptosis in the absence of gemcitabine, fak sirna potentiated gemcitabine-induced cytotoxicity in vitro and in vivo. |
2004-01-05 |
2023-08-12 |
mouse |
| Ya-Min Fu, Zu-Xi Yu, Yi-Qi Li, Xiaokang Ge, Phillip J Sanchez, Xing Fu, Gary G Meadow. Specific amino acid dependency regulates invasiveness and viability of androgen-independent prostate cancer cells. Nutrition and cancer. vol 45. issue 1. 2003-12-11. PMID:12791506. |
therefore, apoptosis of du145 and pc3 cells by amino acid restriction is fak and erk dependent. |
2003-12-11 |
2023-08-12 |
human |
| Peggy Lévy, Hélène Robin, France Bertrand, Michel Kornprobst, Jacqueline Capea. Butyrate-treated colonic Caco-2 cells exhibit defective integrin-mediated signaling together with increased apoptosis and differentiation. Journal of cellular physiology. vol 197. issue 3. 2003-12-05. PMID:14566963. |
we now investigated whether differentiation and apoptosis of caco-2 cells induced by the short-chain fatty acid butyrate (nabt) was associated with alterations in the integrin-mediated signaling pathway with special interest in the expression and activity of focal adhesion kinase (fak), of the downstream phosphatidylinositol 3'-kinase (pi 3-kinase)-akt pathway and in the role of the nuclear factor kappab (nf-kappab). |
2003-12-05 |
2023-08-12 |
human |
| Antonio Scibelli, Simona Tafuri, Maria C Ferrante, Elena Alimenti, Barbara Naso, Antonia Lucisano, Norma Staiano, Rossella Della Mort. Ochratoxin A affects COS cell adhesion and signaling. Toxicology and applied pharmacology. vol 192. issue 3. 2003-11-18. PMID:14575639. |
the down-regulation of fak preceded apoptosis and cell detachment induced by ota. |
2003-11-18 |
2023-08-12 |
Not clear |
| Antonio Scibelli, Simona Tafuri, Maria C Ferrante, Elena Alimenti, Barbara Naso, Antonia Lucisano, Norma Staiano, Rossella Della Mort. Ochratoxin A affects COS cell adhesion and signaling. Toxicology and applied pharmacology. vol 192. issue 3. 2003-11-18. PMID:14575639. |
however, whether fak and shc phosphorylation contribute both to the same pathway leading to the induction of apoptosis by ota or are involved in two parallel signaling pathways remains to be investigated. |
2003-11-18 |
2023-08-12 |
Not clear |