| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenichiro Furuyama, Ryuichiro Doi, Tomohiko Mori, Eiji Toyoda, Daisuke Ito, Kazuhiro Kami, Masayuki Koizumi, Atsushi Kida, Yoshiya Kawaguchi, Koji Fujimot. Clinical significance of focal adhesion kinase in resectable pancreatic cancer. World journal of surgery. vol 30. issue 2. 2006-06-08. PMID:16425085. |
focal adhesion kinase (fak) is a non-receptor, cytoplasmic protein tyrosine kinase that is involved in the regulation of cellular signaling, migration, apoptosis, and cell cycle progression. |
2006-06-08 |
2023-08-12 |
human |
| Huifang M Zhang, Kaspar M Keledjian, Jaladanki N Rao, Tongtong Zou, Lan Liu, Bernard S Marasa, Shelley R Wang, Lisa Ru, Eric D Strauch, Jian-Ying Wan. Induced focal adhesion kinase expression suppresses apoptosis by activating NF-kappaB signaling in intestinal epithelial cells. American journal of physiology. Cell physiology. vol 290. issue 5. 2006-05-22. PMID:16354757. |
focal adhesion kinase (fak) integrates various extracellular and intracellular signals and is implicated in a variety of biological functions, but its exact role and downstream targeting signals in the regulation of apoptosis in intestinal epithelial cells (iecs) remains unclear. |
2006-05-22 |
2023-08-12 |
Not clear |
| Huifang M Zhang, Kaspar M Keledjian, Jaladanki N Rao, Tongtong Zou, Lan Liu, Bernard S Marasa, Shelley R Wang, Lisa Ru, Eric D Strauch, Jian-Ying Wan. Induced focal adhesion kinase expression suppresses apoptosis by activating NF-kappaB signaling in intestinal epithelial cells. American journal of physiology. Cell physiology. vol 290. issue 5. 2006-05-22. PMID:16354757. |
in contrast, inactivation of fak by ectopic expression of dominant-negative mutant of fak (dnm-fak) inhibited nf-kappab activity and increased the sensitivity to tnf-alpha/chx-induced apoptosis. |
2006-05-22 |
2023-08-12 |
Not clear |
| Huifang M Zhang, Kaspar M Keledjian, Jaladanki N Rao, Tongtong Zou, Lan Liu, Bernard S Marasa, Shelley R Wang, Lisa Ru, Eric D Strauch, Jian-Ying Wan. Induced focal adhesion kinase expression suppresses apoptosis by activating NF-kappaB signaling in intestinal epithelial cells. American journal of physiology. Cell physiology. vol 290. issue 5. 2006-05-22. PMID:16354757. |
furthermore, induced expression of endogenous fak by depletion of cellular polyamines increased nf-kappab activity and resulted in increased resistance to tnf-alpha/chx-induced apoptosis, both of which were prevented by overexpression of dnm-fak. |
2006-05-22 |
2023-08-12 |
Not clear |
| Huifang M Zhang, Kaspar M Keledjian, Jaladanki N Rao, Tongtong Zou, Lan Liu, Bernard S Marasa, Shelley R Wang, Lisa Ru, Eric D Strauch, Jian-Ying Wan. Induced focal adhesion kinase expression suppresses apoptosis by activating NF-kappaB signaling in intestinal epithelial cells. American journal of physiology. Cell physiology. vol 290. issue 5. 2006-05-22. PMID:16354757. |
these results indicate that increased expression of fak suppresses tnf-alpha/chx-induced apoptosis, at least partially, through the activation of nf-kappab signaling in iecs. |
2006-05-22 |
2023-08-12 |
Not clear |
| Charles S Smith, Vita M Golubovskaya, Erin Peck, Li-Hui Xu, Brett P Monia, Xihui Yang, William G Canc. Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines. Melanoma research. vol 15. issue 5. 2006-03-21. PMID:16179862. |
inhibition of focal adhesion kinase (fak), a non-receptor tyrosine kinase linked to tumour cell survival, causes cell rounding, loss of adhesion and apoptosis in human cancer cell lines. |
2006-03-21 |
2023-08-12 |
human |
| Charles S Smith, Vita M Golubovskaya, Erin Peck, Li-Hui Xu, Brett P Monia, Xihui Yang, William G Canc. Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines. Melanoma research. vol 15. issue 5. 2006-03-21. PMID:16179862. |
these data show that the downregulation of fak by antisense oligonucleotide combined with 5-fu chemotherapy results in a greater loss of adhesion and greater apoptosis in melanoma cells than treatment with either agent alone, suggesting that the combination may be a potential therapeutic agent for human melanoma in vivo. |
2006-03-21 |
2023-08-12 |
human |
| Klaus Jürgen Schmitz, Florian Grabellus, Rainer Callies, Friedrich Otterbach, Jeremias Wohlschlaeger, Bodo Levkau, Rainer Kimmig, Kurt Werner Schmid, Hideo Andreas Bab. High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome. Breast cancer research : BCR. vol 7. issue 2. 2006-01-31. PMID:15743500. |
focal adhesion kinase (fak) regulates multiple cellular processes including growth, differentiation, adhesion, motility and apoptosis. |
2006-01-31 |
2023-08-12 |
Not clear |
| Jyotsnabaran Halder, Charles N Landen, Susan K Lutgendorf, Yang Li, Nicholas B Jennings, Dominic Fan, Gina M Nelkin, Rosemarie Schmandt, Michael D Schaller, Anil K Soo. Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 11. issue 24 Pt 1. 2006-01-20. PMID:16361572. |
we examined the role of focal adhesion kinase (fak) cleavage in docetaxel-mediated apoptosis. |
2006-01-20 |
2023-08-12 |
Not clear |
| Jing Mi, Xiuwu Zhang, Paloma H Giangrande, James O McNamara, Shahid M Nimjee, Shiva Sarraf-Yazdi, Bruce A Sullenger, Bryan M Clar. Targeted inhibition of alphavbeta3 integrin with an RNA aptamer impairs endothelial cell growth and survival. Biochemical and biophysical research communications. vol 338. issue 2. 2006-01-12. PMID:16256939. |
apt-alphavbeta3 can also reduce pdgf-stimulated tube formation and increase huvec apoptosis through inhibition of fak phosphorylation pathway. |
2006-01-12 |
2023-08-12 |
human |
| Weiyi Mai, Dong Chen, Tianbing Ding, Ingyu Kim, Sujun Park, Sae-youll Cho, Julia S F Chu, Dan Liang, Ning Wang, Dianqing Wu, Song Li, Ping Zhao, Roy Zent, Guanqing W. Inhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells. Molecular biology of the cell. vol 16. issue 9. 2006-01-03. PMID:15975909. |
pkhd1-silenced cells developed abnormalities in cell-cell contact, actin cytoskeleton organization, cell-ecm interactions, cell proliferation, and apoptosis, which may be mediated by dysregulation of extracellular-regulated kinase (erk) and focal adhesion kinase (fak) signaling. |
2006-01-03 |
2023-08-12 |
mouse |
| Shinya Mizuno, Kunio Matsumoto, Ming-Yue Li, Toshikazu Nakamur. HGF reduces advancing lung fibrosis in mice: a potential role for MMP-dependent myofibroblast apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 6. 2005-12-14. PMID:15665032. |
under such conditions, hgf induced caspase-dependent apoptosis, linked with a decrease in a fn central cell binding (ccb) domain involved in fak phosphorylation. |
2005-12-14 |
2023-08-12 |
mouse |
| Shinya Mizuno, Kunio Matsumoto, Ming-Yue Li, Toshikazu Nakamur. HGF reduces advancing lung fibrosis in mice: a potential role for MMP-dependent myofibroblast apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 6. 2005-12-14. PMID:15665032. |
when mmi270 (a broad-spectrum mmp inhibitor) was added together with hgf, decreases in fn-ccb domain expression and fak phosphorylation by hgf were restored, and these events were associated with an inhibition of hgf-induced apoptosis, suggesting that increased activities of mmps underlie the major mechanism of hgf-mediated apoptosis in myofibroblasts. |
2005-12-14 |
2023-08-12 |
mouse |
| Krikor Bijian, Tomoko Takano, Joan Papillon, Ludmilla Le Berre, Jean-Louis Michaud, Chris R J Kennedy, Andrey V Cybulsk. Actin cytoskeleton regulates extracellular matrix-dependent survival signals in glomerular epithelial cells. American journal of physiology. Renal physiology. vol 289. issue 6. 2005-12-12. PMID:16014575. |
adhesion of rat glomerular epithelial cells (gec) to collagen activates focal adhesion kinase (fak) and the ras-extracellular signal-regulated kinase (erk) pathway and supports survival (prevents apoptosis). |
2005-12-12 |
2023-08-12 |
rat |
| Krikor Bijian, Tomoko Takano, Joan Papillon, Ludmilla Le Berre, Jean-Louis Michaud, Chris R J Kennedy, Andrey V Cybulsk. Actin cytoskeleton regulates extracellular matrix-dependent survival signals in glomerular epithelial cells. American journal of physiology. Renal physiology. vol 289. issue 6. 2005-12-12. PMID:16014575. |
parental gec (adherent to collagen) and gec stably transfected with constitutively active mutants of mitogen-activated protein kinase kinase (r4f-mek) or fak (cd2-fak) (on plastic) showed erk activation, low levels of apoptosis, and a cortical distribution of f-actin. |
2005-12-12 |
2023-08-12 |
rat |
| Jian-Min Su, Li-Ying Wang, Yu-Long Liang, Xi-Liang Zh. Role of cell adhesion signal molecules in hepatocellular carcinoma cell apoptosis. World journal of gastroenterology. vol 11. issue 30. 2005-11-02. PMID:16094707. |
the aim of this study is to elucidate the role of these molecules and the signal molecules of integrins and e-cadherins, such as (focal adhesion kinase) fak, (integrin linked kinase) ilk, and beta-catenin in hepatocellular carcinoma cell apoptosis. |
2005-11-02 |
2023-08-12 |
Not clear |
| Ying-Tang Huang, Lung-Ta Lee, Ping-Ping H Lee, Yung-Sheng Lin, Ming-Ting Le. Targeting of focal adhesion kinase by flavonoids and small-interfering RNAs reduces tumor cell migration ability. Anticancer research. vol 25. issue 3B. 2005-11-02. PMID:16158939. |
while not affecting cellular proliferation or apoptosis, the sirna targeting fak almost completely inhibited fak protein expression in miapaca-2 cells and potently blocked the cell migration mediated by fak. |
2005-11-02 |
2023-08-12 |
human |
| Wei Aixinjueluo, Keiko Furukawa, Qing Zhang, Kazunori Hamamura, Noriyo Tokuda, Shoko Yoshida, Ryuzo Ueda, Koichi Furukaw. Mechanisms for the apoptosis of small cell lung cancer cells induced by anti-GD2 monoclonal antibodies: roles of anoikis. The Journal of biological chemistry. vol 280. issue 33. 2005-09-22. PMID:15923178. |
in this study, we analyzed the mechanisms for the apoptosis of these cells by anti-gd2 mabs and elucidated the mechanisms by which apoptosis signals were transduced via reduction in the phosphorylation levels of focal adhesion kinase (fak) and the activation of a mapk family member, p38, upon the antibody binding. |
2005-09-22 |
2023-08-12 |
human |
| Wei Aixinjueluo, Keiko Furukawa, Qing Zhang, Kazunori Hamamura, Noriyo Tokuda, Shoko Yoshida, Ryuzo Ueda, Koichi Furukaw. Mechanisms for the apoptosis of small cell lung cancer cells induced by anti-GD2 monoclonal antibodies: roles of anoikis. The Journal of biological chemistry. vol 280. issue 33. 2005-09-22. PMID:15923178. |
knock down of fak resulted in apoptosis and p38 activation. |
2005-09-22 |
2023-08-12 |
human |
| Wei Aixinjueluo, Keiko Furukawa, Qing Zhang, Kazunori Hamamura, Noriyo Tokuda, Shoko Yoshida, Ryuzo Ueda, Koichi Furukaw. Mechanisms for the apoptosis of small cell lung cancer cells induced by anti-GD2 monoclonal antibodies: roles of anoikis. The Journal of biological chemistry. vol 280. issue 33. 2005-09-22. PMID:15923178. |
taken together with the fact that gd2+ cells showed marked detachment from the plate during apoptosis, gd2+ small cell lung cancer cells seemed to undergo anoikis through the conformational changes of integrin molecules and subsequent fak dephosphorylation. |
2005-09-22 |
2023-08-12 |
human |