| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weiguo Liu, David A Bloom, William G Cance, Elena V Kurenova, Vita M Golubovskaya, Steven N Hochwal. FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis. vol 29. issue 6. 2008-07-29. PMID:18263593. |
decreasing phosphorylation of either fak or igf-1r alone resulted in little inhibition of cell viability or increased apoptosis. |
2008-07-29 |
2023-08-12 |
human |
| Weiguo Liu, David A Bloom, William G Cance, Elena V Kurenova, Vita M Golubovskaya, Steven N Hochwal. FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis. vol 29. issue 6. 2008-07-29. PMID:18263593. |
however, dual inhibition of fak, using either a dominant-negative construct (fak-cd) or small interfering rna, and igf-1r, using a specific small molecule tyrosine kinase inhibitor (aew-541) or stable expression of a truncated, mutated igf-1r, led to a synergistic decrease in cell proliferation and phosphorylation of extracellular signal-regulated kinase (erk) and increase in cell detachment and apoptosis compared with inhibition of either pathway alone. |
2008-07-29 |
2023-08-12 |
human |
| Weiguo Liu, David A Bloom, William G Cance, Elena V Kurenova, Vita M Golubovskaya, Steven N Hochwal. FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis. vol 29. issue 6. 2008-07-29. PMID:18263593. |
dual kinase inhibition with fak-cd and aew-541 resulted in a marked increase in apoptosis when fak was displaced from the focal adhesions. |
2008-07-29 |
2023-08-12 |
human |
| Weiguo Liu, David A Bloom, William G Cance, Elena V Kurenova, Vita M Golubovskaya, Steven N Hochwal. FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis. vol 29. issue 6. 2008-07-29. PMID:18263593. |
inhibition of both tyrosine kinase activities via a novel single small molecular inhibitor (tae 226), at low doses specific for fak and igf-1r, resulted in significant inhibition of cell viability, decrease in phosphorylation of erk and akt and increase in apoptosis accompanied by cleavage of poly (adp-ribose) polymerase (parp) and activation of caspase-3 in pancreatic cancer cells. |
2008-07-29 |
2023-08-12 |
human |
| Gaiyun Liu, Xiangning Meng, Yan Jin, Jing Bai, Yunzhen Zhao, Xiaobo Cui, Feng Chen, Songbin F. Inhibitory role of focal adhesion kinase on anoikis in the lung cancer cell A549. Cell biology international. vol 32. issue 6. 2008-07-09. PMID:18343694. |
it has been shown that down regulation of fak stimulates the apoptosis of cells and the down-regulation of p-erk, p-pi3k, p-src, and p-p38. |
2008-07-09 |
2023-08-12 |
human |
| Irene Mamali, Panagiotis Kotsantis, Maria Lampropoulou, Vassilis J Marmara. Elk-1 associates with FAK, regulates the expression of FAK and MAP kinases as well as apoptosis in HK-2 cells. Journal of cellular physiology. vol 216. issue 1. 2008-06-04. PMID:18247360. |
elk-1 associates with fak, regulates the expression of fak and map kinases as well as apoptosis in hk-2 cells. |
2008-06-04 |
2023-08-12 |
Not clear |
| Irene Mamali, Panagiotis Kotsantis, Maria Lampropoulou, Vassilis J Marmara. Elk-1 associates with FAK, regulates the expression of FAK and MAP kinases as well as apoptosis in HK-2 cells. Journal of cellular physiology. vol 216. issue 1. 2008-06-04. PMID:18247360. |
here, we explored the association of fak with elk-1, the implication of elk-1 in the regulation of fak and map kinases expression as well as apoptosis, in hk-2 cells. |
2008-06-04 |
2023-08-12 |
Not clear |
| Toshihiro Murata, Yoshio Naomoto, Tomoki Yamatsuji, Takaomi Okawa, Yasuhiro Shirakawa, Mehmet Gunduz, Tetsuji Nobuhisa, Munenori Takaoka, Mehmet Sirmali, Motowo Nakajima, Yuko Ohno, Noriaki Tanak. Localization of FAK is related with colorectal carcinogenesis. International journal of oncology. vol 32. issue 4. 2008-06-02. PMID:18360706. |
fak has been reported to be involved in the proliferation, differentiation and apoptosis of cells. |
2008-06-02 |
2023-08-12 |
mouse |
| Isolda Casanova, Rosa Bosch, Adriana Lasa, Matilde Parreño, María Virtudes Céspedes, Salut Brunet, Josep F Nomdedéu, María Antònia Mangues, Jorge Sierra, Ramon Mangue. A celecoxib derivative inhibits focal adhesion signaling and induces caspase-8-dependent apoptosis in human acute myeloid leukemia cells. International journal of cancer. vol 123. issue 1. 2008-06-02. PMID:18398841. |
both compounds induce cell death by inhibiting focal adhesion signaling through p130cas, fak and c-src, leading to caspase-8 dependent apoptosis. |
2008-06-02 |
2023-08-12 |
human |
| Md Firoz Mian, Changkeun Kang, Seunghwan Lee, Jang Hyun Choi, Sun Sik Bae, Sun-Hee Kim, Yun-Hee Kim, Sung Ho Ryu, Pann-Ghill Suh, Jong-Shu Kim, Euikyung Ki. Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis. Chemico-biological interactions. vol 171. issue 1. 2008-04-03. PMID:17888894. |
previously, we showed that thimerosal, a reactive oxygen species (ros) generator, can acutely induce fak tyrosine phosphorylation (within minutes) and chronically induce apoptosis (within days) by redox modulation in hela s cells. |
2008-04-03 |
2023-08-12 |
human |
| Md Firoz Mian, Changkeun Kang, Seunghwan Lee, Jang Hyun Choi, Sun Sik Bae, Sun-Hee Kim, Yun-Hee Kim, Sung Ho Ryu, Pann-Ghill Suh, Jong-Shu Kim, Euikyung Ki. Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis. Chemico-biological interactions. vol 171. issue 1. 2008-04-03. PMID:17888894. |
in the present study, we report that a prolonged oxidative stress by thimerosal induces a remarkable cleavage of fak, which is accompanied with apoptosis. |
2008-04-03 |
2023-08-12 |
human |
| Md Firoz Mian, Changkeun Kang, Seunghwan Lee, Jang Hyun Choi, Sun Sik Bae, Sun-Hee Kim, Yun-Hee Kim, Sung Ho Ryu, Pann-Ghill Suh, Jong-Shu Kim, Euikyung Ki. Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis. Chemico-biological interactions. vol 171. issue 1. 2008-04-03. PMID:17888894. |
in fact, the kinetics of fak cleavage has a good correlation with and actually preceding the apoptosis that was independent of anoikis. |
2008-04-03 |
2023-08-12 |
human |
| Md Firoz Mian, Changkeun Kang, Seunghwan Lee, Jang Hyun Choi, Sun Sik Bae, Sun-Hee Kim, Yun-Hee Kim, Sung Ho Ryu, Pann-Ghill Suh, Jong-Shu Kim, Euikyung Ki. Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis. Chemico-biological interactions. vol 171. issue 1. 2008-04-03. PMID:17888894. |
additionally, the down regulation of fak with antisense oligonucleotide dramatically augmented thimerosal-induced apoptosis. |
2008-04-03 |
2023-08-12 |
human |
| Md Firoz Mian, Changkeun Kang, Seunghwan Lee, Jang Hyun Choi, Sun Sik Bae, Sun-Hee Kim, Yun-Hee Kim, Sung Ho Ryu, Pann-Ghill Suh, Jong-Shu Kim, Euikyung Ki. Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis. Chemico-biological interactions. vol 171. issue 1. 2008-04-03. PMID:17888894. |
taken together, our results show that fak is a critical cellular target of caspases during oxidative stress (particularly by hydrogen peroxide), resulting in the acceleration of subsequent apoptosis regardless of the anchorage status of cells. |
2008-04-03 |
2023-08-12 |
human |
| Md Firoz Mian, Changkeun Kang, Seunghwan Lee, Jang Hyun Choi, Sun Sik Bae, Sun-Hee Kim, Yun-Hee Kim, Sung Ho Ryu, Pann-Ghill Suh, Jong-Shu Kim, Euikyung Ki. Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis. Chemico-biological interactions. vol 171. issue 1. 2008-04-03. PMID:17888894. |
from the present results, it is more likely that not cell detachment but the proteolytic cleavage (or inhibition) of fak is a key modulator as well as a promising indicator of apoptosis in epithelial cells under oxidative stress. |
2008-04-03 |
2023-08-12 |
human |
| Ssang-Taek Lim, Xiao Lei Chen, Yangmi Lim, Dan A Hanson, Thanh-Trang Vo, Kyle Howerton, Nicholas Larocque, Susan J Fisher, David D Schlaepfer, Dusko Ili. Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Molecular cell. vol 29. issue 1. 2008-03-21. PMID:18206965. |
in primary human cells, fak knockdown raised p53-p21 levels and slowed cell proliferation but did not cause apoptosis. |
2008-03-21 |
2023-08-12 |
mouse |
| Ssang-Taek Lim, Xiao Lei Chen, Yangmi Lim, Dan A Hanson, Thanh-Trang Vo, Kyle Howerton, Nicholas Larocque, Susan J Fisher, David D Schlaepfer, Dusko Ili. Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Molecular cell. vol 29. issue 1. 2008-03-21. PMID:18206965. |
notably, fak knockdown plus cisplatin triggered p53-dependent cell apoptosis, which was rescued by either full-length fak or fak ferm re-expression. |
2008-03-21 |
2023-08-12 |
mouse |
| Vita M Golubovskaya, Christopher Virnig, William G Canc. TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR. Molecular carcinogenesis. vol 47. issue 3. 2008-03-17. PMID:17849451. |
we have shown previously that the dominant-negative fak, c-terminal fak-cd, caused detachment and apoptosis in human breast cancer cells, and that overexpression of an activated form of src tyrosine kinase or epidermal growth factor receptor, egfr, suppressed fak-cd induced apoptotic effects in breast cancer cells. |
2008-03-17 |
2023-08-12 |
human |
| Vita M Golubovskaya, Christopher Virnig, William G Canc. TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR. Molecular carcinogenesis. vol 47. issue 3. 2008-03-17. PMID:17849451. |
thus, inhibition of autophosphorylation activity of fak with the tae226 inhibitor at 10-20 microm is effective in causing apoptosis in breast cancer cells, resistant to the ad-fak-cd inhibitor that can be used effectively in therapy. |
2008-03-17 |
2023-08-12 |
human |
| Nina S Funa, Kalpana Reddy, Sulochana Bhandarkar, Elena V Kurenova, Lily Yang, William G Cance, Michael Welsh, Jack L Arbise. Shb gene knockdown increases the susceptibility of SVR endothelial tumor cells to apoptotic stimuli in vitro and in vivo. The Journal of investigative dermatology. vol 128. issue 3. 2008-03-10. PMID:17914455. |
it is concluded that shb regulates apoptosis and cell shape in tumor endothelial cells via fak, and that shb is a potential target for inhibition of angiogenesis. |
2008-03-10 |
2023-08-12 |
Not clear |