| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin-Ling Wang, Tao Yu, Jin-Song Zhang, Qi-Chang Yan, Ya-Hong Lu. Fibronectin and focal adhesion kinase small interfering RNA modulate rat retinal Müller cells adhesion and migration. Cellular and molecular neurobiology. vol 29. issue 4. 2009-08-24. PMID:19172391. |
the specific fak sirna treatment significantly increased g(0)/g(1) percentage and apoptosis rate compared with nt sirna and control group (f = 11.526, p = 0.009; f = 64.772, p < 0.000). |
2009-08-24 |
2023-08-12 |
rat |
| Tao Zhang, Jingcun Zheng, Ning Jiang, Guozeng Wang, Quan Shi, Chunfang Liu, Yuan L. Overexpression of DLC-1 induces cell apoptosis and proliferation inhibition in the renal cell carcinoma. Cancer letters. vol 283. issue 1. 2009-08-18. PMID:19380190. |
the inhibitory effect was partly due to the induction of apoptosis and cell cycle arrest in g(0)/g(1) accompanied by up-regulation of the intracellular signal proteins of p27 and down-regulation of cyclin d1 and cyclin e. furthermore, dlc-1 induced fak dephosphorylation of focal adhesion proteins inhibited cell migration (p<0.05). |
2009-08-18 |
2023-08-12 |
mouse |
| Bhumsoo Kim, Eva L Feldma. Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis. Apoptosis : an international journal on programmed cell death. vol 14. issue 5. 2009-08-05. PMID:19259821. |
in the presence of high glucose, irs-1 underwent caspase-mediated degradation, followed by focal adhesion kinase (fak) and akt degradation and apoptosis. |
2009-08-05 |
2023-08-12 |
human |
| Eun-Kyung Park, Mi Jung Park, Seong-Hee Lee, Ying Chun Li, Jungeun Kim, Jae-Seon Lee, Jung Weon Lee, Sang-Kyu Ye, Jong-Wan Park, Chul-Woo Kim, Byung-Kiu Park, Yong-Nyun Ki. Cholesterol depletion induces anoikis-like apoptosis via FAK down-regulation and caveolae internalization. The Journal of pathology. vol 218. issue 3. 2009-07-31. PMID:19288501. |
cholesterol depletion induces anoikis-like apoptosis via fak down-regulation and caveolae internalization. |
2009-07-31 |
2023-08-12 |
Not clear |
| Eun-Kyung Park, Mi Jung Park, Seong-Hee Lee, Ying Chun Li, Jungeun Kim, Jae-Seon Lee, Jung Weon Lee, Sang-Kyu Ye, Jong-Wan Park, Chul-Woo Kim, Byung-Kiu Park, Yong-Nyun Ki. Cholesterol depletion induces anoikis-like apoptosis via FAK down-regulation and caveolae internalization. The Journal of pathology. vol 218. issue 3. 2009-07-31. PMID:19288501. |
the expression of dominant-active fak was able to delay caveolae internalization and apoptosis and attenuated akt inactivation by mbetacd, whereas dominant-negative fak expression resulted in enhanced apoptosis. |
2009-07-31 |
2023-08-12 |
Not clear |
| Yi Le, Luhong Xu, Jiayun Lu, Jianpei Fang, Valentina Nardi, Li Chai, Leslie E Silberstei. FAK silencing inhibits leukemogenesis in BCR/ABL-transformed hematopoietic cells. American journal of hematology. vol 84. issue 5. 2009-07-24. PMID:19358301. |
in vitro studies showed that treatment with fak shrna resulted in impaired cell proliferation and colony formation, while increasing cell apoptosis. |
2009-07-24 |
2023-08-12 |
mouse |
| Joerg Schwock, Neesha Dhani, Mary Ping-Jiang Cao, Jinzi Zheng, Richard Clarkson, Nikolina Radulovich, Roya Navab, Lars-Christian Horn, David W Hedle. Targeting focal adhesion kinase with dominant-negative FRNK or Hsp90 inhibitor 17-DMAG suppresses tumor growth and metastasis of SiHa cervical xenografts. Cancer research. vol 69. issue 11. 2009-07-15. PMID:19458065. |
recent evidence indicates a central function of fak in neoplasia where the kinase contributes to cell proliferation, resistance to apoptosis and anoikis, invasiveness, and metastasis. |
2009-07-15 |
2023-08-12 |
Not clear |
| Patricio Godoy, Jan G Hengstler, Iryna Ilkavets, Christoph Meyer, Anastasia Bachmann, Alexandra Müller, Gregor Tuschl, Stefan O Mueller, Steven Doole. Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis. Hepatology (Baltimore, Md.). vol 49. issue 6. 2009-07-01. PMID:19274752. |
in contrast to stiff collagen, a softer collagen gel does not activate fak, keeping the hepatocytes in a state where they remain sensitive to tgf-beta-induced apoptosis and do not undergo emt. |
2009-07-01 |
2023-08-12 |
Not clear |
| Hai-tao Zhang, Zhe-ling Feng, Jun Wu, Ya-jun Wang, Xia Guo, Nian-ci Liang, Zhen-yu Zhu, Jian-quan M. Sodium butyrate-induced death-associated protein kinase expression promote Raji cell morphological change and apoptosis by reducing FAK protein levels. Acta pharmacologica Sinica. vol 28. issue 11. 2009-05-12. PMID:17959029. |
sodium butyrate-induced death-associated protein kinase expression promote raji cell morphological change and apoptosis by reducing fak protein levels. |
2009-05-12 |
2023-08-12 |
Not clear |
| Zeenat S Hakim, Laura A DiMichele, Mauricio Rojas, Dane Meredith, Christopher P Mack, Joan M Taylo. FAK regulates cardiomyocyte survival following ischemia/reperfusion. Journal of molecular and cellular cardiology. vol 46. issue 2. 2009-05-05. PMID:19028502. |
in the present study, we sought to determine if fak functions to limit stress-induced cardiomyocyte apoptosis. |
2009-05-05 |
2023-08-12 |
Not clear |
| Zeenat S Hakim, Laura A DiMichele, Mauricio Rojas, Dane Meredith, Christopher P Mack, Joan M Taylo. FAK regulates cardiomyocyte survival following ischemia/reperfusion. Journal of molecular and cellular cardiology. vol 46. issue 2. 2009-05-05. PMID:19028502. |
moreover, deletion of fak in the adult myocardium resulted in significant increases in i/r-induced infarct size and cardiomyocyte apoptosis with a concomitant reduction in left ventricular function. |
2009-05-05 |
2023-08-12 |
Not clear |
| Takayuki Noda, Soichi Iwai, Masakazu Hamada, Yusei Fujita, Yoshiaki Yur. Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G. Apoptosis : an international journal on programmed cell death. vol 14. issue 3. 2009-04-10. PMID:19199036. |
these results suggest that bim, bcl-xl, fak and endonuclease g are involved in safingol-induced apoptosis of detached oral scc cells. |
2009-04-10 |
2023-08-12 |
human |
| Mary F Walsh, Dinakar R Ampasala, Arun K Rishi, Marc D Basso. TGF-beta1 modulates focal adhesion kinase expression in rat intestinal epithelial IEC-6 cells via stimulatory and inhibitory Smad binding elements. Biochimica et biophysica acta. vol 1789. issue 2. 2009-03-31. PMID:19059368. |
tgf-beta and fak modulate cell migration, differentiation, proliferation and apoptosis, and tgf-beta promotes fak transcription in intestinal epithelial cells via smad-dependent and independent pathways. |
2009-03-31 |
2023-08-12 |
rat |
| Vered Shani, Yael Bromberg, Oded Sperling, Esther Zoref-Shan. Involvement of Src tyrosine kinases (SFKs) and of focal adhesion kinase (FAK) in the injurious mechanism in rat primary neuronal cultures exposed to chemical ischemia. Journal of molecular neuroscience : MN. vol 37. issue 1. 2009-03-23. PMID:18584337. |
the inhibition of sfks and fak is probably the cause of the disassembling of sfks-fak complexes, a process known to be associated with apoptosis. |
2009-03-23 |
2023-08-12 |
rat |
| Kazufumi Sakurama, Kazuhiro Noma, Munenori Takaoka, Yasuko Tomono, Nobuyuki Watanabe, Shinji Hatakeyama, Osamu Ohmori, Seiichi Hirota, Takayuki Motoki, Yasuhiro Shirakawa, Tomoki Yamatsuji, Minoru Haisa, Junji Matsuoka, Noriaki Tanaka, Yoshio Naomot. Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor. Molecular cancer therapeutics. vol 8. issue 1. 2009-02-19. PMID:19139121. |
when fak activity in those cells was inhibited by tae226, cell growth was equally suppressed and the cells underwent apoptosis regardless of the c-kit mutation types. |
2009-02-19 |
2023-08-12 |
mouse |
| Sylvie Garneau-Tsodikova, Victor J Thannicka. Protein kinase inhibitors in the treatment of pulmonary fibrosis. Current medicinal chemistry. vol 15. issue 25. 2008-12-18. PMID:18855683. |
the acquired resistance to apoptosis in myofibroblasts is mediated, at least in part, by the sustained activation of two critical pro-survival protein kinases, focal adhesion kinase (fak) and protein kinase b (pkb/akt). |
2008-12-18 |
2023-08-12 |
Not clear |
| Ssang-Taek Lim, David Mikolon, Dwayne G Stupack, David D Schlaepfe. FERM control of FAK function: implications for cancer therapy. Cell cycle (Georgetown, Tex.). vol 7. issue 15. 2008-11-24. PMID:18677107. |
as genetic inactivation of beta1 integrin or fak yield early embryonic lethal phenotypes associated with decreased cell proliferation, and dominant-negative inhibition of fak can cause increased cell apoptosis, there is a concern that fak inhibition may have cytotoxic effects on cell growth or survival. |
2008-11-24 |
2023-08-12 |
human |
| Mary F Walsh, Dinakar R Ampasala, James Hatfield, Richard Vander Heide, Silke Suer, Arun K Rishi, Marc D Basso. Transforming growth factor-beta stimulates intestinal epithelial focal adhesion kinase synthesis via Smad- and p38-dependent mechanisms. The American journal of pathology. vol 173. issue 2. 2008-09-24. PMID:18583311. |
focal adhesion kinase (fak) regulates cell migration, proliferation, and apoptosis. |
2008-09-24 |
2023-08-12 |
human |
| N E Joo, T Watanabe, C Chen, M Chekenya, W B Stallcup, Y L Kapil. NG2, a novel proapoptotic receptor, opposes integrin alpha4 to mediate anoikis through PKCalpha-dependent suppression of FAK phosphorylation. Cell death and differentiation. vol 15. issue 5. 2008-09-18. PMID:18292781. |
ng2 overexpression alone induced apoptosis and, by reducing fak phosphorylation, increased anoikis induced by an altered matrix. |
2008-09-18 |
2023-08-12 |
human |
| Jang-Chang Lee, Chih-Yen Tsai, Jung-Yie Kao, Ming-Ching Kao, Shih-Chang Tsai, Chih-Shiang Chang, Li-Jiau Huang, Sheng-Chu Kuo, Jen-Kun Lin, Tzong-Der Wa. Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells. Molecular nutrition & food research. vol 52. issue 6. 2008-08-20. PMID:18435487. |
to clarify the relationship between focal adhesion kinase (fak) and geraniin-induced apoptosis, we treated human melanoma cells with geraniin and found that this resulted dose- and time-dependent degradation in fak. |
2008-08-20 |
2023-08-12 |
human |